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t(11;18)(q21;q21) BIRC3/MALT1

Written2001-09Mathijs Baens, Peter Marynen
Center for Human Genetics, Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, Catholic University of Leuven, Leuven, Belgium

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 2022
 
  t(11;18)(q21;q21) G-banding - Courtesy Charles Bangs

Clinics and Pathology

Disease B-cell non Hodgkin lymphoma (NHL), marginal zone B-cell lymphoma of Mucosa-Associated Lymphoid Tissue ( ) -type
Phenotype / cell stem origin Marginal zone B-cells
Epidemiology found in extranodal MZBCL or MALT-type (50 %), absent in splenic and nodal MZBCL
Prognosis For gastric MALT-type lymphomas, t(11;18) is a clonal marker for resistance to Helicobacter pylori eradication therapy and antigen independent growth

Cytogenetics

 
  t(11;18) FISH - Baens Mathijs, Peter Marynen

Genes involved and Proteins

Gene Name BIRC3
Location 11q21
Protein 68 kDa; 604 amino acids. Member of the 'inhibitor of apoptosis' (IAP) protein family.
Gene Name MALT1
Location 18q21
Protein 92 kDa; 824 amino acids

Result of the chromosomal anomaly

Hybrid gene
Description 5' API2 on chromosome 11q21 translocated on chromosome 18 in frame with 3' MALT1. Deletions often exclude the expression of the reciprocal 5' MLT ­ API2 3' transcript.
  
Fusion Protein
 
Description N- term API2-MLT C-term fusion protein; All MALT-type lymphomas reported with a t(11;18) express an 'in frame' API2-MLT fusion protein with consistently the three BIR domains of API2 fused to the caspace p20 domain and VDJ4-like domain of MLT.
  

Bibliography

A novel gene, MALT1 at 18q21, is involved in t(11;18) (q21;q21) found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue.
Akagi T, Motegi M, Tamura A, Suzuki R, Hosokawa Y, Suzuki H, Ota H, Nakamura S, Morishima Y, Taniwaki M, Seto M
Oncogene. 1999 ; 18 (42) : 5785-5794.
PMID 10523859
 
The product of the t(11;18), an API2-MLT fusion, marks nearly half of gastric MALT type lymphomas without large cell proliferation.
Baens M, Maes B, Steyls A, Geboes K, Marynen P, De Wolf-Peeters C
The American journal of pathology. 2000 ; 156 (4) : 1433-1439.
PMID 10751367
 
Structure of the MLT gene and molecular characterization of the genomic breakpoint junctions in the t(11;18)(q21;q21) of marginal zone B-cell lymphomas of MALT type.
Baens M, Steyls A, Dierlamm J, De Wolf-Peeters C, Marynen P
Genes, chromosomes & cancer. 2000 ; 29 (4) : 281-291.
PMID 11066071
 
Detection of t(11;18)(q21;q21) by interphase fluorescence in situ hybridization using API2 and MLT specific probes.
Dierlamm J, Baens M, Stefanova-Ouzounova M, Hinz K, Wlodarska I, Maes B, Steyls A, Driessen A, Verhoef G, Gaulard P, Hagemeijer A, Hossfeld DK, De Wolf-Peeters C, Marynen P
Blood. 2000 ; 96 (6) : 2215-2218.
PMID 10979968
 
The product of the t(11;18), an API2-MLT fusion, is an almost exclusive finding in marginal zone cell lymphoma of extranodal MALT-type.
Maes B, Baens M, Marynen P, De Wolf-Peeters C
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO. 2000 ; 11 (5) : 521-526.
PMID 10907943
 

Citation

This paper should be referenced as such :
Baens, M; Marynen, P
t(11;18)(q21;q21)
Atlas Genet Cytogenet Oncol Haematol. 2002;6(1):34-36.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Anomalies/t1118ID2022.html


Other genes implicated (Data extracted from papers in the Atlas) [ 3 ]

Genes BIRC3 MALT1

Translocations implicated (Data extracted from papers in the Atlas)

 t(11;18)(q21;q21) BIRC3/MALT1

External links

arrayMap (UZH-SIB Zurich)BIRC3 (11q22.2) MALT1 (18q21.32)

BIRC3 (11q22.2) MALT1 (18q21.32)

BIRC3 (11q22.2) MALT1 (18q21.32)

Mitelman databaset(11;18)(q21;q21) [Case List]    t(11;18)(q21;q21) [Association List] Mitelman database (CGAP - NCBI)
arrayMap[select an item]
 
Mitelman databaseBIRC3/MALT1 [MCList]  BIRC3 (11q22.2) MALT1 (18q21.32)
Mitelman databaseBIRC3/MALT1 [MCList]  BIRC3 (11q22.2) MALT1 (18q21.32)
TICdbBIRC3/MALT1  BIRC3 (11q22.2) MALT1 (18q21.32)
 
Disease databaset(11;18)(q21;q21) BIRC3/MALT1
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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