WNT

Deep Insight The WNT Signaling Pathway and Its Role in Human Solid Tumors Genes AXIN1 (axin 1) AXIN2 (axin 2) CCND1 (B-cell leukemia/lymphoma 1) BCL9 (B-cell CLL/lymphoma 9) BTRC (beta-transducin repeat containing) CREBBP (CREB binding protein) CDH17 (cadherin 17, LI cadherin (liver-intestine)) CDH1 (cadherin 1, type 1, E-cadherin (epithelial)) CSNK1A1 (casein kinase 1, alpha 1) CTHRC1 (Collagen Triple Helix Repeat Containing 1) CTNNB1 (Catenin, beta-1) DAB2 (disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)) DDR1 (discoidin domain receptor tyrosine kinase 1) DKK1 (dickkopf homolog 1 (Xenopus laevis)) DVL1 (dishevelled, dsh homolog 1 (Drosophila)) AMER1 (APC membrane recruitment protein 1) GSK3B (glycogen synthase kinase 3 beta) HBP1 (HMG-box transcription factor 1) HDAC3 (Histone deacetylase 3) HIPK2 (homeodomain interacting protein kinase 2) KLF4 (Kruppel-like factor 4 (gut)) LGALS3 (lectin, galactoside-binding, soluble, 3) LIMD1 (LIM domains containing 1) LRP5 (low density lipoprotein receptor-related protein 5) MAP3K7 (mitogen-activated protein kinase kinase kinase 7) MARK4 (MAP/microtubule affinity-regulating kinase 4) MTA3 (metastasis associated 1 family, member 3) NME1 (NME/NM23 nucleoside diphosphate kinase 1) OLIG2 (oligodendrocyte lineage transcription factor) OLIG2 (oligodendrocyte lineage transcription factor) PEG3 (paternally expressed 3) PLA2G2A (phospholipase A2, group IIA (platelets, synovial fluid)) PPARD (peroxisome proliferator-activated receptor delta) PRKCI (protein kinase C, iota) PSEN2 (presenilin 2 (Alzheimer disease 4)) PTHLH (parathyroid hormone-like hormone) PTK7 (PTK7 protein tyrosine kinase 7) REST (RE1-silencing transcription factor) ROR2 (receptor tyrosine kinase-like orphan receptor 2) RSPO1 (R-spondin homolog (Xenopus laevis)) RUVBL1 (RuvB-like 1 (E. coli)) RUVBL2 (RuvB-like 2 (E. coli)) SDC1 (syndecan 1) SDCBP (syndecan binding protein (syntenin)) SFRP4 (Secreted Frizzled-Related Protein 4) SLC4A1 (solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)) SLC9A3R1 (solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1) SMAD2 (mothers against decapentaplegic homolog 2 (Drosophila)) SMAD4 (mothers against decapentaplegic homolog 4 (Drosophila)) SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4) SOX2 (SRY (sex determining region Y)-box 2) STK11 (serine/threonine kinase 11) TNKS (tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase) TNS4 (tensin 4) USP15 (ubiquitin specific peptidase 15) WIF1 (WNT inhibitory factor 1) WISP2 (Wnt-1-inducible signaling parthway protein-2) WISP3 (WNT-1 inducible signaling pathway protein 3) WNT5A (wingless-type MMTV integration site family, member 5A) ZBTB33 (zinc finger and BTB domain containing 33)

Iconography Figure from WNT Signaling Pathway Figure from WNT Signaling Pathway Figure from WNT Signaling Pathway Figure from WNT Signaling Pathway Figure from WNT Signaling Pathway Figure from WNT Signaling Pathway Figure from WNT Signaling Pathway Figure from WNT Signaling Pathway Figure from CDH17 Figure from CTNNB1 Figure from CTNNB1 Figure from PRKCI Figure from TNS4 Figure from WIF1 Figure from WIF

Contributor(s)

Written	Oct 2009	Jean-Loup Huret
Updated	May 2013	Jean-Loup Huret

Citation

This paper should be referenced as such :

Huret JL . WNT. Atlas Genet Cytogenet Oncol Haematol. May 2013 . URL : http://AtlasGeneticsOncology.org/Categories/WNT.html