Atlas of Genetics and Cytogenetics in Oncology and Haematology

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Roberto Piergentili
Department of Biology and Biotecnology - Charles Darwin
Sapienza University of Rome - Istituto Genetica, room 1-07 - P.Le A.Moro 5 00185 Roma, Italy

1993: Degree in Biology, Sapienza - Università di Roma (Italy)
1995: Professional Biologist degree, Sapienza - Università di Roma (Italy)
1998: PhD in Genetics and Molecular Biology, Sapienza - Università di Roma (Italy)
1999-2000: international fellowship, UC Davis (CA - USA), Prof. K. C. Burtis’s lab
2008: international fellowship, Umeå University (Sweden), Prof. A. Chabes’ lab
2018: Professional certification as Project Manager

2012-present: Researcher at Institute of Molecular Biology and Pathology (IBPM), CNR National Research Council of Italy

2003-2012: Adjunct Professor of Genetics - Università di Urbino (PU - Italy)
2009-2010: Adjunct Professor of Genetics - Università Pontina (LT - Italy)
2016-2017: Adjunct Professor of Genetics - Sapienza Università di Roma (RM - Italy)

• Formal genetics of Drosophila
• Cytological analysis of Drosophila somatic and germinal tissues
• Indirect and double immunofluorescence
• Microscopy and digital data acquisition/manipulation
Drosophila cell cultures manipulation and RNA interference
• Standard molecular biology techniques
• Digital data mining; Bioinformatics standard tools
• Human Genetics and Cytogenetics
• Epigenetics of human pathologies

Chromatin structure and function (including alternative DNA structures) using mutations in Drosophila melanogaster that affect mitotic and male meiotic divisions. Chromosome structure including the molecular mechanisms of telomeric fusions and the genetic and molecular characterization of mutations causing chromosome breakage. Y chromosome-associated heterochromatin (both D. melanogaster and H. sapiens). Study of the human urogenital tract, its diseases and its development.



  1. Marrocco G, Grammatico P, Vallasciani S, Gulia C, Marrocco F, Heidari Bateni Z, Porrello A, Piergentili R. (2015) Environmental, parental and gestational factors that influence the occurrence of hypospadias. J Ped Urol 11:12-19
  2. Porrello A, Piergentili R. (2016) Contextualizing the genes altered in bladder neoplasms in pediatric and teen patients allows identifying two main classes of biological processes involved and new potential therapeutic targets. Curr Genomics 17(1):33-61
  3. Frappaolo A, Sechi S, Belloni G, Piergentili R, Giansanti MG. (2017) Chapter 6 - Visualization of cleavage furrow proteins in fixed dividing spermatocytes. Methods Cell Biol. 137:85-103
  4. Capozza N, Gulia C, Heidari Bateni Z, Zangari A, Gigli S, Briganti V, Tursini S, Koh CJ, Gaffi M, Baldassarra S, Signore F, Porrello A, Piergentili R. (2017) Vesicoureteral reflux in infants: what do we know about the gender prevalence by age? Eur Rev Med Pharmacol Sci 21(23):5321-5329
  5. Gulia C, Zangari A, Briganti V, Bateni ZH, Porrello A, Piergentili R. (2017) Labia minora hypertrophy: causes, impact on women's health, and treatment options. Int Urogynecol J 28(10):1453-1461
  6. Frappaolo A, Sechi S, Kumagai T, Robinson S, Fraschini R, Karimpour-Ghahnavieh A, Belloni G, Piergentili R, Tiemeyer KH, Tiemeyer M, Giansanti MG. (2017) COG7 deficiency in Drosophila generates multifaceted developmental, behavioral and protein glycosylation phenotypes. J Cell Sci 130:3637-3649
  7. Gulìa C, Baldassarra S, Signore F, Rigon G, Pizzuti V, Gaffi M, Briganti V, Porrello A, Piergentili R. (2017) Role of non-coding RNAs in the etiology of bladder cancer. Genes, 8, 339
  8. Gulía C, Baldassarra S, Zangari A, Briganti V, Gigli S, Gaffi M, Signore F, Vallone C, Nucciotti R, Costantini FM, Pizzuti A, Bernardo S, Porrello A, Piergentili R. (2018) Androgen insensitivity syndrome. Eur Rev Med Pharmacol Sci 22(12):3873-3887
  9. Vallone C, Rigon G, Gulia C, Baffa A, Votino R, Morosetti G, Zaami S, Briganti V, Catania F, Gaffi M, Nucciotti R, Costantini FM, Piergentili R, Putignani L, Signore F. (2018) Non-coding RNAs and endometrial cancer. Genes 9, 187

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