| Description | The human ANLN cDNA encodes a protein (1124 amino acids; 124199 Da) that includes an actin-binding domain and a C-terminal domain with pleckstrin homology (PH). It also contains several consensus nuclear localization sequences (NLS) and one consensus SH3-binding motif. |
| Expression | ANLN is mainly expressed in adult placenta, testis, and spinal cord, and in fetal organs (brain, heart, kidney, liver, lung, skeletal muscle, spleen and thymus). |
| Localisation | ANLN is mainly found in nucleus, cytoplasm, cytoskeleton, cleavage furrow, and cell cortex. |
| Function | Anillin (ANLN) was initially characterized as a human homologue of anillin, a Drosophila actin-binding protein. ANLN localizes not only to the cytoplasm but also to nuclei in some proportion of cancer cells; it is likely to present at the cortex following breakdown of the nuclear envelope, and in the cleavage furrow during cytokinesis. ANLN plays an important role in cell-cycle progression. In late phases ANLN may assemble the actin and myosin contractile ring that separates daughter cells, through interaction with at least two other furrow proteins, actin and septins (SEPTs). ANLN is supposed to be a substrate of the anaphase-promoting complex/cyclosome (APC/C), a ubiquitin ligase that controls mitotic progression. |
| The septin-binding protein anillin is overexpressed in diverse human tumors. |
| Hall PA, Todd CB, Hyland PL, McDade SS, Grabsch H, Dattani M, Hillan KJ, Russell SE. |
| Clin Cancer Res. 2005 Oct 1;11(19 Pt 1):6780-6. |
| PMID 16203764 |
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| ANLN plays a critical role in human lung carcinogenesis through the activation of RHOA and by involvement in the phosphoinositide 3-kinase/AKT pathway. |
| Suzuki C, Daigo Y, Ishikawa N, Kato T, Hayama S, Ito T, Tsuchiya E, Nakamura Y. |
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| PMID 16357138 |
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| Molecular features of hormone-refractory prostate cancer cells by genome-wide gene expression profiles. |
| Tamura K, Furihata M, Tsunoda T, Ashida S, Takata R, Obara W, Yoshioka H, Daigo Y, Nasu Y, Kumon H, Konaka H, Namiki M, Tozawa K, Kohri K, Tanji N, Yokoyama M, Shimazui T, Akaza H, Mizutani Y, Miki T, Fujioka T, Shuin T, Nakamura Y, Nakagawa H. |
| Cancer Res. 2007 Jun 1;67(11):5117-25. |
| PMID 17545589 |
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| Identification of molecular targets in head and neck squamous cell carcinomas based on genome-wide gene expression profiling. |
| Shimizu S, Seki N, Sugimoto T, Horiguchi S, Tanzawa H, Hanazawa T, Okamoto Y. |
| Oncol Rep. 2007 Dec;18(6):1489-97. |
| PMID 17982635 |
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