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t(11;18)(q21;q21) BIRC3::MALT1

Written2001-09Mathijs Baens, Peter Marynen
Center for Human Genetics, Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, Catholic University of Leuven, Leuven, Belgium

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Atlas_Id 2022
  t(11;18)(q21;q21) BIRC3/MALT1 Diagram and G-banding - Courtesy Charles Bangs; R-banded karyotype - Courtesy Karolien Beel, Peter Meeus, Geneviève Ameye and Lucienne Michaux

Clinics and Pathology

Disease B-cell non Hodgkin lymphoma (NHL), marginal zone B-cell lymphoma of Mucosa-Associated Lymphoid Tissue ( ) -type
Phenotype / cell stem origin Marginal zone B-cells
Epidemiology found in extranodal MZBCL or MALT-type (50 %), absent in splenic and nodal MZBCL
Prognosis For gastric MALT-type lymphomas, t(11;18) is a clonal marker for resistance to Helicobacter pylori eradication therapy and antigen independent growth


  t(11;18) FISH - Baens Mathijs, Peter Marynen

Genes involved and Proteins

Gene NameBIRC3 (baculoviral IAP repeat-containing 3)
Location 11q22.2
Protein 68 kDa; 604 amino acids. Member of the 'inhibitor of apoptosis' (IAP) protein family.
Gene NameMALT1 (mucosa associated lymphoid tissue lymphoma translocation gene 1)
Location 18q21.32
Protein 92 kDa; 824 amino acids

Result of the chromosomal anomaly

Hybrid gene
Description 5' API2 on chromosome 11q21 translocated on chromosome 18 in frame with 3' MALT1. Deletions often exclude the expression of the reciprocal 5' MLT ­ API2 3' transcript.
Fusion Protein
Description N- term API2-MLT C-term fusion protein; All MALT-type lymphomas reported with a t(11;18) express an 'in frame' API2-MLT fusion protein with consistently the three BIR domains of API2 fused to the caspace p20 domain and VDJ4-like domain of MLT.


A novel gene, MALT1 at 18q21, is involved in t(11;18) (q21;q21) found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue.
Akagi T, Motegi M, Tamura A, Suzuki R, Hosokawa Y, Suzuki H, Ota H, Nakamura S, Morishima Y, Taniwaki M, Seto M
Oncogene. 1999 ; 18 (42) : 5785-5794.
PMID 10523859
The product of the t(11;18), an API2-MLT fusion, marks nearly half of gastric MALT type lymphomas without large cell proliferation.
Baens M, Maes B, Steyls A, Geboes K, Marynen P, De Wolf-Peeters C
The American journal of pathology. 2000 ; 156 (4) : 1433-1439.
PMID 10751367
Structure of the MLT gene and molecular characterization of the genomic breakpoint junctions in the t(11;18)(q21;q21) of marginal zone B-cell lymphomas of MALT type.
Baens M, Steyls A, Dierlamm J, De Wolf-Peeters C, Marynen P
Genes, chromosomes & cancer. 2000 ; 29 (4) : 281-291.
PMID 11066071
Detection of t(11;18)(q21;q21) by interphase fluorescence in situ hybridization using API2 and MLT specific probes.
Dierlamm J, Baens M, Stefanova-Ouzounova M, Hinz K, Wlodarska I, Maes B, Steyls A, Driessen A, Verhoef G, Gaulard P, Hagemeijer A, Hossfeld DK, De Wolf-Peeters C, Marynen P
Blood. 2000 ; 96 (6) : 2215-2218.
PMID 10979968
The product of the t(11;18), an API2-MLT fusion, is an almost exclusive finding in marginal zone cell lymphoma of extranodal MALT-type.
Maes B, Baens M, Marynen P, De Wolf-Peeters C
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO. 2000 ; 11 (5) : 521-526.
PMID 10907943


This paper should be referenced as such :
Baens, M; Marynen, P
Atlas Genet Cytogenet Oncol Haematol. 2002;6(1):34-36.
Free journal version : [ pdf ]   [ DOI ]
On line version :

Other genes implicated (Data extracted from papers in the Atlas) [ 3 ]


Translocations implicated (Data extracted from papers in the Atlas)

 t(11;18)(q21;q21) BIRC3/MALT1

External links

BIRC3 (11q22.2) MALT1 (18q21.32)

BIRC3 (11q22.2) MALT1 (18q21.32)

BIRC3 (11q22.2) MALT1 (18q21.32)

Mitelman databaset(11;18)(q21;q21)
arrayMap (UZH-SIB Zurich)[select an item]
Mitelman databaseBIRC3::MALT1 [MCList]  BIRC3 (11q22.2) MALT1 (18q21.32)
Mitelman databaseBIRC3::MALT1 [MCList]  BIRC3 (11q22.2) MALT1 (18q21.32)
REVIEW articlesautomatic search in PubMed
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indexed on : Fri Oct 8 16:37:17 CEST 2021

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