Kinase

Deep Insight Genes ABL2 (Abelson homolog 2) ABL1 (v-abl Abelson murine leukemia viral oncogene homolog 1) ACVR1 (activin A receptor, type I) ACVR2A (Activin Receptor Type 2) ACVRL1 (activin A receptor type II-like 1) AKT1 (v-akt murine thymoma viral oncogene homolog 1) AKT2 (v-akt murine thymoma viral oncogene homolog 2) AKT3 (v-akt murine thymoma viral oncogene homolog 3, Protein Kinase B gamma) ALK (anaplastic lymphoma receptor tyrosine kinase) ATM (ataxia telangiectasia mutated) ATR (ataxia telangiectasia and Rad3 related) AURKB (aurora kinase B) AXL (AXL receptor tyrosine kinase) BCR (Breakpoint cluster region) BRAF (v-raf murine sarcoma viral oncogene homolog B1) BTK (Bruton agammaglobulinemia tyrosine kinase) BUB1B (budding uninhibited by benzimidazoles 1 homolog beta (yeast)) BUB1 (budding uninhibited by benzimidazoles 1 homolog (yeast)) CDK20 (cell cycle related kinase) CDK2 (cyclin dependent kinase 2) CDK4 (cyclin-dependent kinase 4) CHEK2 (CHK2 checkpoint homolog (S. pombe)) CHKA (choline kinase alpha) CSF1R (colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog) CSNK1A1 (casein kinase 1, alpha 1) DAPK1 (death-associated protein kinase 1) DDR1 (discoidin domain receptor tyrosine kinase 1) DGKA (diacylglycerol kinase, alpha 80kDa) DYRK1A (dual-specificity tyrosine- (Y)-phosphorylation regulated kinase 1A) DYRK1B (dual-specificity tyrosine- (Y)-phosphorylation regulated kinase 1B) EGFR (Epidermal Growth Factor Receptor) EIF2AK2 (eukaryotic translation initiation factor 2-alpha kinase 2) EPHA1 (EPH receptor A1) EPHA2 (EPH receptor A2) EPHA3 (EPH receptor A3) EPHA7 (EPH receptor A7) ERBB2 (v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)) ERBB3 (v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)) FGFR1 (Fibroblast Growth Factor Receptor 1) FGFR2 (fibroblast growth factor receptor 2) FGFR4 (fibroblast growth factor receptor 4) FGFR3 (Fibroblast Growth Factor Receptor 3) FLT3 (FMS-like tyrosine kinase 3) MTOR (FK506 binding protein 12-rapamycin associated protein 1) GSK3B (glycogen synthase kinase 3 beta) HIPK2 (homeodomain interacting protein kinase 2) IGF1R (insulin-like growth factor 1 receptor) ILK (integrin-linked kinase) ITK (IL2-inducible T-cell kinase) JAK1 (Janus kinase 1) JAK3 (Janus Kinase 3 or Just Another Kinase 3) JAK2 (janus kinase 2) MAPK8 (mitogen-activated protein kinase 8) MAPK9 (mitogen-activated protein kinase 9) MAPK10 (mitogen-activated protein kinase 10) KDR (kinase insert domain receptor)/Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) LATS2 (LATS, large tumor suppressor, homolog 2 (Drosophila)) LCK (lymphocyte-specific protein tyrosine kinase) LIMK1 (LIM domain kinase 1) MAP2K4 (mitogen-activated protein kinase kinase 4) MAP3K7 (mitogen-activated protein kinase kinase kinase 7) MAPK12 (mitogen-activated protein kinase 12) MAPK13 (mitogen-activated protein kinase 13) MAPK14 (mitogen-activated protein kinase 14) MAPK1 (mitogen-activated protein kinase 1) MAPK3 (mitogen-activated protein kinase 3) MAPK4 (mitogen-activated protein kinase 4) MAPK6 (mitogen-activated protein kinase 6) MAPK7 (mitogen-activated protein kinase 7) MAPKAPK2 (mitogen-activated protein kinase-activated protein kinase 2) MARK4 (MAP/microtubule affinity-regulating kinase 4) MELK (maternal embryonic leucine zipper kinase) MERTK (c-mer proto-oncogene tyrosine kinase) MET met proto-oncogene (hepatocyte growth factor receptor) CIITA (MHC class II transactivator) MYLK (myosin light chain kinase) NCOA1 (Nuclear receptor coactivator 1) NME1 (NME/NM23 nucleoside diphosphate kinase 1) NTRK2 (Neurotrophic tyrosine kinase, receptor, type 2) NTRK3 (neurotrophic tyrosine kinase, receptor, type 3) NUAK1 (NUAK family, SNF1-like kinase, 1) PAK1 (p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)) PAK2 (p21 protein (Cdc42/Rac)-activated kinase 2) PDGFRA (platelet-derived growth factor receptor, alpha polypeptide) PDGFRB (platelet-derived growth factor receptor, beta polypeptide) PFKFB2 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2) PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3) PFKFB4 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4) PIK3CA (phosphoinositide-3-kinase, catalytic, alpha polypeptide) PIK3CD (phosphoinositide-3-kinase, catalytic, delta polypeptide) PIM1 (pim-1 oncogene) PIP4K2A (phosphatidylinositol-5-phosphate 4-kinase, type II, alpha) PKM (pyruvate kinase isoenzyme type M2) PLK1 (polo-like kinase 1 (Drosophila)) PRKCD (protein kinase C, delta) PRKCI (protein kinase C, iota) PRKD1 (Protein Kinase D1) PTK2 (PTK2 protein tyrosine kinase 2) PTK6 (protein tyrosine kinase 6) RAF1 (v-raf-1 murine leukemia viral oncogene homolog 1) RET (REarranged during Transfection) ROCK2 (Rho-associated, coiled-coil containing protein kinase 2) MST1R (Macrophage stimulating 1 receptor) ROR2 (receptor tyrosine kinase-like orphan receptor 2) ROS1 (ROS proto-oncogene 1 , receptor tyrosine kinase) RPS6KA1 (ribosomal protein S6 kinase, 90kDa, polypeptide 1) RPS6KA6 (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 6) SGK1 (serum/glucocorticoid regulated kinase 1) SRC (v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)) STK11 (serine/threonine kinase 11) STK4 (serine/threonine kinase 4) SYK (spleen tyrosine kinase) TEK (TEK tyrosine kinase, endothelial) TGFBR2 (Transforming Growth Factor, Beta Receptor II (70/80kDa)) TIE1 (tyrosine kinase with immunoglobulin-like and EGF-like domains 1) TLK2 (Tousled Like Kinase 2) TNIK (TRAF2 and NCK interacting kinase) TPH1 (tryptophan hydroxylase 1) TRIO (triple functional domain (PTPRF interacting)) TYRO3 (TYRO3 protein tyrosine kinase) UHMK1 (U2AF homology motif kinase 1) VRK1 (Vaccinia-related kinase 1) VRK2 (vaccinia related kinase 2) WNK2 (WNK lysine deficient protein kinase 2) ZAP70 (zeta-chain (TCR) associated protein kinase 70kDa)

Iconography Figure from ABL1 Figure from ACVRL1 Figure from AURKB Figure from AURKB Figure from AURKB Figure from DGKA Figure from FGFR1 Figure from FGFR1 Figure from FGFR2 Figure from FGFR4 Figure from ILK Figure from ILK Figure from KDR Figure from NUAK1 Figure from PFKFB2 Figure from PFKFB2 Figure from PIP4K2A Figure from PIP4K2A Figure from PIP4K2A Figure from PTK6 Figure from SGK1 Figure from TGFBR2 Figure from TRIB1 Figure from ZAP70

Contributor(s)

Written	Oct 2009	Jean-Loup Huret
Updated	Oct 2020	Jean-Loup Huret and Philippe Dessen

Citation

This paper should be referenced as such :

, Huret JL, Dessen P.. Kinase. Atlas Genet Cytogenet Oncol Haematol. Oct 2020 . URL : http://AtlasGeneticsOncology.org/Categories/Kinase.html