t(12;19)(q13;q13)
2009-01-01 Jean-Loup Huret   Affiliation1.Genetics, Dept Medical Information, University of Poitiers; CHU Poitiers Hospital, F-86021 Poitiers, France
Clinics and Pathology
Disease
Acute myeloid leukaemia (AML)
Phenotype stem cell origin
Myeloid leukaemias (Paietta et al., 1988; Scheurlen et al., 1999), if we exclude a case of lymphoplasmacytoid lymphoma (Offit el al., 1995). The translocation is found in M1-AML and M2-AML, with erythroid hyperplasia in the bone marrow and the presence of binucleated and trinucleated red cells in at least 3 of 4 cases (Paietta et al., 1988).
Epidemiology
Four cases available, 2 male and 2 female patients, aged 26, 61, 63, and 63.
Prognosis
The clinical outcome is poor, with 2 cases not entering into remission and dead within 2 months after diagnosis, and a third patient with partial remission, relapse after 2 months, and death. The fourth patients outcome is unknown.
Genes Involved and Proteins
Note
The genes involved in this translocation are unknown.
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 7662983 | 1995 | Del (7)(q32) is associated with a subset of small lymphocytic lymphoma with plasmacytoid features. | Offit K et al |
| 3395990 | 1988 | Translocation t(12;19)(q13;q13.3). A new recurrent abnormality in acute nonlymphocytic leukemia with atypical erythropoiesis. | Paietta E et al |
| 10379869 | 1999 | Mapping of the breakpoints on the short arm of chromosome 17 in neoplasms with an i(17q). | Scheurlen WG et al |
Citation
Jean-Loup Huret
t(12;19)(q13;q13)
Atlas Genet Cytogenet Oncol Haematol. 2009-01-01
Online version: http://atlasgeneticsoncology.org/haematological/1532/t(12;19)(q13;q13)
