ATF1 (activating transcription factor 1)

Identity

Other names	TREB36
HGNC	ATF1
Location	12q13
Location_base_pair	Starts at 49444086 and ends at 49501174 bp from pter ( according to hg18-Mar_2006).

DNA/RNA

Transcription

816 bp mRNA

Protein

Description	271 amino acids; possess a basic motif and a leucine-zipper; dimerisation with other ATF family members (e.g. ATF-1 homodimers and ATF-1/CREB heterodimers)
Localisation	nuclear
Function	DNA binding protein, binds the consensus sequence: 5'GTGACGT(A/C)(A/G)-3'; cAMP-inducible transcription factor (cAMP-responsive enhancer-binding protein (CRE), like CREB
Homology	members of the CREB protein family

Implicated in

Entity	malignant melanoma of soft parts
Disease	very rare neuroectodermal tumour
Prognosis	very poor
Cytogenetics	characterised by the translocation t(12;22)(q13;q12)
Hybrid/Mutated Gene	5' EWSR1- 3' ATF1
Abnormal Protein	the chimaeric protein is composed of the N-terminal domain of EWS linked to the bZIP domain of ATF-1
Oncogenesis	binds to ATF sites present in cAMP-responsive promoters via the ATF1 bZIP domain and activates transcription constitutively, dependent on the activation domain (EAD) present in EWSR1

Breakpoints

External links

	Nomenclature
HGNC	ATF1   783
Entrez_Gene	ATF1  466  activating transcription factor 1
	Cards
Atlas	ATF1ID81
GeneCards	ATF1
Ensembl	ENSG00000123268 [Gene_View]  ATF1 [Vega]
Genatlas	ATF1
	Genomic and cartography
GoldenPath	ATF1  -  12q13   chr12:49444086-49501174 +  12q13   [Description]    (hg18-Mar_2006)
Ensembl	ATF1 - 12q13 [CytoView]
NCBI	Mapview
OMIM	123803 Disease map [OMIM]
HomoloGene	ATF1
	Gene and transcription
Genbank	AK313406 [ ENTREZ ]
Genbank	BC029619 [ ENTREZ ]
Genbank	BG502726 [ ENTREZ ]
Genbank	BG545632 [ ENTREZ ]
Genbank	BG611151 [ ENTREZ ]
RefSeq	NM_005171 [ SRS ]    NM_005171 [ ENTREZ ]
RefSeq	AC_000055 [ SRS ]    AC_000055 [ ENTREZ ]
RefSeq	AC_000144 [ SRS ]    AC_000144 [ ENTREZ ]
RefSeq	NC_000012 [ SRS ]    NC_000012 [ ENTREZ ]
RefSeq	NT_029419 [ SRS ]    NT_029419 [ ENTREZ ]
RefSeq	NW_001838057 [ SRS ]    NW_001838057 [ ENTREZ ]
RefSeq	NW_925351 [ SRS ]    NW_925351 [ ENTREZ ]
CCDS	ATF1 CCDS - NCBI
AceView	ATF1 AceView - NCBI
Unigene	Hs.648565 [ SRS ]    Hs.648565 [ NCBI ]
Fast-db	6876 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P18846 [ SRS]    P18846 [ EXPASY ]     P18846 [ INTERPRO ]     P18846 [ UNIPROT ] P18846 [ VarSplice FASTA ]
Prosite	PS50217 BZIP [ SRS ]    PS50217 BZIP [ Expasy ]
Prosite	PS00036 BZIP_BASIC [ SRS ]    PS00036 BZIP_BASIC [ Expasy ]
Prosite	PS50953 KID [ SRS ]    PS50953 KID [ Expasy ]
Interpro	IPR011616 bZIP_1 [ SRS ]    IPR011616 bZIP_1 [ EBI ]
Interpro	IPR003102 Coactivator_CBP_pKID [ SRS ]    IPR003102 Coactivator_CBP_pKID [ EBI ]
Interpro	IPR001630 Leuzip_CREB [ SRS ]    IPR001630 Leuzip_CREB [ EBI ]
Interpro	IPR004827 TF_bZIP [ SRS ]    IPR004827 TF_bZIP [ EBI ]
CluSTr	P18846
Pfam	PF00170 bZIP_1 [ SRS ]    PF00170 bZIP_1 [ Sanger ]    pfam00170 [ NCBI-CDD ]
Pfam	PF02173 pKID [ SRS ]    PF02173 pKID [ Sanger ]    pfam02173 [ NCBI-CDD ]
Smart	SM00338 BRLZ [EMBL]
Blocks	P18846
HPRD	00440
	Protein Interaction databases
DIP	P18846
IntAct	P18846
	Polymorphism : SNP, mutations, diseases
OMIM	123803    [ map ]
GENETests	123803
SNP	ATF1 [dbSNP-NCBI]
SNP	NM_005171 [SNP-NCI]
SNP	ATF1 [GeneSNPs - Utah]  ATF1] [HGBASE - SRS]
HAPMAP	ATF1 [HAPMAP]
COSMIC	ATF1 [Somatic mutation (COSMIC-CGP-Sanger)]
TICdb	ATF1 [Translocation breakpoints In Cancer]
HGMD	ATF1
Genetic Association	ATF1
CDC HuGE	ATF1
	General knowledge
Family Browser	ATF1 [UCSC Family Browser]
SOURCE	NM_005171
SMD	Hs.648565
SAGE	Hs.648565
GO	transcription factor activity [Amigo]  transcription factor activity
GO	transcription factor activity [Amigo]  transcription factor activity
GO	nucleus [Amigo]  nucleus
GO	transcription factor complex [Amigo]  transcription factor complex
GO	transcription [Amigo]  transcription
GO	regulation of transcription, DNA-dependent [Amigo]  regulation of transcription, DNA-dependent
GO	sequence-specific DNA binding [Amigo]  sequence-specific DNA binding
GO	protein dimerization activity [Amigo]  protein dimerization activity
PubGene	ATF1
TreeFam	ATF1
CTD	466 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	Cancer Cytogenetics (Bari)
Probe	ATF1 Related clones (RZPD - Berlin)
	PubMed
PubMed	42 Pubmed reference(s) in Entrez

Bibliography

Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain.

Yoshimura T, Fujisawa J, Yoshida M

The EMBO journal. 1990 ; 9 (8) : 2537-2542.

PMID 2196176

The cAMP-regulated enhancer-binding protein ATF-1 activates transcription in response to cAMP-dependent protein kinase A.

Rehfuss RP, Walton KM, Loriaux MM, Goodman RH

The Journal of biological chemistry. 1991 ; 266 (28) : 18431-18434.

PMID 1655749

EWS and ATF-1 gene fusion induced by t(12;22) translocation in malignant melanoma of soft parts.

Zucman J, Delattre O, Desmaze C, Epstein AL, Stenman G, Speleman F, Fletchers CD, Aurias A, Thomas G

Nature genetics. 1993 ; 4 (4) : 341-345.

PMID 8401579

ATF1 and CREB trans-activate a cell cycle regulated histone H4 gene at a distal nuclear matrix associated promoter element.

Guo B, Stein JL, van Wijnen AJ, Stein GS

Biochemistry. 1997 ; 36 (47) : 14447-14455.

PMID 9398163

The EWS/ATF1 fusion protein contains a dispersed activation domain that functions directly.

Pan S, Ming KY, Dunn TA, Li KK, Lee KA

Oncogene. 1998 ; 16 (12) : 1625-1631.

PMID 9569031

REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

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Contributor(s)

Written	11-1999	Jean-Loup Huret

Citation

This paper should be referenced as such :

Huret JL . ATF1 (activating transcription factor 1). Atlas Genet Cytogenet Oncol Haematol. November 1999 . URL : http://AtlasGeneticsOncology.org/Genes/ATF1ID81.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Dec 6 17:53:54 2008