Atlas of Genetics and Cytogenetics in Oncology and Haematology
t(5;14)(q31;q32)
| Identity |
 | |
| t(5;14)(q31;q32) G- banding - Courtesy Melanie Zenger and Claudia Haferlach. | |
| Clinics and Pathology |
| Disease | B-cell acute lymphoblastic leukemia (ALL) with hypereosinophilia |
| Phenotype / cell stem origin | CD19+, CD10+ ALL; eosinophils are not part of the leukemic cells and do not carry the t(5;14); they represent a reactive population (eosinophilia in association with ALL is usually reactive) |
| Epidemiology | rarely described; 6M/1F; affects both children and adults, general features of ALL with hypereosinophilia are rarity, male predominance; and young age |
| Cytology | marked eosinophilia; basophilia; IL3 is over-expressed |
| Prognosis | prognosis appears to be poor, a feature of ALLs with hypereosinophilia |
| Cytogenetics |
| Additional anomalies | sole anomaly or accompanied with various secondary anomalies: +X, (i(7q), del(12p), +19 |
| Genes involved and Proteins |
| Gene Name | IL3 |
| Location | 5q31 |
| Protein | 152 amino acids; growth factor; colony stimulating factor involved in the survival, proliferation and differentiation of multipotent hematopoietic cells |
| Gene Name | IgH |
| Location | 14q32 |
| Result of the chromosomal anomaly |
| Description | break in the promoter region of IL3 and in the Jh region of IgH |
| Expression Localisation | the immunoglobulin gene promoter controls the expression of IL3 |
| Oncogenesis | over-expression of IL3 |
| External links |
| Other database | t(5;14)(q31;q32) | Mitelman database (CGAP - NCBI) |
| To be noted |
| no recent article has been found; additional cases are needed to delineate this entity; we propose that a Study Group is established and that cases are collected; if you have a case, please, contact us | |
| Case Report | A new case of t(5;14)(q31;q32) in a pediatric acute lymphoblastic leukemia presenting with hypereosinophilia |
| Bibliography |
| Hypereosinophilic syndrome in acute lymphoblastic leukemia with a chromosome translocation [t(5q;14q)]. |
| Tono-oka T, Sato Y, Matsumoto T, Ueno N, Ohkawa M, Shikano T, Takeda T |
| Medical and pediatric oncology. 1984 ; 12 (1) : 33-37. |
| PMID 6583469 |
| Acute lymphoblastic leukemia with chromosomal 5;14 translocation and hypereosinophilia: case report and literature review. |
| Hogan TF, Koss W, Murgo AJ, Amato RS, Fontana JA, VanScoy FL |
| Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 1987 ; 5 (3) : 382-390. |
| PMID 3546615 |
| Three-way reciprocal chromosomal translocation in an acute lymphoblastic leukemia patient with hypereosinophilia syndrome. |
| McConnell TS, Foucar K, Hardy WR, Saiki J |
| Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 1987 ; 5 (12) : 2042-2044. |
| PMID 3479532 |
| Calla-positive acute leukaemia with t(5q;14q) translocation and hypereosinophilia--a unique entity? |
| Baumgarten E, Wegner RD, Fengler R, Ludwig WD, Schulte-Overberg U, Domeyer C, Schˆºˆºrmann J, Henze G |
| Acta haematologica. 1989 ; 82 (2) : 85-90. |
| PMID 2508400 |
| The t(5;14) chromosomal translocation in a case of acute lymphocytic leukemia joins the interleukin-3 gene to the immunoglobulin heavy chain gene. |
| Grimaldi JC, Meeker TC |
| Blood. 1989 ; 73 (8) : 2081-2085. |
| PMID 2499362 |
| Acute lymphoblastic leukemia with eosinophilia. |
| Fishel RS, Farnen JP, Hanson CA, Silver SM, Emerson SG |
| Medicine. 1990 ; 69 (4) : 232-243. |
| PMID 2374508 |
| Activation of the interleukin-3 gene by chromosome translocation in acute lymphocytic leukemia with eosinophilia. |
| Meeker TC, Hardy D, Willman C, Hogan T, Abrams J |
| Blood. 1990 ; 76 (2) : 285-289. |
| PMID 2114933 |
| Non-random involvement of chromosome 5 in ALL. |
| Chen Z, Morgan R, Sandberg AA |
| Cancer genetics and cytogenetics. 1992 ; 61 (1) : 106-107. |
| PMID 1638475 |
| Cytogenetic analysis in relapsed childhood acute lymphoblastic leukemia. |
| Heerema NA, Palmer CG, Weetman R, Bertolone S |
| Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1992 ; 6 (3) : 185-192. |
| PMID 1564954 |
| Power of the MAC (morphology-antibody-chromosomes) method in distinguishing reactive and clonal cells: report of a patient with acute lymphatic leukemia, eosinophilia, and t(5;14). |
| Knuutila S, Alitalo R, Ruutu T |
| Genes, chromosomes & cancer. 1993 ; 8 (4) : 219-223. |
| PMID 7512364 |
| Contributor(s) |
| Written | 12-1999 | Jean-Loup Huret |
| Citation |
| This paper should be referenced as such : |
| Huret JL . t(5;14)(q31;q32). Atlas Genet Cytogenet Oncol Haematol. December 1999 . URL : http://AtlasGeneticsOncology.org/Anomalies/t514ID1111.html |
This paper is referenced by INIST as such : |
| http://documents.irevues.inist.fr/bitstream/2042/37565/1/12-1999-t514ID1111.pdf [ Bibliographic record ] |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Sat Mar 9 12:38:07 CET 2013 |
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