WNT pathway Section Editor - Alesandro Beghini ( alessandro.beghini@unimi.it )

Deep Insight Predicted human structural clusters of miRNAs target cancer genes Tissue specific role of calcium sensing receptor Genes specifically involved in WNT pathway Other Genes involved in WNT pathway ANP32A (acidic (leucine-rich) nuclear phosphoprotein 32 family, member A) APC (adenomatous polyposis coli) ATMIN (ATM Interactor) AXIN1 (axin 1) AXIN2 (axin 2) CCND1 (B-cell leukemia/lymphoma 1) BCL9 (B-cell CLL/lymphoma 9) BTRC (beta-transducin repeat containing) CREBBP (CREB binding protein) CDH17 (cadherin 17, LI cadherin (liver-intestine)) CDH1 (cadherin 1, type 1, E-cadherin (epithelial)) CHST11 (carbohydrate (chondroitin 4) sulfotransferase 11) CSNK1A1 (casein kinase 1, alpha 1) CTHRC1 (Collagen Triple Helix Repeat Containing 1) CTNNB1 (Catenin, beta-1) CXXC5 (CXXC finger protein 5) DAB2 (disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)) DDR1 (discoidin domain receptor tyrosine kinase 1) DKK1 (dickkopf homolog 1 (Xenopus laevis)) DKK3 (dickkopf 3 homolog (Xenopus laevis)) DVL1 (dishevelled, dsh homolog 1 (Drosophila)) AMER1 (APC membrane recruitment protein 1) FOXQ1 (forkhead box Q1) GPC1 (glypican 1) GSK3B (glycogen synthase kinase 3 beta) GSKIP (GSK3-beta interaction protein) HBP1 (HMG-box transcription factor 1) HDAC3 (Histone deacetylase 3) HIPK2 (homeodomain interacting protein kinase 2) ILK (integrin-linked kinase) CEMIP (cell migration inducing protein, hyaluronan binding ) KLF4 (Kruppel-like factor 4 (gut)) LGALS3 (lectin, galactoside-binding, soluble, 3) LIMD1 (LIM domains containing 1) LRP1B (low density lipoprotein receptor-related protein 1B) LRP5 (low density lipoprotein receptor-related protein 5) MAP3K7 (mitogen-activated protein kinase kinase kinase 7) MARK4 (MAP/microtubule affinity-regulating kinase 4) MCC (mutated in colorectal cancers) MIR200C (microRNA 200c) MSX2 (Msh Homeobox 2) NME1 (NME/NM23 nucleoside diphosphate kinase 1) NUAK1 (NUAK family, SNF1-like kinase, 1) OLIG2 (oligodendrocyte lineage transcription factor) PEG3 (paternally expressed 3) PGR (progesterone receptor) PLA2G2A (phospholipase A2, group IIA (platelets, synovial fluid)) PLCG1 (Phospholipase C, Gamma 1) PPARD (peroxisome proliferator-activated receptor delta) PPP2R1A (protein phosphatase 2 regulatory subunit A, alpha) PRKCI (protein kinase C, iota) PSEN2 (presenilin 2 (Alzheimer disease 4)) PTHLH (parathyroid hormone-like hormone) PTK7 (PTK7 protein tyrosine kinase 7) REST (RE1-silencing transcription factor) RHOA (ras homolog gene family, member A) ROR2 (receptor tyrosine kinase-like orphan receptor 2) RSPO1 (R-spondin homolog (Xenopus laevis)) RUVBL1 (RuvB-like 1 (E. coli)) RUVBL2 (RuvB-like 2 (E. coli)) S100A4 (S100 Calcium Binding Protein A4) SDC1 (syndecan 1) SDCBP (syndecan binding protein (syntenin)) SFRP2 (secreted frizzled-related protein 2) SFRP4 (Secreted Frizzled-Related Protein 4) SGK1 (serum/glucocorticoid regulated kinase 1) SIRT1 (sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)) SLC4A1 (solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)) SLC9A3R1 (solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1) SMAD2 (mothers against decapentaplegic homolog 2 (Drosophila)) SMAD4 (mothers against decapentaplegic homolog 4 (Drosophila)) SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4) SOX2 (SRY (sex determining region Y)-box 2) STK11 (serine/threonine kinase 11) SULF2 (sulfatase 2) THRB (Thyroid Hormone Receptor, Beta) TNKS (tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase) TNS4 (tensin 4) USP15 (ubiquitin specific peptidase 15) WIF1 (WNT inhibitory factor 1) WISP2 (Wnt-1-inducible signaling parthway protein-2) WISP3 (WNT-1 inducible signaling pathway protein 3) WNT1 (wingless-type MMTV integration site family, member 1) WNT5A (wingless-type MMTV integration site family, member 5A) WWTR1 (WW domain containing transcription regulator 1) ZBTB33 (zinc finger and BTB domain containing 33)

Iconography Figure from WNT_Signaling_Pathway Figure from WNT_Signaling_Pathway Figure from WNT_Signaling_Pathway Figure from WNT_Signaling_Pathway_ Figure from WNT_Signaling_Pathway_ Figure from WNT_Signaling_Pathway_ Figure from WNT_Signaling_Pathway_ Figure from WNT_Signaling_Pathway_ Figure from ATMIN Figure from CDH17 Figure from CHST11 Figure from CTNNB1 Figure from CTNNB1 Figure from CXXC5 Figure from FOXQ1 Figure from FOXQ1 Figure from ILK Figure from ILK Figure from LRP1B Figure from NUAK1 Figure from PLCG1 Figure from PRKCI Figure from SGK1 Figure from TNS4 Figure from WIF1 Figure from WIF1 Figure from WWTR1

Contributor(s)

Written	Oct 2009	Jean-Loup Huret
Updated	Oct 2017	Jean-Loup Huret and Philippe Dessen

Citation

This paper should be referenced as such :

, Huret JL, Dessen P.. WNT. Atlas Genet Cytogenet Oncol Haematol. Oct 2017 . URL : http://AtlasGeneticsOncology.org/Categories/WNT.html