Proteasome

Deep Insight Ubiquitin, ubiquitination and the ubiquitin-proteasome system in cancer Genes AKT1S1 (AKT1 substrate 1 (proline-rich)) AMFR (autocrine motility factor receptor) ATF4 (activating transcription factor 4 (tax-responsive enhancer element B67)) BAG3 (Bcl-2 associated athanogene 3) BAP1 (BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)) BARD1 (BRCA1 associated RING domain 1) BCL6 (B-Cell Lymphoma 6) BIRC6 (Baculoviral IAP repeat-containing 6) BMI1 (BMI1 polycomb ring finger oncogene) BRCA1 (breast cancer 1, early onset) BABAM2 (brain and reproductive organ-expressed (TNFRSF1A modulator)) CASP8 (Caspase 8, Apoptosis-Related Cysteine Peptidase) CBL (Cas-Br-M (murine) ecotropic retroviral transforming sequence) CHFR (Checkpoint with fork-head associated and ring finger) CLSPN (claspin) COPS2 (COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)) CTSH (cathepsin H) DLG1 (discs, large homolog 1 (Drosophila)) DRAM1 (damage-regulated autophagy modulator) ELF4 (E74-like factor 4 (ets domain transcription factor)) FANCL (FA complementation group L) FBXO11 (F-box protein 11) FKBP8 (FK506 binding protein 8, 38kDa) FOSL1 (FOS-like antigen 1) GFI1 (growth factor independent 1 transcription repressor) GRB2 (Growth factor receptor-bound protein 2) HACE1 (HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1) HIPK2 (homeodomain interacting protein kinase 2) HLTF (helicase-like transcription factor) HNRNPD (heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)) HSPA8 (heat shock 70kDa protein 8) HSPB8 (heat shock 22kDa protein 8) KLK6 (kallikrein-related peptidase 6) MIB2 (mindbomb homolog 2 (Drosophila)) NR3C1 (nuclear receptor subfamily 3, group C, member 1/glucocorticoid receptor) ENC1 (ectodermal-neural cortex (with BTB-like domain)) PA2G4 (proliferation-associated 2G4, 38kDa) PRKN (arkin RBR E3 ubiquitin protein ligase ) PIAS1 (protein inhibitor of activated STAT, 1) ZBTB16 (zinc finger and BTB domain containing 16) PML (promyelocytic leukemia) PRAME (Preferentially Expressed Antigen In Melanoma) PSAP (Prosaposin (variant Gaucher disease and variant metachromatic leukodystrophy)) RCHY1 (ring finger and CHY zinc finger domain containing 1) REST (RE1-silencing transcription factor) RHOBTB1 (Rho-related BTB domain containing 1) RHOBTB2 (Rho-related BTB domain containing 2) RHOBTB3 (Rho-related BTB domain containing 3) RNF11 (ring finger protein 11) RNF7 (RING finger protein-7) SGK1 (serum/glucocorticoid regulated kinase 1) SIAH1 (siah E3 ubiquitin protein ligase 1) SIAH2 (seven in absentia homolog 2 (Drosophila)) SIRT1 (sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)) SLC4A1 (solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)) SOCS2 (suppressor of cytokine signaling 2) SOCS3 (suppressor of cytokine signaling 3) SORBS2 (sorbin and SH3 domain containing 2) RNF139 (translocation in renal carcinoma, chromosome 8 gene) TRIM27 (tripartite motif containing 27) TRIM37 (tripartite motif-containing 37) UBD (ubiquitin D) USP15 (ubiquitin specific peptidase 15) USP1 (ubiquitin specific peptidase 1) USP32 (ubiquitin specific peptidase 32) VCP (valosin containing protein) VMP1 (vacuole membrane protein 1) WWP1 (WW domain containing E3 ubiquitin protein ligase 1) WWTR1 (WW domain containing transcription regulator 1) ZBTB33 (zinc finger and BTB domain containing 33)

Iconography Figure from Autophagy Figure from UbiquitininCancer Figure from UbiquitininCancer Figure from UbiquitininCancer Figure from UbiquitininCancer Figure from UbiquitininCancer Figure from UbiquitininCancer Figure from AKT1S1 Figure from AMFR Figure from ATF4 Figure from BAP1 Figure from BCL6 Figure from BCL6 Figure from BMI1 Figure from BRCA1 Figure from COPS2 Figure from ELF4 Figure from ELF4 Figure from FBXO11 Figure from FKBP8 Figure from FKBP8 Figure from FKBP8 Figure from FOSL1 Figure from FOSL1 Figure from GFI1 Figure from GRB2 Figure from HACE1 Figure from HLTF Figure from HNRNPD Figure from HSPA8 Figure from HSPA8 Figure from HSPB8 Figure from HSPB8 Figure from MIB2 Figure from NR3C1 Figure from PA2G4 Figure from PARK2 Figure from PIAS1 Figure from PSAP Figure from REST Figure from RNF11 Figure from RNF11 Figure from SGK1 Figure from SIAH2 Figure from SOCS2 Figure from TRIM27 Figure from TRIM37 Figure from UBD Figure from USP15 Figure from USP15 Figure from USP32 Figure from USP32 Figure from WWTR1 Figure from ZBTB33 Figure from PARK2 Figure from PARK2 Figure from PARK2

Contributor(s)

Written	Oct 2009	Jean-Loup Huret
Updated	Sep 2019	Jean-Loup Huret and Philippe Dessen

Citation

This paper should be referenced as such :

, Huret JL, Dessen P.. Proteasome. Atlas Genet Cytogenet Oncol Haematol. Sep 2019 . URL : http://AtlasGeneticsOncology.org/Categories/Proteasome.html