| Identity |
| Note | not to be confused with the t(11;22)(q23;q11), involving MLL and hCDCrel |
| Clinics and Pathology |
| Disease | a case of therapy related leukemia, 2.5 yrs after the treatment of a non Hodgkin lymphoma |
| Phenotype / cell stem origin | acute non lymphocytic leukemia |
| Prognosis | unknown (relapse at 20 mths) but likely to be similar to the prognosis associated with other 11q23 therapy related leukemia |
| Genes involved and Proteins |
| Gene Name | MLL |
| Location | in 11q23 |
| Dna / Rna | 13-15 kb mRNA |
| Protein | 431 kDa; contains two DNA binding motifs (a AT hook, and Zinc fingers), a DNA methyl transferase motif, a bromodomain; transcriptional regulatory factor; nuclear localisation |
| Gene Name | P300 |
| Location | 22q13 |
| Dna / Rna | 9 kb mRNA |
| Protein | 264 kDa; widely expressed; possesses a nuclear localization signal, a poly-serine, a bromodomain, a poly-glu, a binding region for E1A adenovirus, and a poly-gln;. interact with transcriptional activators as well as repressors; involved (with CBP) in growth, differentiation , and apoptosis |
| Result of the chromosomal anomaly |
| Transcript | chimeric mRNAs from both derivative chromosomes are found |
| Description | the MLL/p300 fusion transcript encodes a protein of about 3000 amino acids, the N-term half comprising the AT hook and DNA methyltransferase (exons 1 to 9) from MLL and the C-term half comprising the acetyltransferase domain and the TFIIB-binding domain of p300, excluding the nuclear localisation signal and the bromodomain |
| External links |
| Other database | t(11;22)(q23;q13) | Mitelman database (CGAP - NCBI) | |
| Other database | t(11;22)(q23;q13) | CancerChromosomes (NCBI) |
| To be noted |
| Additional cases are needed to delineate the epidemiology of this rare entity: you are welcome to submit a paper to our new Case Report section. |
| Bibliography |
| Adenoviral E1A-associated protein p300 is involved in acute myeloid leukemia with t(11;22)(q23;q13). |
| Ida K, Kitabayashi I, Taki T, Taniwaki M, Noro K, Yamamoto M, Ohki M, Hayashi Y |
| Blood. 1997 ; 90 (12) : 4699-4704. |
| PMID 9389684 |
| Contributor(s) |
| Written | 01-2000 | Jean-Loup Huret |
| Citation |
| This paper should be referenced as such : |
| Huret JL . t(11;22)(q23;q13). Atlas Genet Cytogenet Oncol Haematol. January 2000 . URL : http://AtlasGeneticsOncology.org/Genes/t1122P300ID1121.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Sat Dec 6 18:03:22 2008 |
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