| Clinics and Pathology |
| Disease | M5 acute non lymphocytic leukemia (ANLL) |
| Clinics | poorly known: one case, a 39 year old man with 47,XY,+5,t(11;17)(q23;q12) |
| Genes involved and Proteins |
| Gene Name | MLL |
| Location | 11q23 |
| Dna / Rna | 21 exons, spanning over 100 kb; 13-15 kb mRNA |
| Protein | 431 kDa; contains two DNA binding motifs (a AT hook, and Zinc fingers), a DNA methyl transferase motif, a bromodomain; transcriptional regulatory factor; nuclear localisation |
| Gene Name | RARa |
| Location | 17q12-21 |
| Protein | wide expression; nuclear receptor; binds specific DNA sequences: HRE (hormone response elements); ligand and dimerization domain; role in growth and differentiation |
| External links |
| Other database | t(11;17)(q23;q12) MLL/RARa | Mitelman database (CGAP - NCBI) | |
| Other database | t(11;17)(q23;q12) MLL/RARa | CancerChromosomes (NCBI) |
| To be noted |
| Additional cases are needed to delineate the epidemiology of this rare entity: you are welcome to submit a paper to our new Case Report section. |
| Bibliography |
| Involvement of the MLL and RARalpha genes in a patient with acute monocytic leukemia with t(11;17)(q23;q12) |
| Shekhter-Levin S, Gollin SM, Kaplan SS, Redner RL |
| Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 2000 ; 14 (3) : 520-522. |
| PMID 10720155 |
| Contributor(s) |
| Written | 06-2000 | Jean-Loup Huret |
| Citation |
| This paper should be referenced as such : |
| Huret JL . t(11;17)(q23;q12) MLL/RARa. Atlas Genet Cytogenet Oncol Haematol. June 2000 . URL : http://AtlasGeneticsOncology.org/Anomalies/t1117ID1179.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon May 12 18:13:01 2008 |
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