t(13;19)(q14;p13) TCF3/?
2011-08-01 Jean-Loup Huret Affiliation1.Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Clinics and Pathology
Disease
B cell acute lymphoblastic leukemia (B-ALL)
Note
An apparently identical t(13;19)(q14;p13) has been described in 3 cases of chronic lymphocytic leukemia (CLL) (Finn et al., 1998; Merup et al., 1998; Brown et al.,1993).
Epidemiology
Only one case to date of ALL with this translocation, a 19-year-old female patient with pre-B-ALL; she achieved complete remission and (CR) was in continuing CR 10 months later, at last follow up (Barber et al., 2007).
Genes Involved and Proteins
Note
The translocation involves TCF3 and an unknown partner.
Gene name
TCF3 (transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47))
Location
19p13.3
Protein description
The E2A gene encodes two distinct basic helix-loop-helix transcription factors, E12 (ITF1) and E47 (TCF3) through alternative splicing. It forms homodimers and heterodimers with other basic helix-loop-helix transcription factors. Ubiquitously expressed during development. Role in cell growth, cell commitment, and differentiation. Role in epithelial mesenchymal transition (review in Slattery et al., 2008).
Highly cited references
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 21903672 | 2011 | Maintaining embryonic stem cell pluripotency with Wnt signaling. | 135 |
| 25990863 | 2015 | Transcription factor networks in B-cell differentiation link development to acute lymphoid leukemia. | 128 |
| 32255708 | 2020 | Burkitt lymphoma: bridging the gap between advances in molecular biology and therapy. | 115 |
| 33038982 | 2020 | Molecular markers in ALL: Clinical implications. | 107 |
| 20951344 | 2010 | Regulation of TCF3 by Wnt-dependent phosphorylation during vertebrate axis specification. | 101 |
| 27447672 | 2016 | TCF/LEF Transcription Factors: An Update from the Internet Resources. | 90 |
| 39377397 | 2024 | Integrated multi-omics analysis of PBX1 in mouse adult neural stem- and progenitor cells identifies a transcriptional module that functionally links PBX1 to TCF3/4. | 89 |
| 31902036 | 2020 | Insights into the prenatal origin of childhood acute lymphoblastic leukemia. | 82 |
| 37306722 | 2023 | ZNF384-Related Fusion Genes in Acute Lymphoblastic Leukemia. | 81 |
| 37684687 | 2023 | Distinct requirements for Tcf3 and Tcf12 during oligodendrocyte development in the mouse telencephalon. | 78 |
| 36330928 | 2022 | ID1 and CEBPA coordinate epidermal progenitor cell differentiation. | 74 |
| 36011285 | 2022 | Commonly Assessed Markers in Childhood BCP-ALL Diagnostic Panels and Their Association with Genetic Aberrations and Outcome Prediction. | 74 |
| 24909826 | 2014 | Tcf3 promotes cell migration and wound repair through regulation of lipocalin 2. | 70 |
| 24832538 | 2014 | Tcf3 represses Wnt-β-catenin signaling and maintains neural stem cell population during neocortical development. | 70 |
| 29316906 | 2018 | The function of tcf3 in medaka embryos: efficient knockdown with pePNAs. | 69 |
| 34422820 | 2021 | TCF3 Regulates the Proliferation and Apoptosis of Human Spermatogonial Stem Cells by Targeting PODXL. | 67 |
| 36605621 | 2023 | Netrin-1 mediates nerve innervation and angiogenesis leading to discogenic pain. | 67 |
| 36443297 | 2022 | A p38α-BLIMP1 signalling pathway is essential for plasma cell differentiation. | 63 |
| 24492847 | 2014 | Oncogenic mechanisms in Burkitt lymphoma. | 61 |
| 21547058 | 2011 | Fishing pluripotency mechanisms in vivo. | 60 |
| 38287103 | 2024 | Id2 epigenetically controls CD8(+) T-cell exhaustion by disrupting the assembly of the Tcf3-LSD1 complex. | 57 |
| 38010289 | 2024 | LncRNA-CCAT5-mediated crosstalk between Wnt/β-Catenin and STAT3 signaling suggests novel therapeutic approaches for metastatic gastric cancer with high Wnt activity. | 57 |
| 36631435 | 2023 | Prolyl-tRNA synthetase as a novel therapeutic target in multiple myeloma. | 56 |
| 34871373 | 2022 | Impact of high-risk cytogenetics on outcomes for children and young adults receiving CD19-directed CAR T-cell therapy. | 55 |
| 38338754 | 2024 | CircRNAome of Childhood Acute Lymphoblastic Leukemia: Deciphering Subtype-Specific Expression Profiles and Involvement in TCF3::PBX1 ALL. | 54 |
| 19176587 | 2009 | Tcf3 inhibits spinal cord neurogenesis by regulating sox4a expression. | 54 |
| 37721971 | 2023 | Transcription Factor TCF3 Promotes Macrophage-Mediated Inflammation and MMP Secretion in Abdominal Aortic Aneurysm by Regulating miR-143-5p /CCL20. | 53 |
| 38512021 | 2024 | Distinct Regulation of ASCL1 by the Cell Cycle and Chemotherapy in Small Cell Lung Cancer. | 48 |
| 39205642 | 2024 | TCF3 as a multidimensional biomarker: oncogenicity, genomic alterations, and immune landscape in pan-cancer analysis. | 46 |
| 22885699 | 2012 | Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics. | 44 |
| 34455614 | 2021 | MEX3D is an oncogenic driver in prostate cancer. | 43 |
| 28211472 | 2017 | Proteolysis regulates cardiomyocyte maturation and tissue integration. | 43 |
| 34624079 | 2022 | SHMT2 inhibition disrupts the TCF3 transcriptional survival program in Burkitt lymphoma. | 42 |
| 36829181 | 2023 | CMTM7 inhibits breast cancer progression by regulating Wnt/β-catenin signaling. | 42 |
| 37100457 | 2023 | Senescence-related genes define prognosis, immune contexture, and pharmacological response in gastric cancer. | 42 |
| 37690994 | 2024 | A genetic variant in the immune-related gene ERAP1 affects colorectal cancer prognosis. | 41 |
| 38058209 | 2024 | PELI2 regulates early B-cell progenitor differentiation and related leukemia via the IL-7R expression. | 40 |
| 33602872 | 2021 | XPO7 is a tumor suppressor regulating p21(CIP1)-dependent senescence. | 39 |
| 27166193 | 2016 | Repression of TCF3/E2A contributes to Hodgkin lymphomagenesis. | 38 |
| 25038042 | 2014 | Tcf3 expression marks both stem and progenitor cells in multiple epithelia. | 37 |
| 37277074 | 2023 | TCF3 haploinsufficiency defined by immune, clinical, gene-dosage, and murine studies. | 36 |
| 25375219 | 2014 | Hypomethylation-associated up-regulation of TCF3 expression and recurrence in stage II and III colorectal cancer. | 36 |
| 37867222 | 2023 | Transcription Factor Id1 Plays an Essential Role in Th9 Cell Differentiation by Inhibiting Tcf3 and Tcf4. | 34 |
| 34658308 | 2021 | Transcription factor 3 (TCF3) combined with histone deacetylase 3 (HDAC3) down-regulates microRNA-101 to promote Burkitt lymphoma cell proliferation and inhibit apoptosis. | 34 |
| 21685894 | 2011 | Opposing effects of Tcf3 and Tcf1 control Wnt stimulation of embryonic stem cell self-renewal. | 33 |
| 34278464 | 2021 | Expression of TCF3 in Wilms' tumor and its regulatory role in kidney tumor cell viability, migration and apoptosis in vitro. | 33 |
| 27461063 | 2017 | Idelalisib sensitivity and mechanisms of disease progression in relapsed TCF3-PBX1 acute lymphoblastic leukemia. | 32 |
| 30487223 | 2018 | Transcriptional landscape of B cell precursor acute lymphoblastic leukemia based on an international study of 1,223 cases. | 31 |
| 38515708 | 2024 | EP300 regulates the SLC16A1-AS1-AS1/TCF3 axis to promote lung cancer malignancies through the Wnt signaling pathway. | 29 |
| 31558468 | 2019 | The whole-genome landscape of Burkitt lymphoma subtypes. | 28 |
| 32449435 | 2020 | Burkitt lymphoma-related TCF3 mutations alter TCF3 alternative splicing by disrupting hnRNPH1 binding. | 27 |
| 32563910 | 2020 | Ibrutinib is not an effective drug in primografts of TCF3-PBX1. | 27 |
| 34553842 | 2022 | Genetic features of B-cell lymphoblastic lymphoma with TCF3-PBX1. | 27 |
| 36576946 | 2023 | Identification of TCF3 germline variants in pediatric B-cell acute lymphoblastic leukemia. | 25 |
| 34631502 | 2021 | Increased expression of TCF3, transcription factor 3, is a defense response against methylmercury toxicity in mouse neuronal C17.2 cells. | 24 |
| 31575852 | 2019 | Characterization of TCF3 rearrangements in pediatric B-lymphoblastic leukemia/lymphoma by mate-pair sequencing (MPseq) identifies complex genomic rearrangements and a novel TCF3/TEF gene fusion. | 23 |
| 32245383 | 2020 | Comprehensive chromosomal aberrations in a case of a patient with TCF3-HLF-positive BCP-ALL. | 23 |
| 35125724 | 2022 | Incidence and Prognostic Impact of TCF3-PBX1 Fusion in Childhood Acute Lymphoblastic Leukemia: A Single Centre Experience. | 20 |
| 30262566 | 2019 | B-lymphoblastic lymphoma with TCF3-PBX1 fusion gene. | 19 |
| 36001860 | 2022 | TCF3-HLF-Positive Acute Lymphoblastic Leukemia Resembling Burkitt Leukemia: Cell Morphologic and Immunophenotypic Findings. | 16 |
| 38426288 | 2024 | Proteogenomic profiling uncovers differential therapeutic vulnerabilities between TCF3::PBX1 and TCF3::HLF translocated B-cell acute lymphoblastic leukemia. | 15 |
| 32391417 | 2020 | Targeting the oncogenic activity of TCF3-HLF in leukemia. | 10 |
| 30181358 | 2018 | Alternative pre-mRNA splicing switch controls hESC pluripotency and differentiation. | 9 |
| 37392046 | 2023 | TCF3::HLF acute lymphoblastic leukemia: still challenging to cure thirty years later. | 5 |
| 37995682 | 2023 | Therapeutic targeting of EP300/CBP by bromodomain inhibition in hematologic malignancies. | 0 |
| 38839978 | 2024 | Mapping putative enhancers in mouse oocytes and early embryos reveals TCF3/12 as key folliculogenesis regulators. | 0 |
| 38106088 | 2023 | SINGLE CELL DISSECTION OF DEVELOPMENTAL ORIGINS AND TRANSCRIPTIONAL HETEROGENEITY IN B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA. | 0 |
| 37407363 | 2023 | Transcription factor abnormalities in B-ALL leukemogenesis and treatment. | 0 |
| 35084477 | 2022 | Metabolic path toward TCF3 inactivation in Burkitt lymphoma. | 0 |
| 27888884 | 2016 | Update on Burkitt Lymphoma. | 0 |
| 37058324 | 2023 | TCF3 gene rearrangements in pediatric B-cell acute lymphoblastic leukemia-A single center experience. | 0 |
| 38303515 | 2024 | Transcription factor 3 is dysregulated in megakaryocytes in myelofibrosis. | 0 |
| 22196214 | 2012 | WNTing embryonic stem cells. | 0 |
| 35446002 | 2022 | TCF3 Induces DNMT1 Expression to Regulate Wnt Signaling Pathway in Glioma. | 0 |
| 39182568 | 2024 | RNA-binding protein LSM7 facilitates breast cancer metastasis through mediating alternative splicing of CD44. | 0 |
| 38839977 | 2024 | TCF3, TCF12 and distinct enhancers regulate oocyte transcription. | 0 |
| 34460133 | 2022 | Cryptic TCF3 fusions in childhood leukemia: Detection by RNA sequencing. | 0 |
| 35239510 | 2022 | TCF3 regulates human endometrial stromal cell proliferation and migration in RPL. | 0 |
| 27431573 | 2016 | Regulation of the miRNA expression by TEL/AML1, BCR/ABL, MLL/AF4 and TCF3/PBX1 oncoproteins in acute lymphoblastic leukemia (Review). | 0 |
| 38683392 | 2024 | B-cells absence in patients diagnosed as inborn errors of immunity: a registry-based study. | 0 |
| 32003049 | 2020 | Tcf3-activated lncRNA Gas5 regulates newborn mouse cardiomyocyte apoptosis in diabetic cardiomyopathy. | 0 |
| 29334255 | 2018 | NGS-based methylation profiling differentiates TCF3-HLF and TCF3-PBX1 positive B-cell acute lymphoblastic leukemia. | 0 |
| 36651950 | 2023 | Protocatechuic Aldehyde Alleviates d -Galactose-Induced Cardiomyocyte Senescence by Regulating the TCF3/ATG5 Axis. | 0 |
| 37129918 | 2024 | Rare TCF3 variants associated with pediatric B cell acute lymphoblastic leukemia. | 0 |
| 36208246 | 2022 | [Expression of TCF3 in Burkitt's Lymphoma and Its Proliferative Effect and Prognostic Significance]. | 0 |
| 34034913 | 2021 | Clinical features and prognostic impact of TCF3-PBX1 in childhood acute lymphoblastic leukemia: A single-center retrospective study of 837 patients from China. | 0 |
| 39145779 | 2024 | CD19 CAR T-cell therapy in relapsed TCF3-HLF-positive B-cell acute lymphoblastic leukemia. | 0 |
| 35617527 | 2022 | TCF3 protein was highly expressed in pediatric Burkitt lymphoma and predicts poor prognosis: a single-center study. | 0 |
| 35078577 | 2022 | [T cell factor 3 (TCF3) is overexpressed in hepatocellular carcinoma and promotes their invasion and metastasis]. | 0 |
| 33221150 | 2021 | Long-Term Results of the Risk-Stratified Treatment of TCF3-PBX1-Positive Pediatric Acute Lymphoblastic Leukemia in China. | 0 |
| 28436581 | 2017 | Pediatric acute lymphoblastic leukemia with t(1;19)/TCF3-PBX1 in Taiwan. | 0 |
| 38719770 | 2024 | Evaluation of next-generation sequencing for measurable residual disease monitoring in three major fusion transcript subtypes of B-precursor acute lymphoblastic leukaemia. | 0 |
| 39306917 | 2024 | Dysregulation of metallothionein MT1 sub-types in TCF3::PBX1 pre-B-cell acute lymphoblastic leukemia. | 0 |
| 27105323 | 2016 | Transcription factor 3 controls cell proliferation and migration in glioblastoma multiforme cell lines. | 0 |
| 28604457 | 2017 | Up-regulation of Transcription Factor 3 Is Correlated With Poor Prognosis in Cervical Carcinoma. | 0 |
| 35976539 | 2022 | A case of progressive multifocal leukoencephalopathy with hypogammaglobulinemia and a TCF3 mutation. | 0 |
| 28107608 | 2017 | The increased expression of TCF3 is correlated with poor prognosis in Chinese patients with nasopharyngeal carcinoma. | 0 |
| 35907039 | 2022 | Clonal evolution in adult TCF3::HLF-positive acute lymphoblastic leukemia undergoing stem cell transplantation. | 0 |
| 30051646 | 2018 | Excellent outcome of acute lymphoblastic leukaemia with TCF3-PBX1 rearrangement in Hong Kong. | 0 |
| 28213917 | 2017 | Solid pseudopapillary neoplasm expresses inhibin-α and Tcf-3. | 0 |
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 17311319 | 2007 | Molecular cytogenetic characterization of TCF3 (E2A)/19p13.3 rearrangements in B-cell precursor acute lymphoblastic leukemia. | Barber KE et al |
| 8490658 | 1993 | Evidence for a new tumour suppressor locus (DBM) in human B-cell neoplasia telomeric to the retinoblastoma gene. | Brown AG et al |
| 9798660 | 1998 | Secondary abnormalities of chromosome 6q in B-cell chronic lymphocytic leukemia: a sequential study of karyotypic instability in 51 patients. | Finn WG et al |
| 9742120 | 1998 | The AD1 and AD2 transactivation domains of E2A are essential for the antiapoptotic activity of the chimeric oncoprotein E2A-HLF. | Inukai T et al |
| 9593268 | 1998 | A FISH cosmid 'cocktail' for detection of 13q deletions in chronic lymphocytic leukaemia--comparison with cytogenetics and Southern hybridization. | Merup M et al |
| 17604208 | 2008 | E2A proteins: regulators of cell phenotype in normal physiology and disease. | Slattery C et al |
Citation
Jean-Loup Huret
t(13;19)(q14;p13) TCF3/?
Atlas Genet Cytogenet Oncol Haematol. 2011-08-01
Online version: http://atlasgeneticsoncology.org/haematological/1512/t(13;19)(q14;p13)-tcf3
