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ARMCX3 (arm protein lost in epithelial cancers, X chromosome, 3)

Identity

Other namesALEX3 (arm protein lost in epithelial cancers, X chromosome, 3)
HGNC (Hugo) ARMCX3
LocusID (NCBI) 51566
Location Xq22.1
Location_base_pair Starts at 100878120 and ends at 100882831 bp from pter ( according to hg19-Feb_2009)  [Mapping]

DNA/RNA

Description spans 3.3 kb
Transcription transcript: 2.0 kb

Protein

Description 379 amino acids, 42.5 kDa; contains a transmembrane domain in N term, and a arm (armadillo) repeat
Homology with ALEX1 and ALEX2

Mutations

Note may be involved in tumorigenesis, but further studies are needed

External links

Nomenclature
HGNC (Hugo)ARMCX3   24065
Entrez_Gene (NCBI)ARMCX3  51566  armadillo repeat containing, X-linked 3
Cards
AtlasALEX3Xq22ID479
GeneCards (Weizmann)ARMCX3
Ensembl (Hinxton)ENSG00000102401 [Gene_View]  chrX:100878120-100882831 [Contig_View]  ARMCX3 [Vega]
AceView (NCBI)ARMCX3
Genatlas (Paris)ARMCX3
euGene (Indiana)51566
SOURCE (Stanford)NM_016607 NM_177947 NM_177948
Genomic and cartography
GoldenPath (UCSC)ARMCX3  -  Xq22.1   chrX:100878120-100882831 +  Xq21.33-q22.2   [Description]    (hg19-Feb_2009)
EnsemblARMCX3 - Xq21.33-q22.2 [CytoView]
Mapping of homologs : NCBIARMCX3 [Mapview]
OMIM300364   
Gene and transcription
Genbank (Entrez)AB039669 AF211175 AK222655 AK291225 AL708980
RefSeq transcript (SRS)NM_016607 NM_177947 NM_177948
RefSeq transcript (Entrez)NM_016607 NM_177947 NM_177948
RefSeq genomic (SRS)AC_000155 NC_000023 NG_013222 NT_011651 NW_001842387
RefSeq genomic (Entrez)AC_000155 NC_000023 NG_013222 NT_011651 NW_001842387
Consensus coding sequences : CCDS (NCBI)ARMCX3
Cluster EST : UnigeneHs.592225 [ SRS ] Hs.592225 [ NCBI ]
Alternative Splicing : Fast-db (Paris)12458
Alternative Splicing GalleryENSG00000102401
Gene ExpressionARMCX3 [ NCBI-GEO ]   ARMCX3 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UH62 (SRS) Q9UH62 (Uniprot)
With graphics : InterProQ9UH62
Splice isoforms : SwissVarQ9UH62(Swissvar)
Domaine pattern : Prosite (SRS)ARM_REPEAT (PS50176)   
Domaine pattern : Prosite (Expaxy)ARM_REPEAT (PS50176)   
Domains : Interpro (SRS)ARM-like    ARM-type_fold    Armadillo    DUF634   
Domains : Interpro (EBI)ARM-like    ARM-type_fold    Armadillo    DUF634   
Related proteins : CluSTrQ9UH62
Domain families : Pfam (SRS)Arm_2 (PF04826)   
Domain families : Pfam (Sanger)Arm_2 (PF04826)   
Domain families : Pfam (NCBI)pfam04826   
Blocks (Seattle)Q9UH62
Human Protein AtlasENSG00000102401
HPRD02294
IPIIPI00009906   
Protein Interaction databases
DIP (DOE-UCLA)Q9UH62
IntAct (EBI)Q9UH62
FunCoupENSG00000102401
REACTOMEARMCX3
BioGRIDARMCX3
InParanoidQ9UH62
Interologous Interaction database Q9UH62
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)ARMCX3
SNP (GeneSNP Utah)ARMCX3
SNP : HGBaseARMCX3
Genetic variants : HAPMAPARMCX3
Somatic Mutations in Cancer : COSMICARMCX3 
CONAN: Copy Number AnalysisARMCX3 
Mutations and Diseases : HGMDARMCX3
OMIM300364   
GENETests300364   
Disease Genetic AssociationARMCX3
Huge Navigator ARMCX3 [HugePedia]  ARMCX3 [HugeCancerGEM]
Genomic VariantsARMCX3
snp3D : Map Gene to Disease51566
General knowledge
Homologs : HomoloGeneARMCX3
Homology/Alignments : Family Browser (UCSC)ARMCX3
Phylogenetic Trees/Animal Genes : TreeFamARMCX3
Chemical/Protein Interactions : CTD51566
Chemical/Pharm GKB GenePA134977725
Clinical trialARMCX3
Cancer Resource (Charite)ENSG00000102401
Ontology : AmiGObinding  membrane  integral to membrane  
Ontology : EGO-EBIbinding  membrane  integral to membrane  
Other databases
Probes
Probes : ImagenesARMCX3 Related clones (RZPD - Berlin)
Litterature
PubMed16 Pubmed reference(s) in Entrez
PubGeneARMCX3
iHOPARMCX3

Bibliography

ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas.
Kurochkin IV, Yonemitsu N, Funahashi SI, Nomura H
Biochemical and biophysical research communications. 2001 ; 280 (1) : 340-347.
PMID 11162520
 
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written07-2003Jean-Loup Huret, Sylvie Senon

Citation

This paper should be referenced as such :
Huret JL, Senon S . ARMCX3 (arm protein lost in epithelial cancers, X chromosome, 3). Atlas Genet Cytogenet Oncol Haematol. July 2003 .
URL : http://AtlasGeneticsOncology.org/Genes/ALEX3Xq22ID479.html

This paper is referenced by INIST as such :
http://documents.irevues.inist.fr/bitstream/2042/37981/1/07-2003-ALEX3Xq22ID479.pdf   [ Bibliographic record ]

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