Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

t(11;19)(q13;p13) FSTL3::CCND1

Written2015-02Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Abstract Review on t(11;19)(q13;p13) FSTL3/CCND1, with data on clinics, and the genes involved.

Keywords t(11;19)(q13;p13); FSTL3; CCND1; chronic lymphocytic leukemia

(Note : for Links provided by Atlas : click)


Atlas_Id 1527

Clinics and Pathology

Disease B-cell chronic lymphocytic leukemia (B-CLL)
Epidemiology Only one case to date, a 67 year-old female patient (Rimokh et al., 1993; Hayette et al., 1998).
Prognosis No data


Cytogenetics Morphological Complex karyotype.

Genes involved and Proteins

Gene NameCCND1 (B-cell leukemia/lymphoma 1)
Location 11q13.3
Protein Binds and activates the G1 cyclin dependent kinases; Phosphorylates SMAD3 and inhibits its transcriptional activity and antiproliferative function.
Gene NameFSTL3 (follistatin-like 3 (secreted glycoprotein))
Location 19p13.3
Protein Binds activin A and with lower affinity several other members of the TGF beta family; interacts with ADAM12, FN1 (fibronectin type 1,), and MLLT10 (Grusch, 2012).

Result of the chromosomal anomaly

Hybrid gene
Description The breaks occurred at nucleotide 2276 in the 3' untranslated region of the last CCND1 exon, and about 7 kbp upstream of FSTL3.

To be noted

Additional cases are needed to delineate the epidemiology of this rare entity:
you are welcome to submit a paper to our new Case Report section.


FSTL3 (follistatin-like 3 (secreted glycoprotein))
Grusch, M
Atlas Genet Cytogenet Oncol Haematol. 2013;17(3):151-154.
FLRG (follistatin-related gene), a new target of chromosomal rearrangement in malignant blood disorders.
Hayette S, Gadoux M, Martel S, Bertrand S, Tigaud I, Magaud JP, Rimokh R.
Oncogene. 1998 Jun 4;16(22):2949-54.
PMID 9671416
Rearrangement and overexpression of the BCL-1/PRAD-1 gene in intermediate lymphocytic lymphomas and in t(11q13)-bearing leukemias.
Rimokh R, Berger F, Delsol G, Charrin C, Berthéas MF, Ffrench M, Garoscio M, Felman P, Coiffier B, Bryon PA, et al.
Blood. 1993 Jun 1;81(11):3063-7.
PMID 8499640


This paper should be referenced as such :
Jean-Loup Huret
t(11;19)(q13;p13) FSTL3/CCND1
Atlas Genet Cytogenet Oncol Haematol. 2016;20(3):-.
Free journal version : [ pdf ]   [ DOI ]
On line version :

Other genes implicated (Data extracted from papers in the Atlas) [ 2 ]


Translocations implicated (Data extracted from papers in the Atlas)

 t(11;19)(q13;p13) FSTL3/CCND1

External links

FSTL3 (19p13.3) CCND1 (11q13.3)

FSTL3 (19p13.3) CCND1 (11q13.3)

Mitelman databaset(11;19)(q13;p13)
arrayMap (UZH-SIB Zurich)[select an item]
Mitelman databaseFSTL3::CCND1 [MCList]  FSTL3 (19p13.3) CCND1 (11q13.3)
Mitelman databaseFSTL3::CCND1 [MCList]  FSTL3 (19p13.3) CCND1 (11q13.3)
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Oct 8 16:37:18 CEST 2021

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us