| Written | 2003-07 | Jean-Loup Huret, Sylvie Senon |
| Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France |
| Identity |
| Other alias | ALEX3 (arm protein lost in epithelial cancers, X chromosome, 3) |
| LocusID (NCBI) | 51566 |
| Atlas_Id | 479 |
| Location | Xq22.1 [Link to chromosome band Xq22] |
| Location_base_pair | Starts at and ends at bp from pter |
| Fusion genes (updated 2017) | Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands) |
| FRAS1 (4q21.21) / ARMCX3 (Xq22.1) | NEDD4 (15q21.3) / ARMCX3 (Xq22.1) |
| DNA/RNA |
| Description | spans 3.3 kb |
| Transcription | transcript: 2.0 kb |
| Protein |
| Description | 379 amino acids, 42.5 kDa; contains a transmembrane domain in N term, and a arm (armadillo) repeat |
| Homology | with ALEX1 and ALEX2 |
| Mutations |
| Note | may be involved in tumorigenesis, but further studies are needed |
| Bibliography |
| ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas. |
| Kurochkin IV, Yonemitsu N, Funahashi SI, Nomura H |
| Biochemical and biophysical research communications. 2001 ; 280 (1) : 340-347. |
| PMID 11162520 |
| Citation |
| This paper should be referenced as such : |
| Huret, JL ; Senon, S |
| ALEX3 (arm protein lost in epithelial cancers, X chromosome, 3) |
| Atlas Genet Cytogenet Oncol Haematol. 2003;7(3):168-168. |
| Free journal version : [ pdf ] [ DOI ] |
| On line version : http://AtlasGeneticsOncology.org/Genes/ALEX3Xq22ID479.html |
| External links |
| Nomenclature | |
|---|---|
| Cards | |
| Atlas | ALEX3Xq22ID479.txt |
| Aliases | |
| Genomic and cartography | |
| Gene and transcription | |
| RefSeq transcript (Entrez) | |
| RefSeq genomic (Entrez) | |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| BioGPS (Tissue expression) | 51566 |
| Protein : pattern, domain, 3D structure | |
| Domain families : Pfam (Sanger) | |
| Domain families : Pfam (NCBI) | |
| Protein Interaction databases | |
| Ontologies - Pathways | |
| Clinical trials, drugs, therapy | |
| Miscellaneous | |
| canSAR (ICR) | (select the gene name) |
| Probes | |
| Litterature |
| REVIEW articles | automatic search in PubMed |
| Last year publications | automatic search in PubMed |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Thu Oct 18 17:28:04 CEST 2018 |
For comments and suggestions or contributions, please contact us