Atlas of Genetics and Cytogenetics in Oncology and Haematology
AF9 (ALL1 fused gene from chromosome 9)
MLLT3 (myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3)
| Identity |
| Other names | LTG9 |
| MLLT3 (myeloid/lymphoid leukemia translocated to 3) | |
| HGNC (Hugo) | MLLT3 |
| Location | 9p22 |
| Location_base_pair | Starts at 20334968 and ends at 20612514 bp from pter ( according to hg18-Mar_2006) [Mapping] |
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| AF9 (9p22) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics. Laboratories willing to validate the probes are welcome : contact rocchi@biologia.uniba.it | |
| DNA/RNA |
| Transcription | 5 kb mRNA; coding sequence: 1.7 kb |
| Protein |
| Description | 568 amino acids; 63 kDa; serine and proline rich in many places; possesses a nuclear targeting sequence |
| Localisation | nuclear |
| Function | transcription activator |
| Homology | with ENL (human) |
| Implicated in |
| Entity | t(9;11) (p22;q23)/ANLL -->MLL -AF9 |
| Disease | M5/M4 de novo and therapy related ANLL |
| Prognosis | the prognosis may not be as poor as in other 11q23 leukaemias in de novo cases; very poor prognosis in secondary ANLL cases |
| Cytogenetics | may be overlooked; often as a sole anomaly |
| Hybrid/Mutated Gene | variable breakpoints on both genes |
| Abnormal Protein | N-term -- AT hook and DNA methyltransferase from MLL fused to the 192 C-term amino acids from AF9 (as breakpoints are variable, this is only an exemple) |
| External links |
| Bibliography |
| Identification of MLL and chimeric MLL gene products involved in 11q23 translocation and possible mechanisms of leukemogenesis by MLL truncation. |
| Joh T, Kagami Y, Yamamoto K, Segawa T, Takizawa J, Takahashi T, Ueda R, Seto M |
| Oncogene. 1996 ; 13 (9) : 1945-1953. |
| PMID 8934541 |
| Chromosome abnormalities in leukaemia: the 11q23 paradigm. |
| Young BD, Saha V |
| Cancer surveys. 1996 ; 28 : 225-245. |
| PMID 8977038 |
| Implication of prior treatment with drug combinations including inhibitors of topoisomerase II in therapy-related monocytic leukemia with a 9;11 translocation. |
| Albain KS, Le Beau MM, Ullirsch R, Schumacher H |
| Genes, chromosomes & cancer. 1990 ; 2 (1) : 53-58. |
| PMID 2177642 |
| Molecular basis of 11q23 rearrangements in hematopoietic malignant proliferations. |
| Bernard OA, Berger R |
| Genes, chromosomes & cancer. 1995 ; 13 (2) : 75-85. |
| PMID 7542910 |
| 11q23 rearrangements in acute leukemia. |
| Rubnitz JE, Behm FG, Downing JR |
| Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1996 ; 10 (1) : 74-82. |
| PMID 8558942 |
| REVIEW articles | automatic search in PubMed |
| Last year publications | automatic search in PubMed |
| Contributor(s) |
| Written | 12-1997 | Jean-Loup Huret |
| Citation |
| This paper should be referenced as such : |
| Huret JL . AF9 (ALL1 fused gene from chromosome 9); MLLT3 (myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3). Atlas Genet Cytogenet Oncol Haematol. December 1997 . URL : http://AtlasGeneticsOncology.org/Genes/AF9.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Sat Jun 27 16:39:18 CEST 2009 |
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