| Implication of prior treatment with drug combinations including inhibitors of topoisomerase II in therapy-related monocytic leukemia with a 9;11 translocation. |
| Albain KS, Le Beau MM, Ullirsch R, Schumacher H |
| Genes, chromosomes & cancer. 1990 ; 2 (1) : 53-58. |
| PMID 2177642 |
| |
| Molecular basis of 11q23 rearrangements in hematopoietic malignant proliferations. |
| Bernard OA, Berger R |
| Genes, chromosomes & cancer. 1995 ; 13 (2) : 75-85. |
| PMID 7542910 |
| |
| Identification of MLL and chimeric MLL gene products involved in 11q23 translocation and possible mechanisms of leukemogenesis by MLL truncation. |
| Joh T, Kagami Y, Yamamoto K, Segawa T, Takizawa J, Takahashi T, Ueda R, Seto M |
| Oncogene. 1996 ; 13 (9) : 1945-1953. |
| PMID 8934541 |
| |
| 11q23 rearrangements in acute leukemia. |
| Rubnitz JE, Behm FG, Downing JR |
| Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1996 ; 10 (1) : 74-82. |
| PMID 8558942 |
| |
| Chromosome abnormalities in leukaemia: the 11q23 paradigm. |
| Young BD, Saha V |
| Cancer surveys. 1996 ; 28 : 225-245. |
| PMID 8977038 |
| |
| Nomenclature |
|---|
| HGNC (Hugo) | MLLT3 7136 |
| Cards |
|---|
| Atlas | AF9ID5 |
| Entrez_Gene (NCBI) | MLLT3 MLLT3 super elongation complex subunit |
| Aliases | AF9; YEATS3 |
| GeneCards (Weizmann) | MLLT3 |
| Ensembl hg19 (Hinxton) | ENSG00000171843 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000171843 [Gene_View] ENSG00000171843 [Sequence] chr9:20341669-20622499 [Contig_View] MLLT3 [Vega] |
| ICGC DataPortal | ENSG00000171843 |
| TCGA cBioPortal | MLLT3 |
| AceView (NCBI) | MLLT3 |
| Genatlas (Paris) | MLLT3 |
| SOURCE (Princeton) | MLLT3 |
| Genetics Home Reference (NIH) | MLLT3 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | MLLT3 - chr9:20341669-20622499 - 9p21.3 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | MLLT3 - 9p21.3 [Description] (hg19-Feb_2009) |
| GoldenPath | MLLT3 - 9p21.3 [CytoView hg19] MLLT3 - 9p21.3 [CytoView hg38] |
| ImmunoBase | ENSG00000171843 |
| genome Data Viewer NCBI | MLLT3 [Mapview hg19] |
| OMIM | 159558 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AK128222 AK225957 AK297587 AK301474 AK312914 |
| RefSeq transcript (Entrez) | NM_001286691 NM_004529 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | MLLT3 |
| Alternative Splicing Gallery | ENSG00000171843 |
| Gene Expression | MLLT3 [ NCBI-GEO ] MLLT3 [ EBI - ARRAY_EXPRESS ]
MLLT3 [ SEEK ] MLLT3 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | MLLT3 [ Firebrowse - Broad ] |
| Genevisible | Expression of MLLT3 in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 4300 |
| GTEX Portal (Tissue expression) | MLLT3 |
| Human Protein Atlas | ENSG00000171843-MLLT3 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P42568 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | P42568 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | P42568 |
| Splice isoforms : SwissVar | P42568 |
| PhosPhoSitePlus | P42568 |
| Domaine pattern : Prosite (Expaxy) | YEATS (PS51037) |
| Domains : Interpro (EBI) | AF-9_AHD YEAST_sf YEATS |
| Domain families : Pfam (Sanger) | AHD (PF17793) YEATS (PF03366) |
| Domain families : Pfam (NCBI) | pfam17793 pfam03366 |
| Conserved Domain (NCBI) | MLLT3 |
| Blocks (Seattle) | MLLT3 |
| PDB (RSDB) | 2LM0 2MV7 2N4Q 2NDF 2NDG 4TMP 5HJB 5HJD 5YYF 6B7G 6MIL 6MIM |
| PDB Europe | 2LM0 2MV7 2N4Q 2NDF 2NDG 4TMP 5HJB 5HJD 5YYF 6B7G 6MIL 6MIM |
| PDB (PDBSum) | 2LM0 2MV7 2N4Q 2NDF 2NDG 4TMP 5HJB 5HJD 5YYF 6B7G 6MIL 6MIM |
| PDB (IMB) | 2LM0 2MV7 2N4Q 2NDF 2NDG 4TMP 5HJB 5HJD 5YYF 6B7G 6MIL 6MIM |
| Structural Biology KnowledgeBase | 2LM0 2MV7 2N4Q 2NDF 2NDG 4TMP 5HJB 5HJD 5YYF 6B7G 6MIL 6MIM |
| SCOP (Structural Classification of Proteins) | 2LM0 2MV7 2N4Q 2NDF 2NDG 4TMP 5HJB 5HJD 5YYF 6B7G 6MIL 6MIM |
| CATH (Classification of proteins structures) | 2LM0 2MV7 2N4Q 2NDF 2NDG 4TMP 5HJB 5HJD 5YYF 6B7G 6MIL 6MIM |
| Superfamily | P42568 |
| Human Protein Atlas [tissue] | ENSG00000171843-MLLT3 [tissue] |
| Peptide Atlas | P42568 |
| HPRD | 01163 |
| IPI | IPI01015721 IPI00000033 IPI00644625 IPI00478977 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P42568 |
| IntAct (EBI) | P42568 |
| BioGRID | MLLT3 |
| STRING (EMBL) | MLLT3 |
| ZODIAC | MLLT3 |
| Ontologies - Pathways |
|---|
| QuickGO | P42568 |
| Ontology : AmiGO | "DNA-binding transcription factor activity, RNA polymerase II-specific DNA binding chromatin binding protein binding nucleus nucleoplasm nucleoplasm chromosome cytosol regulation of transcription by RNA polymerase II transcription by RNA polymerase II transcription elongation from RNA polymerase II promoter segment specification transcription elongation factor complex anterior/posterior pattern specification histone binding positive regulation of transcription, DNA-templated hematopoietic stem cell differentiation extracellular exosome lysine-acetylated histone binding negative regulation of canonical Wnt signaling pathway negative regulation of canonical Wnt signaling pathway modification-dependent protein binding regulation of chromatin organization regulation of stem cell division positive regulation of Wnt signaling pathway, planar cell polarity pathway" |
| Ontology : EGO-EBI | "DNA-binding transcription factor activity, RNA polymerase II-specific DNA binding chromatin binding protein binding nucleus nucleoplasm nucleoplasm chromosome cytosol regulation of transcription by RNA polymerase II transcription by RNA polymerase II transcription elongation from RNA polymerase II promoter segment specification transcription elongation factor complex anterior/posterior pattern specification histone binding positive regulation of transcription, DNA-templated hematopoietic stem cell differentiation extracellular exosome lysine-acetylated histone binding negative regulation of canonical Wnt signaling pathway negative regulation of canonical Wnt signaling pathway modification-dependent protein binding regulation of chromatin organization regulation of stem cell division positive regulation of Wnt signaling pathway, planar cell polarity pathway" |
| Pathways : KEGG | Transcriptional misregulation in cancer |
| REACTOME | P42568 [protein] |
| REACTOME Pathways | R-HSA-75955 [pathway] |
| NDEx Network | MLLT3 |
| Atlas of Cancer Signalling Network | MLLT3 |
| Wikipedia pathways | MLLT3 |
| Orthology - Evolution |
|---|
| OrthoDB | 4300 |
| GeneTree (enSembl) | ENSG00000171843 |
| Phylogenetic Trees/Animal Genes : TreeFam | MLLT3 |
| HOGENOM | P42568 |
| Homologs : HomoloGene | MLLT3 |
| Homology/Alignments : Family Browser (UCSC) | MLLT3 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Mitelman | MLLT3/CISD3 [9p21.3/17q12] |
| Fusion : Mitelman | MLLT3/IZUMO3 [9p21.3/9p21.3] |
| Fusion : Mitelman | MLLT3/SLC28A3 [9p21.3/9q21.32] |
| Fusion : COSMIC | MLLT3 [9p21.3] - KMT2A [11q23.3] [fusion_1984] |
| Fusion Portal | MLLT3 9p21.3 CISD3 17q12 BRCA |
| Fusion Portal | MLLT3 9p21.3 IZUMO3 9p21.3 GBM |
| Fusion Portal | MLLT3 9p21.3 SLC28A3 9q21.32 BRCA |
| Fusion Portal | MLL MLLT3 9p21.3 LAML |
| Fusion : TICdb | KMT2A [11q23.3] - MLLT3 [9p21.3] |
| Fusion : Fusion_Hub | FOCAD--MLLT3 GPI--MLLT3 IZUMO3--MLLT3 KCND2--MLLT3 KLHL9--MLLT3 KMT2A--MLLT3 MLL--MLLT3 MLLT3--AKAP13 MLLT3--BAG1 MLLT3--BNC2 MLLT3--CISD3 MLLT3--CMC1 MLLT3--DST MLLT3--FLJ35282 MLLT3--FOCAD |
| MLLT3--FUS MLLT3--HNRNPK MLLT3--IZUMO3 MLLT3--KMT2A MLLT3--MLL MLLT3--PALM2 MLLT3--PAX5 MLLT3--PLIN2 MLLT3--PPP6R1 MLLT3--PSMB1 MLLT3--SLC28A3 MLLT3--SNX30 MLLT3--SYT10 MLLT3--TEK MLLT3--TGFBR1 |
| MLLT3--TYRP1 MLLT3--UBQLN1 MLLT3--UGCG MLLT3--ZZZ3 NAP1L4--MLLT3 NBEAL1--MLLT3 PALM2--MLLT3 PAX5--MLLT3 PPP6R1--MLLT3 SCFD1--MLLT3 TMPRSS2--MLLT3 UHRF2--MLLT3 |
| Fusion : Quiver | MLLT3 |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | MLLT3 [hg38] |
| dbVar | MLLT3 |
| ClinVar | MLLT3 |
| Monarch | MLLT3 |
| 1000_Genomes | MLLT3 |
| Exome Variant Server | MLLT3 |
| GNOMAD Browser | ENSG00000171843 |
| Varsome Browser | MLLT3 |
| Genomic Variants (DGV) | MLLT3 [DGVbeta] |
| DECIPHER | MLLT3 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | MLLT3 |
| Mutations |
|---|
| ICGC Data Portal | MLLT3 |
| TCGA Data Portal | MLLT3 |
| Broad Tumor Portal | MLLT3 |
| OASIS Portal | MLLT3 [ Somatic mutations - Copy number] |
| Cancer Gene: Census | MLLT3 |
| Somatic Mutations in Cancer : COSMIC | MLLT3 [overview] [genome browser] [tissue] [distribution] |
| Somatic Mutations in Cancer : COSMIC3D | MLLT3 |
| Mutations and Diseases : HGMD | MLLT3 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search MLLT3 |
| DgiDB (Drug Gene Interaction Database) | MLLT3 |
| DoCM (Curated mutations) | MLLT3 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | MLLT3 (select a term) |
| intoGen | MLLT3 |
| OncoKB | MLLT3 |
| NCG6 (London) | select MLLT3 |
| Cancer3D | MLLT3(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 159558 |
| Orphanet | 22870 |
| DisGeNET | MLLT3 |
| Medgen | MLLT3 |
| Genetic Testing Registry | MLLT3
|
| NextProt | P42568 [Medical] |
| GENETests | MLLT3 |
| Target Validation | MLLT3 |
| Huge Navigator |
MLLT3 [HugePedia] |
| ClinGen | MLLT3 |
| Clinical trials, drugs, therapy |
|---|
| MyCancerGenome | MLLT3 |
| Protein Interactions : CTD | |
| Pharm GKB Gene | PA30852 |
| Pharos | P42568 |
| Drug Sensitivity | MLLT3 |
| Clinical trial | MLLT3 |
| Miscellaneous |
|---|
| canSAR (ICR) | MLLT3 (select the gene name) |
| Harmonizome | MLLT3 |
| DataMed Index | MLLT3 |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 90 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| EVEX | MLLT3 |
