Atlas of Genetics and Cytogenetics in Oncology and Haematology

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AML1 (acute myeloid leukemia 1)

RUNX1 (runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene))

CBFA2 (core binding factor A2)

Identity

Other namesPEBPaB (polyomavirus enhancer binding protein aB)
HGNC RUNX1
Location 21q22.3
Location_base_pair Starts at 35081968 and ends at 35182857 bp from pter ( according to hg18-Mar_2006).
 
  AML1 (21q22.3) in normal cells: clone dJ1107L6 - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics. Laboratories willing to validate the probes are wellcome: contact M Rocchi

DNA/RNA

 
  DNA Diagram
Description the gene spans a region of more than 120 kb
Transcription transcription is from telomere to centromere --> the fusion gene is located on the 'other' chromosome (eg the der(8) of the t(8;21), the der(3) of the t(3;21)...); alternate splicing --> transcripts of 2, 3.3, ->7.5 and 8 kb

Protein

 
  Protein Diagram
Description 250, 453 amino acids and other forms; forms heterodimers with CBFB
Expression widely expressed, including hematopoietic cells at various stages of differenciation: role in haematopoiesis
Localisation nuclear
Function transcription factor (activator) for various hematopoietic-specific genes: binds to the core site 5' PyGPyGGTPy 3' of a number of promotors and enhancers, as in GM-CSF (granulocyte-macrophage colony stimulating factor, CSF1R (colony stimulating factor 1 receptor), TCRb sites (T cell antigen receptors), and myeloid myeloperoxidase
Homology 1- Runt (drosophila): nuclear DNA binding protein; role in segmentation (embryology); 2- AML2 (also called: CBFA3, CBFa3, PEBPaC), located in 1p35-36, expressed in B lineage (3 and 5 kb RNA); AML3: (also called: CBFA1, CBFa1, PEBPaA) in 6p21; 3- cbfa family (mouse)

Implicated in

Entity Familial platelet disorder with predisposition to acute non lymphocytic leukemia
  
Entity t(1;21)(p36;q22) treatment related acute non lymphocytic leukemia (ANLL) --> ?/ AML1
  
Entity t(2;21)(p11;q22) ANLL --> ?/ AML1
  
Entity t(3;21)(q26;q22)/ myelodysplastic syndrome (MDS) or ANLL --> -EVI1 or EAP/ MDS1 - AML1
Disease CML-BC of myeloid type; ANLL and MDS, often therapy related (secondary to antitopoisomerase II)
Hybrid/Mutated Gene 5' AML1 - 3' EAP or MDS1 or EVI1
  
Entity t(4;21)(q31;q22) T-cell acute lymphoblastic leukemia (T-ALL) --> ?/ AML1
  
Entity t(5;21)(q13;q22) myelodysplastic syndrome (MDS) and ANLL --> ?/ AML1
  
Entity t(8;21)(q22;q22)/ANLL. --> ETO - AML1
Disease ANLL, M2 mostly
Prognosis CR is obtained; median survival (1.5-2 yrs) is the range with other ANLL or relatively better
Cytogenetics additional anomalies are frequent: loss of Y or X chromosome, del(7q)/-7, +8, del (9q); complex t(8;21;Var) are known and have revealed that the crucial event lies on der(8); in agrement with the fact that both genes are transcribed from telomere to centromere
Hybrid/Mutated Gene 5' AML1 - 3' ETO
Abnormal Protein N-term AML1 with the Runt domain fused to the nearly entire ETO
Oncogenesis the fusion protein retain the ability to recognize the AML1 concensus binding site (--> negative dominant competitor with the normal AML1) and to dimerize with the cbtb/CBTB subunit --> probable altered transcriptional regulation of normal AML1 target genes
  
Entity t(8;21)(q23;q22) MDS --> FOG2 / AML1
  
Entity t(8;21)(q24;q22) ALL and ANLL --> TRPS1 / AML1
  
Entity t(12;21)(p13;q22)/ALL --> ETV6-AML1
Disease B cell ALL (CD10+)
Prognosis CR in all cases; prognosis seems good
Cytogenetics often undetectable without FISH; additional anomalies: frequent del(12)(p12) on the other allele
Hybrid/Mutated Gene 5' ETV6 - 3' AML1on the der(21)
Abnormal Protein Helix loop helix of TEL fused to the nearly entire AML1 protein; the other TEL allele is often deleted
  
Entity t(12;21)(q24;q22) ANLL --> ?/ AML1
  
Entity t(16;21)(q24;q22) ANLL --> MTG16-AML1
Disease ANLL and therapy related ANLL; mainly with preceeding MDS
Prognosis very poor
  
Entity t(17;21)(q11;q22) ANLL
  
Entity t(19;21)(q13;q22) treatment related ANLL --> AMP19 / AML1
  
Entity t(20;21)(q1;3q22) treatment related ANL --> ? / AML1
  
Entity t(21;21)(q11;q22) MDS --> UPS25 / AML1
  

Breakpoints

 

External links

Nomenclature
HGNCRUNX1   10471
Entrez_GeneRUNX1  861  runt-related transcription factor 1
Cards
AtlasAML1
GeneCardsRUNX1
EnsemblENSG00000159216 [Gene_View]  RUNX1 [Vega]
GenatlasRUNX1
Genomic and cartography
GoldenPathRUNX1  -  21q22.3   chr21:35081968-35182857 -  21q22.3   [Description]    (hg18-Mar_2006)
EnsemblRUNX1 - 21q22.3 [CytoView]
NCBIMapview
OMIM151385 Disease map [OMIM]
OMIM180300 Disease map [OMIM]
OMIM601399 Disease map [OMIM]
OMIM601626 Disease map [OMIM]
HomoloGeneRUNX1
Gene and transcription
GenbankAA878154 [ ENTREZ ]
GenbankAK226159 [ ENTREZ ]
GenbankAK310587 [ ENTREZ ]
GenbankAL581043 [ ENTREZ ]
GenbankAV761975 [ ENTREZ ]
RefSeqNM_001001890 [ SRS ]    NM_001001890 [ ENTREZ ]
RefSeqNM_001122607 [ SRS ]    NM_001122607 [ ENTREZ ]
RefSeqNM_001754 [ SRS ]    NM_001754 [ ENTREZ ]
RefSeqAC_000064 [ SRS ]    AC_000064 [ ENTREZ ]
RefSeqAC_000153 [ SRS ]    AC_000153 [ ENTREZ ]
RefSeqNC_000021 [ SRS ]    NC_000021 [ ENTREZ ]
RefSeqNT_011512 [ SRS ]    NT_011512 [ ENTREZ ]
RefSeqNW_001838706 [ SRS ]    NW_001838706 [ ENTREZ ]
RefSeqNW_927384 [ SRS ]    NW_927384 [ ENTREZ ]
CCDSRUNX1 CCDS - NCBI
AceViewRUNX1 AceView - NCBI
UnigeneHs.612648 [ SRS ]    Hs.612648 [ NCBI ]
Fast-db2368 (alternative variants)
Protein : pattern, domain, 3D structure
SwissProtQ01196 [ SRS]    Q01196 [ EXPASY ]     Q01196 [ INTERPRO ]     Q01196 [ UNIPROT ] Q01196 [ VarSplice FASTA ]
PrositePS51062 RUNT [ SRS ]    PS51062 RUNT [ Expasy ]
InterproIPR013524 AML1/Runt_N [ SRS ]    IPR013524 AML1/Runt_N [ EBI ]
InterproIPR000040 AML1_Runt [ SRS ]    IPR000040 AML1_Runt [ EBI ]
InterproIPR012346 p53_RUNT_DNA_bd [ SRS ]    IPR012346 p53_RUNT_DNA_bd [ EBI ]
InterproIPR013711 RunxI [ SRS ]    IPR013711 RunxI [ EBI ]
InterproIPR016554 TF_Runt-rel_RUNX [ SRS ]    IPR016554 TF_Runt-rel_RUNX [ EBI ]
CluSTrQ01196
PfamPF00853 Runt [ SRS ]    PF00853 Runt [ Sanger ]    pfam00853 [ NCBI-CDD ]
PfamPF08504 RunxI [ SRS ]    PF08504 RunxI [ Sanger ]    pfam08504 [ NCBI-CDD ]
BlocksQ01196
PDB1CMO [ SRS ]    1CMO [ PdbSum ],   1CMO [ IMB ]   1CMO [ RSDB ]
PDB1CO1 [ SRS ]    1CO1 [ PdbSum ],   1CO1 [ IMB ]   1CO1 [ RSDB ]
PDB1E50 [ SRS ]    1E50 [ PdbSum ],   1E50 [ IMB ]   1E50 [ RSDB ]
PDB1H9D [ SRS ]    1H9D [ PdbSum ],   1H9D [ IMB ]   1H9D [ RSDB ]
PDB1LJM [ SRS ]    1LJM [ PdbSum ],   1LJM [ IMB ]   1LJM [ RSDB ]
HPRD01043
Protein Interaction databases
DIPQ01196
IntActQ01196
Polymorphism : SNP, mutations, diseases
OMIM151385    [ map ]   
OMIM180300    [ map ]   
OMIM601399    [ map ]   
OMIM601626    [ map ]   
GENETests151385
GENETests180300
GENETests601399
GENETests601626
SNPRUNX1 [dbSNP-NCBI]  
SNPNM_001001890 [SNP-NCI]  
SNPNM_001122607 [SNP-NCI]  
SNPNM_001754 [SNP-NCI]  
SNPRUNX1 [GeneSNPs - Utah]  RUNX1] [HGBASE - SRS]
HAPMAPRUNX1 [HAPMAP]  
COSMICRUNX1 [Somatic mutation (COSMIC-CGP-Sanger)]  
TICdbRUNX1 [Translocation breakpoints In Cancer]  
HGMDRUNX1
Genetic AssociationRUNX1
CDC HuGERUNX1
General knowledge
Family BrowserRUNX1 [UCSC Family Browser]
SOURCENM_001001890
SOURCENM_001122607
SOURCENM_001754
SMDHs.612648
SAGEHs.612648
GOmolecular_function [Amigo]  molecular_function
GOtranscription factor activity [Amigo]  transcription factor activity
GOprotein binding [Amigo]  protein binding
GOATP binding [Amigo]  ATP binding
GOcellular_component [Amigo]  cellular_component
GOnucleus [Amigo]  nucleus
GOregulation of transcription, DNA-dependent [Amigo]  regulation of transcription, DNA-dependent
GOmulticellular organismal development [Amigo]  multicellular organismal development
GObiological_process [Amigo]  biological_process
GOtranscription activator activity [Amigo]  transcription activator activity
GOpositive regulation of granulocyte differentiation [Amigo]  positive regulation of granulocyte differentiation
GOchloride ion binding [Amigo]  chloride ion binding
GOpositive regulation of angiogenesis [Amigo]  positive regulation of angiogenesis
GOpositive regulation of transcription from RNA polymerase II promoter [Amigo]  positive regulation of transcription from RNA polymerase II promoter
PubGeneRUNX1
TreeFamRUNX1
CTD861 [Comparative ToxicoGenomics Database]
Other databases
Probes
ProbeAML1 (21q22.3) in normal cells (Bari)
ProbeRUNX1 Related clones (RZPD - Berlin)
PubMed
PubMed206 Pubmed reference(s) in Entrez

Bibliography

Molecular basis of the t(8;21) translocation in acute myeloid leukaemia.
Ohki M
Seminars in cancer biology. 1993 ; 4 (6) : 369-375.
PMID 8142622
 
AML1 and the 8;21 and 3;21 translocations in acute and chronic myeloid leukemia.
Nucifora G, Rowley JD
Blood. 1995 ; 86 (1) : 1-14.
PMID 7795214
 
High frequency of t(12;21) in childhood B-lineage acute lymphoblastic leukemia.
Romana SP, Poirel H, Leconiat M, Flexor MA, Mauchauffˆ© M, Jonveaux P, Macintyre EA, Berger R, Bernard OA
Blood. 1995 ; 86 (11) : 4263-4269.
PMID 7492786
 
CBFA2(AML1) translocations with novel partner chromosomes in myeloid leukemias: association with prior therapy.
Roulston D, Espinosa R 3rd, Nucifora G, Larson RA, Le Beau MM, Rowley JD
Blood. 1998 ; 92 (8) : 2879-2885.
PMID 9763573
 
Combined spectral karyotyping and DAPI banding analysis of chromosome abnormalities in myelodysplastic syndrome.
Kakazu N, Taniwaki M, Horiike S, Nishida K, Tatekawa T, Nagai M, Takahashi T, Akaogi T, Inazawa J, Ohki M, Abe T
Genes, chromosomes & cancer. 1999 ; 26 (4) : 336-345.
PMID 10534769
 
A new angle on a pervasive oncogene.
Cleary ML
Nature genetics. 1999 ; 23 (2) : 134-135.
PMID 10508502
 
Concurrent translocations of MLL and CBFA2 (AML1) genes with new partner breakpoints in a child with secondary myelodysplastic syndrome after treatment of acute lymphoblastic leukemia.
Mathew S, Head D, Rubnitz JE, Raimondi SC
Genes, chromosomes & cancer. 2000 ; 28 (2) : 227-232.
PMID 10825008
 
Identification of two new translocations that disrupt the AML1 gene.
Richkind K, Hromas R, Lytle C, Crenshaw D, Velasco J, Roherty S, Srinivasiah J, Varella-Garcia M
Cancer genetics and cytogenetics. 2000 ; 122 (2) : 141-143.
PMID 11106827
 
A novel syndrome of radiation-associated acute myeloid leukemia involving AML1 gene translocations.
Hromas R, Shopnick R, Jumean HG, Bowers C, Varella-Garcia M, Richkind K
Blood. 2000 ; 95 (12) : 4011-4013.
PMID 10845943
 
A novel CBFA2 single-nucleotide mutation in familial platelet disorder with propensity to develop myeloid malignancies.
Buijs A, Poddighe P, van Wijk R, van Solinge W, Borst E, Verdonck L, Hagenbeek A, Pearson P, Lokhorst H
Blood. 2001 ; 98 (9) : 2856-2858.
PMID 11675361
 
Novel cryptic, complex rearrangements involving ETV6-CBFA2 (TEL-AML1) genes identified by fluorescence in situ hybridization in pediatric patients with acute lymphoblastic leukemia.
Mathew S, Shurtleff SA, Raimondi SC
Genes, chromosomes & cancer. 2001 ; 32 (2) : 188-193.
PMID 11550288
 
AML1-TRPS1 chimeric protein is generated by t(8;21)(q24;q22) in relapsing acute myeloblastic leukemia.
Asou N, Matsuno N, Mitsuya H
Am Soc Hematol,. 1943.
 
In vitro analyses of known and novel RUNX1/AML1 mutations in dominant familial platelet disorder with predisposition to acute myelogenous leukemia: implications for mechanisms of pathogenesis.
Michaud J, Wu F, Osato M, Cottles GM, Yanagida M, Asou N, Shigesada K, Ito Y, Benson KF, Raskind WH, Rossier C, Antonarakis SE, Israels S, McNicol A, Weiss H, Horwitz M, Scott HS
Blood. 2002 ; 99 (4) : 1364-1372.
PMID 11830488
 
A new translocation that rearranges the AML1 gene in a patient with T-cell acute lymphoblastic leukemia.
Mikhail FM, Serry KA, Hatem N, Mourad ZI, Farawela HM, El Kaffash DM, Coignet L, Nucifora G
Cancer genetics and cytogenetics. 2002 ; 135 (1) : 96-100.
PMID 12072207
 
High frequency of t(12;21) in childhood B-lineage acute lymphoblastic leukemia.
Romana SP, et al.
Blood. 1995 Dec 1;86(11):4263-9.
PMID 7492786
 
CBFA2(AML1) Translocations With Novel Partner Chromosomes in Myeloid Leukemias: Association With Prior Therapy.
Roulston D, Espinosa IIIR, Nucifora G, Larson RA, Le Beau MM, Rowley JD.
Blood 1998; 92: 2879-2885.
 
Combined spectral karyotyping and DAPI banding analysis of chromosome abnormalities in myelodysplastic syndrome.
Kakazu N, Taniwaki M, Horiike S, Nishida K, Tatekawa T, Nagai M, Takahashi T, Akaogi T, Inazawa J, Ohki M, Abe T.
Genes Chromosomes Cancer 1999; 26: 336-345.
 
Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia.
Song WJ, Sullivan MG, Legare RD, Hutchings S, Tan X, Kufrin D, Ratajczak J, Resende IC, Haworth C, Hock R, Loh M, Felix C, Roy DC, Busque L, Kurnit D, Willman C, Gewirtz AM, Speck NA, Bushweller JH, Li FP, Gardiner K, Poncz M, Maris JM, Gilliland DG.
Nat Genet. 1999;23:134-135.
 
Concurrent translocations of MLL and CBFA2 (AML1) genes with new partner breakpoints in a child with secondary myelodysplastic syndrome after treatment of acute lymphoblastic leukemia.
Mathew S, Head D, Rubnitz JE, Raimondi SC.
Genes Chromosomes Cancer 2000; 28: 227-232.
PMID 10825008
 
Identification of two new translocations that disrupt the AML1 gene.
Richkind K, Hromas R, Lytle C, Crenshaw D, Velasco J, Roherty S, Srinivasiah J, Varella-Garcia M.
Cancer Genet Cytogenet 2000; 122: 141-143.
 
A novel syndrome of radiation-associated acute myeloid leukemia involving AML1 gene translocations
Hromas R, Shopnick R, Jumean HG, Bowers C, Varella-Garcia M, Richkind K.
Blood 2000; 95:4011-4013
 
A novel CBFA2 single-nucleotide mutation in familial platelet disorder with propensity to develop myeloid malignancies.
Buijs A, Poddighe P, van Wijk R, van Solinge W, Borst E, Verdonck L, Hagenbeek A, Pearson P, Lokhorst H.
Blood 2001; 98:2856-2858.
 
Novel cryptic, complex rearrangements involving ETV6-CBFA2 (TEL-AML1) genes identified by fluorescence in situ hybridization in pediatric patients with acute lymphoblastic leukemia.
Mathew S, Shurtleff SA, Raimondi SC.
Genes Chromosomes Cancer. 2001; 32: 188-193.
PMID 11550288
 
AML1-TRPS1 chimeric protein is generated by t(8;21)(q24;q22) in relapsing acute myeloblastic leukemia.
Asou N, Matsuno N, Mitsuya H.
Am Soc Hematol, 43 Annual meeting, Blood 2001; 98 11: 564a.
 
In vitro analyses of known and novel RUNX1/AML1 mutations in dominant familial platelet disorder with predisposition to acute myelogenous leukemia: implications for mechanisms of pathogenesis.
Michaud J, Wu F, Osato M, Cottles GM, Yanagida M, Asou N, Shigesada K, Ito Y, Benson KF, Raskind WH, Rossier C, Antonarakis SE, Israels S, McNicol A, Weiss H, Horwitz M, Scott HS.
Blood 2002;99:1364-1372.
 
A new translocation that rearranges the AML1 gene in a patient with T-cell acute lymphoblastic leukemia.
Mikhail FM, Serry KA, Hatem N, Mourad ZI, Farawela HM, El Kaffash DM, Coignet L, Nucifora G.
Cancer Genet Cytogenet 2002; 135: 96-100.
 
Molecular basis of the t(8;21) translocation in acute myeloid leukaemia.
Ohki M
Seminars in cancer biology. 1993 ; 4 (6) : 369-375.
PMID 8142622
 
AML1 and the 8;21 and 3;21 translocations in acute and chronic myeloid leukemia.
Nucifora G, Rowley JD
Blood. 1995 ; 86 (1) : 1-14.
PMID 7795214
 
High frequency of t(12;21) in childhood B-lineage acute lymphoblastic leukemia.
Romana SP, Poirel H, Leconiat M, Flexor MA, Mauchauffˆ© M, Jonveaux P, Macintyre EA, Berger R, Bernard OA
Blood. 1995 ; 86 (11) : 4263-4269.
PMID 7492786
 
CBFA2(AML1) translocations with novel partner chromosomes in myeloid leukemias: association with prior therapy.
Roulston D, Espinosa R 3rd, Nucifora G, Larson RA, Le Beau MM, Rowley JD
Blood. 1998 ; 92 (8) : 2879-2885.
PMID 9763573
 
Combined spectral karyotyping and DAPI banding analysis of chromosome abnormalities in myelodysplastic syndrome.
Kakazu N, Taniwaki M, Horiike S, Nishida K, Tatekawa T, Nagai M, Takahashi T, Akaogi T, Inazawa J, Ohki M, Abe T
Genes, chromosomes & cancer. 1999 ; 26 (4) : 336-345.
PMID 10534769
 
A new angle on a pervasive oncogene.
Cleary ML
Nature genetics. 1999 ; 23 (2) : 134-135.
PMID 10508502
 
Concurrent translocations of MLL and CBFA2 (AML1) genes with new partner breakpoints in a child with secondary myelodysplastic syndrome after treatment of acute lymphoblastic leukemia.
Mathew S, Head D, Rubnitz JE, Raimondi SC
Genes, chromosomes & cancer. 2000 ; 28 (2) : 227-232.
PMID 10825008
 
Identification of two new translocations that disrupt the AML1 gene.
Richkind K, Hromas R, Lytle C, Crenshaw D, Velasco J, Roherty S, Srinivasiah J, Varella-Garcia M
Cancer genetics and cytogenetics. 2000 ; 122 (2) : 141-143.
PMID 11106827
 
A novel syndrome of radiation-associated acute myeloid leukemia involving AML1 gene translocations.
Hromas R, Shopnick R, Jumean HG, Bowers C, Varella-Garcia M, Richkind K
Blood. 2000 ; 95 (12) : 4011-4013.
PMID 10845943
 
A novel CBFA2 single-nucleotide mutation in familial platelet disorder with propensity to develop myeloid malignancies.
Buijs A, Poddighe P, van Wijk R, van Solinge W, Borst E, Verdonck L, Hagenbeek A, Pearson P, Lokhorst H
Blood. 2001 ; 98 (9) : 2856-2858.
PMID 11675361
 
Novel cryptic, complex rearrangements involving ETV6-CBFA2 (TEL-AML1) genes identified by fluorescence in situ hybridization in pediatric patients with acute lymphoblastic leukemia.
Mathew S, Shurtleff SA, Raimondi SC
Genes, chromosomes & cancer. 2001 ; 32 (2) : 188-193.
PMID 11550288
 
AML1-TRPS1 chimeric protein is generated by t(8;21)(q24;q22) in relapsing acute myeloblastic leukemia.
Asou N, Matsuno N, Mitsuya H
Am Soc Hematol,. 1943.
 
In vitro analyses of known and novel RUNX1/AML1 mutations in dominant familial platelet disorder with predisposition to acute myelogenous leukemia: implications for mechanisms of pathogenesis.
Michaud J, Wu F, Osato M, Cottles GM, Yanagida M, Asou N, Shigesada K, Ito Y, Benson KF, Raskind WH, Rossier C, Antonarakis SE, Israels S, McNicol A, Weiss H, Horwitz M, Scott HS
Blood. 2002 ; 99 (4) : 1364-1372.
PMID 11830488
 
A new translocation that rearranges the AML1 gene in a patient with T-cell acute lymphoblastic leukemia.
Mikhail FM, Serry KA, Hatem N, Mourad ZI, Farawela HM, El Kaffash DM, Coignet L, Nucifora G
Cancer genetics and cytogenetics. 2002 ; 135 (1) : 96-100.
PMID 12072207
 
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Contributor(s)

Written11-1997Jean-Loup Huret
Updated12-1997Jean-Loup Huret
Updated01-2003Jean-Loup Huret and Sylvie Senon

Citation

This paper should be referenced as such :
Huret JL . AML1 (acute myeloid leukemia 1); RUNX1 (runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene)); CBFA2 (core binding factor A2). Atlas Genet Cytogenet Oncol Haematol. November 1997 .
URL : http://AtlasGeneticsOncology.org/Genes/AML1.html
Huret JL . AML1 (acute myeloid leukemia 1); RUNX1 (runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene)); CBFA2 (core binding factor A2). Atlas Genet Cytogenet Oncol Haematol. December 1997 .
URL : http://AtlasGeneticsOncology.org/Genes/AML1.html
Huret JL, Senon S . AML1 (acute myeloid leukemia 1); RUNX1 (runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene)); CBFA2 (core binding factor A2). Atlas Genet Cytogenet Oncol Haematol. January 2003 .
URL : http://AtlasGeneticsOncology.org/Genes/AML1.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Dec 6 17:53:47 2008

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