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ARMCX3 (arm protein lost in epithelial cancers, X chromosome, 3)

Written2003-07Jean-Loup Huret, Sylvie Senon
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)

Identity

Alias_symbol (synonym)ALEX3
GASP6
Other aliasALEX3 (arm protein lost in epithelial cancers, X chromosome, 3)
HGNC (Hugo) ARMCX3
LocusID (NCBI) 51566
Atlas_Id 479
Location Xq22.1  [Link to chromosome band Xq22]
Location_base_pair Starts at 101623130 and ends at 101627841 bp from pter ( according to hg19-Feb_2009)  [Mapping ARMCX3.png]
Fusion genes
(updated 2016)		FRAS1 (4q21.21) / ARMCX3 (Xq22.1)NEDD4 (15q21.3) / ARMCX3 (Xq22.1)

DNA/RNA

Description spans 3.3 kb
Transcription transcript: 2.0 kb

Protein

Description 379 amino acids, 42.5 kDa; contains a transmembrane domain in N term, and a arm (armadillo) repeat
Homology with ALEX1 and ALEX2

Mutations

Note may be involved in tumorigenesis, but further studies are needed

Bibliography

ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas.
Kurochkin IV, Yonemitsu N, Funahashi SI, Nomura H
Biochemical and biophysical research communications. 2001 ; 280 (1) : 340-347.
PMID 11162520
 

Citation

This paper should be referenced as such :
Huret, JL ; Senon, S
ALEX3 (arm protein lost in epithelial cancers, X chromosome, 3)
Atlas Genet Cytogenet Oncol Haematol. 2003;7(3):168-168.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/ALEX3Xq22ID479.html

External links

Nomenclature
HGNC (Hugo)ARMCX3   24065
Cards
AtlasALEX3Xq22ID479
Entrez_Gene (NCBI)ARMCX3  51566  armadillo repeat containing, X-linked 3
AliasesALEX3; GASP6; dJ545K15.2
GeneCards (Weizmann)ARMCX3
Ensembl hg19 (Hinxton)ENSG00000102401 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000102401 [Gene_View]  chrX:101623130-101627841 [Contig_View]  ARMCX3 [Vega]
ICGC DataPortalENSG00000102401
TCGA cBioPortalARMCX3
AceView (NCBI)ARMCX3
Genatlas (Paris)ARMCX3
WikiGenes51566
SOURCE (Princeton)ARMCX3
Genetics Home Reference (NIH)ARMCX3
Genomic and cartography
GoldenPath hg38 (UCSC)ARMCX3  -     chrX:101623130-101627841 +  Xq22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ARMCX3  -     Xq22.1   [Description]    (hg19-Feb_2009)
EnsemblARMCX3 - Xq22.1 [CytoView hg19]  ARMCX3 - Xq22.1 [CytoView hg38]
Mapping of homologs : NCBIARMCX3 [Mapview hg19]  ARMCX3 [Mapview hg38]
OMIM300364   
Gene and transcription
Genbank (Entrez)AB039669 AF211175 AK222655 AK291225 AL708980
RefSeq transcript (Entrez)NM_016607 NM_177947 NM_177948
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ARMCX3
Cluster EST : UnigeneHs.592225 [ NCBI ]
CGAP (NCI)Hs.592225
Alternative Splicing GalleryENSG00000102401
Gene ExpressionARMCX3 [ NCBI-GEO ]   ARMCX3 [ EBI - ARRAY_EXPRESS ]   ARMCX3 [ SEEK ]   ARMCX3 [ MEM ]
Gene Expression Viewer (FireBrowse)ARMCX3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51566
GTEX Portal (Tissue expression)ARMCX3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UH62   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UH62  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UH62
Splice isoforms : SwissVarQ9UH62
PhosPhoSitePlusQ9UH62
Domaine pattern : Prosite (Expaxy)ARM_REPEAT (PS50176)   
Domains : Interpro (EBI)ARM-like    ARM-rpt_dom    ARM-type_fold    Armadillo   
Domain families : Pfam (Sanger)Arm_2 (PF04826)   
Domain families : Pfam (NCBI)pfam04826   
Conserved Domain (NCBI)ARMCX3
DMDM Disease mutations51566
Blocks (Seattle)ARMCX3
SuperfamilyQ9UH62
Human Protein AtlasENSG00000102401
Peptide AtlasQ9UH62
HPRD02294
IPIIPI00009906   
Protein Interaction databases
DIP (DOE-UCLA)Q9UH62
IntAct (EBI)Q9UH62
FunCoupENSG00000102401
BioGRIDARMCX3
STRING (EMBL)ARMCX3
ZODIACARMCX3
Ontologies - Pathways
QuickGOQ9UH62
Ontology : AmiGOintegral component of mitochondrial outer membrane  cellular protein localization  positive regulation of transcription from RNA polymerase II promoter  
Ontology : EGO-EBIintegral component of mitochondrial outer membrane  cellular protein localization  positive regulation of transcription from RNA polymerase II promoter  
NDEx NetworkARMCX3
Atlas of Cancer Signalling NetworkARMCX3
Wikipedia pathwaysARMCX3
Orthology - Evolution
OrthoDB51566
GeneTree (enSembl)ENSG00000102401
Phylogenetic Trees/Animal Genes : TreeFamARMCX3
HOVERGENQ9UH62
HOGENOMQ9UH62
Homologs : HomoloGeneARMCX3
Homology/Alignments : Family Browser (UCSC)ARMCX3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARMCX3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARMCX3
dbVarARMCX3
ClinVarARMCX3
1000_GenomesARMCX3 
Exome Variant ServerARMCX3
ExAC (Exome Aggregation Consortium)ARMCX3 (select the gene name)
Genetic variants : HAPMAP51566
Genomic Variants (DGV)ARMCX3 [DGVbeta]
DECIPHERARMCX3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisARMCX3 
Mutations
ICGC Data PortalARMCX3 
TCGA Data PortalARMCX3 
Broad Tumor PortalARMCX3
OASIS PortalARMCX3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARMCX3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDARMCX3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch ARMCX3
DgiDB (Drug Gene Interaction Database)ARMCX3
DoCM (Curated mutations)ARMCX3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ARMCX3 (select a term)
intoGenARMCX3
NCG5 (London)ARMCX3
Cancer3DARMCX3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300364   
Orphanet
MedgenARMCX3
Genetic Testing Registry ARMCX3
NextProtQ9UH62 [Medical]
TSGene51566
GENETestsARMCX3
Target ValidationARMCX3
Huge Navigator ARMCX3 [HugePedia]
snp3D : Map Gene to Disease51566
BioCentury BCIQARMCX3
ClinGenARMCX3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51566
Chemical/Pharm GKB GenePA134977725
Clinical trialARMCX3
Miscellaneous
canSAR (ICR)ARMCX3 (select the gene name)
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineARMCX3
EVEXARMCX3
GoPubMedARMCX3
iHOPARMCX3
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:20:33 CEST 2017
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