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t(1;2)(p22;p12) IGK/BCL10

t(1;14)(p22;q32) IGH/BCL10

Written2001-01Antonio Cuneo, Gianluigi Castoldi
Hematology Section, Department of Biomedical Sciences, University of Ferrara, Corso Giovecca 203, Ferrara, Italy

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 2044

Clinics and Pathology

Disease the translocation is cytogenetically detectable in a minority of extranodal MALT lymphomas; irrespective of the presence of the 1;14 translocation, mutation or deletion of the BCL10 gene located at 1p22 can be detected by molecular genetic methods in 5-10% of extra-nodal MALT lymphomas, follicle centre cell lymphoma and diffuse large B-cell lymphoma; among MALT lymphoma a preferential association was noted with high-grade histology
Prognosis in MALT lymphoma there may be an association with aggressive histology and antibiotic-unresponsive forms

Cytogenetics

Cytogenetics Morphological the translocation is readily detectable by conventional karyotyping

Genes involved and Proteins

Note the breakpoints on chromosome 1p22 are located upstream of the promoter of the BCL10 gene, which shows inactivating mutations or deletions
Gene Name BCL10
Location 1p22
Protein 322 amino acids; contains a caspase recruitment domain; role in the apoptosis
Gene Name IGH
Location 14q32

Bibliography

BCL10 gene mutation in lymphoma.
Du MQ, Peng H, Liu H, Hamoudi RA, Diss TC, Willis TG, Ye H, Dogan A, Wotherspoon AC, Dyer MJ, Isaacson PG
Blood. 2000 ; 95 (12) : 3885-3890.
PMID 10845924
 
Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types.
Willis TG, Jadayel DM, Du MQ, Peng H, Perry AR, Abdul-Rauf M, Price H, Karran L, Majekodunmi O, Wlodarska I, Pan L, Crook T, Hamoudi R, Isaacson PG, Dyer MJ
Cell. 1999 ; 96 (1) : 35-45.
PMID 9989495
 
Cytogenetic study of B-cell lymphoma of mucosa-associated lymphoid tissue.
Wotherspoon AC, Pan LX, Diss TC, Isaacson PG
Cancer genetics and cytogenetics. 1992 ; 58 (1) : 35-38.
PMID 1728948
 
Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32).
Zhang Q, Siebert R, Yan M, Hinzmann B, Cui X, Xue L, Rakestraw KM, Naeve CW, Beckmann G, Weisenburger DD, Sanger WG, Nowotny H, Vesely M, Callet-Bauchu E, Salles G, Dixit VM, Rosenthal A, Schlegelberger B, Morris SW
Nature genetics. 1999 ; 22 (1) : 63-68.
PMID 10319863
 

Citation

This paper should be referenced as such :
Cuneo, A ; Castoldi, GL
t(1;14)(p22;q32) in non Hodgkin's lymphoma (NHL)
Atlas Genet Cytogenet Oncol Haematol. 2001;5(1):54-54.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Anomalies/t114ID2044.html


Other genes implicated (Data extracted from papers in the Atlas) [ 2 ]

Genes BCL10 IGH

Translocations implicated (Data extracted from papers in the Atlas)

 t(1;14)(p22;q32) IGH/BCL10
 t(1;2)(p22;p12) IGK/BCL10

External links

arrayMap (UZH-SIB Zurich)IGH (14q32.33) BCL10 (1p22.3)

IGK (14q32.33) BCL10 (1p22.3)

IGK (14q32.33) BCL10 (1p22.3)

Mitelman databaset(1;14)(p22;q32) [Case List]    t(1;14)(p22;q32) [Association List] Mitelman database (CGAP - NCBI)
Mitelman databaset(1;2)(p22;p12) [Case List]    t(1;2)(p22;p12) [Association List] Mitelman database (CGAP - NCBI)
arrayMap[select an item]
 
Mitelman databaseIGH/BCL10 [MCList]  IGH (14q32.33) BCL10 (1p22.3)
Mitelman databaseIGK/BCL10 [MCList]  IGK (14q32.33) BCL10 (1p22.3)
Mitelman databaseIGK/BCL10 [MCList]  IGK (14q32.33) BCL10 (1p22.3)
 
Disease databaset(1;2)(p22;p12) IGK/BCL10
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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