Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Portal   Teaching

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

JOÃO AGOSTINHO MACHADO-NETO

João Agostinho Machado-Neto
University of São Paulo
Av. Bandeirantes, 3900
Ribeirão Preto- SP, 13083-970
Brazil
jamachadoneto@gmail.com

I am interested in the development of research focused on the identification and characterization of antineoplastic agents and the investigation of expression, activation and function of genes involved in altered cell signaling pathways in cancer, especially hematological malignancies.

EDUCATION
Postdoctoral in Internal Medicine
University of São Paulo at Ribeirão Preto Medical School
Project: Investigation of IRS2 protein function in hematopoietic cells>
2016

PhD in Internal Medicine
University of Campinas- UNICAMP
Thesis: Functional investigation of ANKHD1 and its related proteins in hematological neoplasms
2015

MSc in Internal Medicine
University of Campinas - UNICAMP
Dissertation: IRS1 and IRS2 function and expression in normal, myelodysplastic, and leukemia hematopoiesis
2011

BSc in Biology
University Center Nossa Senhora do Patrocínio - CEUNSP
Dissertation: PI3KCA, JAK2 and FLT3 mutations in myelodysplastic syndromes
2009

GRANTS AND AWARDS
- Postdoctoral Fellowship from São Paulo Research Foundation (FAPESP).
- PhD Fellowship from São Paulo Research Foundation (FAPESP).
- MSc Fellowship from São Paulo Research Foundation (FAPESP).
- Scientific initiative Fellowship from São Paulo Research Foundation (FAPESP).
- ASH (American Society of Hematology) Abstract Achievement Award in 2010, 2011, 2012, 2013, 2014 and 2016.

FIVE MORE RELEVANT PUBLICATIONS
- Machado-Neto, J. A., et al. Stathmin 1 inhibition amplifies ruxolitinib-induced apoptosis in JAK2V617F cells. Oncotarget, v.6, p. 29573-29584, 2015.
- Machado-Neto, J. A., et al. ANKHD1 silencing inhibits Stathmin 1 activity, cell proliferation and migration of leukemia cells. Biochimica et Biophysica Acta Molecular Cell Research, v.1853, p.583 - 593, 2015.
- Machado-Neto, J. A., et al. ANKHD1, a novel component of the Hippo signaling pathway, promotes YAP1 activation and cell cycle progression in prostate cancer cells. Experimental Cell Research, v.324, p.137 - 145, 2014.
- Machado-Neto, J. A., et al. Stathmin 1 is involved in the highly proliferative phenotype of high-risk myelodysplastic syndromes and acute leukemia cells. Leukemia Research, v.38, p.251 - 257, 2014.
- Machado-Neto, J. A., et al. Knockdown of insulin receptor substrate 1 reduces proliferation and downregulates Akt/mTOR and MAPK pathways in K562 cells. Biochimica et Biophysica Acta Molecular Cell Research, p.1404 - 1411, 2011.

RESEARCH EXPERIENCE
University of São Paulo, São Paulo, Brazil
Postdoctoral, Avidsor: Dr Fabiola Traina
Investigation of IRS2 protein function in hematopoietic cells. Analysis of hematopoiesis-related process in Irs2 KO mice. Functional studies of cell proliferation, migration and apoptosis.
University of Campinas, São Paulo, Brazil
PhD, Avidsor: Dr Fabiola Traina
Investigation of molecular interaction and function of ANKHD1 in hematological neoplasms. Analysis of protein interaction. Gene silencing by shRNA lentivirus-delivery. Analysis of gene and protein expression. Functional studies of cell proliferation, migration and apoptosis. Xenograft leukemia mice models
Master of Science, Avidsor: Dr Fabiola Traina
Investigation of IRS1 and IRS2 functions in hemalogical neoplasms. Analysis of cell signaling. Gene silencing by shRNA lentivirus-delivery. Induction of hematopoetic cell differentiation Functional studies of cell proliferation and apoptosis.
Scientific initiative, Avidsor: Dr Sara Teresinha Olalla Saad
Investigation of PI3KCA, JAK2 and FLT3 mutations in myelodysplastic syndromes. PCR and DNA sequencing.

TEACHING EXPERIENCE
University of São Paulo, São Paulo, Brazil
Teaching in cell biology and pharmacology program, 2015 and 2016.
University of Campinas, São Paulo, Brazil
Teaching internship program in practice of science for students of medical school, 2013 and 2014.

 


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case reports   Journals   Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA