ALEX3 (arm protein lost in epithelial cancers, X chromosome, 3)

Identity

Hugo	ARMCX3
Location	Xq22.1

DNA/RNA

Description	spans 3.3 kb
Transcription	transcript: 2.0 kb

Protein

Description	379 amino acids, 42.5 kDa; contains a transmembrane domain in N term, and a arm (armadillo) repeat
Homology	with ALEX1 and ALEX2

Mutations

Note	may be involved in tumorigenesis, but further studies are needed

External links

	Nomenclature
Hugo	ARMCX3
GDB	ARMCX3
Entrez_Gene	ARMCX3  51566  armadillo repeat containing, X-linked 3
	Cards
Atlas	ALEX3Xq22ID479
GeneCards	ARMCX3
Ensembl	ARMCX3 [Search_View]   ENSG00000102401 [Gene_View]
Genatlas	ARMCX3
GeneLynx	ARMCX3
eGenome	ARMCX3
euGene	51566
	Genomic and cartography
GoldenPath	ARMCX3  -  Xq22.1   chrX:100764776-100769487 +  Xq21.33-q22.2   [Description]    (hg18-Mar_2006)
Ensembl	ARMCX3 - Xq21.33-q22.2 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	ARMCX3
	Gene and transcription
Genbank	AB039669 [ ENTREZ ]
Genbank	AF211175 [ ENTREZ ]
Genbank	AK222655 [ ENTREZ ]
Genbank	AL708980 [ ENTREZ ]
Genbank	AY359079 [ ENTREZ ]
RefSeq	NM_016607 [ SRS ]    NM_016607 [ ENTREZ ]
RefSeq	NM_177947 [ SRS ]    NM_177947 [ ENTREZ ]
RefSeq	NM_177948 [ SRS ]    NM_177948 [ ENTREZ ]
RefSeq	AC_000066 [ SRS ]    AC_000066 [ ENTREZ ]
RefSeq	NC_000023 [ SRS ]    NC_000023 [ ENTREZ ]
RefSeq	NT_011651 [ SRS ]    NT_011651 [ ENTREZ ]
RefSeq	NW_927715 [ SRS ]    NW_927715 [ ENTREZ ]
AceView	ARMCX3 AceView - NCBI
Unigene	Hs.592225 [ SRS ]    Hs.592225 [ NCBI ]     HS592225 [ spliceNest ]
Fast-db	12458 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q9UH62 [ SRS]    Q9UH62 [ EXPASY ]     Q9UH62 [ INTERPRO ]
Prosite	PS50176 ARM_REPEAT [ SRS ]    PS50176 ARM_REPEAT [ Expasy ]
Interpro	IPR011989 ARM-like [ SRS ]    IPR011989 ARM-like [ EBI ]
Interpro	IPR000225 Armadillo [ SRS ]    IPR000225 Armadillo [ EBI ]
Interpro	IPR006911 DUF634 [ SRS ]    IPR006911 DUF634 [ EBI ]
CluSTr	Q9UH62
Pfam	PF04826 DUF634 [ SRS ]    PF04826 DUF634 [ Sanger ]    pfam04826 [ NCBI-CDD ]
Blocks	Q9UH62
HPRD	02294
	Protein Interaction databases
DIP	Q9UH62
IntAct	Q9UH62
	Polymorphism : SNP, mutations, diseases
OMIM	300364    [ map ]
GENECLINICS	300364
SNP	ARMCX3 [dbSNP-NCBI]
SNP	NM_016607 [SNP-NCI]
SNP	NM_177947 [SNP-NCI]
SNP	NM_177948 [SNP-NCI]
SNP	ARMCX3 [GeneSNPs - Utah]  ARMCX3] [HGBASE - SRS]
HAPMAP	ARMCX3 [HAPMAP]
COSMIC	ARMCX3 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	ARMCX3
	General knowledge
Family Browser	ARMCX3 [UCSC Family Browser]
SOURCE	NM_016607
SOURCE	NM_177947
SOURCE	NM_177948
SMD	Hs.592225
SAGE	Hs.592225
GO	binding [Amigo]  binding
GO	membrane [Amigo]  membrane
GO	integral to membrane [Amigo]  integral to membrane
PubGene	ARMCX3
TreeFam	ARMCX3
CTD	51566 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	ARMCX3 Related clones (RZPD - Berlin)
	PubMed
PubMed	10 Pubmed reference(s) in LocusLink

Bibliography

ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas.

Kurochkin IV, Yonemitsu N, Funahashi SI, Nomura H

Biochemical and biophysical research communications. 2001 ; 280 (1) : 340-347.

PMID 11162520

REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	07-2003	Jean-Loup Huret, Sylvie Senon

Citation

This paper should be referenced as such :

Huret JL, Senon S . ALEX3 (arm protein lost in epithelial cancers, X chromosome, 3). Atlas Genet Cytogenet Oncol Haematol. July 2003 . URL : http://AtlasGeneticsOncology.org/Genes/ALEX3Xq22ID479.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Wed Jul 2 08:21:46 2008