Written | 2014-10 | Guangyu Gu, Sarah South |
Genetics Associates, Inc. Nashville, TN ggu@geneticsassociates.com (GG); Department of Pathology, University of Utah; ARUP Institute for Clinical, Experimental Pathology, ARUP Laboratories, Salt Lake City, UT Sarah.south@aruplab.com (SS) |
Abstract | IGH rearrangements are a common chromosomal abnormality seen in lymphoproliferative disorders, including ALL. Numerous translocation partners of IGH gene have been identified. Here we report a B-ALL case with a t(14;17)(q32;q21) IGH/IGF2BP1. |
Keywords | IGH partner, t(14;17)(q32;q21), IGF2BP1, acute B lymphoblastic leukemia |
Identity |
ICD-Topo | C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS |
ICD-Morpho | 9811/3 B lymphoblastic leukaemia/lymphoma, NOS |
Atlas_Id | 1706 |
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t(14;17)(q32;q21) G- Banding | |
Clinics and Pathology |
Disease | B-cell acute lymphoblastic leukemia (ALL) |
Phenotype / cell stem origin | CD10+, CD19+, CD38+, cytoplastic CD22+ ALL |
Epidemiology | Only one case, a 16 year old boy (Gu et al., 2014) |
Clinics | Severe pancytopenia and an elevated lactate dehydrogenase (1048U/L); WBC was 2.7 X 10 9 with 20% blasts; no central nervous system involvement. |
Cytogenetics |
Cytogenetics Morphological | An additional copy of the derivative 14 was found |
Genes involved and Proteins |
Gene Name | IGH (Immunoglobulin Heavy) |
Location | 14q32.33 |
Gene Name | IGF2BP1 (insulin-like growth factor 2 mRNA binding protein 1) |
Location | 17q21.32 |
Protein | IGF2BP1 is a member of Insulin-like growth factor 2 mRNA-binding protein family; pro-oncogenic RNA-binding; post-transcriptional regulation of gene expression (Bell et al., 2013; Lederer et al., 2014). |
Result of the chromosomal anomaly |
Description | likely head-to-head fusion of IGF2BP1 with the IGH locus. |
Oncogenesis | Overexpression of the IGF2BP1 gene. |
To be noted |
Additional cases are needed to delineate the epidemiology of this rare entity: you are welcome to submit a paper to our new Case Report section. |
Bibliography |
Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression? Cell Mol Life Sci |
Bell JL, Wächter K, Mühleck B, Pazaitis N, Köhn M, Lederer M, Hüttelmaier S |
2013 Aug;70(15):2657-75 doi: 10 |
PMID 23069990 |
IGF2BP1: a novel IGH translocation partner in B acute lymphoblastic leukemia |
Gu G, Sederberg MC, Drachenberg MR, South ST |
Cancer Genet 2014 Jul-Aug;207(7-8):332-4 |
PMID 25195122 |
The role of the oncofetal IGF2 mRNA-binding protein 3 (IGF2BP3) in cancer |
Lederer M, Bley N, Schleifer C, Hüttelmaier S |
Semin Cancer Biol 2014 Dec;29:3-12 |
PMID 25068994 |
Citation |
This paper should be referenced as such : |
Guangyu Gu, Sarah South |
t(14;17)(q32;q21) IGH/IGF2BP1 |
Atlas Genet Cytogenet Oncol Haematol. 2015;19(8):541-542. |
Free journal version : [ pdf ] [ DOI ] |
On line version : http://AtlasGeneticsOncology.org/Anomalies/t1417q32q21IGH-IGF2BP1ID1706.html |
Translocations implicated (Data extracted from papers in the Atlas) |
t(14;17)(q32;q21) IGH/IGF2BP1 | |
External links |
REVIEW articles | automatic search in PubMed |
Last year articles | automatic search in PubMed |
All articles | automatic search in PubMed |
© Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon Dec 14 18:26:39 CET 2020 |
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