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t(13;19)(q14;p13) TCF3/?

Written2011-08Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)


ICD-Morpho 9811/3 B lymphoblastic leukaemia/lymphoma, NOS
Atlas_Id 1512

Clinics and Pathology

Disease B cell acute lymphoblastic leukemia (B-ALL)
Note An apparently identical t(13;19)(q14;p13) has been described in 3 cases of chronic lymphocytic leukemia (CLL) (Finn et al., 1998; Merup et al., 1998; Brown et al.,1993).
Epidemiology Only one case to date of ALL with this translocation, a 19-year-old female patient with pre-B-ALL; she achieved complete remission and (CR) was in continuing CR 10 months later, at last follow up (Barber et al., 2007).

Genes involved and Proteins

Note The translocation involves TCF3 and an unknown partner.
Gene NameTCF3 (transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47))
Location 19p13.3
Protein The E2A gene encodes two distinct basic helix-loop-helix transcription factors, E12 (ITF1) and E47 (TCF3) through alternative splicing. It forms homodimers and heterodimers with other basic helix-loop-helix transcription factors. Ubiquitously expressed during development. Role in cell growth, cell commitment, and differentiation. Role in epithelial mesenchymal transition (review in Slattery et al., 2008).

To be noted

Additional cases are needed to delineate the epidemiology of this rare entity:
you are welcome to submit a paper to our new Case Report section.


Molecular cytogenetic characterization of TCF3 (E2A)/19p13.3 rearrangements in B-cell precursor acute lymphoblastic leukemia.
Barber KE, Harrison CJ, Broadfield ZJ, Stewart AR, Wright SL, Martineau M, Strefford JC, Moorman AV.
Genes Chromosomes Cancer. 2007 May;46(5):478-86.
PMID 17311319
Evidence for a new tumour suppressor locus (DBM) in human B-cell neoplasia telomeric to the retinoblastoma gene.
Brown AG, Ross FM, Dunne EM, Steel CM, Weir-Thompson EM.
Nat Genet. 1993 Jan;3(1):67-72.
PMID 8490658
Secondary abnormalities of chromosome 6q in B-cell chronic lymphocytic leukemia: a sequential study of karyotypic instability in 51 patients.
Finn WG, Kay NE, Kroft SH, Church S, Peterson LC.
Am J Hematol. 1998 Nov;59(3):223-9.
PMID 9798660
The AD1 and AD2 transactivation domains of E2A are essential for the antiapoptotic activity of the chimeric oncoprotein E2A-HLF.
Inukai T, Inaba T, Ikushima S, Look AT.
Mol Cell Biol. 1998 Oct;18(10):6035-43.
PMID 9742120
A FISH cosmid 'cocktail' for detection of 13q deletions in chronic lymphocytic leukaemia--comparison with cytogenetics and Southern hybridization.
Merup M, Jansson M, Corcoran M, Liu Y, Wu X, Rasool O, Stellan B, Hermansson M, Juliusson G, Gahrton G, Einhorn S.
Leukemia. 1998 May;12(5):705-9.
PMID 9593268
E2A proteins: regulators of cell phenotype in normal physiology and disease.
Slattery C, Ryan MP, McMorrow T.
Int J Biochem Cell Biol. 2008;40(8):1431-6. Epub 2007 May 29.
PMID 17604208


This paper should be referenced as such :
Huret, JL
Atlas Genet Cytogenet Oncol Haematol. 2012;16(1):48-48.
Free journal version : [ pdf ]   [ DOI ]
On line version :

Other genes implicated (Data extracted from papers in the Atlas) [ 1 ]

Genes TCF3

Translocations implicated (Data extracted from papers in the Atlas)

 t(13;19)(q14;p13) TCF3/?

External links

Mitelman databaset(13;19)(q14;p13)
arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9811/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed

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