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AIFM2 (apoptosis-inducing factor, mitochondrion-associated, 2)

Written2009-06Miroslav Varecha
Centre for Biomedical Image Analysis, Faculty of Informatics, Masaryk University, Botanicka 68a, Brno 60200, Czech Republic

(Note : for Links provided by Atlas : click)

Identity

Other aliasAMID
PRG3
RP11-367H5.2
LocusID (NCBI) 84883
Atlas_Id 41842
Location 10q22.1  [Link to chromosome band 10q22]
Location_base_pair Starts at and ends at bp from pter
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AIFM2 (10q22.1) / AIFM2 (10q22.1)AIFM2 (10q22.1) / GAS7 (17p13.1)TYSND1 (10q22.1) / AIFM2 (10q22.1)

DNA/RNA

Description The gene spans approximately 20.66kb. Number of exons: 14, minus strand.
Transcription The length of AIFM2 transcript is 3240 bp.

Protein

 
  Stably transfected (by lipofection) living cells U-2 OS (human osteosarcoma) cell line with plasmid producing red fluorescent fusion protein AIFM2-tHcRed.
Description AIFM2 is oxidoreductase of 373 AA lenght. It is predicted to take part in caspase-independent apoptosis similarly to homologous AIFM1 (AIF, PDCD8). AIFM2 is p53-responsive gene and production of AIFM2 was found to be suppressed in many human cancers.
Expression AIFM2 was detected in most healthy tissues in form of two transcripts (1.8 and 4.0 kb). It is highly expressed in heart, moderately in liver and skeletal muscles, and expressed at low levels in placenta, lung, kidney, and pancreas.
Localisation Cytoplasmic side of cellular membranes.
Function Oxidoreductase, that may be important in mediating a TP53/p53-dependent apoptotic response. Predicted to be caspase-independent effector of apoptotic cell death, but not shown by other authors. Function of this protein is thus unknown.
Homology Homologous to AIFM1 (AIF, PDCD8). They share 22% aminoacid identity. It belongs to the FAD-dependent oxidoreductase family.

Implicated in

Note
  
Entity Apoptosis and Cancer
Note AIFM2 expression was found to be activated by overexpression of p53, which leads to cell cycle arrest or apoptosis. Inactivation of p53 was observed in many human cancers.
  

Bibliography

AMID: new insights on its intracellular localization and expression at apoptosis.
Bilyy R, Kit Y, Hellman U, Stoika R.
Apoptosis. 2008 May;13(5):729-32.
PMID 18368494
 
DNA binding suppresses human AIF-M2 activity and provides a connection between redox chemistry, reactive oxygen species, and apoptosis.
Gong M, Hay S, Marshall KR, Munro AW, Scrutton NS.
J Biol Chem. 2007 Oct 12;282(41):30331-40. Epub 2007 Aug 20.
PMID 17711848
 
The human apoptosis-inducing protein AMID is an oxidoreductase with a modified flavin cofactor and DNA binding activity.
Marshall KR, Gong M, Wodke L, Lamb JH, Jones DJ, Farmer PB, Scrutton NS, Munro AW.
J Biol Chem. 2005 Sep 2;280(35):30735-40. Epub 2005 Jun 15.
PMID 15958387
 
The p53-inducible apoptotic protein AMID is not required for normal development and tumor suppression.
Mei J, Webb S, Zhang B, Shu HB.
Oncogene. 2006 Feb 9;25(6):849-56.
PMID 16186796
 
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N.
FEBS Lett. 2002 Jul 31;524(1-3):163-71.
PMID 12135761
 
Bioinformatic and image analyses of the cellular localization of the apoptotic proteins endonuclease G, AIF, and AMID during apoptosis in human cells.
Varecha M, Amrichova J, Zimmermann M, Ulman V, Lukasova E, Kozubek M.
Apoptosis. 2007 Jul;12(7):1155-71.
PMID 17347867
 
AMID is a p53-inducible gene downregulated in tumors.
Wu M, Xu LG, Su T, Tian Y, Zhai Z, Shu HB.
Oncogene. 2004 Sep 2;23(40):6815-9.
PMID 15273740
 

Citation

This paper should be referenced as such :
Varecha, M
AIFM2 (apoptosis-inducing factor, mitochondrion-associated, 2)
Atlas Genet Cytogenet Oncol Haematol. 2010;14(5):435-436.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/AIFM2ID41842ch10q22.html


External links

Nomenclature
Cards
AtlasAIFM2ID41842ch10q22.txt
Aliases
Genomic and cartography
Gene and transcription
RefSeq transcript (Entrez)
RefSeq genomic (Entrez)
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)84883
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Protein Interaction databases
Ontologies - Pathways
Clinical trials, drugs, therapy
Miscellaneous
canSAR (ICR) (select the gene name)
Probes
Litterature
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed


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