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ARMCX1 (arm protein lost in epithelial cancers, X chromosome, 1)

Written2003-07Jean-Loup Huret, Sylvie Senon
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)

Identity

Alias_symbol (synonym)ALEX1
GASP7
Other aliasALEX1 (arm protein lost in epithelial cancers, X chromosome, 1)
HGNC (Hugo) ARMCX1
LocusID (NCBI) 51309
Atlas_Id 477
Location Xq22.1  [Link to chromosome band Xq22]
Location_base_pair Starts at 101550531 and ends at 101554692 bp from pter ( according to hg19-Feb_2009)  [Mapping ARMCX1.png]
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

DNA/RNA

Description spans 4.2 kb; 4 exons; exon 4 is the only coding exon
Transcription cDNA: 2141 bp

Protein

Description 453 amino acids, 49 kDa.; contains a transmembrane domain in N term, an ATP/GTP binding site, 2 arm (armadillo) repeats, and potential phosphorylation sites
Expression wide in normal tissues, except leucocytes; lost or significantly reduced in carcinomas
Homology with ALEX2 and ALEX3

Bibliography

ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas.
Kurochkin IV, Yonemitsu N, Funahashi SI, Nomura H
Biochemical and biophysical research communications. 2001 ; 280 (1) : 340-347.
PMID 11162520
 

Citation

This paper should be referenced as such :
Huret, JL ; Senon, S
ALEX1 (arm protein lost in epithelial cancers, X chromosome, 1)
Atlas Genet Cytogenet Oncol Haematol. 2003;7(3):166-166.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/ALEX1Xq22ID477.html

External links

Nomenclature
HGNC (Hugo)ARMCX1   18073
Cards
AtlasALEX1Xq22ID477
Entrez_Gene (NCBI)ARMCX1  51309  armadillo repeat containing, X-linked 1
AliasesALEX1; GASP7
GeneCards (Weizmann)ARMCX1
Ensembl hg19 (Hinxton)ENSG00000126947 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000126947 [Gene_View]  chrX:101550531-101554692 [Contig_View]  ARMCX1 [Vega]
ICGC DataPortalENSG00000126947
TCGA cBioPortalARMCX1
AceView (NCBI)ARMCX1
Genatlas (Paris)ARMCX1
WikiGenes51309
SOURCE (Princeton)ARMCX1
Genetics Home Reference (NIH)ARMCX1
Genomic and cartography
GoldenPath hg38 (UCSC)ARMCX1  -     chrX:101550531-101554692 +  Xq22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ARMCX1  -     Xq22.1   [Description]    (hg19-Feb_2009)
EnsemblARMCX1 - Xq22.1 [CytoView hg19]  ARMCX1 - Xq22.1 [CytoView hg38]
Mapping of homologs : NCBIARMCX1 [Mapview hg19]  ARMCX1 [Mapview hg38]
OMIM300362   
Gene and transcription
Genbank (Entrez)AB039670 AF248963 AK074785 AK222578 BC002691
RefSeq transcript (Entrez)NM_016608
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ARMCX1
Cluster EST : UnigeneHs.9728 [ NCBI ]
CGAP (NCI)Hs.9728
Alternative Splicing GalleryENSG00000126947
Gene ExpressionARMCX1 [ NCBI-GEO ]   ARMCX1 [ EBI - ARRAY_EXPRESS ]   ARMCX1 [ SEEK ]   ARMCX1 [ MEM ]
Gene Expression Viewer (FireBrowse)ARMCX1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51309
GTEX Portal (Tissue expression)ARMCX1
Human Protein AtlasENSG00000126947-ARMCX1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9P291   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9P291  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9P291
Splice isoforms : SwissVarQ9P291
PhosPhoSitePlusQ9P291
Domaine pattern : Prosite (Expaxy)ARM_REPEAT (PS50176)   
Domains : Interpro (EBI)ARM-like    ARM-rpt_dom    ARM-type_fold    Armadillo   
Domain families : Pfam (Sanger)Arm_2 (PF04826)   
Domain families : Pfam (NCBI)pfam04826   
Domain families : Smart (EMBL)ARM (SM00185)  
Conserved Domain (NCBI)ARMCX1
DMDM Disease mutations51309
Blocks (Seattle)ARMCX1
SuperfamilyQ9P291
Human Protein Atlas [tissue]ENSG00000126947-ARMCX1 [tissue]
Peptide AtlasQ9P291
HPRD02292
IPIIPI00009908   IPI01013872   
Protein Interaction databases
DIP (DOE-UCLA)Q9P291
IntAct (EBI)Q9P291
FunCoupENSG00000126947
BioGRIDARMCX1
STRING (EMBL)ARMCX1
ZODIACARMCX1
Ontologies - Pathways
QuickGOQ9P291
Ontology : AmiGOprotein binding  mitochondrial outer membrane  integral component of membrane  
Ontology : EGO-EBIprotein binding  mitochondrial outer membrane  integral component of membrane  
NDEx NetworkARMCX1
Atlas of Cancer Signalling NetworkARMCX1
Wikipedia pathwaysARMCX1
Orthology - Evolution
OrthoDB51309
GeneTree (enSembl)ENSG00000126947
Phylogenetic Trees/Animal Genes : TreeFamARMCX1
HOVERGENQ9P291
HOGENOMQ9P291
Homologs : HomoloGeneARMCX1
Homology/Alignments : Family Browser (UCSC)ARMCX1
Gene fusions - Rearrangements
Fusion : QuiverARMCX1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARMCX1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARMCX1
dbVarARMCX1
ClinVarARMCX1
1000_GenomesARMCX1 
Exome Variant ServerARMCX1
ExAC (Exome Aggregation Consortium)ENSG00000126947
GNOMAD BrowserENSG00000126947
Genetic variants : HAPMAP51309
Genomic Variants (DGV)ARMCX1 [DGVbeta]
DECIPHERARMCX1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisARMCX1 
Mutations
ICGC Data PortalARMCX1 
TCGA Data PortalARMCX1 
Broad Tumor PortalARMCX1
OASIS PortalARMCX1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARMCX1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDARMCX1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch ARMCX1
DgiDB (Drug Gene Interaction Database)ARMCX1
DoCM (Curated mutations)ARMCX1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ARMCX1 (select a term)
intoGenARMCX1
NCG5 (London)ARMCX1
Cancer3DARMCX1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300362   
Orphanet
DisGeNETARMCX1
MedgenARMCX1
Genetic Testing Registry ARMCX1
NextProtQ9P291 [Medical]
TSGene51309
GENETestsARMCX1
Target ValidationARMCX1
Huge Navigator ARMCX1 [HugePedia]
snp3D : Map Gene to Disease51309
BioCentury BCIQARMCX1
ClinGenARMCX1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51309
Chemical/Pharm GKB GenePA128394658
Clinical trialARMCX1
Miscellaneous
canSAR (ICR)ARMCX1 (select the gene name)
Probes
Litterature
PubMed15 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineARMCX1
EVEXARMCX1
GoPubMedARMCX1
iHOPARMCX1
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Feb 28 13:47:29 CET 2018
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