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Proteasome

Deep Insight

Ubiquitin, ubiquitination and the ubiquitin-proteasome system in cancer

Genes

AKT1S1 (AKT1 substrate 1 (proline-rich))
AMFR (autocrine motility factor receptor)
ATF4 (activating transcription factor 4 (tax-responsive enhancer element B67))
BAG3 (Bcl-2 associated athanogene 3)
BAP1 (BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase))
BARD1 (BRCA1 associated RING domain 1)
BCL6 (B-Cell Lymphoma 6)
BIRC6 (Baculoviral IAP repeat-containing 6)
BMI1 (BMI1 polycomb ring finger oncogene)
BRCA1 (breast cancer 1, early onset)
BABAM2 (brain and reproductive organ-expressed (TNFRSF1A modulator))
CASP8 (Caspase 8, Apoptosis-Related Cysteine Peptidase)
CBL (Cas-Br-M (murine) ecotropic retroviral transforming sequence)
CHFR (Checkpoint with fork-head associated and ring finger)
CLSPN (claspin)
COPS2 (COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis))
CTSH (cathepsin H)
DLG1 (discs, large homolog 1 (Drosophila))
DRAM1 (damage-regulated autophagy modulator)
ELF4 (E74-like factor 4 (ets domain transcription factor))
FBXO11 (F-box protein 11)
FKBP8 (FK506 binding protein 8, 38kDa)
FOSL1 (FOS-like antigen 1)
GFI1 (growth factor independent 1 transcription repressor)
GRB2 (Growth factor receptor-bound protein 2)
HACE1 (HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1)
HIPK2 (homeodomain interacting protein kinase 2)
HLTF (helicase-like transcription factor)
HNRNPD (heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa))
HSPA8 (heat shock 70kDa protein 8)
HSPB8 (heat shock 22kDa protein 8)
MIB2 (mindbomb homolog 2 (Drosophila))
NR3C1 (nuclear receptor subfamily 3, group C, member 1/glucocorticoid receptor)
ENC1 (ectodermal-neural cortex (with BTB-like domain))
PA2G4 (proliferation-associated 2G4, 38kDa)
PRKN (arkin RBR E3 ubiquitin protein ligase )
PIAS1 (protein inhibitor of activated STAT, 1)
ZBTB16 (zinc finger and BTB domain containing 16)
PML (promyelocytic leukemia)
PRAME (Preferentially Expressed Antigen In Melanoma)
PSAP (Prosaposin (variant Gaucher disease and variant metachromatic leukodystrophy))
RCHY1 (ring finger and CHY zinc finger domain containing 1)
REST (RE1-silencing transcription factor)
RHOBTB1 (Rho-related BTB domain containing 1)
RHOBTB2 (Rho-related BTB domain containing 2)
RHOBTB3 (Rho-related BTB domain containing 3)
RNF11 (ring finger protein 11)
RNF7 (RING finger protein-7)
SGK1 (serum/glucocorticoid regulated kinase 1)
SIAH1 (siah E3 ubiquitin protein ligase 1)
SIAH2 (seven in absentia homolog 2 (Drosophila))
SIRT1 (sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae))
SLC4A1 (solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group))
SOCS2 (suppressor of cytokine signaling 2)
SOCS3 (suppressor of cytokine signaling 3)
SORBS2 (sorbin and SH3 domain containing 2)
RNF139 (translocation in renal carcinoma, chromosome 8 gene)
TRIM27 (tripartite motif containing 27)
TRIM37 (tripartite motif-containing 37)
UBD (ubiquitin D)
USP15 (ubiquitin specific peptidase 15)
USP1 (ubiquitin specific peptidase 1)
USP32 (ubiquitin specific peptidase 32)
VCP (valosin containing protein)
VMP1 (vacuole membrane protein 1)
WWP1 (WW domain containing E3 ubiquitin protein ligase 1)
WWTR1 (WW domain containing transcription regulator 1)
ZBTB33 (zinc finger and BTB domain containing 33)

Iconography


Figure from Autophagy


Figure from UbiquitininCancer


Figure from UbiquitininCancer


Figure from UbiquitininCancer


Figure from UbiquitininCancer


Figure from UbiquitininCancer


Figure from UbiquitininCancer


Figure from AKT1S1


Figure from AMFR


Figure from ATF4


Figure from BAP1


Figure from BCL6


Figure from BCL6


Figure from BMI1


Figure from BRCA1


Figure from COPS2


Figure from ELF4


Figure from ELF4


Figure from FBXO11


Figure from FKBP8


Figure from FKBP8


Figure from FKBP8


Figure from FOSL1


Figure from FOSL1


Figure from GFI1


Figure from GRB2


Figure from HACE1


Figure from HLTF


Figure from HNRNPD


Figure from HSPA8


Figure from HSPA8


Figure from HSPB8


Figure from HSPB8


Figure from MIB2


Figure from NR3C1


Figure from PA2G4


Figure from PARK2


Figure from PIAS1


Figure from PSAP


Figure from REST


Figure from RNF11


Figure from RNF11


Figure from SGK1


Figure from SIAH2


Figure from SOCS2


Figure from TRIM27


Figure from TRIM37


Figure from UBD


Figure from USP15


Figure from USP15


Figure from USP32


Figure from USP32


Figure from WWTR1


Figure from ZBTB33


Figure from PARK2


Figure from PARK2


Figure from PARK2

Contributor(s)

WrittenOct 2009Jean-Loup Huret
Updated Jean-Loup Huret and Philippe Dessen

Citation

This paper should be referenced as such :
, Huret JL, Dessen P.. Proteasome. Atlas Genet Cytogenet Oncol Haematol. .
URL : http://AtlasGeneticsOncology.org/Categories/Proteasome.html


© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Dec 6 14:53:39 CET 2017

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