Atlas of Genetics and Cytogenetics in Oncology and Haematology

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ATF1 (activating transcription factor 1)

Written1999-11Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)


Other aliasTREB36
LocusID (NCBI) 466
Atlas_Id 81
Location 12q13.12  [Link to chromosome band 12q13]
Location_base_pair Starts at and ends at bp from pter
  Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ATF1 (12q13.12) / ATF1 (12q13.12)ATF1 (12q13.12) / EWSR1 (22q12.2)ATF1 (12q13.12) / FUS (16p11.2)
ATF1 (12q13.12) / GRIP1 (12q14.3)EWSR1 (22q12.2) / ATF1 (12q13.12)FUS (16p11.2) / ATF1 (12q13.12)


Transcription 816 bp mRNA


Description 271 amino acids; possess a basic motif and a leucine-zipper; dimerisation with other ATF family members (e.g. ATF-1 homodimers and ATF-1/CREB heterodimers)
Localisation nuclear
Function DNA binding protein, binds the consensus sequence: 5'GTGACGT(A/C)(A/G)-3'; cAMP-inducible transcription factor (cAMP-responsive enhancer-binding protein (CRE), like CREB
Homology members of the CREB protein family

Implicated in

Entity malignant melanoma of soft parts
Disease very rare neuroectodermal tumour
Prognosis very poor
Cytogenetics characterised by the translocation t(12;22)(q13;q12)
Hybrid/Mutated Gene 5' EWSR1- 3' ATF1
Abnormal Protein the chimaeric protein is composed of the N-terminal domain of EWS linked to the bZIP domain of ATF-1
Oncogenesis binds to ATF sites present in cAMP-responsive promoters via the ATF1 bZIP domain and activates transcription constitutively, dependent on the activation domain (EAD) present in EWSR1




ATF1 and CREB trans-activate a cell cycle regulated histone H4 gene at a distal nuclear matrix associated promoter element.
Guo B, Stein JL, van Wijnen AJ, Stein GS
Biochemistry. 1997 ; 36 (47) : 14447-14455.
PMID 9398163
The EWS/ATF1 fusion protein contains a dispersed activation domain that functions directly.
Pan S, Ming KY, Dunn TA, Li KK, Lee KA
Oncogene. 1998 ; 16 (12) : 1625-1631.
PMID 9569031
The cAMP-regulated enhancer-binding protein ATF-1 activates transcription in response to cAMP-dependent protein kinase A.
Rehfuss RP, Walton KM, Loriaux MM, Goodman RH
The Journal of biological chemistry. 1991 ; 266 (28) : 18431-18434.
PMID 1655749
Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain.
Yoshimura T, Fujisawa J, Yoshida M
The EMBO journal. 1990 ; 9 (8) : 2537-2542.
PMID 2196176
EWS and ATF-1 gene fusion induced by t(12;22) translocation in malignant melanoma of soft parts.
Zucman J, Delattre O, Desmaze C, Epstein AL, Stenman G, Speleman F, Fletchers CD, Aurias A, Thomas G
Nature genetics. 1993 ; 4 (4) : 341-345.
PMID 8401579


This paper should be referenced as such :
Huret, JL
ATF1 (activating transcription factor 1)
Atlas Genet Cytogenet Oncol Haematol. 1999;3(4):179-180.
Free journal version : [ pdf ]   [ DOI ]
On line version :

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 10 ]
  Soft Tissues: Angiomatoid fibrous histiocytoma
Soft Tissues: Clear cell sarcoma
Soft Tissues: Low grade fibromyxoid sarcoma
Soft Tissues: Melanoma: Malignant melanoma of soft parts
Malignant Mesothelioma
Soft Tissues: Liposarcoma: Myxoid liposarcoma
Soft tissue tumors: an overview
Soft Tissues: Angiomatoid fibrous histiocytoma with t(2;22)(q34;q12) EWSR1/CREB1
Soft Tissues: Angiomatoid fibrous histiocytoma with t(12;22)(q13;q12) EWSR1/ATF1
t(12;12)(q13;q14) ATF1/GRIP1

External links

Genomic and cartography
Gene and transcription
RefSeq transcript (Entrez)
RefSeq genomic (Entrez)
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)466
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Protein Interaction databases
Ontologies - Pathways
Clinical trials, drugs, therapy
canSAR (ICR) (select the gene name)
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Oct 18 17:28:47 CEST 2018

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