| Implication of prior treatment with drug combinations including inhibitors of topoisomerase II in therapy-related monocytic leukemia with a 9;11 translocation. |
| Albain KS, Le Beau MM, Ullirsch R, Schumacher H |
| Genes, chromosomes & cancer. 1990 ; 2 (1) : 53-58. |
| PMID 2177642 |
| |
| Molecular basis of 11q23 rearrangements in hematopoietic malignant proliferations. |
| Bernard OA, Berger R |
| Genes, chromosomes & cancer. 1995 ; 13 (2) : 75-85. |
| PMID 7542910 |
| |
| Identification of MLL and chimeric MLL gene products involved in 11q23 translocation and possible mechanisms of leukemogenesis by MLL truncation. |
| Joh T, Kagami Y, Yamamoto K, Segawa T, Takizawa J, Takahashi T, Ueda R, Seto M |
| Oncogene. 1996 ; 13 (9) : 1945-1953. |
| PMID 8934541 |
| |
| 11q23 rearrangements in acute leukemia. |
| Rubnitz JE, Behm FG, Downing JR |
| Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1996 ; 10 (1) : 74-82. |
| PMID 8558942 |
| |
| Chromosome abnormalities in leukaemia: the 11q23 paradigm. |
| Young BD, Saha V |
| Cancer surveys. 1996 ; 28 : 225-245. |
| PMID 8977038 |
| |
| Nomenclature |
|---|
| HGNC (Hugo) | MLLT3 7136 |
| Cards |
|---|
| Atlas | AF9ID5 |
| Entrez_Gene (NCBI) | MLLT3 4300 MLLT3, super elongation complex subunit |
| Aliases | AF9; YEATS3 |
| GeneCards (Weizmann) | MLLT3 |
| Ensembl hg19 (Hinxton) | ENSG00000171843 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000171843 [Gene_View] ENSG00000171843 [Sequence] chr9:20341665-20622543 [Contig_View] MLLT3 [Vega] |
| ICGC DataPortal | ENSG00000171843 |
| TCGA cBioPortal | MLLT3 |
| AceView (NCBI) | MLLT3 |
| Genatlas (Paris) | MLLT3 |
| WikiGenes | 4300 |
| SOURCE (Princeton) | MLLT3 |
| Genetics Home Reference (NIH) | MLLT3 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | MLLT3 - chr9:20341665-20622543 - 9p21.3 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | MLLT3 - 9p21.3 [Description] (hg19-Feb_2009) |
MLLT3 - 9p21.3 [CytoView hg19] MLLT3 - 9p21.3 [CytoView hg38] |
| Mapping of homologs : NCBI | MLLT3 [Mapview hg19] MLLT3 [Mapview hg38] |
| OMIM | 159558 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AK128222 AK225957 AK297587 AK301474 AK312914 |
| RefSeq transcript (Entrez) | NM_001286691 NM_004529 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | MLLT3 |
| Cluster EST : Unigene | Hs.591085 [ NCBI ] |
| CGAP (NCI) | Hs.591085 |
| Alternative Splicing Gallery | ENSG00000171843 |
| Gene Expression | MLLT3 [ NCBI-GEO ] MLLT3 [ EBI - ARRAY_EXPRESS ]
MLLT3 [ SEEK ] MLLT3 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | MLLT3 [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevestigator | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 4300 |
| GTEX Portal (Tissue expression) | MLLT3 |
| Human Protein Atlas | ENSG00000171843-MLLT3 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P42568 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | P42568 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | P42568 |
| Splice isoforms : SwissVar | P42568 |
| PhosPhoSitePlus | P42568 |
| Domaine pattern : Prosite (Expaxy) | YEATS (PS51037) |
| Domains : Interpro (EBI) | YEAST_sf YEATS |
| Domain families : Pfam (Sanger) | YEATS (PF03366) |
| Domain families : Pfam (NCBI) | pfam03366 |
| Conserved Domain (NCBI) | MLLT3 |
| DMDM Disease mutations | 4300 |
| Blocks (Seattle) | MLLT3 |
| PDB (RSDB) | 2LM0 2MV7 2N4Q 2NDF 2NDG 4TMP 5HJB 5HJD |
| PDB Europe | 2LM0 2MV7 2N4Q 2NDF 2NDG 4TMP 5HJB 5HJD |
| PDB (PDBSum) | 2LM0 2MV7 2N4Q 2NDF 2NDG 4TMP 5HJB 5HJD |
| PDB (IMB) | 2LM0 2MV7 2N4Q 2NDF 2NDG 4TMP 5HJB 5HJD |
| Structural Biology KnowledgeBase | 2LM0 2MV7 2N4Q 2NDF 2NDG 4TMP 5HJB 5HJD |
| SCOP (Structural Classification of Proteins) | 2LM0 2MV7 2N4Q 2NDF 2NDG 4TMP 5HJB 5HJD |
| CATH (Classification of proteins structures) | 2LM0 2MV7 2N4Q 2NDF 2NDG 4TMP 5HJB 5HJD |
| Superfamily | P42568 |
| Human Protein Atlas [tissue] | ENSG00000171843-MLLT3 [tissue] |
| Peptide Atlas | P42568 |
| HPRD | 01163 |
| IPI | IPI01015721 IPI00000033 IPI00644625 IPI00478977 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P42568 |
| IntAct (EBI) | P42568 |
| FunCoup | ENSG00000171843 |
| BioGRID | MLLT3 |
| STRING (EMBL) | MLLT3 |
| ZODIAC | MLLT3 |
| Ontologies - Pathways |
|---|
| QuickGO | P42568 |
| Ontology : AmiGO | DNA-binding transcription factor activity, RNA polymerase II-specific chromatin binding protein binding nucleus nucleoplasm chromosome regulation of transcription by RNA polymerase II transcription by RNA polymerase II transcription elongation from RNA polymerase II promoter segment specification transcription elongation factor complex anterior/posterior pattern specification histone binding positive regulation of transcription, DNA-templated extracellular exosome lysine-acetylated histone binding negative regulation of canonical Wnt signaling pathway negative regulation of canonical Wnt signaling pathway modification-dependent protein binding positive regulation of Wnt signaling pathway, planar cell polarity pathway |
| Ontology : EGO-EBI | DNA-binding transcription factor activity, RNA polymerase II-specific chromatin binding protein binding nucleus nucleoplasm chromosome regulation of transcription by RNA polymerase II transcription by RNA polymerase II transcription elongation from RNA polymerase II promoter segment specification transcription elongation factor complex anterior/posterior pattern specification histone binding positive regulation of transcription, DNA-templated extracellular exosome lysine-acetylated histone binding negative regulation of canonical Wnt signaling pathway negative regulation of canonical Wnt signaling pathway modification-dependent protein binding positive regulation of Wnt signaling pathway, planar cell polarity pathway |
| Pathways : KEGG | Transcriptional misregulation in cancer |
| REACTOME | P42568 [protein] |
| REACTOME Pathways | R-HSA-75955 [pathway] |
| NDEx Network | MLLT3 |
| Atlas of Cancer Signalling Network | MLLT3 |
| Wikipedia pathways | MLLT3 |
| Orthology - Evolution |
|---|
| OrthoDB | 4300 |
| GeneTree (enSembl) | ENSG00000171843 |
| Phylogenetic Trees/Animal Genes : TreeFam | MLLT3 |
| HOGENOM | P42568 |
| Homologs : HomoloGene | MLLT3 |
| Homology/Alignments : Family Browser (UCSC) | MLLT3 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Mitelman | MLLT3/CISD3 [9p21.3/17q12] |
| Fusion : Mitelman | MLLT3/IZUMO3 [9p21.3/9p21.3] [t(9;9)(p21;p21)] |
| Fusion : Mitelman | MLLT3/SLC28A3 [9p21.3/9q21.32] [t(9;9)(p21;q21)] |
| Fusion : COSMIC | KMT2A [11q23.3] - MLLT3 [9p21.3] [fusion_1856] [fusion_1857] [fusion_1858] [fusion_1861] [fusion_1983] [fusion_1985] [fusion_1986] |
| [fusion_1987] [fusion_2081] [fusion_2082] [fusion_2083] [fusion_2084] [fusion_2085] [fusion_2086] [fusion_2087] [fusion_2088] [fusion_2089] |
| |
| Fusion : COSMIC | MLLT3 [9p21.3] - KMT2A [11q23.3] [fusion_1984] |
| Fusion Portal | MLLT3 9p21.3 CISD3 17q12 BRCA |
| Fusion Portal | MLLT3 9p21.3 IZUMO3 9p21.3 GBM |
| Fusion Portal | MLLT3 9p21.3 SLC28A3 9q21.32 BRCA |
| Fusion Portal | MLL MLLT3 9p21.3 LAML |
| Fusion : TICdb | KMT2A [11q23.3] - MLLT3 [9p21.3] |
| Fusion : FusionGDB | 19103 22163 22164 22165 22166 22167 22168 22169 22170 22171 22172 23486 23495 25861 32817 |
| 3831 38760 42644 43585 |
| Fusion : Quiver | MLLT3 |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | MLLT3 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | MLLT3 |
| dbVar | MLLT3 |
| ClinVar | MLLT3 |
| 1000_Genomes | MLLT3 |
| Exome Variant Server | MLLT3 |
| ExAC (Exome Aggregation Consortium) | ENSG00000171843 |
| GNOMAD Browser | ENSG00000171843 |
| Varsome Browser | MLLT3 |
| Genetic variants : HAPMAP | 4300 |
| Genomic Variants (DGV) | MLLT3 [DGVbeta] |
| DECIPHER | MLLT3 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | MLLT3 |
| Mutations |
|---|
| ICGC Data Portal | MLLT3 |
| TCGA Data Portal | MLLT3 |
| Broad Tumor Portal | MLLT3 |
| OASIS Portal | MLLT3 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | MLLT3 [overview] [genome browser] [tissue] [distribution] |
| Mutations and Diseases : HGMD | MLLT3 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search MLLT3 |
| DgiDB (Drug Gene Interaction Database) | MLLT3 |
| DoCM (Curated mutations) | MLLT3 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | MLLT3 (select a term) |
| intoGen | MLLT3 |
| NCG5 (London) | MLLT3 |
| Cancer3D | MLLT3(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 159558 |
| Orphanet | 22870 |
| DisGeNET | MLLT3 |
| Medgen | MLLT3 |
| Genetic Testing Registry | MLLT3
|
| NextProt | P42568 [Medical] |
| TSGene | 4300 |
| GENETests | MLLT3 |
| Target Validation | MLLT3 |
| Huge Navigator |
MLLT3 [HugePedia] |
| snp3D : Map Gene to Disease | 4300 |
| BioCentury BCIQ | MLLT3 |
| ClinGen | MLLT3 |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 4300 |
| Chemical/Pharm GKB Gene | PA30852 |
| Drug Sensitivity | MLLT3 |
| Clinical trial | MLLT3 |
| Miscellaneous |
|---|
| canSAR (ICR) | MLLT3 (select the gene name) |
| DataMed Index | MLLT3 |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 80 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | MLLT3 |
| EVEX | MLLT3 |
| GoPubMed | MLLT3 |
| iHOP | MLLT3 |
