Atlas of Genetics and Cytogenetics in Oncology and Haematology


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Apoptosis

Deep Insight

Adiponectin and cancer
Caspase-8 and Cancer
A role of actin-to-CD95 connection in CD-95 apoptotic pathway
Cell cycle, checkpoints and cancer
The contribution of circadian rhythms to cancer formation and mortality
DNA methylation in cancer
FOXP3 expression in tumor cells and its role in cancer progression
The Hippo Kinase Pathway: a master regulator of proliferation, development and differentiation
Role of p38α in apoptosis: implication in cancer development and therapy
Mechanisms of rDNA silencing and the Nucleolar Remodelling Complex (NoRC)
TGFβ and Bim: Partners in cell death
Tissue specific role of calcium sensing receptor
Role of TWIST proteins in cancer progression
Vacuolar H(+)-ATPase in Cancer Cells: Structure and Function

Genes

AATF (Apoptosis Antagonizing Transcription Factor)
ACLY (ATP citrate lyase)
ACVR2A (Activin Receptor Type 2)
FOXO3 (forkhead box O3A)
AFAP1L2 (actin filament associated protein 1-like 2)
AIFM2 (apoptosis-inducing factor, mitochondrion-associated, 2)
ANP32A (acidic (leucine-rich) nuclear phosphoprotein 32 family, member A)
ANXA1 (annexin A1)
APAF1 (Apoptotic protease activating factor 1)
ATF4 (activating transcription factor 4 (tax-responsive enhancer element B67))
ATF5 (activating transcription factor 5)
ATMIN (ATM Interactor)
AVEN (apoptosis, caspase activation inhibitor)
AXIN1 (axin 1)
BACH2 (BTB and CNC homology 1, basic leucine zipper transcription factor 2)
BAD (BCL2-antagonist of cell death)
BAG1 (BCL2-associated athanogene)
BAG3 (Bcl-2 associated athanogene 3)
BAK1 (BCL2-antagonist/killer 1)
BAX (BCL2-associated X protein)
BBC3 (BCL2 binding component 3)
BCAR1 (breast cancer anti-estrogen resistance 1)
BCL10 (B-cell CLL/lymphoma 10)
BCL2 (B-cell leukemia/lymphoma 2)
BCL2L11 (BCL2-like 11 (apoptosis facilitator))
BCL2L12 (BCL2-like 12 (proline-rich))
BCL2L14 (BCL2-like 14 (apoptosis facilitator))
BCL2L15 (BCL2-like 15)
BCL2L1 (BCL2-like 1)
BCL6 (B-Cell Lymphoma 6)
BCLAF1 (BCL2-associated transcription factor 1)
BEX2 (brain expressed X-linked 2)
BIRC2 (baculoviral IAP repeat-containing 2)
BIRC3 (baculoviral IAP repeat-containing 3)
BIRC6 (Baculoviral IAP repeat-containing 6)
BNIP3 (Bcl-2/adenovirus E1B 19kD-interacting protein 3)
BOK (BCL2-related ovarian killer)
BABAM2 (brain and reproductive organ-expressed (TNFRSF1A modulator))
TIGAR (chromosome 12 open reading frame 5)
CALR (calreticulin)
CARD10 (caspase recruitment domain family, member 10)
CASP7 (caspase 7, apoptosis-related cysteine peptidase)
CASP8AP2 (caspase 8 associated protein 2)
CASP8 (Caspase 8, Apoptosis-Related Cysteine Peptidase)
CASP9 (caspase 9, apoptosis-related cysteine peptidase)
CDK20 (cell cycle related kinase)
CDC25A (Cell division cycle 25A)
CDKN1A (cyclin-dependent kinase inhibitor 1A)
CDT1 (chromatin licensing and DNA replication factor 1)
CELF2 (CUGBP, Elav-like family member 2)
AGAP2 (Centaurin , gamma1)
CFLAR (CASP8 and FADD-like apoptosis regulator)
CHST11 (carbohydrate (chondroitin 4) sulfotransferase 11)
CLIC1 (chloride intracellular channel 1)
CLU (clusterin)
CSE1L (CSE1 chromosome segregation 1-like (yeast))
CUX1 (cut-like homeobox 1)
CX3CL1 (chemokine (C-X3-C motif) ligand 1)
CXCL10 (chemokine (C-X-C motif) ligand 10)
CXCL12 (chemokine (C-X-C motif) ligand 12)
CXXC5 (CXXC finger protein 5)
CYR61 (cysteine-rich, angiogenic inducer, 61)
DAPK1 (death-associated protein kinase 1)
DAPK2 (death-associated protein kinase 2)
DCC (deleted in colorectal carcinoma)
DDX25 (DEAD (Asp-Glu-Ala-Asp) box helicase 25)
DDX5 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 5)
DIABLO (diablo, IAP-binding mitochondrial protein)
DIRAS3 (DIRAS family, GTP-binding RAS-like 3)
DLX4 (distal-less homeobox 4)
DNAJA3 (DnaJ (Hsp40) homolog, subfamily A, member 3)
DUSP26 (dual specificity phosphatase 26)
DYRK1A (dual-specificity tyrosine- (Y)-phosphorylation regulated kinase 1A)
E2F4 (E2F transcription factor 4, p107/p130-binding)
EDIL3 (EGF-Like Repeats And Discoidin I-Like Domains 3)
EEF1A1 (eukaryotic translation elongation factor 1 alpha 1)
EHF (ets homologous factor)
EIF2AK2 (eukaryotic translation initiation factor 2-alpha kinase 2)
EIF3A (eukaryotic translation initiation factor 3, subunit A)
EIF3F (eukaryotic translation initiation factor 3, subunit F)
EIF4EBP1 (Eukaryotic translation initiation factor 4E binding protein 1)
EP400 (E1A binding protein p400)
EPB41L3 (erythrocyte membrane protein band 4.1-like 3)
ERBB3 (v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian))
MECOM (Ecotropic Viral Integration Site 1 (EVI1) and Myelodysplastic Syndrome 1 (MDS1-EVI1)
EWSR1 (Ewing sarcoma breakpoint region 1)
FAIM (Fas apoptotic inhibitory molecule)
FAS (Fas cell surface death receptor)
FAU (Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed)
FKBP8 (FK506 binding protein 8, 38kDa)
FOSL1 (FOS-like antigen 1)
FOXF1 (forkhead box F1)
FOXQ1 (forkhead box Q1)
FPR1 (formyl peptide receptor 1)
FUBP1 (far upstream element (FUSE) binding protein 1)
GADD45A (growth arrest and DNA-damage-inducible, alpha)
GAS5 (growth arrest-specific 5 (non-protein coding))
GFI1 (growth factor independent 1 transcription repressor)
NOP53 (ribosome biogenesis factor)
GSDMA (gasdermin A)
GSK3B (glycogen synthase kinase 3 beta)
GZMA (granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3))
CCDC6 (coiled-coil domain containing 6)
HELLS (Helicase, Lymphoid-Specific)
HIP1 (Huntingtin interactin protein 1)
HIPK2 (homeodomain interacting protein kinase 2)
HRK (harakiri, BCL2 interacting protein (contains only BH3 domain))
HSPB8 (heat shock 22kDa protein 8)
HTATIP2 (HIV-1 Tat interactive protein 2, 30kDa)
HTRA1 (HtrA serine peptidase 1)
HTRA2 (HtrA serine peptidase 2)
HTRA3 (HtrA serine peptidase 3)
HUS1 (HUS1 checkpoint homolog (S. pombe))
ID1 (inhibitor of DNA binding 1, dominant negative helix-loop-helix protein)
IER3 (immediate early response 3)
IGF1 (Insulin-Like Growth Factor 1 (Somatomedin C))
ILK (integrin-linked kinase)
ING1 (inhibitor of growth family, member 1)
ING3 (inhibitor of growth family, member 3)
ING4 (inhibitor of growth family, member 4)
INGX (inhibitor of growth family, X-linked, pseudogene)
IRF4 (interferon regulatory factor 4)
IRS2 (insulin receptor substrate 2)
MAPK8 (mitogen-activated protein kinase 8)
MAPK9 (mitogen-activated protein kinase 9)
MAPK10 (mitogen-activated protein kinase 10)
JUN (V-Jun sarcoma virus 17 oncogene homolog (avian))
KDR (kinase insert domain receptor)/Vascular Endothelial Growth Factor Receptor 2 (VEGFR2)
CCAR2 cell cycle and apoptosis regulator 2
KLLN (killin, p53-regulated DNA replication inhibitor)
LATS1 (Large Tumor Suppressor 1)
LATS2 (LATS, large tumor suppressor, homolog 2 (Drosophila))
LDOC1 (leucine zipper, down-regulated in cancer 1)
LGALS3 (lectin, galactoside-binding, soluble, 3)
LMO1 (LIM domain only 1 (rhombotin 1))
MACROD1 (MACRO domain containing 1)
MAGEA3 (melanoma antigen family A, 3)
MKL1 (megakaryoblastic leukemia (translocation) 1)
MAL (mal, T-cell differentiation protein)
MAPKAPK2 (mitogen-activated protein kinase-activated protein kinase 2)
MBD4 (methyl-CpG binding domain protein 4)
MDM2 (transformed mouse 3T3 cell double minute 2, p53 binding protein)
MELK (maternal embryonic leucine zipper kinase)
MIF (macrophage migration inhibitory factor (glycosylation-inhibiting factor))
MIR100 (microRNA 100)
MIR133B (microRNA 133b)
MIR200C (microRNA 200c)
MIR26A1 (microRNA 26a-1)
MIR449A (microRNA 449a)
MOAP1 (Modulator Of Apoptosis 1)
MST1 (macrophage stimulating 1 (hepatocyte growth factor-like))
MSX2 (Msh Homeobox 2)
MYLK (myosin light chain kinase)
NAMPT (nicotinamide phosphoribosyltransferase)
NAPA (N-ethylmaleimide-sensitive factor attachment protein, alpha)
NDRG1 (N-myc downstream regulated 1)
NDUFA13 (NADH:ubiquinone oxidoreductase subunit A13)
NEU3 (sialidase 3 (membrane sialidase))
NGFR (nerve growth factor receptor)
NLRC4 (NLR Family, CARD domain containing 4)
NOL3 (nucleolar protein 3 (apoptosis repressor with CARD domain))
NR3C1 (nuclear receptor subfamily 3, group C, member 1/glucocorticoid receptor)
NR4A1 (nuclear receptor subfamily 4, group A, member 1)
NR5A1 (nuclear receptor subfamily 5, group A, member 1)
NUDT6 (nudix (nucleoside diphosphate linked moiety X)-type motif 6)
POU2AF1 (POU domain, class 2, associating factor 1)
OLFM4 (olfactomedin 4)
ORAOV1 (oral cancer overexpressed 1)
OSGIN1 (oxidative stress induced growth inhibitor 1)
TP53 (Tumour protein p53 (Li-Fraumeni syndrome))
PAEP (progestagen-associated endometrial protein)
PAK2 (p21 protein (Cdc42/Rac)-activated kinase 2)
PRKN (arkin RBR E3 ubiquitin protein ligase )
PARK7 (Parkinsonism associated deglycase)
PAWR (PRKC apoptosis WT1 regulator protein; Prostate apoptosis response-4, Par-4)
PDCD10 (Programmed cell death 10)
PDCD5 (programmed cell death 5)
PDSS2 (prenyl (decaprenyl) diphosphate synthase, subunit 2)
PEA15 (phosphoprotein enriched in astrocytes 15)
PEG10 (paternally expressed 10)
PEG3 (paternally expressed 3)
PERP (PERP, TP53 apoptosis effector)
PGR (progesterone receptor)
PHLDA1 (pleckstrin homology-like domain, family A, member 1)
PIM1 (pim-1 oncogene)
PIP4K2A (phosphatidylinositol-5-phosphate 4-kinase, type II, alpha)
PLA2G2A (phospholipase A2, group IIA (platelets, synovial fluid))
PLCG1 (Phospholipase C, Gamma 1)
PML (promyelocytic leukemia)
POU4F1 (POU class 4 homeobox 1)
PPP1R13L (protein phosphatase 1, regulatory (inhibitor) subunit 13 like)
PPP2R1A (protein phosphatase 2 regulatory subunit A, alpha)
PTPA ( protein phosphatase 2 phosphatase activator)
PRAME (Preferentially Expressed Antigen In Melanoma)
PSEN2 (presenilin 2 (Alzheimer disease 4))
PTK7 (PTK7 protein tyrosine kinase 7)
PTPN13 (Protein tyrosine phosphatase, non-receptor type 13)
PTPN6 (protein tyrosine phosphatase, non-receptor type 6)
PTTG1 (pituitary tumor-transforming 1)
PYCARD (PYD and CARD domain containing)
RAD9A (RAD9 homolog A (S. pombe))
RAF1 (v-raf-1 murine leukemia viral oncogene homolog 1)
RAN (RAN, member RAS oncogene family)
RAPGEF1 (Rap guanine nucleotide exchange factor (GEF) 1)
RARRES3 (retinoic acid receptor responder (tazarotene induced) 3)
RASSF5 (Ras association (RalGDS/AF-6) domain family member 5)
RASSF6 (Ras association (RalGDS/AF-6) domain family member 6)
RBM5 (RNA binding motif protein 5)
REST (RE1-silencing transcription factor)
RHOBTB2 (Rho-related BTB domain containing 2)
RLN2 (relaxin 2)
S100A2 (S100 calcium binding protein A2)
S100A4 (S100 Calcium Binding Protein A4)
S100A8 (S100 calcium binding protein A8)
S100A9 (S100 calcium binding protein A9)
SEMA3B (sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B)
SERPINB3 (Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 3)
SGK1 (serum/glucocorticoid regulated kinase 1)
SIAH1 (siah E3 ubiquitin protein ligase 1)
SIRT1 (sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae))
SIVA1 (SIVA1, Apoptosis-Inducing Factor)
SOCS3 (suppressor of cytokine signaling 3)
SOX2 (SRY (sex determining region Y)-box 2)
SRSF1 (serine/arginine-rich splicing factor 1)
STK4 (serine/threonine kinase 4)
TGFBR3 (transforming growth factor, beta receptor III)
THRB (Thyroid Hormone Receptor, Beta)
THY1 (Thy-1 cell surface antigen)
TNFRSF6B (tumor necrosis factor receptor superfamily, member 6b, decoy)
TNFSF10 (tumor necrosis factor (ligand) superfamily, member 10)
TNFSF15 (tumor necrosis factor (ligand) superfamily, member 15)
TNFSF18 (tumor necrosis factor (ligand) superfamily, member 18)
TNS4 (tensin 4)
TP53BP2 (tumor protein p53 binding protein, 2)
TP53INP1 (tumor protein p53 inducible nuclear protein 1)
TP63 (tumor protein p63)
TRAF3 (TNF Receptor Associated Factor 3)
TRAP1 (TNF receptor-associated protein 1)
TRIAP1 (TP53 regulated inhibitor of apoptosis 1)
TRPV2 (transient receptor potential cation channel, subfamily V, member 2)
TXN (thioredoxin)
UBD (ubiquitin D)
USP15 (ubiquitin specific peptidase 15)
USP7 (ubiquitin specific peptidase 7 (herpes virus-associated))
VDAC1 (voltage-dependent anion channel 1)
VRK1 (Vaccinia-related kinase 1)
WRAP53 (WD repeat containing, antisense to TP53)
WWOX (WW domain containing oxidoreductase)
XAF1 (XIAP associated factor-1)
XRCC5 (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining))
XRCC6 (X-ray repair complementing defective repair in Chinese hamster cells 6)
YAP1 (Yes-associated protein 1, 65kDa)
ZFP36L1 (Zinc finger protein 36, C3H type-like 1)

Iconography


Figure from ATM


Figure from Autophagy


Figure from CD95_Apoptosis_Pathway


Figure from "Cell_cycle,_checkpoints_and_cancer"


Figure from "Cell_cycle,_checkpoints_and_cancer"


Figure from "Cell_cycle,_checkpoints_and_cancer"


Figure from The_contribution_of_circadian_rhythms_to_cancer_formation_and_mortality


Figure from FAS-FAS_ligand


Figure from FAS-FAS_ligand


Figure from AATF


Figure from AFAP1L2


Figure from AKT1__


Figure from AKT2__


Figure from APAF1


Figure from ATMIN


Figure from BCL2L14


Figure from BCL6


Figure from BCL6


Figure from BIRC6


Figure from TIGAR


Figure from TIGAR


Figure from TIGAR


Figure from CARD10


Figure from CASP7


Figure from CELF2


Figure from CFLAR_


Figure from CHST11


Figure from CXXC5


Figure from DDX25


Figure from DDX25


Figure from DUSP26


Figure from DUSP26


Figure from E2F4


Figure from EHF


Figure from EIF2AK2


Figure from EIF4EBP1


Figure from ERBB3


Figure from FAS


Figure from FAS


Figure from FKBP8


Figure from FKBP8


Figure from FKBP8


Figure from FKBP8


Figure from FOSL1


Figure from FOSL1


Figure from FOXQ1


Figure from FOXQ1


Figure from FPR1


Figure from FUBP1


Figure from FUBP1


Figure from HELLS


Figure from HSPB8


Figure from HSPB8


Figure from HTRA2


Figure from HTRA3


Figure from ILK


Figure from ILK


Figure from ING1


Figure from ING1


Figure from ING3


Figure from INGX


Figure from LATS1


Figure from MAGEA3


Figure from MAGEA3


Figure from MIR100


Figure from MIR100


Figure from MIR133B


Figure from MST1


Figure from MYLK


Figure from NGFR


Figure from NOL3


Figure from NR3C1


Figure from NR5A1


Figure from OSGIN1


Figure from PARK2


Figure from PDSS2


Figure from PEA15


Figure from PHLDA1


Figure from PIP4K2A


Figure from PIP4K2A


Figure from PLCG1


Figure from PRKCD


Figure from PRKCD


Figure from PTK7


Figure from RASSF6


Figure from S100A2


Figure from SGK1


Figure from SHC1


Figure from SRSF1


Figure from TGFBR3


Figure from TNS4Fig2


Figure from TP63


Figure from TRPV2


Figure from USP7


Figure from XRCC5


Figure from CXCL12


Figure from KDR


Figure from LATS1


Figure from NDUFA13


Figure from PARK2


Figure from PARK2


Figure from PARK2


Figure from PIP4K2A

Contributor(s)

WrittenOct 2009Jean-Loup Huret
UpdatedAug 2017Jean-Loup Huret and Philippe Dessen

Citation

This paper should be referenced as such :
, Huret JL, Dessen P.. Apoptosis. Atlas Genet Cytogenet Oncol Haematol. Aug 2017 .
URL : http://AtlasGeneticsOncology.org/Categories/Apoptosis.html


© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Aug 14 13:46:10 CEST 2017

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