| Disease |
CD10+ acute lymphoblastic leukaemia (B-ALL) |
| Epidemiology | Only 4 cases to date of t(14;14)(q11;q32)/inv(14)(q11q32) with CEBPE and IGH involvements (Akasaka et al., 2007). Five other cases of t(14;14)(q11;q32)/inv(14)(q11q32) in B-cell leukemias are known (Denny et al., 1986; Speleman et al., 1991; Chervinsky et al., 1995; Wong et al., 1995; Thomas et al., 2001), but without proof that CEBPE was involved. As a matter of fact, a t(4;11)(q21;q23) was found in 2 of these cases, and a t(8;14)(q24;q32) in another case; this latter group is certainly heterogeneous. |
| Clinics | The four patients were male patients, aged 15, 25, 45, and 45 yrs, with a WBC under 50 x 109/l. Survival is available only for two cases: 19 mths+ and 48 mths+, resembling the relatively fair survival of patients with a t(8;14)(q11;q32) CEBPD/IGH translocation. One case was a Down syndrome patient; this may not be anecdotical, since more than 1/4 of t(8;14)(q11;q32) case are also Down syndrome patients. |
| Five members of the CEBP transcription factor family are targeted by recurrent IGH translocations in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). |
| Akasaka T, Balasas T, Russell LJ, Sugimoto KJ, Majid A, Walewska R, Karran EL, Brown DG, Cain K, Harder L, Gesk S, Martin-Subero JI, Atherton MG, Bruggemann M, Calasanz MJ, Davies T, Haas OA, Hagemeijer A, Kempski H, Lessard M, Lillington DM, Moore S, Nguyen-Khac F, Radford-Weiss I, Schoch C, Struski S, Talley P, Welham MJ, Worley H, Strefford JC, Harrison CJ, Siebert R, Dyer MJ. |
| Blood. 2007 Apr 15;109(8):3451-61. Epub 2006 Dec 14. |
| PMID 17170124 |
| |
| Concurrent presence of inv(14)(q11q32) and t(4;11)(q21;q23) in pre-B acute lymphoblastic leukemia. |
| Chervinsky DS, Grossi M, Kakati S, Block AW, Aplan PD. |
| Genes Chromosomes Cancer. 1995 Mar;12(3):229-36. |
| PMID 7536464 |
| |
| Common mechanism of chromosome inversion in B- and T-cell tumors: relevance to lymphoid development. |
| Denny CT, Hollis GF, Hecht F, Morgan R, Link MP, Smith SD, Kirsch IR. |
| Science. 1986 Oct 10;234(4773):197-200. |
| PMID 3092355 |
| |
| The C/EBP family of transcription factors: a paradigm for interaction between gene expression and proliferation control. |
| Nerlov C. |
| Trends Cell Biol. 2007 Jul;17(7):318-24. Epub 2007 Jul 19. (Review) |
| PMID 17658261 |
| |
| CCAAT/enhancer-binding proteins: structure, function and regulation. |
| Ramji DP, Foka P. |
| Biochem J. 2002 Aug 1;365(Pt 3):561-75. (Review) |
| PMID 12006103 |
| |
| Analysis of whole-arm translocations in malignant blood cells by nonisotopic in situ hybridization. |
| Speleman F, Mangelschots K, Vercruyssen M, Dal Cin P, Aventin A, Offner F, Laureys G, Van den Berghe H, Leroy. |
| Cytogenet Cell Genet. 1991;56(1):14-7. |
| PMID 2004549 |
| |
| Acute lymphoblastic leukemia in the elderly: The Edouard Herriot Hospital experience. |
| Thomas X, Olteanu N, Charrin C, Lhéritier V, Magaud JP, Fiere D. |
| Am J Hematol. 2001 Jun;67(2):73-83. |
| PMID 11343378 |
| |
| Inversion 14q in acute lymphoblastic leukemia of B-lineage. |
| Wong KF, Kwong YL, Wong TK. |
| Cancer Genet Cytogenet. 1995 Mar;80(1):72-4. |
| PMID 7697638 |
| |
