Written | 2003-07 | Jean-Loup Huret, Sylvie Senon |
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France |
Identity |
Alias (NCBI) | ALEX3 (arm protein lost in epithelial cancers, X chromosome, 3) |
HGNC (Hugo) | ARMCX3 |
HGNC Alias symb | ALEX3 | GASP6 |
LocusID (NCBI) | 51566 |
Atlas_Id | 479 |
Location | Xq22.1 [Link to chromosome band Xq22] |
Location_base_pair | Starts at 101623361 and ends at 101627841 bp from pter ( according to GRCh38/hg38-Dec_2013) [Mapping ARMCX3.png] |
Fusion genes (updated 2017) | Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands) |
FRAS1 (4q21.21) / ARMCX3 (Xq22.1) | NEDD4 (15q21.3) / ARMCX3 (Xq22.1) |
DNA/RNA |
Description | spans 3.3 kb |
Transcription | transcript: 2.0 kb |
Protein |
Description | 379 amino acids, 42.5 kDa; contains a transmembrane domain in N term, and a arm (armadillo) repeat |
Homology | with ALEX1 and ALEX2 |
Mutations |
Note | may be involved in tumorigenesis, but further studies are needed |
Bibliography |
ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas. |
Kurochkin IV, Yonemitsu N, Funahashi SI, Nomura H |
Biochemical and biophysical research communications. 2001 ; 280 (1) : 340-347. |
PMID 11162520 |
Citation |
This paper should be referenced as such : |
Huret, JL ; Senon, S |
ALEX3 (arm protein lost in epithelial cancers, X chromosome, 3) |
Atlas Genet Cytogenet Oncol Haematol. 2003;7(3):168-168. |
Free journal version : [ pdf ] [ DOI ] |
External links |
REVIEW articles | automatic search in PubMed |
Last year publications | automatic search in PubMed |
© Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Fri Feb 19 17:45:30 CET 2021 |
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