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ARMCX2 (arm protein lost in epithelial cancers, X chromosome, 2)

Written2003-07Jean-Loup Huret, Sylvie Senon
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)

Identity

Other namesALEX2 (arm protein lost in epithelial cancers, X chromosome, 2)
HGNC (Hugo) ARMCX2
LocusID (NCBI) 9823
Atlas_Id 478
Location Xq22.1
Location_base_pair Starts at 100910268 and ends at 100914876 bp from pter ( according to hg19-Feb_2009)  [Mapping ARMCX2.png]
Fusion genes
(updated 2016)
ARMCX2 (Xq22.1) / ARMCX2 (Xq22.1)

DNA/RNA

Description spans 4.6 kb
Transcription main transcript: 2.7 kb; other transcripts: 1.4 and 7 kb.

Protein

Description 632 amino acids; contains a transmembrane domain in N term, and a arm (armadillo) repeat
Expression wide in normal tissues, except leucocytes; lost or significantly reduced in carcinomas
Homology with ALEX1 and ALEX3

Bibliography

ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas.
Kurochkin IV, Yonemitsu N, Funahashi SI, Nomura H
Biochemical and biophysical research communications. 2001 ; 280 (1) : 340-347.
PMID 11162520
 

Citation

This paper should be referenced as such :
Huret, JL ; Senon, S
ALEX2 (arm protein lost in epithelial cancers, X chromosome, 2)
Atlas Genet Cytogenet Oncol Haematol. 2003;7(3):167-167.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/ALEX2Xq22ID478.html


External links

Nomenclature
HGNC (Hugo)ARMCX2   16869
Cards
AtlasALEX2Xq22ID478
Entrez_Gene (NCBI)ARMCX2  9823  armadillo repeat containing, X-linked 2
AliasesALEX2; GASP9
GeneCards (Weizmann)ARMCX2
Ensembl hg19 (Hinxton)ENSG00000184867 [Gene_View]  chrX:100910268-100914876 [Contig_View]  ARMCX2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000184867 [Gene_View]  chrX:100910268-100914876 [Contig_View]  ARMCX2 [Vega]
ICGC DataPortalENSG00000184867
TCGA cBioPortalARMCX2
AceView (NCBI)ARMCX2
Genatlas (Paris)ARMCX2
WikiGenes9823
SOURCE (Princeton)ARMCX2
Genomic and cartography
GoldenPath hg19 (UCSC)ARMCX2  -     chrX:100910268-100914876 -  Xq22.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ARMCX2  -     Xq22.1   [Description]    (hg38-Dec_2013)
EnsemblARMCX2 - Xq22.1 [CytoView hg19]  ARMCX2 - Xq22.1 [CytoView hg38]
Mapping of homologs : NCBIARMCX2 [Mapview hg19]  ARMCX2 [Mapview hg38]
OMIM300363   
Gene and transcription
Genbank (Entrez)AB011084 AK291342 AL709063 BC012541 BC015926
RefSeq transcript (Entrez)NM_001282231 NM_014782 NM_177949
RefSeq genomic (Entrez)NC_000023 NC_018934 NG_013221 NT_011651 NW_004929444
Consensus coding sequences : CCDS (NCBI)ARMCX2
Cluster EST : UnigeneHs.48924 [ NCBI ]
CGAP (NCI)Hs.48924
Alternative Splicing GalleryENSG00000184867
Gene ExpressionARMCX2 [ NCBI-GEO ]   ARMCX2 [ EBI - ARRAY_EXPRESS ]   ARMCX2 [ SEEK ]   ARMCX2 [ MEM ]
Gene Expression Viewer (FireBrowse)ARMCX2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9823
GTEX Portal (Tissue expression)ARMCX2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7L311 (Uniprot)
NextProtQ7L311  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7L311
Splice isoforms : SwissVarQ7L311 (Swissvar)
PhosPhoSitePlusQ7L311
Domains : Interpro (EBI)ARM-like    ARM-rpt_dom    ARM-type_fold   
Domain families : Pfam (Sanger)Arm_2 (PF04826)   
Domain families : Pfam (NCBI)pfam04826   
DMDM Disease mutations9823
Blocks (Seattle)ARMCX2
SuperfamilyQ7L311
Human Protein AtlasENSG00000184867
Peptide AtlasQ7L311
HPRD02293
IPIIPI00006142   IPI00641716   IPI00643546   IPI00642670   IPI00647371   IPI00647957   
Protein Interaction databases
DIP (DOE-UCLA)Q7L311
IntAct (EBI)Q7L311
FunCoupENSG00000184867
BioGRIDARMCX2
STRING (EMBL)ARMCX2
ZODIACARMCX2
Ontologies - Pathways
QuickGOQ7L311
Ontology : AmiGOintegral component of membrane  
Ontology : EGO-EBIintegral component of membrane  
NDEx Network
Atlas of Cancer Signalling NetworkARMCX2
Wikipedia pathwaysARMCX2
Orthology - Evolution
OrthoDB9823
GeneTree (enSembl)ENSG00000184867
Phylogenetic Trees/Animal Genes : TreeFamARMCX2
Homologs : HomoloGeneARMCX2
Homology/Alignments : Family Browser (UCSC)ARMCX2
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerARMCX2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARMCX2
dbVarARMCX2
ClinVarARMCX2
1000_GenomesARMCX2 
Exome Variant ServerARMCX2
ExAC (Exome Aggregation Consortium)ARMCX2 (select the gene name)
Genetic variants : HAPMAP9823
Genomic Variants (DGV)ARMCX2 [DGVbeta]
Mutations
ICGC Data PortalARMCX2 
TCGA Data PortalARMCX2 
Broad Tumor PortalARMCX2
OASIS PortalARMCX2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARMCX2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch ARMCX2
DgiDB (Drug Gene Interaction Database)ARMCX2
DoCM (Curated mutations)ARMCX2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ARMCX2 (select a term)
intoGenARMCX2
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)X:100910268-100914876  ENSG00000184867
CONAN: Copy Number AnalysisARMCX2 
Mutations and Diseases : HGMDARMCX2
OMIM300363   
MedgenARMCX2
Genetic Testing Registry ARMCX2
NextProtQ7L311 [Medical]
TSGene9823
GENETestsARMCX2
Huge Navigator ARMCX2 [HugePedia]
snp3D : Map Gene to Disease9823
BioCentury BCIQARMCX2
ClinGenARMCX2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9823
Chemical/Pharm GKB GenePA134985862
Clinical trialARMCX2
Miscellaneous
canSAR (ICR)ARMCX2 (select the gene name)
Probes
Litterature
PubMed12 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineARMCX2
EVEXARMCX2
GoPubMedARMCX2
iHOPARMCX2
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat May 28 11:36:01 CEST 2016

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