Atlas of Genetics and Cytogenetics in Oncology and Haematology
t(11;18)(q21;q21)
| Identity |
 | |
| t(11;18)(q21;q21) G-banding - Courtesy Charles Bangs | |
| Clinics and Pathology |
| Disease | B-cell non Hodgkin lymphoma (NHL), marginal zone B-cell lymphoma of Mucosa-Associated Lymphoid Tissue ( |
| Phenotype / cell stem origin | Marginal zone B-cells |
| Epidemiology | found in extranodal MZBCL or MALT-type (50 %), absent in splenic and nodal MZBCL |
| Prognosis | For gastric MALT-type lymphomas, t(11;18) is a clonal marker for resistance to Helicobacter pylori eradication therapy and antigen independent growth |
| Cytogenetics |
 | |
| t(11;18) FISH - Baens Mathijs, Peter Marynen | |
| Genes involved and Proteins |
| Gene Name | BIRC3 |
| Location | 11q21 |
| Protein | 68 kDa; 604 amino acids. Member of the Œinhibitor of apoptosis' (IAP) protein family. |
| Gene Name | MALT1 |
| Location | 18q21 |
| Protein | 92 kDa; 824 amino acids |
| Result of the chromosomal anomaly |
| Description | 5' API2 on chromosome 11q21 translocated on chromosome 18 in frame with 3' MALT1. Deletions often exclude the expression of the reciprocal 5' MLT API2 3' transcript. |
 | |
| BIRC3/MALT1 fusion protein - Baens Mathijs, Peter Marynen | |
| Description | N- term API2-MLT C-term fusion protein; All MALT-type lymphomas reported with a t(11;18) express an Œin frame' API2-MLT fusion protein with consistently the three BIR domains of API2 fused to the caspace p20 domain and VDJ4-like domain of MLT. |
| External links |
| Other database | t(11;18)(q21;q21) | Mitelman database (CGAP - NCBI) | |
| Other database | t(11;18)(q21;q21) | CancerChromosomes (NCBI) |
| Bibliography |
| A novel gene, MALT1 at 18q21, is involved in t(11;18) (q21;q21) found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue. |
| Akagi T, Motegi M, Tamura A, Suzuki R, Hosokawa Y, Suzuki H, Ota H, Nakamura S, Morishima Y, Taniwaki M, Seto M |
| Oncogene. 1999 ; 18 (42) : 5785-5794. |
| PMID 10523859 |
| The apoptosis inhibitor gene API2 and a novel 18q gene, MLT, are recurrently rearranged in the t(11;18)(q21;q21) associated with mucosa-associated lymphoid tissue lymphomas. |
| Dierlamm J, Baens M, Wlodarska I, Stefanova-Ouzounova M, Hernandez JM, Hossfeld DK, De Wolf-Peeters C, Hagemeijer A, Van den Berghe H, Marynen P |
| Blood. 1999 ; 93 (11) : 3601-3609. |
| PMID 10339464 |
| The product of the t(11;18), an API2-MLT fusion, marks nearly half of gastric MALT type lymphomas without large cell proliferation. |
| Baens M, Maes B, Steyls A, Geboes K, Marynen P, De Wolf-Peeters C |
| The American journal of pathology. 2000 ; 156 (4) : 1433-1439. |
| PMID 10751367 |
| The product of the t(11;18), an API2-MLT fusion, is an almost exclusive finding in marginal zone cell lymphoma of extranodal MALT-type. |
| Maes B, Baens M, Marynen P, De Wolf-Peeters C |
| Annals of oncology : official journal of the European Society for Medical Oncology / ESMO. 2000 ; 11 (5) : 521-526. |
| PMID 10907943 |
| Detection of t(11;18)(q21;q21) by interphase fluorescence in situ hybridization using API2 and MLT specific probes. |
| Dierlamm J, Baens M, Stefanova-Ouzounova M, Hinz K, Wlodarska I, Maes B, Steyls A, Driessen A, Verhoef G, Gaulard P, Hagemeijer A, Hossfeld DK, De Wolf-Peeters C, Marynen P |
| Blood. 2000 ; 96 (6) : 2215-2218. |
| PMID 10979968 |
| Structure of the MLT gene and molecular characterization of the genomic breakpoint junctions in the t(11;18)(q21;q21) of marginal zone B-cell lymphomas of MALT type. |
| Baens M, Steyls A, Dierlamm J, De Wolf-Peeters C, Marynen P |
| Genes, chromosomes & cancer. 2000 ; 29 (4) : 281-291. |
| PMID 11066071 |
| Contributor(s) |
| Written | 09-2001 | Baens Mathijs, Peter Marynen |
| Citation |
| This paper should be referenced as such : |
| Mathijs B, Marynen P . t(11;18)(q21;q21). Atlas Genet Cytogenet Oncol Haematol. Septem
ber 2001 . URL : http://AtlasGeneticsOncology.org/Anomalies/t1118ID2022.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Sat Jul 3 11:54:26 CEST 2010 |
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