ARMCX1 (arm protein lost in epithelial cancers, X chromosome, 1)

2003-07-01   Jean-Loup Huret , Sylvie Senon 

Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Identity

HGNC
LOCATION
Xq22.1
LOCUSID
ALIAS
ALEX1 (arm protein lost in epithelial cancers, X chromosome, 1)

DNA/RNA

Description

spans 4.2 kb; 4 exons; exon 4 is the only coding exon

Transcription

cDNA: 2141 bp

Proteins

Description

453 amino acids, 49 kDa.; contains a transmembrane domain in N term, an ATP/GTP binding site, 2 arm (armadillo) repeats, and potential phosphorylation sites

Expression

wide in normal tissues, except leucocytes; lost or significantly reduced in carcinomas

Homology

with ALEX2 and ALEX3

Implicated in

Bibliography

Pubmed IDLast YearTitleAuthors
111625202001ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas.Kurochkin IV et al

Other Information

Locus ID:

NCBI: 51309
MIM: 300362
HGNC: 18073
Ensembl: ENSG00000126947

Variants:

dbSNP: 51309
ClinVar: 51309
TCGA: ENSG00000126947
COSMIC: ARMCX1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000126947ENST00000372829Q9P291
ENSG00000126947ENST00000372829A0A024RCI6

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203980522010Human Arm protein lost in epithelial cancers, on chromosome X 1 (ALEX1) gene is transcriptionally regulated by CREB and Wnt/beta-catenin signaling.7
224940582012ALEX1 suppresses colony formation ability of human colorectal carcinoma cell lines.6
283150042018ALEX1, a novel tumor suppressor gene, inhibits gastric cancer metastasis via the PAR-1/Rho GTPase signaling pathway.4
259211342015ALEX1 Regulates Proliferation and Apoptosis in Breast Cancer Cells.3
264647002015ALEX1 may be a novel biomarker for human cervical squamous cell carcinoma.2
309079882019miR-106b Promotes Metastasis of Early Gastric Cancer by Targeting ALEX1 in Vitro and in Vivo.2

Citation

Jean-Loup Huret ; Sylvie Senon

ARMCX1 (arm protein lost in epithelial cancers, X chromosome, 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-07-01

Online version: http://atlasgeneticsoncology.org/gene/477/armcx1