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GAIA ROVERSI

 

Gaia Roversi
via Cadore 48 - 20900 Monza (MB), Italy
phone +039.02-6448-8188; +039.039-233-4348
gaia.roversi@unimib.it

 

EDUCATION AND WORK EXPERIENCE
October 2015, ASST-Monza, San Gerardo Hospital, Unit of Medical Genetics, Genetic counselor
November 2011, University of Milano-Bicocca- School of Medicine, Researcher in Medical Genetics
February 2009-October 2011, Fondazione IRCSS Istituto Nazionale dei Tumori, Milan, Unit of Medical Genetics, Genetic counselor for breast cancer predisposition syndrome
November 2006-November 2008, University of Milan, San Paolo Hospital, Department of Medicine, Surgery and Dentistry, Temporary Research Fellow; assigned project : The role of cancer stem cells in gliomagenesis
November 2004-November 2006, University of Milan, San Paolo Hospital, Department of Medicine, Surgery and Dentistry, Temporary Research Fellow; assigned project : The WNT signaling pathway and its role in human brain tumors
2000-2004 Post Graduate School of Specialization in Medical Genetics (University of Milan)
2000 University Degree in Medicine and Surgery  (University of Milan).

MAIN RESEARCH INTEREST
Cancer Predisposition Syndromes

CURRENT SCIENTIFIC ACTIVITY
- Genomic characterization by array CGH of Thyroid Cancers
- Search for genes involved in cancer predisposition to Familial Non-Medullary Thyroid Carcinoma (FNMTC) by exome sequencing.

MAIN TECHNICAL SKILLS AND COMPETENCES
- Genetic Counseling in Cancer Care
- Molecular biology in cancer genetics

AWARD:
October 2009, Milan, "Nastro Rosa Estèe Lauder Compani"e award organized by LILT (Lega Italiana per la Lotta contro i Tumori)

PUBLICATIONS
- Manzoni M, Roversi G, Di Bella C, Pincelli AI, Cimino V, Perotti M, Garancini M, Pagni F. Solid cell nests of the thyroid gland: morphological, immunohistochemical and genetic features. Histopathology. 2016 May;68(6):866-74.
- Bentivegna A*, Roversi G*, et al: The Effect of Culture on Human Bone Marrow Mesenchymal Stem Cells: Focus on DNA Methylation Profiles. Stem Cells Int. 2016 Published online 2016 Jan 6.
- La Verde N, Corsi F, Moretti A, Peissel B, Dalu D, Girelli S, Fasola C, Gambaro A, Roversi G, Azzollini J, Radice P, Pensotti V, Farina G, Manoukian S. A targeted approach to genetic counseling in breast cancer patients: the experience of an Italian local project. Tumori. 2016 Jan-Feb;102(1):45-50.
- Roversi G. et al; Constitutional de novo deletion of the FBXW7 gene in a patientwith focal segmental glomerulosclerosis and multiple  primitive tumors. Sci Rep. 201 Oct 20;5:15454.
- Peterlongo P. et al: FANCM c.5791C>T nonsense mutation (rs144567652) induces exon skipping, affects DNA repair activity and is a familial breast cancer risk factor. Hum Mol Genet. 2015 Sep 15;24(18):5345-55.
- Pagni F, L'Imperio V, Bono F, Garancini M, Roversi G, De Sio G, Galli M, Smith AJ, Chinello C, Magni F. Proteome analysis in thyroid pathology. Expert Rev Proteomics. 2015 Aug;12(4):375-90.
- Kuchenbaecker KB, et al; Associations of common breast cancer susceptibility alleles with risk of breast cancer subtypes in BRCA1 and BRCA2 mutation carriers. Breast Cancer Res. 2014 Dec 31;16(6):3416.
- Colombo EA, Fontana L, Roversi G, Negri G, Castiglia D, Paradisi M, Zambruno G, Larizza L.: Novel physiological RECQL4 alternative transcript disclosed by molecular characterisation of Rothmund-Thomson Syndrome sibs with mild phenotype. Eur J Hum Genet. 2014 Feb 12.
- Mainini V, Pagni F, Garancini M, Giardini V, De Sio G, Cusi C, Arosio C, Roversi G, Chinello C, Caria P, Vanni R, Magni F.: An Alternative Approach in Endocrine Pathology Research: MALDI-IMS in Papillary Thyroid Carcinoma.  Endocr Pathol. 2013 Dec;24(4):250-3.
- Larizza L, Roversi G, Verloes A.: Clinical utility gene card for: Rothmund-Thomson syndrome. Eur J Hum Genet. 2013 Jul;21(7).
- Manoukian S, Peissel B, Frigerio S, Lecis D, Bartkova J, Roversi G, Radice P, Bartek J, Delia D. Two new CHEK germ-line variants detected in breast cancer/sarcoma families negative for BRCA1, BRCA2, and TP53 gene mutations. Breast Cancer Res Tr. 2011 Nov;130(1):207-15.
- Bonifaci N, Palafox M, Pellegrini P, Osorio A, Benítez J, Peterlongo P, Manoukian S, Peissel B, Zaffaroni D, Roversi G, Barile M, Viel A, Mariette F, Bernard L, Radice P, Kaufman B, Laitman Y, Milgrom R, Friedman E, Sáez ME, Climent F, Soler MT, Diez O, Balmaña J, Lasa A, Ramón y Cajal T, Miramar MD, de la Hoya M, Pérez-Segura P, Caldés T, Moreno V, Urruticoechea A, Brunet J, Lázaro C, Blanco I, Pujana MA, González-Suárez E. Evidence for a link between TNFRSF11A and risk of breast cancer. Breast Cancer Res Tr. 2011 Oct;129(3):947-54.
- Martrat G, Maxwell CM, Tominaga E, Porta-de-la-Riva M, Bonifaci N, Gómez-Baldó L, Bogliolo M, Lázaro C, Blanco I, Brunet J, Aguilar H, Fernández-Rodríguez J, Seal S, Renwick A, Rahman N, Kühl J, Neveling K, Schindler D, Ramírez MJ, Castellà M, Hernández G; EMBRACE, Easton DF, Peock S, Cook M, Oliver CT, Frost D, Platte R, Evan DG, Lalloo F, Eeles R, Izatt L, Chu C, Davidson R, Ong KR, Cook J, Douglas F, Hodgson S, Brewer C, Morrison PJ, Porteous M, Peterlongo P, Manoukian S, Peissel B, Zaffaroni D, Roversi G, et al. Exploring the link between MORF4L1 and risk of breast cancer. Breast Cancer Res. 2011 Apr 5;13(2):R40.
- Ramus SJ, Kartsonaki C, Gayther SA, Pharoah PD, Sinilnikova OM, Beesley J, Chen X, McGuffog L, Healey S, Couch FJ, Wang X, Fredericksen Z, Peterlongo P, Manoukian S, Peissel B, Zaffaroni D, Roversi G, et al. Genetic Variation at 9p22.2 and Ovarian Cancer Risk for BRCA1 and BRCA2 Mutation Carriers. J Natl Cancer Inst. 2011 Jan 19;103(2):105-116.
- Concolino D, Roversi G, Muzzi GL, Sestito S, Colombo EA, Volpi L, Larizza L, Strisciuglio P. Clericuzio-type poikiloderma with neutropenia syndrome in three sibs with mutations in the C16orf57 gene: delineationof the phenotype. Am J Med Genet A. 2010 Oct;152A(10):2588-94
- Catucci I, Verderio P, Pizzamiglio S, Manoukian S, Peissel B, Zaffaroni D, Roversi G, Ripamonti CB, Pasini B, Barile M, Viel A, Giannini G, Papi L, Varesco L, Martayan A, Riboni M, Volorio S, Radice P, Peterlongo P. The CASP8 rs3834129 polymorphism and breast cancer risk in BRCA1 mutation carriers. Breast Cancer Res Tr. 2011 Feb;125(3):855-60
- Pedranzini L, Mottadelli F, Ronzoni S, Rossella F, Ferracin M, Magnani I, Roversi G, Colapietro P, Negrini M, Pelicci PG, Larizza L. Differential cytogenomics and miRNA signature of the Acute Myeloid Leukaemia Kasumi-1 cell line CD34+38- compartment. Leukemia Res. 2010 Oct;34(10):1287-95
- Larizza L, Roversi G, Volpi L. Rothmund-Thomson syndrome. Orphanet J Rare Dis. 2010 Jan 29;5:2. Review - Volpi L*, Roversi G*, Colombo EA, Leijsten N, Concolino D, Calabria A, Mencarelli MA, Fimiani M, Macciardi F, Pfundt R, Schoenmakers EF, Larizza L. (*These authors contributed equally to this work): Targeted next-generation sequencing appoints c16orf57 as clericuzio-type poikiloderma with neutropenia gene. Am J Hum Genet. 2010 Jan;86(1):72-6. Epub 2009 Dec 10. Erratum in: Am J Hum Genet. 2010 Sep 10;87(3):445 - Magnani I, Novielli C, Bellini M, Roversi G, Bello L, Larizza L.: Multiple localization of endogenous MARK4L protein in human glioma. Cell Oncol. 2009;31(5):357-70
- Gervasini C, Pfundt R, Castronovo P, Russo S, Roversi G, Masciadri M, Milani D, Zampino G, Selicorni A, Schoenmakers E, Larizza L.: Search for genomic imbalances in a cohort of 24 Cornelia de Lange patients negative for mutations in the NIPBL and SMC1L1 genes. Clin Genet. 2008 Dec;74(6):531-8
- Sznajer Y, Siitonen HA, Roversi G, Dangoisse C, Scaillon M, Ziereisen F, Tenoutasse S, Kestila M, Larizza L.: Atypical Rothmund-Thomson syndrome in a patient with compound Heterozygous Mutations in RECQL4 Gene and phenotypic features in RECQL4 syndromes. Eur J Pediatr. 2008 Feb;167(2):175-81
- Bondanza S*, Bellini M*, Roversi G*, Raskovic D, Maurelli R, Paionni E, Paterna P, Dellambra E, Larizza L, Guerra L.: Piebald trait: implication of kit mutation on in vitro melanocyte survival and on the clinical application of cultured epidermal autografts. J Invest Dermatol. 2007 Mar;127(3):676-86
- Larizza L, Magnani I, Roversi G.: Rothmund-Thomson syndrome and RECQL4 defect: Splitting and lumping. Cancer Lett. 2006 Jan 28;232(1):107-20. Review
- Roversi G, Pfundt R, Moroni RF, Magnani I, van Reijmersdal S, Pollo B, Straatman H, Larizza L, Schoenmakers EF. Identification of novel genomic markers related to progression to glioblastoma through genomic profiling of 25 primary glioma cell lines. Oncogene. 2006 Mar9;25(10):1571-83
- Magnani I, Ramona RF, Roversi G, Beghini A, Pfundt R, Schoenmakers EF, Larizza L.: Identification of oligodendroglioma specific chromosomal copy number changes in the glioblastoma M-4 cell line by array-CGH and FISH analyses. Cancer Genet Cytogen. 2005 Sep;161(2):140-5
- Beghini A, Castorina P, Roversi G, Modiano P, Larizza L.: RNA processing defects of the helicase gene RECQL4 in a compound heterozygous Rothmund-Thomson patient. Am J Med Genet. A 2003 Jul 30;120A(3):395-9
- Beghini A, Magnani I, Roversi G, Piepoli T, Di Terlizzi S, Moroni RF, Pollo B, Fuhrman Conti AM, Cowell JK, Finocchiaro G, Larizza L.: The neural progenitor-restricted isoform of the MARK4 gene in 19q13.2 is upregulated in human gliomas and overexpressed in a subset of glioblastoma cell lines. Oncogene 2003 May 1;22(17):2581-91
- Roversi G, Beghini A, Zambruno G, Paradisi M, Larizza L. Identification of two novel RECQL4exonic SNPs and genomic characterization of the IVS12 minisatellite. J. Hum Genet.2003;48(2):107-9
- Beghini A, Tibiletti MG, Roversi G, Chiaravalli AM, Serio G, Capella C, Larizza L.: Germline mutation in the juxtamembrane domain of the kit gene in a family with gastrointestinal stromal tumors and urticaria pigmentosa. Cancer. 2001 Aug 1;92(3):657-62
- Beghini A, Ripamonti CB, Peterlongo P, Roversi G, Cairoli R, Morra E, Larizza L.: RNA hyperediting and alternative splicing of hematopoietic cell phosphatase (PTPN6) gene in acute myeloid leukemia. Hum Mol Genet. 2000 Sep 22;9(15):2297-304
(*These authors contributed equally to this work)

 


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