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ARMCX2 (arm protein lost in epithelial cancers, X chromosome, 2)

Written2003-07Jean-Loup Huret, Sylvie Senon
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)

Identity

Alias (NCBI)ALEX2 (arm protein lost in epithelial cancers, X chromosome, 2)
HGNC (Hugo) ARMCX2
HGNC Alias symbALEX2
KIAA0512
GASP9
LocusID (NCBI) 9823
Atlas_Id 478
Location Xq22.1  [Link to chromosome band Xq22]
Location_base_pair Starts at 101655281 and ends at 101659850 bp from pter ( according to GRCh38/hg38-Dec_2013)  [Mapping ARMCX2.png]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARMCX2 (Xq22.1)::ARMCX2 (Xq22.1)

DNA/RNA

Description spans 4.6 kb
Transcription main transcript: 2.7 kb; other transcripts: 1.4 and 7 kb.

Protein

Description 632 amino acids; contains a transmembrane domain in N term, and a arm (armadillo) repeat
Expression wide in normal tissues, except leucocytes; lost or significantly reduced in carcinomas
Homology with ALEX1 and ALEX3

Bibliography

ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas.
Kurochkin IV, Yonemitsu N, Funahashi SI, Nomura H
Biochemical and biophysical research communications. 2001 ; 280 (1) : 340-347.
PMID 11162520
 

Citation

This paper should be referenced as such :
Huret, JL ; Senon, S
ALEX2 (arm protein lost in epithelial cancers, X chromosome, 2)
Atlas Genet Cytogenet Oncol Haematol. 2003;7(3):167-167.
Free journal version : [ pdf ]   [ DOI ]


External links

 

Nomenclature
HGNC (Hugo)ARMCX2   16869
Cards
AtlasALEX2Xq22ID478
Atlas Explorer : (Salamanque)ARMCX2
Entrez_Gene (NCBI)ARMCX2    armadillo repeat containing X-linked 2
AliasesALEX2; GASP9
GeneCards (Weizmann)ARMCX2
Ensembl hg19 (Hinxton)ENSG00000184867 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000184867 [Gene_View]  ENSG00000184867 [Sequence]  chrX:101655281-101659850 [Contig_View]  ARMCX2 [Vega]
ICGC DataPortalENSG00000184867
TCGA cBioPortalARMCX2
AceView (NCBI)ARMCX2
Genatlas (Paris)ARMCX2
SOURCE (Princeton)ARMCX2
Genetics Home Reference (NIH)ARMCX2
Genomic and cartography
GoldenPath hg38 (UCSC)ARMCX2  -     chrX:101655281-101659850 -  Xq22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ARMCX2  -     Xq22.1   [Description]    (hg19-Feb_2009)
GoldenPathARMCX2 - Xq22.1 [CytoView hg19]  ARMCX2 - Xq22.1 [CytoView hg38]
ImmunoBaseENSG00000184867
Genome Data Viewer NCBIARMCX2 [Mapview hg19]  
OMIM300363   
Gene and transcription
Genbank (Entrez)AB011084 AK291342 AL709063 BC012541 BC015926
RefSeq transcript (Entrez)NM_001282231 NM_014782 NM_177949
Consensus coding sequences : CCDS (NCBI)ARMCX2
Gene ExpressionARMCX2 [ NCBI-GEO ]   ARMCX2 [ EBI - ARRAY_EXPRESS ]   ARMCX2 [ SEEK ]   ARMCX2 [ MEM ]
Gene Expression Viewer (FireBrowse)ARMCX2 [ Firebrowse - Broad ]
GenevisibleExpression of ARMCX2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9823
GTEX Portal (Tissue expression)ARMCX2
Human Protein AtlasENSG00000184867-ARMCX2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7L311   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7L311  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7L311
PhosPhoSitePlusQ7L311
Domains : Interpro (EBI)ARM-like    ARM-rpt_dom    ARM-type_fold    Armadillo   
Domain families : Pfam (Sanger)Arm_2 (PF04826)   
Domain families : Pfam (NCBI)pfam04826   
Domain families : Smart (EMBL)ARM (SM00185)  
Conserved Domain (NCBI)ARMCX2
SuperfamilyQ7L311
AlphaFold pdb e-kbQ7L311   
Human Protein Atlas [tissue]ENSG00000184867-ARMCX2 [tissue]
HPRD02293
Protein Interaction databases
DIP (DOE-UCLA)Q7L311
IntAct (EBI)Q7L311
BioGRIDARMCX2
STRING (EMBL)ARMCX2
ZODIACARMCX2
Ontologies - Pathways
QuickGOQ7L311
Ontology : AmiGOmitochondrion  mitochondrial outer membrane  integral component of membrane  
Ontology : EGO-EBImitochondrion  mitochondrial outer membrane  integral component of membrane  
NDEx NetworkARMCX2
Atlas of Cancer Signalling NetworkARMCX2
Wikipedia pathwaysARMCX2
Orthology - Evolution
OrthoDB9823
GeneTree (enSembl)ENSG00000184867
Phylogenetic Trees/Animal Genes : TreeFamARMCX2
Homologs : HomoloGeneARMCX2
Homology/Alignments : Family Browser (UCSC)ARMCX2
Gene fusions - Rearrangements
Fusion : FusionHubARMCX2--ARMCX2   
Fusion : QuiverARMCX2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARMCX2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARMCX2
dbVarARMCX2
ClinVarARMCX2
MonarchARMCX2
1000_GenomesARMCX2 
Exome Variant ServerARMCX2
GNOMAD BrowserENSG00000184867
Varsome BrowserARMCX2
ACMGARMCX2 variants
VarityQ7L311
Genomic Variants (DGV)ARMCX2 [DGVbeta]
DECIPHERARMCX2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisARMCX2 
Mutations
ICGC Data PortalARMCX2 
TCGA Data PortalARMCX2 
Broad Tumor PortalARMCX2
OASIS PortalARMCX2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARMCX2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DARMCX2
Mutations and Diseases : HGMDARMCX2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaARMCX2
DgiDB (Drug Gene Interaction Database)ARMCX2
DoCM (Curated mutations)ARMCX2
CIViC (Clinical Interpretations of Variants in Cancer)ARMCX2
Cancer3DARMCX2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300363   
Orphanet
DisGeNETARMCX2
MedgenARMCX2
Genetic Testing Registry ARMCX2
NextProtQ7L311 [Medical]
GENETestsARMCX2
Target ValidationARMCX2
Huge Navigator ARMCX2 [HugePedia]
ClinGenARMCX2
Clinical trials, drugs, therapy
MyCancerGenomeARMCX2
Protein Interactions : CTDARMCX2
Pharm GKB GenePA134985862
PharosQ7L311
Clinical trialARMCX2
Miscellaneous
canSAR (ICR)ARMCX2
HarmonizomeARMCX2
ARCHS4ARMCX2
DataMed IndexARMCX2
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXARMCX2
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 20 14:01:44 CET 2022

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