| Written | 2017-06 | Adriana Zamecnikova |
| Kuwait Cancer Control Center, Department of Hematology, Laboratory of Cancer Genetics, Kuwait; annaadria@yahoo.com |
| Abstract | Chromosome translocation between the short arm of chromosome 18 and the long arm of chromosome 21 including the t(18;21)(p11;q11) is a rare event, reported only in sporadic cases. |
| Keywords | Chromosome 18; Chromosome 21; Acute erythroleukemia; AML-M6; Acute lymphoblastic leukemia; Follicular lymphoma. |
| Identity |
| ICD-Topo | C420,C421,C424 |
| ICD-Morpho | 9840/3 Acute erythroid leukaemia |
| ICD-Morpho | 9811/3 B lymphoblastic leukaemia/lymphoma, NOS |
| ICD-Morpho | 9690/3 Follicular lymphoma; Paediatric follicular lymphoma |
| Atlas_Id | 1791 |
 | |
| Partial karyotypes with t(18;21)(p11;q11) (A). Fluorescence in situ hybridization with LSI TEL-AML1 probe (Vysis/Abott Molecular, US) probe showing relocation of AML1 (RUNX1) sequences from 21q22 to the short arm of chromosome 18 (B). | |
| Clinics and Pathology |
| Disease | Acute erythroleukemia (FAB type M6), acute lymphoblastic leukemia (ALL) and follicular lymphoma |
| Epidemiology | Only 3 cases to date: a 71-years old male diagnosed with acute erythroleukemia (Cigudosa et al., 2003), a female patient with follicular lymphoma (Lestou et al., 2003) and a 27-years old male with B-cell ALL (present case, personal observation). |
| Prognosis | Unknown (sporadic cases described). The ALL patient relapsed after 7 months of therapy and was alive in the last follow-up 2 years from the diagnosis. |
| Cytogenetics |
| Note | Breakpoints on 18p and 21q are difficult to ascertain in suboptimal preparations. |
| Additional anomalies | Associated with del(5)(q13q31) del(5)(q13q31), monosomy 7, hsr and complex karyotype in the AML case (Cigadusa et al., 2003), del(5)(q15q31), +7, t(14;18)(q32;q21) in the lymphoma case (Lestou et al., 2003) and with homozygous 9p deletion (70% of cells), detected by fluorescence in situ hybridization in the present case. |
| Variants | Genes involved are unknown. |
| To be noted |
| Additional cases are needed to delineate the epidemiology of this rare entity: you are welcome to submit a paper to our new Case Report section. |
| Bibliography |
| De novo erythroleukemia chromosome features include multiple rearrangements, with special involvement of chromosomes 11 and 19. |
| Cigudosa JC, Odero MD, Calasanz MJ, Solé F, Salido M, Arranz E, Martènez-Ramirez A, Urioste M, Alvarez S, Cervera JV, MacGrogan D, Sanz MA, Nimer SD, Benitez J. |
| Genes Chromosomes Cancer 2003 Apr;36(4):406-12. |
| PMID 12619165 |
| Multicolour fluorescence in situ hybridization analysis of t(14;18)-positive follicular lymphoma and correlation with gene expression data and clinical outcome. |
| Lestou VS, Gascoyne RD, Sehn L, Ludkovski O, Chhanabhai M, Klasa RJ, Husson H, Freedman AS, Connors JM, Horsman DE. |
| Br J Haematol 2003 Sep;122(5):745-59. |
| PMID 12930384 |
| Citation |
| This paper should be referenced as such : |
| Adriana Zamecnikova |
| t(18;21)(p11;q11) |
| Atlas Genet Cytogenet Oncol Haematol. 2018;22(8):356-357. |
| Free journal version : [ pdf ] [ DOI ] |
| On line version : http://AtlasGeneticsOncology.org/Anomalies/t1821p11q11ID1791.html |
| Translocations implicated (Data extracted from papers in the Atlas) |
| t(18;21)(p11;q11) | |
| External links |
| REVIEW articles | automatic search in PubMed |
| Last year articles | automatic search in PubMed |
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| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon Jul 8 15:28:21 CEST 2019 |
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