ARMCX1 (arm protein lost in epithelial cancers, X chromosome, 1)

2003-07-01   Jean-Loup Huret  , Sylvie Senon  

Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Identity

HGNC
ARMCX1
LOCATION
Xq22.1
LOCUSID
51309
ALIAS
ALEX1 (arm protein lost in epithelial cancers, X chromosome, 1)

DNA/RNA

Description

spans 4.2 kb; 4 exons; exon 4 is the only coding exon

Transcription

cDNA: 2141 bp

Proteins

Description

453 amino acids, 49 kDa.; contains a transmembrane domain in N term, an ATP/GTP binding site, 2 arm (armadillo) repeats, and potential phosphorylation sites

Expression

wide in normal tissues, except leucocytes; lost or significantly reduced in carcinomas

Homology

with ALEX2 and ALEX3

Implicated in

Article Bibliography

Pubmed IDLast YearTitleAuthors
111625202001ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas.Kurochkin IV et al

Other Information

Locus ID:

NCBI: 51309
MIM: 300362
HGNC: 18073
Ensembl: ENSG00000126947

Variants:

dbSNP: 51309
ClinVar: 51309
TCGA: ENSG00000126947
COSMIC: ARMCX1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000126947ENST00000372829Q9P291
ENSG00000126947ENST00000372829A0A024RCI6

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
367264912023The Expression of ARMCX1 in Gastric Cancer Contributes to Prognosis and Influences Chemotherapy.0
367264912023The Expression of ARMCX1 in Gastric Cancer Contributes to Prognosis and Influences Chemotherapy.0
326854722020ARMCX Family Gene Expression Analysis and Potential Prognostic Biomarkers for Prediction of Clinical Outcome in Patients with Gastric Carcinoma.9
326854722020ARMCX Family Gene Expression Analysis and Potential Prognostic Biomarkers for Prediction of Clinical Outcome in Patients with Gastric Carcinoma.9
309079882019miR-106b Promotes Metastasis of Early Gastric Cancer by Targeting ALEX1 in Vitro and in Vivo.12
309079882019miR-106b Promotes Metastasis of Early Gastric Cancer by Targeting ALEX1 in Vitro and in Vivo.12
283150042018ALEX1, a novel tumor suppressor gene, inhibits gastric cancer metastasis via the PAR-1/Rho GTPase signaling pathway.12
283150042018ALEX1, a novel tumor suppressor gene, inhibits gastric cancer metastasis via the PAR-1/Rho GTPase signaling pathway.12
259211342015ALEX1 Regulates Proliferation and Apoptosis in Breast Cancer Cells.6
264647002015ALEX1 may be a novel biomarker for human cervical squamous cell carcinoma.5
259211342015ALEX1 Regulates Proliferation and Apoptosis in Breast Cancer Cells.6
264647002015ALEX1 may be a novel biomarker for human cervical squamous cell carcinoma.5
224940582012ALEX1 suppresses colony formation ability of human colorectal carcinoma cell lines.12
224940582012ALEX1 suppresses colony formation ability of human colorectal carcinoma cell lines.12
203980522010Human Arm protein lost in epithelial cancers, on chromosome X 1 (ALEX1) gene is transcriptionally regulated by CREB and Wnt/beta-catenin signaling.13

Citation

Jean-Loup Huret ; Sylvie Senon

ARMCX1 (arm protein lost in epithelial cancers, X chromosome, 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-07-01

Online version: http://atlasgeneticsoncology.org/gene/477/armcx1