Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

t(11;14)(q11;q32)

Written2017-11Adriana Zamecnikova
Kuwait Cancer Control Center, Kuwait annaadria@yahoo.com

Abstract Review on t(11;14)(q11;q32), with data on clinics, and the genes involved.

Keywords Immunoglobulin translocations, B-cell lymphoproliferative malignancies, multiple myeloma, gene overexpression

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424
ICD-Morpho 9823/3 Chronic lymphocytic leukaemia /small lymphocytic lymphoma
ICD-Morpho 9733/3
ICD-Morpho 9673/3 Mantle cell lymphoma
ICD-Morpho 9732/3 Plasma cell myeloma / Multiple myeloma
Atlas_Id 1806

Clinics and Pathology

Disease B-cell lymphoid malignancies and multiple myeloma.
Etiology B-cell lymphoid malignancies in 5: 3 chronic lymphocytic leukemia (CLL) (Schroder et al., 1981; Weisenburger et al., 1987; Bird et al., 1989), 1 plasma cell leukemia (PCL) (Ueshima et al., 1983), 1 mantle cell lymphoma (MCL) (Espinet et al., 1999) and 2 multiple myeloma (MM) patients (Sawyer et al., 1995; Gozzetti et al., 2011).
Epidemiology 2 males and 5 females aged 45 to 78 years, median 63 years.
Prognosis Chromosome 14q32 translocations that are part of complex karyotypes are associated with an adverse prognosis in B-cell malignancies.

Cytogenetics

Note The breakpoint on chromosome 11 is 11q13 in the most common t(11;14)(q13;32), therefore some of the translocations described as t(11;14)(q11;q32) in early reports may involve 11q13 breakpoint.
Additional anomalies Found in association with highly complex karyotypes, thus it is unclear if t(11;14)(q11;q32) was a primary aberration in these patients or it appeared as a secondary change during karyotypic progression.

Genes involved and Proteins

Gene NameIGH (Immunoglobulin Heavy Locus)
Location 14q32.33
Note IGH translocations relocate genes near active regulatory sequences of the partner gene, resulting in their overexpression.

Result of the chromosomal anomaly

Fusion Protein
Oncogenesis Translocations involving chromosome 14 at band q32, at the site of the immunoglobulin heavy chain (IGH) locus have been described in a spectrum of B-cell malignancies. In these translocations, various partner chromosomes have been described, including chromosome 11, of which the t(11;14)(q13;q32) that leads to the overexpression of the CCND1 gene is the most common. Chromosome translocations involving centromeric 11q breakpoints are less frequent and have been described only in sporadic cases of B-cell lymphoid malignancies and multiple myeloma. Although the mechanism of neoplastic transformation remains unknown, deregulation of the translocated partner gene as a consequence of its transposition into the IGH locus may represent a mechanism of oncogene activation.
  

To be noted

Additional cases are needed to delineate the epidemiology of this rare entity:
you are welcome to submit a paper to our new Case Report section.

Bibliography

Chromosome abnormalities in B cell chronic lymphocytic leukemia and their clinical correlations
Bird ML, Ueshima Y, Rowley JD, Haren JM, Vardiman JW
Leukemia 1989 Mar;3(3):182-91
PMID 2918755
 
Translocation (11;14)(q13;q32) and preferential involvement of chromosomes 1, 2, 9, 13, and 17 in mantle cell lymphoma
Espinet B, Solé F, Woessner S, Bosch F, Florensa L, Campo E, Costa D, Lloveras E, Vilà RM, Besses C, Montserrat E, Sans-Sabrafen J
Cancer Genet Cytogenet 1999 May;111(1):92-8
PMID 10326598
 
A central nervous system CD56 positive multiple myeloma patient with a t(11;14) (q11;q32): a case report
Gozzetti A, Cerase A, Crupi R, Raspadori D, Defina M, Bocchia M, Lauria F
Leuk Res 2011 Nov;35(11):e206-8
PMID 21767877
 
Cytogenetic findings in 200 patients with multiple myeloma
Sawyer JR, Waldron JA, Jagannath S, Barlogie B
Cancer Genet Cytogenet 1995 Jul 1;82(1):41-9
PMID 7627933
 
Chromosome changes in human chronic lymphocytic leukemia
Schröder J, Vuopio P, Autio K
Cancer Genet Cytogenet 1981 Aug;4(1):11-21
PMID 6974590
 
Cytogenetic studies and clinical aspects of patients with plasma cell leukemia and leukemic macroglobulinemia
Ueshima Y, Fukuhara S, Nagai K, Takatsuki K, Uchino H
Cancer Res 1983 Feb;43(2):905-12
PMID 6401225
 
Intermediate lymphocytic lymphoma: immunophenotypic and cytogenetic findings
Weisenburger DD, Sanger WG, Armitage JO, Purtilo DT
Blood 1987 Jun;69(6):1617-21
PMID 3555648
 

Citation

This paper should be referenced as such :
Zamecnikova A
t(11;14)(q11;q32);
Atlas Genet Cytogenet Oncol Haematol. in press
On line version : http://AtlasGeneticsOncology.org/Anomalies/t1114q11q32ID1806.html


Translocations implicated (Data extracted from papers in the Atlas)

 t(11;14)(q11;q32) ?/IGH

External links

Mitelman databaset(11;14)(q11;q32) [Case List]    t(11;14)(q11;q32) [Transloc-MCList] ?/IGH [Fusion-MCList]
arrayMap (UZH-SIB Zurich)Morph ( 9823/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)Morph ( 9733/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)Morph ( 9673/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)Morph ( 9732/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon May 14 13:40:40 CEST 2018


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.