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ARMCX1 (arm protein lost in epithelial cancers, X chromosome, 1)

Written2003-07Jean-Loup Huret, Sylvie Senon
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)

Identity

Alias (NCBI)ALEX1 (arm protein lost in epithelial cancers, X chromosome, 1)
HGNC (Hugo) ARMCX1
HGNC Alias symbALEX1
GASP7
LocusID (NCBI) 51309
Atlas_Id 477
Location Xq22.1  [Link to chromosome band Xq22]
Location_base_pair Starts at 101550547 and ends at 101554692 bp from pter ( according to GRCh38/hg38-Dec_2013)  [Mapping ARMCX1.png]
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

DNA/RNA

Description spans 4.2 kb; 4 exons; exon 4 is the only coding exon
Transcription cDNA: 2141 bp

Protein

Description 453 amino acids, 49 kDa.; contains a transmembrane domain in N term, an ATP/GTP binding site, 2 arm (armadillo) repeats, and potential phosphorylation sites
Expression wide in normal tissues, except leucocytes; lost or significantly reduced in carcinomas
Homology with ALEX2 and ALEX3

Bibliography

ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas.
Kurochkin IV, Yonemitsu N, Funahashi SI, Nomura H
Biochemical and biophysical research communications. 2001 ; 280 (1) : 340-347.
PMID 11162520
 

Citation

This paper should be referenced as such :
Huret, JL ; Senon, S
ALEX1 (arm protein lost in epithelial cancers, X chromosome, 1)
Atlas Genet Cytogenet Oncol Haematol. 2003;7(3):166-166.
Free journal version : [ pdf ]   [ DOI ]

External links

 

Nomenclature
HGNC (Hugo)ARMCX1   18073
Cards
AtlasALEX1Xq22ID477
Atlas Explorer : (Salamanque)ARMCX1
Entrez_Gene (NCBI)ARMCX1    armadillo repeat containing X-linked 1
AliasesALEX1; GASP7
GeneCards (Weizmann)ARMCX1
Ensembl hg19 (Hinxton)ENSG00000126947 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000126947 [Gene_View]  ENSG00000126947 [Sequence]  chrX:101550547-101554692 [Contig_View]  ARMCX1 [Vega]
ICGC DataPortalENSG00000126947
TCGA cBioPortalARMCX1
AceView (NCBI)ARMCX1
Genatlas (Paris)ARMCX1
SOURCE (Princeton)ARMCX1
Genetics Home Reference (NIH)ARMCX1
Genomic and cartography
GoldenPath hg38 (UCSC)ARMCX1  -     chrX:101550547-101554692 +  Xq22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ARMCX1  -     Xq22.1   [Description]    (hg19-Feb_2009)
GoldenPathARMCX1 - Xq22.1 [CytoView hg19]  ARMCX1 - Xq22.1 [CytoView hg38]
ImmunoBaseENSG00000126947
Genome Data Viewer NCBIARMCX1 [Mapview hg19]  
OMIM300362   
Gene and transcription
Genbank (Entrez)AB039670 AF248963 AK074785 AK222578 BC002691
RefSeq transcript (Entrez)NM_016608
Consensus coding sequences : CCDS (NCBI)ARMCX1
Gene ExpressionARMCX1 [ NCBI-GEO ]   ARMCX1 [ EBI - ARRAY_EXPRESS ]   ARMCX1 [ SEEK ]   ARMCX1 [ MEM ]
Gene Expression Viewer (FireBrowse)ARMCX1 [ Firebrowse - Broad ]
GenevisibleExpression of ARMCX1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51309
GTEX Portal (Tissue expression)ARMCX1
Human Protein AtlasENSG00000126947-ARMCX1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9P291   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9P291  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9P291
PhosPhoSitePlusQ9P291
Domaine pattern : Prosite (Expaxy)ARM_REPEAT (PS50176)   
Domains : Interpro (EBI)ARM-like    ARM-rpt_dom    ARM-type_fold    Armadillo   
Domain families : Pfam (Sanger)Arm_2 (PF04826)   
Domain families : Pfam (NCBI)pfam04826   
Domain families : Smart (EMBL)ARM (SM00185)  
Conserved Domain (NCBI)ARMCX1
SuperfamilyQ9P291
AlphaFold pdb e-kbQ9P291   
Human Protein Atlas [tissue]ENSG00000126947-ARMCX1 [tissue]
HPRD02292
Protein Interaction databases
DIP (DOE-UCLA)Q9P291
IntAct (EBI)Q9P291
BioGRIDARMCX1
STRING (EMBL)ARMCX1
ZODIACARMCX1
Ontologies - Pathways
QuickGOQ9P291
Ontology : AmiGOprotein binding  mitochondrion  mitochondrial outer membrane  integral component of membrane  hematopoietic stem cell homeostasis  
Ontology : EGO-EBIprotein binding  mitochondrion  mitochondrial outer membrane  integral component of membrane  hematopoietic stem cell homeostasis  
NDEx NetworkARMCX1
Atlas of Cancer Signalling NetworkARMCX1
Wikipedia pathwaysARMCX1
Orthology - Evolution
OrthoDB51309
GeneTree (enSembl)ENSG00000126947
Phylogenetic Trees/Animal Genes : TreeFamARMCX1
Homologs : HomoloGeneARMCX1
Homology/Alignments : Family Browser (UCSC)ARMCX1
Gene fusions - Rearrangements
Fusion : FusionHubARMCX4--ARMCX1   
Fusion : QuiverARMCX1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARMCX1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARMCX1
dbVarARMCX1
ClinVarARMCX1
MonarchARMCX1
1000_GenomesARMCX1 
Exome Variant ServerARMCX1
GNOMAD BrowserENSG00000126947
Varsome BrowserARMCX1
ACMGARMCX1 variants
VarityQ9P291
Genomic Variants (DGV)ARMCX1 [DGVbeta]
DECIPHERARMCX1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisARMCX1 
Mutations
ICGC Data PortalARMCX1 
TCGA Data PortalARMCX1 
Broad Tumor PortalARMCX1
OASIS PortalARMCX1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARMCX1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DARMCX1
Mutations and Diseases : HGMDARMCX1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaARMCX1
DgiDB (Drug Gene Interaction Database)ARMCX1
DoCM (Curated mutations)ARMCX1
CIViC (Clinical Interpretations of Variants in Cancer)ARMCX1
Cancer3DARMCX1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300362   
Orphanet
DisGeNETARMCX1
MedgenARMCX1
Genetic Testing Registry ARMCX1
NextProtQ9P291 [Medical]
GENETestsARMCX1
Target ValidationARMCX1
Huge Navigator ARMCX1 [HugePedia]
ClinGenARMCX1
Clinical trials, drugs, therapy
MyCancerGenomeARMCX1
Protein Interactions : CTDARMCX1
Pharm GKB GenePA128394658
PharosQ9P291
Clinical trialARMCX1
Miscellaneous
canSAR (ICR)ARMCX1
HarmonizomeARMCX1
ARCHS4ARMCX1
DataMed IndexARMCX1
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXARMCX1
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 20 14:01:43 CET 2022
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