| ICD-Topo |
C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS |
| ICD-Morpho |
9807/3 Mixed phenotype acute leukaemia with t(v;11q23); MLL rearranged
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| ICD-Morpho |
9813/3 B lymphoblastic leukaemia/lymphoma with t(v;11q23); MLL rearranged
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| ICD-Morpho |
9861/3 AML with mutated NPM1; AML with mutated CEBPA; Acute myeloid leukaemia, NOS
|
| Atlas_Id |
1027 |
| Note |
not to be confused with the t(11;17)(q23;q12-21) involving MLL and LASP1 or the t(11;17)(q23;q12-21) involving MLL and ACACA |
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t(11;17)(q23;q12) G-banding - Courtesy Cytogenetics Laboratory of the CCRI, Children's Cancer Research Institute, Vienna. |
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| Gene Name | MLLT6 (myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6) |
| Location | 17q12 |
| Note | previously LASP1 and AF17 (alias MLLT6) were mapped to 17q21, but according to the most recent genome assembly built by the Genome Bioinformatics Group of the University of California Santa Cruz and recent FISH data both genes are localized in 17q12 and proximal to RARA |
| Dna / Rna | encompasses 19.97 kb of genomic DNA; 4914 bp mRNA; 20 exons, 3282 bp coding sequence |
| Protein | 1023 amino acids, 112 kDa; MLLT6 (alias AF17), MLLT10 (alias AF10), and BRPF1 (alias BR140) belong to a small evolutionary highly conserved family of putative nuclear transcription factors, which contain amino-terminal PHD fingers, a highly conserved octapeptide, and a classical leucine zipper dimerization motif; nuclear localization |
| A diagnostic biochip for the comprehensive analysis of MLL translocations in acute leukemia. |
| Maroc N, Morel A, Beillard E, De La Chapelle AL, Fund X, Mozziconacci MJ, Dupont M, Cayuela JM, Gabert J, Koki A, Fert V, Hermitte F |
| Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 2004 ; 18 (9) : 1522-1530. |
| PMID 15322560 |
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| Acute myelocytic leukemia with t(11;17)(q23;q12-q21) involves a fusion of MLL and AF17. |
| Moore SD, Strehl S, Dal Cin P |
| Cancer genetics and cytogenetics. 2005 ; 157 (1) : 87-89. |
| PMID 15676155 |
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| Leucine-zipper dimerization motif encoded by the AF17 gene fused to ALL-1 (MLL) in acute leukemia. |
| Prasad R, Leshkowitz D, Gu Y, Alder H, Nakamura T, Saito H, Huebner K, Berger R, Croce CM, Canaani E |
| Proceedings of the National Academy of Sciences of the United States of America. 1994 ; 91 (17) : 8107-8111. |
| PMID 8058765 |
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| AML with 11q23/MLL abnormalities as defined by the WHO classification: incidence, partner chromosomes, FAB subtype, age distribution, and prognostic impact in an unselected series of 1897 cytogenetically analyzed AML cases. |
| Schoch C, Schnittger S, Klaus M, Kern W, Hiddemann W, Haferlach T |
| Blood. 2003 ; 102 (7) : 2395-2402. |
| PMID 12805060 |
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