Laboratory of Pathology
National Cancer Institute
10 Center Drive, Room 2S235, MSC 1500
Bethesda, MD 20892
B.A. (1980), Summa Cum Laude, Williams College, Williamstown, MA
M.D. (1987), Washington University, St. Louis, MO
Ph.D. (1987), Washington University, Division of Biology & Biomed Sciences, Molecular Biology Program, St. Louis, MO
1987-1992 - Resident, Pathology & Laboratory Medicine, Hospital of the University of Pennsylvania
1989-1992 - Research fellow, Human Genetics & Molecular Biology, Children's Hospital of Philadelphia
1992-1998 - Assistant Professor, Department of Pathology & Lab Med, University of PA School of Medicine
1998-2011 - Associate Professor, Department of Pathology & Lab Med, University of PA School of Medicine
2011-Present - Senior Investigator & Deputy Chief, Laboratory of Pathology, National Cancer Institute
My research laboratory uses a multidisciplinary approach involving genomics and bioinformatics along with cell culture and animal models to study recurrent chromosomal alterations, such as translocations and amplification, in cancer.
For our studies of recurrent chromosomal alterations, we currently focus on rhabdomyosarcoma, a family of myogenic soft tissue cancers usually occurring in children, in which we are investigating the genetic basis, biological consequences, and therapeutic implications of these chromosomal changes.