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t(18;21)(q21;q22) RUNX1/?

Written2000-02Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
ICD-Morpho 9920/3 Therapy-related myeloid neoplasms
Atlas_Id 1187

Clinics and Pathology

Disease acute myeloid leukemia (AML) secondary to toxic exposure
Note only one case, but with features identical to 2 other cases: one case of t(1;21)(p36;q22), and one case of t(19;21)(q13.4;q22)
Phenotype / cell stem origin M2-AML
Etiology about 50 years after radiation exposure from nuclear explosion
Clinics pancytopenia preceeded leukemia
Evolution complete remission was obtained and the patient returned to the previous pancytopenia; subsequent relapse occurred

Genes involved and Proteins

Note the gene involved in 18q21 is unknown
Gene NameRUNX1 (runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene))
Location 21q22.12
Dna / Rna transcription is from telomere to centromere
Protein contains a Runt domain and, in the C-term, a transactivation domain; forms heterodimers; widely expressed; nuclear localisation; transcription factor (activator) for various hematopoietic-specific genes

To be noted

Additional cases are needed to delineate the epidemiology of this rare entity:
you are welcome to submit a paper to our new Case Report section.

Bibliography

Cloning of an AML1 translocation in a novel syndrome of radiation-induced acute myeloid leukemia.
Hromas RA, Busse TM, Shopnick R, Jumean H, Bowers C, Richkind K
Blood. 1999 ; 94 (numero suppl 1).
 

Citation

This paper should be referenced as such :
Huret, JL
t(18;21)(q21;q22)
Atlas Genet Cytogenet Oncol Haematol. 2000;4(1):38-38.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Anomalies/t1821ID1187.html


Translocations implicated (Data extracted from papers in the Atlas)

 t(18;21)(q21;q22) RUNX1/?

External links

Mitelman databaset(18;21)(q21;q22) [Case List]    t(18;21)(q21;q22) [Association List] Mitelman database (CGAP - NCBI)
arrayMapTopo ( C42) Morph ( 9920/3) - arrayMap (UZH-SIB Zurich)  [auto + random 100 samples .. if exist ]   [tabulated segments]
 
 
Disease databaset(18;21)(q21;q22) RUNX1/?
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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indexed on : Mon Sep 18 17:20:18 CEST 2017


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