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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret
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t(5;14)(q31;q32) IGH/IL3


  t(5;14)(q31;q32) G- banding - Courtesy Melanie Zenger and Claudia Haferlach.

Clinics and Pathology

Disease B-cell acute lymphoblastic leukemia (ALL) with hypereosinophilia
Phenotype / cell stem origin CD19+, CD10+ ALL; eosinophils are not part of the leukemic cells and do not carry the t(5;14); they represent a reactive population (eosinophilia in association with ALL is usually reactive)
Epidemiology rarely described; 6M/1F; affects both children and adults, general features of ALL with hypereosinophilia are rarity, male predominance; and young age
Cytology marked eosinophilia; basophilia; IL3 is over-expressed
Prognosis prognosis appears to be poor, a feature of ALLs with hypereosinophilia


Additional anomalies sole anomaly or accompanied with various secondary anomalies: +X, (i(7q), del(12p), +19

Genes involved and Proteins

Gene Name IL3
Location 5q31
Protein 152 amino acids; growth factor; colony stimulating factor involved in the survival, proliferation and differentiation of multipotent hematopoietic cells
Gene Name IgH
Location 14q32

Result of the chromosomal anomaly

Hybrid gene
Description break in the promoter region of IL3 and in the Jh region of IgH
Fusion Protein
Expression Localisation the immunoglobulin gene promoter controls the expression of IL3
Oncogenesis over-expression of IL3

To be noted

no recent article has been found; additional cases are needed to delineate this entity; we propose that a Study Group is established and that cases are collected; if you have a case, please, contact us
Case Report A new case of t(5;14)(q31;q32) in a pediatric acute lymphoblastic leukemia presenting with hypereosinophilia

Other genes implicated (Data extracted from papers in the Atlas)

Genes IGH IL3

Translocations implicated (Data extracted from papers in the Atlas)

 t(5;14)(q31;q32) IGH/IL3

External links

Mitelman database
t(5;14)(q31;q32) - Mitelman database (CGAP - NCBI)


Hypereosinophilic syndrome in acute lymphoblastic leukemia with a chromosome translocation [t(5q;14q)].
Tono-oka T, Sato Y, Matsumoto T, Ueno N, Ohkawa M, Shikano T, Takeda T
Medical and pediatric oncology. 1984 ; 12 (1) : 33-37.
PMID 6583469
Acute lymphoblastic leukemia with chromosomal 5;14 translocation and hypereosinophilia: case report and literature review.
Hogan TF, Koss W, Murgo AJ, Amato RS, Fontana JA, VanScoy FL
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 1987 ; 5 (3) : 382-390.
PMID 3546615
Three-way reciprocal chromosomal translocation in an acute lymphoblastic leukemia patient with hypereosinophilia syndrome.
McConnell TS, Foucar K, Hardy WR, Saiki J
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 1987 ; 5 (12) : 2042-2044.
PMID 3479532
Calla-positive acute leukaemia with t(5q;14q) translocation and hypereosinophilia--a unique entity?
Baumgarten E, Wegner RD, Fengler R, Ludwig WD, Schulte-Overberg U, Domeyer C, Schˆºˆºrmann J, Henze G
Acta haematologica. 1989 ; 82 (2) : 85-90.
PMID 2508400
The t(5;14) chromosomal translocation in a case of acute lymphocytic leukemia joins the interleukin-3 gene to the immunoglobulin heavy chain gene.
Grimaldi JC, Meeker TC
Blood. 1989 ; 73 (8) : 2081-2085.
PMID 2499362
Acute lymphoblastic leukemia with eosinophilia.
Fishel RS, Farnen JP, Hanson CA, Silver SM, Emerson SG
Medicine. 1990 ; 69 (4) : 232-243.
PMID 2374508
Activation of the interleukin-3 gene by chromosome translocation in acute lymphocytic leukemia with eosinophilia.
Meeker TC, Hardy D, Willman C, Hogan T, Abrams J
Blood. 1990 ; 76 (2) : 285-289.
PMID 2114933
Non-random involvement of chromosome 5 in ALL.
Chen Z, Morgan R, Sandberg AA
Cancer genetics and cytogenetics. 1992 ; 61 (1) : 106-107.
PMID 1638475
Cytogenetic analysis in relapsed childhood acute lymphoblastic leukemia.
Heerema NA, Palmer CG, Weetman R, Bertolone S
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1992 ; 6 (3) : 185-192.
PMID 1564954
Power of the MAC (morphology-antibody-chromosomes) method in distinguishing reactive and clonal cells: report of a patient with acute lymphatic leukemia, eosinophilia, and t(5;14).
Knuutila S, Alitalo R, Ruutu T
Genes, chromosomes & cancer. 1993 ; 8 (4) : 219-223.
PMID 7512364
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed


Written12-1999Jean-Loup Huret


This paper should be referenced as such :
Huret, JL
Atlas Genet Cytogenet Oncol Haematol. 1999;3(4):203-204.
Free journal version : [ pdf ]   [ DOI ]

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