Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

t(5;14)(q31;q32) IGH::IL3

Written1999-12Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)


ICD-Morpho 9811/3 B lymphoblastic leukaemia/lymphoma, NOS
Atlas_Id 1111
  t(5;14)(q31;q32) G- banding - Courtesy Melanie Zenger and Claudia Haferlach.

Clinics and Pathology

Disease B-cell acute lymphoblastic leukemia (ALL) with hypereosinophilia
Phenotype / cell stem origin CD19+, CD10+ ALL; eosinophils are not part of the leukemic cells and do not carry the t(5;14); they represent a reactive population (eosinophilia in association with ALL is usually reactive)
Epidemiology rarely described; 6M/1F; affects both children and adults, general features of ALL with hypereosinophilia are rarity, male predominance; and young age
Cytology marked eosinophilia; basophilia; IL3 is over-expressed
Prognosis prognosis appears to be poor, a feature of ALLs with hypereosinophilia


Additional anomalies sole anomaly or accompanied with various secondary anomalies: +X, (i(7q), del(12p), +19

Genes involved and Proteins

Gene NameIL3 (interleukin-3)
Location 5q31.1
Protein 152 amino acids; growth factor; colony stimulating factor involved in the survival, proliferation and differentiation of multipotent hematopoietic cells
Gene NameIGH (Immunoglobulin Heavy)
Location 14q32.33

Result of the chromosomal anomaly

Hybrid gene
Description break in the promoter region of IL3 and in the Jh region of IgH
Fusion Protein
Expression Localisation the immunoglobulin gene promoter controls the expression of IL3
Oncogenesis over-expression of IL3

To be noted

no recent article has been found; additional cases are needed to delineate this entity; we propose that a Study Group is established and that cases are collected; if you have a case, please, contact us
Case Report A new case of t(5;14)(q31;q32) in a pediatric acute lymphoblastic leukemia presenting with hypereosinophilia


Calla-positive acute leukaemia with t(5q;14q) translocation and hypereosinophilia--a unique entity?
Baumgarten E, Wegner RD, Fengler R, Ludwig WD, Schulte-Overberg U, Domeyer C, Schüürmann J, Henze G
Acta haematologica. 1989 ; 82 (2) : 85-90.
PMID 2508400
Non-random involvement of chromosome 5 in ALL.
Chen Z, Morgan R, Sandberg AA
Cancer genetics and cytogenetics. 1992 ; 61 (1) : 106-107.
PMID 1638475
Acute lymphoblastic leukemia with eosinophilia.
Fishel RS, Farnen JP, Hanson CA, Silver SM, Emerson SG
Medicine. 1990 ; 69 (4) : 232-243.
PMID 2374508
The t(5;14) chromosomal translocation in a case of acute lymphocytic leukemia joins the interleukin-3 gene to the immunoglobulin heavy chain gene.
Grimaldi JC, Meeker TC
Blood. 1989 ; 73 (8) : 2081-2085.
PMID 2499362
Cytogenetic analysis in relapsed childhood acute lymphoblastic leukemia.
Heerema NA, Palmer CG, Weetman R, Bertolone S
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1992 ; 6 (3) : 185-192.
PMID 1564954
Acute lymphoblastic leukemia with chromosomal 5;14 translocation and hypereosinophilia: case report and literature review.
Hogan TF, Koss W, Murgo AJ, Amato RS, Fontana JA, VanScoy FL
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 1987 ; 5 (3) : 382-390.
PMID 3546615
Power of the MAC (morphology-antibody-chromosomes) method in distinguishing reactive and clonal cells: report of a patient with acute lymphatic leukemia, eosinophilia, and t(5;14).
Knuutila S, Alitalo R, Ruutu T
Genes, chromosomes & cancer. 1993 ; 8 (4) : 219-223.
PMID 7512364
Three-way reciprocal chromosomal translocation in an acute lymphoblastic leukemia patient with hypereosinophilia syndrome.
McConnell TS, Foucar K, Hardy WR, Saiki J
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 1987 ; 5 (12) : 2042-2044.
PMID 3479532
Activation of the interleukin-3 gene by chromosome translocation in acute lymphocytic leukemia with eosinophilia.
Meeker TC, Hardy D, Willman C, Hogan T, Abrams J
Blood. 1990 ; 76 (2) : 285-289.
PMID 2114933
Hypereosinophilic syndrome in acute lymphoblastic leukemia with a chromosome translocation [t(5q;14q)].
Tono-oka T, Sato Y, Matsumoto T, Ueno N, Ohkawa M, Shikano T, Takeda T
Medical and pediatric oncology. 1984 ; 12 (1) : 33-37.
PMID 6583469


This paper should be referenced as such :
Huret, JL
Atlas Genet Cytogenet Oncol Haematol. 1999;3(4):203-204.
Free journal version : [ pdf ]   [ DOI ]
On line version :

Other genes implicated (Data extracted from papers in the Atlas) [ 2 ]

Genes IGH IL3

Translocations implicated (Data extracted from papers in the Atlas)

 t(5;14)(q31;q32) IGH/IL3

External links

IGH (14q32.33) IL3 (5q31.1)

Mitelman databaset(5;14)(q31;q32)
arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9811/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
Mitelman databaseIGH::IL3 [MCList]  IGH (14q32.33) IL3 (5q31.1)
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Oct 8 16:37:34 CEST 2021

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us