| Gene Name | DACH2 (dachshund family transcription factor 2) |
| Location | Xq21.2 |
| Dna / Rna | 7 splice transcript variants. |
| Protein | 599 amino acids and shorter forms; from N-term to C-term, contains a Poly-Gly (amino acids (aa) 56-61), a Dachshund domain motif N (aa 69-155), which interact with HDAC3 (histone deacetylase 3, 5q31), NCOR1 (nuclear receptor corepressor 1, 17p11.2), and SIX6 (SIX homeobox 6, 14q23.1), a Poly-Ala (aa 350-353), a Dachshund Domain motif C, which interact with EYA2 (eyes absent homolog 2 (Drosophila), 20q13.1), and a Coiled coil domain (aa 459-554) (Swiss-Prot). DACH2 is a transcriptional repressor of MYOG (myogenin, 1q32.1). PAX3 (paired box gene 3, 2q36.1) and DACH2 positively regulate each other, and support the existence of a PAX3/SIX1/EYA2/LBX1/DACH2 network in regulating the myogenic differentiation program (Mennerich and Braun, 2001; Kardon et al., 2002). Histone deacetylase (HDAC4) activity, imported into the nucleus, suppresses DACH2 gene expression in denervated muscle (Tang and Goldman, 2006; Cohen et al., 2007). DACH2 represses SIX1 (SIX homeobox 1, 14q23.1), and SIX1 overexpression has been described in gliomas. DACH1 (13q22) and DACH2 are required for Müllerian duct development. DACH2 is abundantly expressed in fallopian tubes, and it has been implicated in premature ovarian failure syndrome (Bione et al., 2004; Suzumori et al., 2007). In ovarian cancer, DACH2 is expressed, and a significantly reduced overall survival was found for tumours expressing high levels of DACH2 in the subgroup of serous carcinoma, but not in other subgroups (Nodin et al., 2012). |
| Mutation analysis of two candidate genes for premature ovarian failure, DACH2 and POF1B. |
| Bione S, Rizzolio F, Sala C, Ricotti R, Goegan M, Manzini MC, Battaglia R, Marozzi A, Vegetti W, Dalpra L, Crosignani PG, Ginelli E, Nappi R, Bernabini S, Bruni V, Torricelli F, Zuffardi O, Toniolo D. |
| Hum Reprod. 2004 Dec;19(12):2759-66. Epub 2004 Sep 30. |
| PMID 15459172 |
| |
| Pax5: the guardian of B cell identity and function. |
| Cobaleda C, Schebesta A, Delogu A, Busslinger M. |
| Nat Immunol. 2007 May;8(5):463-70. (REVIEW) |
| PMID 17440452 |
| |
| The histone deacetylase HDAC4 connects neural activity to muscle transcriptional reprogramming. |
| Cohen TJ, Waddell DS, Barrientos T, Lu Z, Feng G, Cox GA, Bodine SC, Yao TP. |
| J Biol Chem. 2007 Nov 16;282(46):33752-9. Epub 2007 Sep 16. |
| PMID 17873280 |
| |
| Wide diversity of PAX5 alterations in B-ALL: a Groupe Francophone de Cytogenetique Hematologique study. |
| Coyaud E, Struski S, Prade N, Familiades J, Eichner R, Quelen C, Bousquet M, Mugneret F, Talmant P, Pages MP, Lefebvre C, Penther D, Lippert E, Nadal N, Taviaux S, Poppe B, Luquet I, Baranger L, Eclache V, Radford I, Barin C, Mozziconacci MJ, Lafage-Pochitaloff M, Antoine-Poirel H, Charrin C, Perot C, Terre C, Brousset P, Dastugue N, Broccardo C. |
| Blood. 2010 Apr 15;115(15):3089-97. doi: 10.1182/blood-2009-07-234229. Epub 2010 Feb 16. |
| PMID 20160164 |
| |
| Pax5 induces V-to-DJ rearrangements and locus contraction of the immunoglobulin heavy-chain gene. |
| Fuxa M, Skok J, Souabni A, Salvagiotto G, Roldan E, Busslinger M. |
| Genes Dev. 2004 Feb 15;18(4):411-22. |
| PMID 15004008 |
| |
| B cell-specific loss of histone 3 lysine 9 methylation in the V(H) locus depends on Pax5. |
| Johnson K, Pflugh DL, Yu D, Hesslein DG, Lin KI, Bothwell AL, Thomas-Tikhonenko A, Schatz DG, Calame K. |
| Nat Immunol. 2004 Aug;5(8):853-61. Epub 2004 Jul 18. |
| PMID 15258579 |
| |
| Pax3 and Dach2 positive regulation in the developing somite. |
| Kardon G, Heanue TA, Tabin CJ. |
| Dev Dyn. 2002 Jul;224(3):350-5. |
| PMID 12112464 |
| |
| Pax5: a master regulator of B cell development and leukemogenesis. |
| Medvedovic J, Ebert A, Tagoh H, Busslinger M. |
| Adv Immunol. 2011;111:179-206. doi: 10.1016/B978-0-12-385991-4.00005-2. (REVIEW) |
| PMID 21970955 |
| |
| Activation of myogenesis by the homeobox gene Lbx1 requires cell proliferation. |
| Mennerich D, Braun T. |
| EMBO J. 2001 Dec 17;20(24):7174-83. |
| PMID 11742994 |
| |
| Discovery of dachshund 2 protein as a novel biomarker of poor prognosis in epithelial ovarian cancer. |
| Nodin B, Fridberg M, Uhlen M, Jirstrom K. |
| J Ovarian Res. 2012 Jan 27;5(1):6. doi: 10.1186/1757-2215-5-6. |
| PMID 22284433 |
| |
| Candidate genes for premature ovarian failure. |
| Suzumori N, Pangas SA, Rajkovic A. |
| Curr Med Chem. 2007;14(3):353-7. (REVIEW) |
| PMID 17305537 |
| |
| Activity-dependent gene regulation in skeletal muscle is mediated by a histone deacetylase (HDAC)-Dach2-myogenin signal transduction cascade. |
| Tang H, Goldman D. |
| Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16977-82. Epub 2006 Oct 30. |
| PMID 17075071 |
| |
| Transcription factor Pax5 (BSAP) transactivates the RAG-mediated V(H)-to-DJ(H) rearrangement of immunoglobulin genes. |
| Zhang Z, Espinoza CR, Yu Z, Stephan R, He T, Williams GS, Burrows PD, Hagman J, Feeney AJ, Cooper MD. |
| Nat Immunol. 2006 Jun;7(6):616-24. Epub 2006 May 7. |
| PMID 16680144 |
| |
