| Written | 2014-10 | Guangyu Gu, Sarah South |
| Genetics Associates, Inc. Nashville, TN ggu@geneticsassociates.com (GG); Department of Pathology, University of Utah; ARUP Institute for Clinical, Experimental Pathology, ARUP Laboratories, Salt Lake City, UT Sarah.south@aruplab.com (SS) |
| Abstract | IGH rearrangements are a common chromosomal abnormality seen in lymphoproliferative disorders, including ALL. Numerous translocation partners of IGH gene have been identified. Here we report a B-ALL case with a t(14;17)(q32;q21) IGH/IGF2BP1. |
| Keywords | IGH partner, t(14;17)(q32;q21), IGF2BP1, acute B lymphoblastic leukemia |
| Identity |
| ICD-Topo | C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS |
| ICD-Morpho | 9811/3 B lymphoblastic leukaemia/lymphoma, NOS |
| Atlas_Id | 1706 |
 | |
| t(14;17)(q32;q21) G- Banding | |
| Clinics and Pathology |
| Disease | B-cell acute lymphoblastic leukemia (ALL) |
| Phenotype / cell stem origin | CD10+, CD19+, CD38+, cytoplastic CD22+ ALL |
| Epidemiology | Only one case, a 16 year old boy (Gu et al., 2014) |
| Clinics | Severe pancytopenia and an elevated lactate dehydrogenase (1048U/L); WBC was 2.7 X 10 9 with 20% blasts; no central nervous system involvement. |
| Cytogenetics |
| Cytogenetics Morphological | An additional copy of the derivative 14 was found |
| Genes involved and Proteins |
| Gene Name | IGH (Immunoglobulin Heavy) |
| Location | 14q32.33 |
| Gene Name | IGF2BP1 (insulin-like growth factor 2 mRNA binding protein 1) |
| Location | 17q21.32 |
| Protein | IGF2BP1 is a member of Insulin-like growth factor 2 mRNA-binding protein family; pro-oncogenic RNA-binding; post-transcriptional regulation of gene expression (Bell et al., 2013; Lederer et al., 2014). |
| Result of the chromosomal anomaly |
| Description | likely head-to-head fusion of IGF2BP1 with the IGH locus. |
| Oncogenesis | Overexpression of the IGF2BP1 gene. |
| To be noted |
| Additional cases are needed to delineate the epidemiology of this rare entity: you are welcome to submit a paper to our new Case Report section. |
| Bibliography |
| Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression? Cell Mol Life Sci |
| Bell JL, Wächter K, Mühleck B, Pazaitis N, Köhn M, Lederer M, Hüttelmaier S |
| 2013 Aug;70(15):2657-75 doi: 10 |
| PMID 23069990 |
| IGF2BP1: a novel IGH translocation partner in B acute lymphoblastic leukemia |
| Gu G, Sederberg MC, Drachenberg MR, South ST |
| Cancer Genet 2014 Jul-Aug;207(7-8):332-4 |
| PMID 25195122 |
| The role of the oncofetal IGF2 mRNA-binding protein 3 (IGF2BP3) in cancer |
| Lederer M, Bley N, Schleifer C, Hüttelmaier S |
| Semin Cancer Biol 2014 Dec;29:3-12 |
| PMID 25068994 |
| Citation |
| This paper should be referenced as such : |
| Guangyu Gu, Sarah South |
| t(14;17)(q32;q21) IGH/IGF2BP1 |
| Atlas Genet Cytogenet Oncol Haematol. 2015;19(8):541-542. |
| Free journal version : [ pdf ] [ DOI ] |
| On line version : http://AtlasGeneticsOncology.org/Anomalies/t1417q32q21IGH-IGF2BP1ID1706.html |
| Translocations implicated (Data extracted from papers in the Atlas) |
| t(14;17)(q32;q21) IGH/IGF2BP1 | |
| External links |
| REVIEW articles | automatic search in PubMed |
| Last year articles | automatic search in PubMed |
| All articles | automatic search in PubMed |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon Sep 18 17:20:15 CEST 2017 |
For comments and suggestions or contributions, please contact us