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DNA repair


Section Editor - Godefridus Peters

( GJ.Peters@vumc.nl )

Deep Insight

Understanding the structure and function of ASH2L
Ataxia-Telangiectasia and variants
Cell cycle, checkpoints and cancer
Common Chromosomal Fragile Sites: Breakages and Rearrangements in Somatic and Germline Cells
Mechanisms of chromosomal instability and carcinogenesis
Chromothripsis: a new molecular mechanism in cancer development
Cohesins and cohesin-regulators: Role in Chromosome Segregation/Repair and Potential in Tumorigenesis
Common fragile sites and genomic instability
DNA methylation in cancer
Nucleotide excision repair
Genetic Instability in Cancer

Genes specifically involved in DNA repair

Other Genes involved in DNA repair

ASH2L (ash2 (absent, small, or homeotic)-like (Drosophila))
ATMIN (ATM Interactor)
ATR (ataxia telangiectasia and Rad3 related)
AURKB (aurora kinase B)
AVEN (apoptosis, caspase activation inhibitor)
AXIN1 (axin 1)
BAP1 (BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase))
BCR (Breakpoint cluster region)
BLM (Bloom)
BRCA2 (breast cancer 2, early onset)
BABAM2 (brain and reproductive organ-expressed (TNFRSF1A modulator))
EMSY (BRCA2-interacting transcriptional repressor)
TIGAR (chromosome 12 open reading frame 5)
CHEK2 (CHK2 checkpoint homolog (S. pombe))
CHFR (Checkpoint with fork-head associated and ring finger)
CLSPN (claspin)
ERCC8 (excision repair cross-complementing rodent repair deficiency, complementation group 8)
ERCC6 (excision repair cross-complementing rodent repair deficiency, complementation group 6)
DEK (DEK proto-oncogene)
DLX4 (distal-less homeobox 4)
DOT1L (DOT1 like histone H3K79 methyltransferase)
E2F1 (E2F transcription factor 1)
E2F4 (E2F transcription factor 4, p107/p130-binding)
EIF2AK2 (eukaryotic translation initiation factor 2-alpha kinase 2)
EIF3A (eukaryotic translation initiation factor 3, subunit A)
ELF4 (E74-like factor 4 (ets domain transcription factor))
ERCC1 (excision repair complementing defective repair in Chinese hamster.)
EWSR1 (Ewing sarcoma breakpoint region 1)
FANCA (Fanconi anemia, complementation group A)
FANCC (Fanconi anaemia complementation group C)
FANCE (Fanconi anemia, complementation group E)
FANCF (Fanconi anemia, complementation group F)
FANCG (Fanconi anemia, complementation group G)
FEN1 (flap structure-specific endonuclease 1)
FHL2 (four and a half LIM domains 2)
GADD45A (growth arrest and DNA-damage-inducible, alpha)
GSK3B (glycogen synthase kinase 3 beta)
GUCY2C (guanylate cyclase 2C (heat stable enterotoxin receptor))
CCDC6 (coiled-coil domain containing 6)
HELLS (Helicase, Lymphoid-Specific)
HLTF (helicase-like transcription factor)
HMGA2 (high mobility group AT-hook 2)
KAT5 (HIV-1 Tat interacting protein, 60kDa)
HUS1 (HUS1 checkpoint homolog (S. pombe))
IGFBP6 (insulin-like growth factor binding protein 6)
INGX (inhibitor of growth family, X-linked, pseudogene)
INPP4B (Inositol Polyphosphate-4-Phosphate Type II B)
PCLAF (PCNA clamp associated factor)
KSR1 (kinase suppressor of ras 1)
MACROD1 (MACRO domain containing 1)
MAPKAPK2 (mitogen-activated protein kinase-activated protein kinase 2)
MBD4 (methyl-CpG binding domain protein 4)
MIR100 (microRNA 100)
MIR146B (microRNA 146b)
MIR449A (microRNA 449a)
MLH1 (human mutL homolog 1)
MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
MSH2 (human mutS homolog 2)
MSH3 mutS homolog 3 (E. coli)
MSH6 (mutS homolog 6 (E. Coli))
MUTYH (mutY homolog (E. coli))
NAMPT (nicotinamide phosphoribosyltransferase)
NDRG1 (N-myc downstream regulated 1)
NEIL1 (nei endonuclease VIII-like 1 (E. coli))
NME1 (NME/NM23 nucleoside diphosphate kinase 1)
TP53 (Tumour protein p53 (Li-Fraumeni syndrome))
PCNA (proliferating cell nuclear antigen)
PIAS1 (protein inhibitor of activated STAT, 1)
PIWIL2 (piwi-like RNA-mediated gene silencing 2)
PLK1 (polo-like kinase 1 (Drosophila))
PML (promyelocytic leukemia)
PMS1 (PMS1 postmeiotic segregation increased 1 (S. cerevisiae))
PPP2R1A (protein phosphatase 2 regulatory subunit A, alpha)
RAD51D (RAD51-like 3 (S. cerevisiae))
RAD52 (RAD52 homolog (S. cerevisiae))
RAD9A (RAD9 homolog A (S. pombe))
RANBP2 (RAN binding protein 2)
RECQL4 (RecQ protein-like 4
RECQL RecQ protein-like (DNA helicase Q1-like)
RPA2 (replication protein A2, 32kDa)
RPS27 (ribosomal protein S27)
RRM1 (ribonucleotide reductase M1)
S100A4 (S100 Calcium Binding Protein A4)
SGK1 (serum/glucocorticoid regulated kinase 1)
SIRT1 (sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae))
TERF2 (telomeric repeat binding factor 2)
TNKS (tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase)
TRIAP1 (TP53 regulated inhibitor of apoptosis 1)
USP1 (ubiquitin specific peptidase 1)
VCP (valosin containing protein)
XPA xeroderma pigmentosum, complementation group A)
ERCC3 (Excision repair cross-complementing rodent repair deficiency, complementation group 3)
XPC (xeroderma pigmentosum, complementation group C)
ERCC2 (Excision repair cross-complementing rodent repair deficiency, complementation group 2)
DDB2 (xeroderma pigmentosum, complementation group E)
ERCC4 (xeroderma pigmentosum, complementation group F)
ERCC5 (xeroderma pigmentosum, complementation group G)
POLH (polymerase (DNA direct), eta)
XRCC3 (X-ray repair complementing defective repair in Chinese hamster cells 3)
XRCC5 (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining))
XRCC6 (X-ray repair complementing defective repair in Chinese hamster cells 6)

Iconography


Figure from ATM


Figure from "Cell_cycle,_checkpoints_and_cancer"


Figure from "Cell_cycle,_checkpoints_and_cancer"


Figure from "Cell_cycle,_checkpoints_and_cancer"


Figure from ChromFragSites


Figure from Mechanisms_of_chromosomal_instability_and_carcinogenesis


Figure from Mechanisms_of_chromosomal_instability_and_carcinogenesis


Figure from Mechanisms_of_chromosomal_instability_and_carcinogenesis


Figure from Cohesins


Figure from Cohesins


Figure from Cohesins


Figure from ATMIN


Figure from AURKB


Figure from AURKB


Figure from AURKB


Figure from BAP1


Figure from BRCA2


Figure from TIGAR


Figure from TIGAR


Figure from TIGAR


Figure from E2F1


Figure from E2F4


Figure from EIF2AK2


Figure from EIF3A


Figure from ELF4


Figure from ELF4


Figure from EWSR1


Figure from FANCA


Figure from FANCA


Figure from FEN1


Figure from FEN1


Figure from GSK3B


Figure from HELLS


Figure from HLTF


Figure from HLTF


Figure from KAT5


Figure from HUS1


Figure from IGFBP6


Figure from INGX


Figure from KSR1


Figure from MBD4


Figure from MIR100


Figure from MIR100


Figure from MIR146B


Figure from MLH1


Figure from MSH2


Figure from MUTYH


Figure from NDRG1


Figure from PCNA


Figure from PIAS1


Figure from PIWIL2


Figure from RAD51L3


Figure from RAD52


Figure from RAD52


Figure from RAD52


Figure from RAD9A


Figure from RANBP2


Figure from RANBP2


Figure from RECQL4


Figure from RPA2


Figure from SGK1


Figure from SIRT1


Figure from TNKS


Figure from TRIAP1


Figure from XRCC5


Figure from XRCC6


Figure from XRCC6


Figure from XRCC6

Contributor(s)

WrittenOct 2009Jean-Loup Huret
UpdatedAug 2017Jean-Loup Huret and Philippe Dessen

Citation

This paper should be referenced as such :
, Huret JL, Dessen P.. DNA_repair. Atlas Genet Cytogenet Oncol Haematol. Aug 2017 .
URL : http://AtlasGeneticsOncology.org/Categories/DNA_repair.html


© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Aug 14 13:46:10 CEST 2017

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