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ALEX2 (arm protein lost in epithelial cancers, X chromosome, 2)

Identity

HGNC (Hugo) ARMCX2
Location Xq22.1
Location_base_pair Starts at 100796926 and ends at 100801519 bp from pter ( according to hg18-Mar_2006)  [Mapping]

DNA/RNA

Description spans 4.6 kb
Transcription main transcript: 2.7 kb; other transcripts: 1.4 and 7 kb.

Protein

Description 632 amino acids; contains a transmembrane domain in N term, and a arm (armadillo) repeat
Expression wide in normal tissues, except leucocytes; lost or significantly reduced in carcinomas
Homology with ALEX1 and ALEX3

External links

Nomenclature
HGNC (Hugo)ARMCX2   16869
Entrez_Gene (NCBI)ARMCX2  9823  armadillo repeat containing, X-linked 2
Cards
AtlasALEX2Xq22ID478
GeneCards (Weizmann)ARMCX2
Ensembl (Hinxton)ENSG00000184867 [Gene_View]  ARMCX2 [Vega]
AceView (NCBI)ARMCX2
Genatlas (Paris)ARMCX2
euGene (Indiana)9823
SOURCE (Stanford)NM_014782 NM_177949
Genomic and cartography
GoldenPath (UCSC)ARMCX2  -  Xq22.1   chrX:100796926-100801519 -  Xq21.33-q22.2   [Description]    (hg18-Mar_2006)
EnsemblARMCX2 - Xq21.33-q22.2 [CytoView]
Mapping of homologs : NCBIARMCX2 [Mapview]
OMIM300363   
Gene and transcription
Gene : Genbank (Entrez)AB011084 AK291342 AL709063 BC012541 BC015926
Reference sequence (RefSeq transcript) :SRSNM_014782 NM_177949
Reference transcript : EntrezNM_014782 NM_177949
RefSeq genomic : SRSAC_000066 AC_000155 NC_000023 NT_011651 NW_001842387 NW_927715
RefSeq genomic : EntrezAC_000066 AC_000155 NC_000023 NT_011651 NW_001842387 NW_927715
Consensus coding sequences : CCDS NCBIARMCX2
Cluster EST : UnigeneHs.48924 [ SRS ] Hs.48924 [ NCBI ]
Alternative Splicing : Fast-db (Paris)12469
Protein : pattern, domain, 3D structure
Protein : UniProt/SwissProtQ7L311 (SRS) Q7L311 (Expasy) Q7L311 (Uniprot)
With graphics : InterProQ7L311
Splice isoforms : VarSplice FASTAQ7L311(VarSplice FASTA)
Domaine pattern : Prosite (SRS)ARM_REPEAT (PS50176)   
Domain pattern : Prosite (Expaxy)ARM_REPEAT (PS50176)   
Domains : Interpro (SRS)ARM-like    Armadillo    DUF634   
Domains : Interpro (EBI)ARM-like    Armadillo    DUF634   
Related proteins : CluSTrQ7L311
Domain families : Pfam SRSDUF634 (PF04826)   
Domain families : Pfam SangerDUF634 (PF04826)   
Domain families : Pfam NCBIpfam04826   
Blocks (Seattle)Q7L311
Crystal structure of protein : PDB SRS
Crystal structure of protein : PDBSum
Crystal structure of protein : IMB
Crystal structure of protein : PDB RSDB
HPRD02293
Protein Interaction databases
DIP (DOE-UCLA)Q7L311
IntAct (EBI)Q7L311
Polymorphism : SNP, mutations, diseases
Single Nucleotide Polymorphism (SNP) : dbSNP NCBIARMCX2
SNP : GeneSNP UtahARMCX2
SNP : HGBaseARMCX2
Genetic variants : HAPMAPARMCX2
Somatic Mutations in Cancer : COSMICARMCX2 
Mutations and Diseases : HGMDARMCX2
Hereditary diseases : OMIM300363   
Hereditary diseases : GENETests300363   
Diseases : Genetic AssociationARMCX2
General knowledge
Homologs : HomoloGeneARMCX2
Homology/Alignments : Family Browser UCSCARMCX2
Phylogenetic Trees/Animal Genes : TreeFamARMCX2
Chemical/Protein Interactions : CTD9823
Keywords Ontology : AmiGObinding  membrane  integral to membrane  
Keywords Ontology : EGO-EBIbinding  membrane  integral to membrane  
Pathways : BIOCARTA
Pathways : KEGG
Other databases
Probes
Probes : ImagenesARMCX2 Related clones (RZPD - Berlin)
Literature
PubMed7 Pubmed reference(s) in Entrez
PubGeneARMCX2

Bibliography

ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas.
Kurochkin IV, Yonemitsu N, Funahashi SI, Nomura H
Biochemical and biophysical research communications. 2001 ; 280 (1) : 340-347.
PMID 11162520
 
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written07-2003Jean-Loup Huret, Sylvie Senon

Citation

This paper should be referenced as such :
Huret JL, Senon S . ALEX2 (arm protein lost in epithelial cancers, X chromosome, 2). Atlas Genet Cytogenet Oncol Haematol. July 2003 .
URL : http://AtlasGeneticsOncology.org/Genes/ALEX2Xq22ID478.html

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indexed on : Sat Jun 27 16:39:10 CEST 2009
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