Atlas of Genetics and Cytogenetics in Oncology and Haematology


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RAS-RAF-MAPK

Deep Insight

Role of p38α in apoptosis: implication in cancer development and therapy
The tumour suppressor function of the scaffolding protein spinophilin

Genes

ADRB2 (adrenoceptor beta 2, surface)
AGER (advanced glycosylation end product-specific receptor)
ATF4 (activating transcription factor 4 (tax-responsive enhancer element B67))
ATF5 (activating transcription factor 5)
AXIN1 (axin 1)
AXL (AXL receptor tyrosine kinase)
BAG3 (Bcl-2 associated athanogene 3)
BCL2L14 (BCL2-like 14 (apoptosis facilitator))
BRAF (v-raf murine sarcoma viral oncogene homolog B1)
CASP8 (Caspase 8, Apoptosis-Related Cysteine Peptidase)
CD74 (CD74 molecule, major histocompatibility complex, class II invariant chain)
CHST11 (carbohydrate (chondroitin 4) sulfotransferase 11)
CIC (capicua transcriptional repressor)
CRK (v-crk sarcoma virus CT10 oncogene homolog (avian))
CSE1L (CSE1 chromosome segregation 1-like (yeast))
CXCL10 (chemokine (C-X-C motif) ligand 10)
CXCL12 (chemokine (C-X-C motif) ligand 12)
CXCR1 (chemokine (C-X-C motif) receptor 1)
CXXC5 (CXXC finger protein 5)
CYLD (cylindromatosis (turban tumor syndrome))
CYR61 (cysteine-rich, angiogenic inducer, 61)
DDR1 (discoidin domain receptor tyrosine kinase 1)
DDX5 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 5)
DGKA (diacylglycerol kinase, alpha 80kDa)
DIRAS3 (DIRAS family, GTP-binding RAS-like 3)
DLC1 (deleted in liver cancer 1)
DMTF1 (cyclin D binding myb-like transcription factor 1)
DPP4 (dipeptidyl-peptidase 4)
DUSP10 (dual specificity phosphatase 10)
DUSP1 (dual specificity phosphatase 1)
DUSP26 (dual specificity phosphatase 26)
DUSP6 (dual specificity phosphatase 6)
DYRK1A (dual-specificity tyrosine- (Y)-phosphorylation regulated kinase 1A)
EEF2K (eukaryotic elongation factor 2 kinase)
EHF (ets homologous factor)
EIF2AK2 (eukaryotic translation initiation factor 2-alpha kinase 2)
EIF4B (eukaryotic translation initiation factor 4B)
EPHA2 (EPH receptor A2)
EPHB6 (EPH receptor B6)
ERBB3 (v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian))
FAM57A (family with sequence similarity 57, member A)
FAS (Fas cell surface death receptor)
FGFR4 (fibroblast growth factor receptor 4)
FOSL1 (FOS-like antigen 1)
FPR1 (formyl peptide receptor 1)
GNA11 (guanine nucleotide binding protein (G protein), alpha 11 (Gq class))
GNAQ (guanine nucleotide binding protein (G protein), q polypeptide)
GRB10 (growth factor receptor-bound protein 10)
GRM1 (glutamate receptor, metabotropic 1)
GSTA1 (glutathione S-transferase alpha 1)
HRAS (Harvey rat sarcoma viral oncogene homolog)
IGF1 (Insulin-Like Growth Factor 1 (Somatomedin C))
IGFBP6 (insulin-like growth factor binding protein 6)
IL7R (interleukin 7 receptor)
ILK (integrin-linked kinase)
IRS1 (insulin receptor substrate 1)
IRS2 (insulin receptor substrate 2)
ITGA1 (integrin, alpha 1)
ITGA6 (integrin, alpha 6)
KRAS (Kirsten rat sarcoma 2 viral oncogene homolog)
KSR1 (kinase suppressor of ras 1)
LGALS3 (lectin, galactoside-binding, soluble, 3)
LIFR (leukemia inhibitory factor receptor alpha)
LPAR2 (lysophosphatidic acid receptor 2)
MAPK12 (mitogen-activated protein kinase 12)
MAPK13 (mitogen-activated protein kinase 13)
MAPK1 (mitogen-activated protein kinase 1)
MAPK3 (mitogen-activated protein kinase 3)
MAPK4 (mitogen-activated protein kinase 4)
MAPK6 (mitogen-activated protein kinase 6)
MAPK7 (mitogen-activated protein kinase 7)
MAPKAPK2 (mitogen-activated protein kinase-activated protein kinase 2)
MED28 (mediator complex subunit 28)
KITLG (KIT ligand)
MIF (macrophage migration inhibitory factor (glycosylation-inhibiting factor))
MIR191 (microRNA 191)
MIR200C (microRNA 200c)
MST1 (macrophage stimulating 1 (hepatocyte growth factor-like))
MSX2 (Msh Homeobox 2)
NEU3 (sialidase 3 (membrane sialidase))
NF1 (neurofibromin 1)
NGFR (nerve growth factor receptor)
NME1 (NME/NM23 nucleoside diphosphate kinase 1)
NPY1R (neuropeptide Y receptor Y1)
NRAS (neuroblastoma RAS viral oncogene homolog)
NUAK1 (NUAK family, SNF1-like kinase, 1)
PA2G4 (proliferation-associated 2G4, 38kDa)
PEA15 (phosphoprotein enriched in astrocytes 15)
PGR (progesterone receptor)
PIK3R1 (phosphoinositide-3-kinase, regulatory subunit 1 (alpha))
PLA2G4A (phospholipase A2, group IVA (cytosolic, calcium-dependent))
PLCD1 (phospholipase C, delta 1)
PLCG1 (Phospholipase C, Gamma 1)
PLD1 (phospholipase D1, phosphatidylcholine-specific)
PLD2 (phospholipase D2)
PML (promyelocytic leukemia)
PPP2R1A (protein phosphatase 2 regulatory subunit A, alpha)
PRKCI (protein kinase C, iota)
PRLR (prolactin receptor)
PTHLH (parathyroid hormone-like hormone)
PTPN7 (protein tyrosine phosphatase, non-receptor type 7)
PTPRR (protein tyrosine phosphatase, receptor type, R)
PYCARD (PYD and CARD domain containing)
RAB31 (Ras-related protein in brain 31)
RAC3 (ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3))
RACGAP1 (Rac GTPase activating protein 1)
RAP1A (RAP11, member of RAS oncogene family)
RAP1B (RAP1B, member of RAS oncogene family)
RAP1GAP (RAP1 GTPase activating protein)
RAPGEF1 (Rap guanine nucleotide exchange factor (GEF) 1)
RASL11B (RAS-like, family 11, member B)
RASSF1 (Ras association (RalGDS/AF-6) domain family member)
RASSF2 (Ras association (RalGDS/AF-6) domain family member 2)
RASSF5 (Ras association (RalGDS/AF-6) domain family member 5)
RASSF6 (Ras association (RalGDS/AF-6) domain family member 6)
RPS6KA6 (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 6)
S100A4 (S100 Calcium Binding Protein A4)
S100A8 (S100 calcium binding protein A8)
S100A9 (S100 calcium binding protein A9)
SERPINB3 (Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 3)
SGK1 (serum/glucocorticoid regulated kinase 1)
SHC4 (SHC (Src homology 2 domain containing) family, member 4)
SIAH1 (siah E3 ubiquitin protein ligase 1)
SIAH2 (seven in absentia homolog 2 (Drosophila))
SIPA1 (signal-induced proliferation-associated 1)
SNCG (synuclein, gamma (breast cancer-specific protein 1))
SOCS2 (suppressor of cytokine signaling 2)
SOCS3 (suppressor of cytokine signaling 3)
SPRY1 (Sprouty Homolog 1, Antagonist Of FGF Signaling (Drosophila))
STARD13 (StAR-related lipid transfer (START) domain containing 13)
STMN1 (stathmin 1)
SULF2 (sulfatase 2)
SYK (spleen tyrosine kinase)
TACC2 (transforming, acidic coiled-coil containing protein 2)
TGFB1 (transforming growth factor, beta 1)
THRB (Thyroid Hormone Receptor, Beta)
THY1 (Thy-1 cell surface antigen)
TNFRSF17 (tumor necrosis factor receptor superfamily, member 17)
TNKS (tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase)
TNS4 (tensin 4)
TRPV2 (transient receptor potential cation channel, subfamily V, member 2)
VAV1 (vav 1 oncogene)
VAV3 (vav 3 guanine nucleotide exchange factor)
WNK2 (WNK lysine deficient protein kinase 2)
ZAP70 (zeta-chain (TCR) associated protein kinase 70kDa)

Iconography


Figure from ADRB2


Figure from AGER


Figure from ATF4


Figure from ATF5


Figure from AXIN1


Figure from AXL


Figure from BCL2L14


Figure from BRAF


Figure from CD74


Figure from CHST11


Figure from CXCR1


Figure from CXXC5


Figure from CYLD


Figure from DDR1


Figure from DDX5


Figure from DGKA


Figure from DIRAS3


Figure from DLC1


Figure from DMTF1


Figure from DPP4


Figure from DUSP1


Figure from DUSP26


Figure from DUSP26


Figure from DUSP6


Figure from DYRK1A


Figure from EHF


Figure from EIF2AK2


Figure from EIF4B


Figure from EIF4B


Figure from EIF4B


Figure from EPHA2


Figure from EPHA2


Figure from EPHB6


Figure from ERBB3


Figure from FAM57A


Figure from FAS


Figure from FAS


Figure from FGFR1


Figure from FGFR4


Figure from FOSL1


Figure from FOSL1


Figure from FPR1


Figure from GNA11


Figure from GNAQ


Figure from GRB10


Figure from GRM1


Figure from GRM1


Figure from GSTA1


Figure from GSTA1


Figure from IGFBP6


Figure from ILK


Figure from ILK


Figure from ITGA1


Figure from ITGA1


Figure from KSR1


Figure from LIFR


Figure from LPAR2


Figure from MAPK12


Figure from MAPK13


Figure from MAPK14


Figure from MAPK14


Figure from MAPK7


Figure from MST1


Figure from NEU3


Figure from NGFR


Figure from NUAK1


Figure from PA2G4


Figure from PEA15


Figure from PLA2G4A


Figure from PLCD1


Figure from PLCG1


Figure from PLD1


Figure from PRKCI


Figure from RAC3


Figure from RAP1B


Figure from RAPGEF1


Figure from RAPGEF1


Figure from RASL11B


Figure from RASSF2


Figure from RASSF2


Figure from RASSF2


Figure from RASSF6


Figure from RASSF6


Figure from SGK1


Figure from SHC4


Figure from SIAH2


Figure from SIPA1


Figure from STARD13


Figure from STMN1


Figure from STMN1


Figure from STMN1


Figure from TACC2


Figure from THY1


Figure from TMSB10


Figure from TNKS


Figure from TNS4Fig2


Figure from TRPV2


Figure from VAV1


Figure from VAV3


Figure from VAV3


Figure from WNK2


Figure from CIC


Figure from CXCL12


Figure from ZAP70

Contributor(s)

WrittenOct 2009Jean-Loup Huret
UpdatedAug 2017Jean-Loup Huret and Philippe Dessen

Citation

This paper should be referenced as such :
, Huret JL, Dessen P.. RAS-RAF-MAPK. Atlas Genet Cytogenet Oncol Haematol. Aug 2017 .
URL : http://AtlasGeneticsOncology.org/Categories/RAS-RAF-MAPK.html


© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Aug 14 13:46:11 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

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