| Written | 1997-12 | Jean-Loup Huret |
| Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France |
| Identity |
| Alias_names | myeloid/lymphoid or mixed-lineage leukemia (trithorax (Drosophila) homolog); translocated to, 6 |
| myeloid/lymphoid or mixed-lineage leukemia; translocated to, 6 | |
| Alias_symbol (synonym) | AF17 |
| FLJ23480 | |
| Other alias | AF17 (ALL1 fused gene from chromosome 17) |
| HGNC (Hugo) | MLLT6 |
| LocusID (NCBI) | 4302 |
| Atlas_Id | 7 |
| Location | 17q12 [Link to chromosome band 17q12] |
| Location_base_pair | Starts at 38705620 and ends at 38729803 bp from pter ( according to hg19-Feb_2009) [Mapping MLLT6.png] |
| Local_order | proximal to RARA, also in 17q21; HLF is even more distal in 17q22 |
 | |
| Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics | |
| Fusion genes (updated 2017) | Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands) |
| C19orf70 (19p13.3) / MLLT6 (17q12) | CACNB1 (17q12) / MLLT6 (17q12) | KMT2A (11q23.3) / MLLT6 (17q12) | |
| MLLT6 (17q12) / AATF (17q12) | MLLT6 (17q12) / ACE (17q23.3) | MLLT6 (17q12) / KIRREL3 (11q24.2) | |
| MLLT6 (17q12) / KMT2A (11q23.3) | MLLT6 (17q12) / PLEKHH1 (14q24.1) | MLLT6 (17q12) / PPP1R12A (12q21.2) | |
| MLLT6 (17q12) / RRNAD1 (1q23.1) | MLLT6 (17q12) / TUBB (6p21.33) | MRPL35 (2p11.2) / MLLT6 (17q12) | |
| USF1 (1q23.3) / MLLT6 (17q12) |
| DNA/RNA |
| Transcription | 7.5 and 5 kb mRNA; coding sequence: 3.3 kb |
| Protein |
| Description | 1093 amino acids; N- term - 3 Zn fingers (LAP type) and a leucine zipper - C-term; a leucine zipper is a dimerization motif |
| Localisation | nuclear |
| Function | transcriptional regulation factor |
| Homology | with AF10 and BR140, a gene sitting in 3p25 |
| Implicated in |
| Note | |
| Entity | t(11;17)(q23;q21) /AML --> KMT2A -AF17 |
| Disease | AML and MDS |
| Cytogenetics | additional anomaly: +8 |
| Hybrid/Mutated Gene | 5' MLL - 3' AF17 |
| Abnormal Protein | N-term AT hook and DNA methyltransferase from MLL fused to the leucine zipper C-term of AF17 |
| Bibliography |
| Molecular basis of 11q23 rearrangements in hematopoietic malignant proliferations. |
| Bernard OA, Berger R |
| Genes, chromosomes & cancer. 1995 ; 13 (2) : 75-85. |
| PMID 7542910 |
| Leucine-zipper dimerization motif encoded by the AF17 gene fused to ALL-1 (MLL) in acute leukemia. |
| Prasad R, Leshkowitz D, Gu Y, Alder H, Nakamura T, Saito H, Huebner K, Berger R, Croce CM, Canaani E |
| Proceedings of the National Academy of Sciences of the United States of America. 1994 ; 91 (17) : 8107-8111. |
| PMID 8058765 |
| 11q23 rearrangements in acute leukemia. |
| Rubnitz JE, Behm FG, Downing JR |
| Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1996 ; 10 (1) : 74-82. |
| PMID 8558942 |
| Chromosome abnormalities in leukaemia: the 11q23 paradigm. |
| Young BD, Saha V |
| Cancer surveys. 1996 ; 28 : 225-245. |
| PMID 8977038 |
| Citation |
| This paper should be referenced as such : |
| Huret, JL |
| AF17 (ALL1 fused gene from chromosome 17) |
| Atlas Genet Cytogenet Oncol Haematol. 1997;1(2):53-53. |
| Free journal version : [ pdf ] [ DOI ] |
| On line version : http://AtlasGeneticsOncology.org/Genes/AF17ID7.html |
| Other Leukemias implicated (Data extracted from papers in the Atlas) [ 3 ] |
|
t(11;17)(q23;q12-21) KMT2A/MLLT6
t(11;17)(q23;q12) KMT2A/MLLT6 t(11;17)(q23;q12) MLLT6/KMT2A |
| Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ] |
|
t(11;17)(q24;q12) MLLT6/KIRREL3
t(12;17)(q21;q12) MLLT6/PPP1R12A t(17;17)(q12;q23) MLLT6/ACE |
| External links |
| REVIEW articles | automatic search in PubMed |
| Last year publications | automatic search in PubMed |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon Dec 10 13:36:54 CET 2018 |
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