| Disease |
Mantle cell lymphoma (MCL) |
| Note |
This review does not include a case of t(2;12)(p12;p13) found in myeloid malignancy (Lai et al., 1995), a case of acute lymphoblastic leukemia with a t(12;14)(p13;q32) and IgH/ETV6 involvement (Lu et al., 2002); five cases of t(12;22)(p13;q11), not herein included either, have also been described in lymphoid malignancies, but with an unknown CCND2 status (see Mitelman database). Finally, there are a number of chronic myeloid leukemia aberrant translocations with t(12;22), which again represent other diseases. |
| Phenotype / cell stem origin |
The cases of mantle cell lymphomas with the above translocations were typical mantle cell cases, with CD5+, CD20+, CD10-, CD23- expression, except for the lack of CCND1 expression. |
| Epidemiology | Five cases are available: 4 cases of MCL (Gesk et al., 2006; Herens et al., 2008; Wlodarska et al., 2008), and a case of chronic lymphocytic leukemia (CLL) transforming into a Richter disease (Qian et al., 1999). |
| Clinics | The patients are in stage IV of the disease, with a nodular, or nodular/diffuse pattern. There was 3 male and 2 female patients, aged 33, 52, 65, 70, and ? years. |
| Prognosis | Data is missing in most cases; the two patients with data on prognosis died: the patient with Richter disease, and a MCL case, who died 64 months after diagnosis. |
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