Written | 2003-07 | Jean-Loup Huret, Sylvie Senon |
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France |
Identity |
Alias (NCBI) | ALEX1 (arm protein lost in epithelial cancers, X chromosome, 1) |
HGNC (Hugo) | ARMCX1 |
HGNC Alias symb | ALEX1 | GASP7 |
LocusID (NCBI) | 51309 |
Atlas_Id | 477 |
Location | Xq22.1 [Link to chromosome band Xq22] |
Location_base_pair | Starts at 101550547 and ends at 101554692 bp from pter ( according to GRCh38/hg38-Dec_2013) [Mapping ARMCX1.png] |
Fusion genes (updated 2017) | Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands) |
DNA/RNA |
Description | spans 4.2 kb; 4 exons; exon 4 is the only coding exon |
Transcription | cDNA: 2141 bp |
Protein |
Description | 453 amino acids, 49 kDa.; contains a transmembrane domain in N term, an ATP/GTP binding site, 2 arm (armadillo) repeats, and potential phosphorylation sites |
Expression | wide in normal tissues, except leucocytes; lost or significantly reduced in carcinomas |
Homology | with ALEX2 and ALEX3 |
Bibliography |
ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas. |
Kurochkin IV, Yonemitsu N, Funahashi SI, Nomura H |
Biochemical and biophysical research communications. 2001 ; 280 (1) : 340-347. |
PMID 11162520 |
Citation |
This paper should be referenced as such : |
Huret, JL ; Senon, S |
ALEX1 (arm protein lost in epithelial cancers, X chromosome, 1) |
Atlas Genet Cytogenet Oncol Haematol. 2003;7(3):166-166. |
Free journal version : [ pdf ] [ DOI ] |
External links |
REVIEW articles | automatic search in PubMed |
Last year publications | automatic search in PubMed |
© Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Fri Feb 19 17:45:29 CET 2021 |
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