Disease |
Mantle cell lymphoma (MCL) |
Note |
This review does not include a case of t(2;12)(p12;p13) found in myeloid malignancy (Lai et al., 1995), a case of acute lymphoblastic leukemia with a t(12;14)(p13;q32) and IgH/ETV6 involvement (Lu et al., 2002); five cases of t(12;22)(p13;q11), not herein included either, have also been described in lymphoid malignancies, but with an unknown CCND2 status (see Mitelman database). Finally, there are a number of chronic myeloid leukemia aberrant translocations with t(12;22), which again represent other diseases. |
Phenotype / cell stem origin |
The cases of mantle cell lymphomas with the above translocations were typical mantle cell cases, with CD5+, CD20+, CD10-, CD23- expression, except for the lack of CCND1 expression. |
Epidemiology | Five cases are available: 4 cases of MCL (Gesk et al., 2006; Herens et al., 2008; Wlodarska et al., 2008), and a case of chronic lymphocytic leukemia (CLL) transforming into a Richter disease (Qian et al., 1999). |
Clinics | The patients are in stage IV of the disease, with a nodular, or nodular/diffuse pattern. There was 3 male and 2 female patients, aged 33, 52, 65, 70, and ? years. |
Prognosis | Data is missing in most cases; the two patients with data on prognosis died: the patient with Richter disease, and a MCL case, who died 64 months after diagnosis. |
Regulation and function of cyclin D2 in B lymphocyte subsets. |
Chiles TC. |
J Immunol. 2004 Sep 1;173(5):2901-7. (Review) |
PMID 15322145 |
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A chromosomal translocation in cyclin D1-negative/cyclin D2-positive mantle cell lymphoma fuses the CCND2 gene to the IGK locus. |
Gesk S, Klapper W, Martin-Subero JI, Nagel I, Harder L, Fu K, Bernd HW, Weisenburger DD, Parwaresch R, Siebert R. |
Blood. 2006 Aug 1;108(3):1109-10. |
PMID 16861358 |
|
Cyclin D1-negative mantle cell lymphoma with cryptic t(12;14)(p13;q32) and cyclin D2 overexpression. |
Herens C, Lambert F, Quintanilla-Martinez L, Bisig B, Deusings C, de Leval L. |
Blood. 2008 Feb 1;111(3):1745-6. |
PMID 18223179 |
|
Myelodysplastic syndromes and acute myeloid leukemia with 17p deletion. An entity characterized by specific dysgranulopoïesis and a high incidence of P53 mutations. |
Lai JL, Preudhomme C, Zandecki M, Flactif M, Vanrumbeke M, Lepelley P, Wattel E, Fenaux P. |
Leukemia. 1995 Mar;9(3):370-81. |
PMID 7885035 |
|
The utility of spectral karyotyping in the cytogenetic analysis of newly diagnosed pediatric acute lymphoblastic leukemia. |
Lu XY, Harris CP, Cooley L, Margolin J, Steuber PC, Sheldon M, Rao PH, Lau CC. |
Leukemia. 2002 Nov;16(11):2222-7. |
PMID 12399965 |
|
Cyclin D2 promoter disrupted by t(12;22)(p13;q11.2) during transformation of chronic lymphocytic leukaemia to non-Hodgkin's lymphoma. |
Qian L, Gong J, Liu J, Broome JD, Koduru PR. |
Br J Haematol. 1999 Aug;106(2):477-85. |
PMID 10460609 |
|
Translocations targeting CCND2, CCND3, and MYCN do occur in t(11;14)-negative mantle cell lymphomas. |
Wlodarska I, Dierickx D, Vanhentenrijk V, Van Roosbroeck K, Pospisilova H, Minnei F, Verhoef G, Thomas J, Vandenberghe P, De Wolf-Peeters C. |
Blood. 2008 Jun 15;111(12):5683-90. |
PMID 18391076 |
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