ALEX2 (arm protein lost in epithelial cancers, X chromosome, 2)

Identity

HGNC	ARMCX2
Location	Xq22.1
Location_base_pair	Starts at 100796926 and ends at 100801519 bp from pter ( according to hg18-Mar_2006).

DNA/RNA

Description	spans 4.6 kb
Transcription	main transcript: 2.7 kb; other transcripts: 1.4 and 7 kb.

Protein

Description	632 amino acids; contains a transmembrane domain in N term, and a arm (armadillo) repeat
Expression	wide in normal tissues, except leucocytes; lost or significantly reduced in carcinomas
Homology	with ALEX1 and ALEX3

External links

	Nomenclature
HGNC	ARMCX2   16869
Entrez_Gene	ARMCX2  9823  armadillo repeat containing, X-linked 2
	Cards
Atlas	ALEX2Xq22ID478
GeneCards	ARMCX2
Ensembl	ARMCX2 [Search_View]   ENSG00000184867 [Gene_View]
Genatlas	ARMCX2
GeneLynx	ARMCX2
eGenome	ARMCX2
euGene	9823
	Genomic and cartography
GoldenPath	ARMCX2  -  Xq22.1   chrX:100796926-100801519 -  Xq21.33-q22.2   [Description]    (hg18-Mar_2006)
Ensembl	ARMCX2 - Xq21.33-q22.2 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	ARMCX2
	Gene and transcription
Genbank	AB011084 [ ENTREZ ]
Genbank	AK291342 [ ENTREZ ]
Genbank	AL709063 [ ENTREZ ]
Genbank	BC012541 [ ENTREZ ]
Genbank	BC015926 [ ENTREZ ]
RefSeq	NM_014782 [ SRS ]    NM_014782 [ ENTREZ ]
RefSeq	NM_177949 [ SRS ]    NM_177949 [ ENTREZ ]
RefSeq	AC_000066 [ SRS ]    AC_000066 [ ENTREZ ]
RefSeq	AC_000155 [ SRS ]    AC_000155 [ ENTREZ ]
RefSeq	NC_000023 [ SRS ]    NC_000023 [ ENTREZ ]
RefSeq	NT_011651 [ SRS ]    NT_011651 [ ENTREZ ]
RefSeq	NW_001842387 [ SRS ]    NW_001842387 [ ENTREZ ]
RefSeq	NW_927715 [ SRS ]    NW_927715 [ ENTREZ ]
AceView	ARMCX2 AceView - NCBI
Unigene	Hs.48924 [ SRS ]    Hs.48924 [ NCBI ]     HS48924 [ spliceNest ]
Fast-db	12469 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q5H9D7 [ SRS]    Q5H9D7 [ EXPASY ]     Q5H9D7 [ INTERPRO ]     Q5H9D7 [ UNIPROT ]
CluSTr	Q5H9D7
Blocks	Q5H9D7
HPRD	02293
	Protein Interaction databases
DIP	Q5H9D7
IntAct	Q5H9D7
	Polymorphism : SNP, mutations, diseases
OMIM	300363    [ map ]
GENECLINICS	300363
SNP	ARMCX2 [dbSNP-NCBI]
SNP	NM_014782 [SNP-NCI]
SNP	NM_177949 [SNP-NCI]
SNP	ARMCX2 [GeneSNPs - Utah]  ARMCX2] [HGBASE - SRS]
HAPMAP	ARMCX2 [HAPMAP]
COSMIC	ARMCX2 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	ARMCX2
	General knowledge
Family Browser	ARMCX2 [UCSC Family Browser]
SOURCE	NM_014782
SOURCE	NM_177949
SMD	Hs.48924
SAGE	Hs.48924
GO	binding [Amigo]  binding
GO	membrane [Amigo]  membrane
GO	integral to membrane [Amigo]  integral to membrane
PubGene	ARMCX2
TreeFam	ARMCX2
CTD	9823 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	ARMCX2 Related clones (RZPD - Berlin)
	PubMed
PubMed	7 Pubmed reference(s) in Entrez

Bibliography

ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas.

Kurochkin IV, Yonemitsu N, Funahashi SI, Nomura H

Biochemical and biophysical research communications. 2001 ; 280 (1) : 340-347.

PMID 11162520

REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	07-2003	Jean-Loup Huret, Sylvie Senon

Citation

This paper should be referenced as such :

Huret JL, Senon S . ALEX2 (arm protein lost in epithelial cancers, X chromosome, 2). Atlas Genet Cytogenet Oncol Haematol. July 2003 . URL : http://AtlasGeneticsOncology.org/Genes/ALEX2Xq22ID478.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Tue Oct 14 21:15:35 2008