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BAG1 (BCL2-associated athanogene)

Written2008-11Samantha L Southern, Victoria Skeen, Ann C Williams.
Department of Cellular, Molecular Medicine, University of Bristol, School of Medical Sciences, Bristol,BS8 1TD, UK

(Note : for Links provided by Atlas : click)

Identity

Alias_namesBCL2 associated athanogene
Other aliasBAG-1
HAP
HAP46
RAP46
HGNC (Hugo) BAG1
LocusID (NCBI) 573
Atlas_Id 742
Location 9p13.3  [Link to chromosome band 9p13]
Location_base_pair Starts at 33252471 and ends at 33264761 bp from pter ( according to hg19-Feb_2009)  [Mapping BAG1.png]
Fusion genes
(updated 2016)		B4GALT1 (9p21.1) / BAG1 (9p13.3)BAG1 (9p13.3) / USP34 (2p15)BCYRN1 (Xq13.1) / BAG1 (9p13.3)
DDAH2 (6p21.33) / BAG1 (9p13.3)NFX1 (9p13.3) / BAG1 (9p13.3)UBE3C (7q36.3) / BAG1 (9p13.3)

DNA/RNA

Description centromere to telomerase orientation; 7 exons.
Transcription 5 alternative transcripts; 1079 nucleotides mRNA.

Protein

 
  BAG-1 isoforms and their domains. The human BAG-1 gene, located on chromosome 9p12, comprises seven exons which generate an mRNA product of approximately 1.5kb. Three major BAG-1 isoforms are produced from alternative translation start sites within BAG-1 mRNA. The 50kDa BAG-1L isoform is translated from the first in-frame CUG codon by CAP-dependent translation, while BAG-1M and BAG-1S are produced from two downstream AUG codons. BAG-1M is also produced by a CAP-dependent translation mechanism, while BAG-1S is generated by IRES-dependent translation resulting in highest abundance of this short isoform. BAG-1L contains a bipartite nuclear localisation sequence (NLS, purple), the amino-terminal portion of which overlaps with a DNA binding domain (blue). BAG-1M contains a partial NLS, while the NLS is completely absent from BAG-1S. An acidic serine/threonine rich region (green) has been implicated in protein-protein interactions. The ubiquitin-like domain (yellow) and BAG domain (red) are present in all three isoforms.
Description Three isoforms generated by alternative translation initiation; 50kDa (BAG-1L), 46kDa (BAG-1M) and 36kDa (BAG-1S)(Yang et al., 1998). Each BAG-1 isoform contains a conserved BAG domain and ubiquitin-like domain, with variation in length of their N-terminal sequences.
Expression Expressed ubiquitously and found to be over-expressed in a number of cancers.
Localisation The BAG-1 isoforms differ in their subcellular localisation. BAG-1L is predominantly nuclear, BAG-1M is both nuclear and cytoplasmic and BAG-1S is predominantly cytoplasmic (Packham et al., 1997; Takayama et al., 1998; Yang et al., 1998; Brimmell et al., 1999). However, subcellular localisation can be cell type and context dependent, for example in response to heat shock and hormonal stimulation (Schneikert et al., 1999; Zeiner et al., 1999).
Function Multifunctional protein: Identified as having a role in many different cellular processes including the regulation of apoptosis, proliferation, transcription, proteasome-mediated degradation and a possible role in motility and metastasis (reviewed in Cutress et al., 2003). BAG-1 affects many cellular processes through interaction with a wide variety of cellular proteins, summarised in the table 1.
 
  Table 1. Summary of proteins that interact with BAG-1 and some of the reported cellular functions. BAG-1 associates with a wide range of proteins and through these interactions may have multiple cellular effects, any of which might contribute to cancerous cell phenotypes.
Homology BAG family of proteins that share a common BAG domain. At present six BAG family proteins have been identified in humans: BAG-1 (Rap46) BAG-2, BAG-3, BAG-4 (sodd), BAG-5 and BAG-6 (BAT3).

Mutations

Note Unknown

Implicated in

Note
  
Entity Various cancers
Disease BAG-1 expression is frequently altered in human cancer (Townsend et al., 2003). It has been shown to be over-expressed relative to normal cells in a number of cancers including breast cancer (Tang et al., 1999), colorectal cancer (Kikuchi et al., 2002; Clemo et al. 2008) and human squamous cell carcinoma(Shindoh et al., 2000), endometrial cancer(Moriyama et al., 2004), prostate cancer (Krajewska et al., 2006) and lung cancer (Rorke et al., 2001). Altered expression has been found in pre-malignant lesions (Clemo et al., 2008), implicating a role early in tumour development. BAG-1 has also been suggested to be involved in metastatic disease (Takaoka et al., 1997; Yawata et al., 1998; Hague et al., 2002, reviewed by Sharp et al., 2004).
Prognosis BAG-1 expression has been shown to be a prognostic factor in a number of cancers. Kikuchi et al (2002) showed in colorectal cancer, that high nuclear BAG-1 expression resulted in a poorer prognosis and a higher risk of metastases. In oesophageal cancer, BAG-1 expression has also been linked to poor prognosis (Takeno et al., 2007). In breast cancer over-expression of BAG-1 has been suggested to be a poor prognostic factor (Krajewski et al., 1999). However, there is conflicting data, with some studies finding increased BAG-1 expression results in a good prognosis (Turner et al., 2001; Nadler et al., 2008), or establishing no link between expression and prognosis (Sjostrom et al., 2002; Tang et al., 2004).
  

Bibliography

Retinoblastoma Protein Interacts with BAG-1 in Human Colonic Adenoma and Carcinoma Derived Cell Lines.
Arhel NJ, Packham G, Townsend PA, Collard TJ, H-Zadeh AM, Sharp A, Cutress RI, Malik K, Hague A, Paraskeva C, Williams AC.
Int J Cancer. 2003 Sep 1;106(3):364-71.
PMID 12845674
 
HGF Receptor Associates with the Anti-apoptotic BAG-1 and Prevents Cell Death
Bardelli A, Longati P, Albero D, Goruppi S, Schneider C, Ponzetto C, Comoglio PM.
EMBO J. 1996 Nov 15;15(22):6205-12.
PMID 8947043
 
Nuclear BAG-1 expression inhibits apoptosis in colorectal adenoma-derived epithelial cells.
Barnes JD, Arhel NJ, Lee SS, Sharp A, Al-Okail M, Packham G, Hague A, Paraskeva C, Williams AC.
Apoptosis. 2005 Mar;10(2):301-11.
PMID 15843891
 
High level expression of differentially localized BA-1 isoforms in some oestrogen receptor-positive human breast cancers.
Brimmell M, Burns JS, Munson P, McDonald L, O'Hare MJ, Lakhani SR, Packham G.
Br J Cancer. 1999 Nov;81(6):1042-51.
PMID 10576663
 
The role of the retinoblastoma protein (Rb) in the nuclear localization of BAG-1: implications for colorectal tumour cell survival.
Clemo NK, Arhel NJ, Barnes JD, Baker J, Moorghen M, Packham GK, Paraskeva C, Williams AC.
Biochem Soc Trans. 2005 Aug;33(Pt 4):676-8.
PMID 16042572
 
BAG-1 is up-regulated in colorectal tumour progression and promotes colorectal tumour cell survival through increased NF-KappaB activity.
Clemo NK, Collard TJ, Southern SL, Edwards KD, Moorghen M, Packham G, Hague A, Paraskeva C, Williams AC.
Carcinogenesis. 2008 Apr;29(4):849-57. Epub 2008 Jan 19.
PMID 18204076
 
The Nuclear BAG-1 Isoform, BAG-1L, Enhances Oestrogen-dependent Transcription.
Cutress RI, Townsend PA, Sharp A, Maison A, Wood L, Lee R, Brimmell M, Mullee MA, Johnson PW, Royle GT, Bateman AC, Packham G.
Oncogene. 2003 Aug 7;22(32):4973-82.
PMID 12902980
 
Cooperation of a ubiquitin domain protein and an E3 ubiquitin ligase during chaperone/proteasome coupling.
Demand J, Alberti S, Patterson C, Hohfeld J.
Curr Biol. 2001 Oct 16;11(20):1569-77.
PMID 11676916
 
BAG-1L Protein Enhances Androgen Receptor Function.
Froesch BA, Takayama S, Reed JC.
J Biol Chem. 1998 May 8;273(19):11660-6.
PMID 9565586
 
Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells.
Gotz R, Wiese S, Takayama S, Camarero GC, Rossoll W, Schweizer U, Troppmair J, Jablonka S, Holtmann B, Reed JC, Rapp UR, Sendtner M.
Nat Neurosci. 2005 Sep;8(9):1169-78. Epub 2005 Aug 21.
PMID 16116448
 
Deregulated Bag-1 protein expression in human oral squamous cell carcinomas and lymph node metastases.
Hague A, Packham G, Huntley S, Shefford K, Eveson JW.
J Pathol. 2002 May;197(1):60-71.
PMID 12081206
 
Nuclear BAG-1 Expression Reflects Malignant Potential in Colorectal Carcinomas.
Kikuchi R, Noguchi T, Takeno S, Funada Y, Moriyama H, Uchida Y.
Br J Cancer. 2002 Nov 4;87(10):1136-9.
PMID 12402153
 
Expression of BAG-1 protein correlates with aggressive behaviour of prostate cancers.
Krajewska M, Turner BC, Shabaik A, Krajewski S, Reed JC.
Prostate. 2006 Jun 1;66(8):801-10.
PMID 16482527
 
Prognostic significance of apoptosis regulators in breast cancer.
Krajewski S, Krajewska M, Turner BC, Pratt C, Howard B, Zapata JM, Frenkel V, Robertson S, Ionov Y, Yamamoto H, Perucho M, Takayama S, Reed JC.
Endocr Relat Cancer. 1999 Mar;6(1):29-40. (Review).
PMID 10732784
 
RAP46 Is a Negative Regulator of Glucocorticoid Receptor Action and Hormone-induced Apoptosis.
Kullmann M, Schneikert J, Moll J, Heck S, Zeiner M, Gehring U, Cato AC.
J Biol Chem. 1998 Jun 5;273(23):14620-5.
PMID 9603979
 
BAG-1 is a novel cytoplasmic binding partner of the membrane form of heparin-binding EGF-like growth factor: a unique role for proHB-EGF in cell survival regulation.
Lin J, Hutchinson L, Gaston SM, Raab G, Freeman MR.
J Biol Chem. 2001 Aug 10;276(32):30127-32. Epub 2001 May 4.
PMID 11340068
 
Distinct Isoforms of the Cofactor BAG-1 Differentially Affect Hsc70 Chaperone Function.
Luders J, Demand J, Papp O, Hohfeld J.
J Biol Chem. 2000 May 19;275(20):14817-23.
PMID 10809723
 
p53-inducible Human Homologue of Drosophila Seven in Abstensia (Siah) Inhibits Cell Growth: Suppression by BAG-1.
Matsuzawa S, Takayama S, Froesch BA, Zapata JM, Reed JC.
EMBO J. 1998 May 15;17(10):2736-47.
PMID 9582267
 
BAG-1 expression in normal and neoplastic endometrium.
Moriyama T, Littell RD, Debernardo R, Oliva E, Lynch MP, Rueda BR, Duska LR.
Gynecol Oncol. 2004 Aug;94(2):289-95.
PMID 15297164
 
Expression patterns and prognostic value of Bag-1 and Bcl-2 in breast cancer.
Nadler Y, Camp RL, Giltnane JM, Moeder C, Rimm DL, Kluger HM, Kluger Y.
Breast Cancer Res. 2008;10(2):R35. Epub 2008 Apr 23.
PMID 18430249
 
Transcriptional activation by the human Hsp70-associating protein Hap50.
Niyaz Y, Zeiner M, Gehring U.
J Cell Sci. 2001 May;114(Pt 10):1839-45.
PMID 11329370
 
Mammalian cells express two differently localized Bag-1 isoforms generated by alternative translation initiation.
Packham G, Brimmell M, Cleveland JL.
Biochem J. 1997 Dec 15;328 ( Pt 3):807-13.
PMID 9396724
 
Prognostic significance of BAG-1 expression in nonsmall cell lung cancer.
Rorke S, Murphy S, Khalifa M, Chernenko G, Tang SC.
Int J Cancer. 2001 Sep 20;95(5):317-22.
PMID 11494232
 
A nuclear action of the eukaryotic cochaperone RAP46 in downregulation of glucocorticoid receptor activity.
Schneikert J, Hubner S, Martin E, Cato AC.
J Cell Biol. 1999 Sep 6;146(5):929-40.
PMID 10477749
 
BAG-1 in carcinogenesis.
Sharp A, Crabb SJ, Townsend PA, Cutress RI, Brimmell M, Wang XH, Packham G.
Expert Rev Mol Med. 2004 Mar 22;6(7):1-15. (Review).
PMID 15033003
 
BAG-1 expression correlates highly with the malignant potential in early lesions (T1 and T2) of oral squamous cell carcinoma.
Shindoh M, Adachi M, Higashino F, Yasuda M, Hida K, Nishioka T, Ono M, Takayama S, Reed JC, Imai K, Totsuka Y, Kohgo T.
Oral Oncol. 2000 Sep;36(5):444-9.
PMID 10964051
 
The predictive value of bcl-2, bax, bcl-xL, bag-1, fas, and fasL for chemotherapy response in advanced breast cancer.
Sjostrom J, Blomqvist C, von Boguslawski K, Bengtsson NO, Mjaaland I, Malmstrom P, Ostenstadt B, Wist E, Valvere V, Takayama S, Reed JC, Saksela E.
Clin Cancer Res. 2002 Mar;8(3):811-6.
PMID 11895913
 
Bag1-Hsp70 mediates a physiological stress signalling pathway that regulates Raf-1/ERK and cell growth.
Song J, Takeda M, Morimoto RI.
Nat Cell Biol. 2001 Mar;3(3):276-82.
PMID 11231577
 
Anti-cell death activity promotes pulmonary metastasis of melanoma cells.
Takaoka A, Adachi M, Okuda H, Sato S, Yawata A, Hinoda Y, Takayama S, Reed JC, Imai K.
Oncogene. 1997 Jun 19;14(24):2971-7.
PMID 9205104
 
Expression and location of Hsp70/Hsc-binding anti-apoptotic protein BAG-1 and its variants in normal tissues and tumour cell lines.
Takayama S, Krajewski S, Krajewska M, Kitada S, Zapata JM, Kochel K, Knee D, Scudiero D, Tudor G, Miller GJ, Miyashita T, Yamada M, Reed JC.
Cancer Res. 1998 Jul 15;58(14):3116-31.
PMID 9679980
 
Assessment of clinical outcome in patients with esophageal squamous cell carcinoma using TNM classification score and molecular biological classification.
Takeno S, Noguchi T, Takahashi Y, Fumoto S, Shibata T, Kawahara K.
Ann Surg Oncol. 2007 Apr;14(4):1431-8. Epub 2007 Jan 28.
PMID 17260107
 
BAG-1 expression correlates with Bcl-2, p53, differentiation, estrogen and progesterone receptors in invasive breast carcinoma.
Tang SC, Beck J, Murphy S, Chernenko G, Robb D, Watson P, Khalifa M.
Breast Cancer Res Treat. 2004 Apr;84(3):203-13.
PMID 15026618
 
BAG-1: a multi-functional pro-survival molecule.
Townsend PA, Stephanou A, Packham G, Latchman DS.
Int J Biochem Cell Biol. 2005 Feb;37(2):251-9. (Review).
PMID 15474970
 
BAG-1: a novel biomarker predicting long-term survival in early-stage breast cancer.
Turner BC, Krajewski S, Krajewska M, Takayama S, Gumbs AA, Carter D, Rebbeck TR, Haffty BG, Reed JC.
J Clin Oncol. 2001 Feb 15;19(4):992-1000.
PMID 11181661
 
Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1.
Wang HG, Takayama S, Rapp UR, Reed JC.
Proc Natl Acad Sci U S A. 1996 Jul 9;93(14):7063-8.
PMID 8692945
 
Human BAG-1/RAP46 protein is generated as four isoforms by alternative translation initiation and over-expressed in cancer cells.
Yang X, Chernenko G, Hao Y, Ding Z, Pater MM, Pater A, Tang SC.
Oncogene. 1998 Aug 27;17(8):981-9.
PMID 9747877
 
Prolonged Cell Survival Enhances Peritoneal Dissemination of Gastric Cancer Cells
Yawata A, Adachi M, Okuda H, Naishiro Y, Takamura T, Hareyama M, Takayama S, Reed JC, Imai K.
Oncogene. 1998 May;16(20):2681-6.
PMID 9632144
 
A protein that interacts with members of the nuclear hormone receptor family: identification and cDNA cloning.
Zeiner M, Gehring U.
Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11465-9.
PMID 8524784
 
The Hsp70-associating Protein Hap46 Binds to DNA and Stimulates Transcription.
Zeiner M, Niyaz Y, Gehring U.
Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10194-9.
PMID 10468585
 

Citation

This paper should be referenced as such :
Southern, SL ; Skeen, V ; Williams, AC
BAG1 (BCL2-associated athanogene)
Atlas Genet Cytogenet Oncol Haematol. 2009;13(10):712-715.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/BAG1ID742ch9p13.html

External links

Nomenclature
HGNC (Hugo)BAG1   937
Cards
AtlasBAG1ID742ch9p13
Entrez_Gene (NCBI)BAG1  573  BCL2 associated athanogene 1
AliasesBAG-1; HAP; RAP46
GeneCards (Weizmann)BAG1
Ensembl hg19 (Hinxton)ENSG00000107262 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000107262 [Gene_View]  chr9:33252471-33264761 [Contig_View]  BAG1 [Vega]
ICGC DataPortalENSG00000107262
TCGA cBioPortalBAG1
AceView (NCBI)BAG1
Genatlas (Paris)BAG1
WikiGenes573
SOURCE (Princeton)BAG1
Genetics Home Reference (NIH)BAG1
Genomic and cartography
GoldenPath hg38 (UCSC)BAG1  -     chr9:33252471-33264761 -  9p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)BAG1  -     9p13.3   [Description]    (hg19-Feb_2009)
EnsemblBAG1 - 9p13.3 [CytoView hg19]  BAG1 - 9p13.3 [CytoView hg38]
Mapping of homologs : NCBIBAG1 [Mapview hg19]  BAG1 [Mapview hg38]
OMIM601497   
Gene and transcription
Genbank (Entrez)AF022224 AF116273 AK093238 AK096038 AK222749
RefSeq transcript (Entrez)NM_001172415 NM_001349286 NM_001349299 NM_004323
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)BAG1
Cluster EST : UnigeneHs.377484 [ NCBI ]
CGAP (NCI)Hs.377484
Alternative Splicing GalleryENSG00000107262
Gene ExpressionBAG1 [ NCBI-GEO ]   BAG1 [ EBI - ARRAY_EXPRESS ]   BAG1 [ SEEK ]   BAG1 [ MEM ]
Gene Expression Viewer (FireBrowse)BAG1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)573
GTEX Portal (Tissue expression)BAG1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99933   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ99933  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ99933
Splice isoforms : SwissVarQ99933
PhosPhoSitePlusQ99933
Domaine pattern : Prosite (Expaxy)BAG (PS51035)    UBIQUITIN_2 (PS50053)   
Domains : Interpro (EBI)BAG_domain    Ubiquitin-rel_dom    Ubiquitin_dom   
Domain families : Pfam (Sanger)BAG (PF02179)    ubiquitin (PF00240)   
Domain families : Pfam (NCBI)pfam02179    pfam00240   
Domain families : Smart (EMBL)BAG (SM00264)  UBQ (SM00213)  
Conserved Domain (NCBI)BAG1
DMDM Disease mutations573
Blocks (Seattle)BAG1
PDB (SRS)1HX1    1WXV    3FZF    3FZH    3FZK    3FZL    3FZM    3LDQ    3M3Z    5AQF    5AQG    5AQH    5AQI    5AQJ    5AQK    5AQL    5AQM    5AQN    5AQO    5AQP    5AQQ    5AQR    5AQS    5AQT    5AQU    5AQV   
PDB (PDBSum)1HX1    1WXV    3FZF    3FZH    3FZK    3FZL    3FZM    3LDQ    3M3Z    5AQF    5AQG    5AQH    5AQI    5AQJ    5AQK    5AQL    5AQM    5AQN    5AQO    5AQP    5AQQ    5AQR    5AQS    5AQT    5AQU    5AQV   
PDB (IMB)1HX1    1WXV    3FZF    3FZH    3FZK    3FZL    3FZM    3LDQ    3M3Z    5AQF    5AQG    5AQH    5AQI    5AQJ    5AQK    5AQL    5AQM    5AQN    5AQO    5AQP    5AQQ    5AQR    5AQS    5AQT    5AQU    5AQV   
PDB (RSDB)1HX1    1WXV    3FZF    3FZH    3FZK    3FZL    3FZM    3LDQ    3M3Z    5AQF    5AQG    5AQH    5AQI    5AQJ    5AQK    5AQL    5AQM    5AQN    5AQO    5AQP    5AQQ    5AQR    5AQS    5AQT    5AQU    5AQV   
Structural Biology KnowledgeBase1HX1    1WXV    3FZF    3FZH    3FZK    3FZL    3FZM    3LDQ    3M3Z    5AQF    5AQG    5AQH    5AQI    5AQJ    5AQK    5AQL    5AQM    5AQN    5AQO    5AQP    5AQQ    5AQR    5AQS    5AQT    5AQU    5AQV   
SCOP (Structural Classification of Proteins)1HX1    1WXV    3FZF    3FZH    3FZK    3FZL    3FZM    3LDQ    3M3Z    5AQF    5AQG    5AQH    5AQI    5AQJ    5AQK    5AQL    5AQM    5AQN    5AQO    5AQP    5AQQ    5AQR    5AQS    5AQT    5AQU    5AQV   
CATH (Classification of proteins structures)1HX1    1WXV    3FZF    3FZH    3FZK    3FZL    3FZM    3LDQ    3M3Z    5AQF    5AQG    5AQH    5AQI    5AQJ    5AQK    5AQL    5AQM    5AQN    5AQO    5AQP    5AQQ    5AQR    5AQS    5AQT    5AQU    5AQV   
SuperfamilyQ99933
Human Protein AtlasENSG00000107262
Peptide AtlasQ99933
HPRD03292
IPIIPI00300531   IPI00218546   IPI00954014   IPI00641336   IPI01011709   IPI00945635   IPI00945861   
Protein Interaction databases
DIP (DOE-UCLA)Q99933
IntAct (EBI)Q99933
FunCoupENSG00000107262
BioGRIDBAG1
STRING (EMBL)BAG1
ZODIACBAG1
Ontologies - Pathways
QuickGOQ99933
Ontology : AmiGOadenyl-nucleotide exchange factor activity  adenyl-nucleotide exchange factor activity  signal transducer activity, downstream of receptor  protein binding  nucleus  cytoplasm  cytosol  apoptotic process  cell surface receptor signaling pathway  negative regulation of apoptotic process  regulation of catalytic activity  chaperone binding  chaperone cofactor-dependent protein refolding  regulation of cellular response to heat  
Ontology : EGO-EBIadenyl-nucleotide exchange factor activity  adenyl-nucleotide exchange factor activity  signal transducer activity, downstream of receptor  protein binding  nucleus  cytoplasm  cytosol  apoptotic process  cell surface receptor signaling pathway  negative regulation of apoptotic process  regulation of catalytic activity  chaperone binding  chaperone cofactor-dependent protein refolding  regulation of cellular response to heat  
Pathways : KEGGProtein processing in endoplasmic reticulum   
REACTOMEQ99933 [protein]
REACTOME PathwaysR-HSA-3371453 [pathway]   
NDEx NetworkBAG1
Atlas of Cancer Signalling NetworkBAG1
Wikipedia pathwaysBAG1
Orthology - Evolution
OrthoDB573
GeneTree (enSembl)ENSG00000107262
Phylogenetic Trees/Animal Genes : TreeFamBAG1
HOVERGENQ99933
HOGENOMQ99933
Homologs : HomoloGeneBAG1
Homology/Alignments : Family Browser (UCSC)BAG1
Gene fusions - Rearrangements
Fusion : MitelmanB4GALT1/BAG1 [9p21.1/9p13.3]  [t(9;9)(p13;p21)]  
Fusion: TCGAB4GALT1 9p21.1 BAG1 9p13.3 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerBAG1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)BAG1
dbVarBAG1
ClinVarBAG1
1000_GenomesBAG1 
Exome Variant ServerBAG1
ExAC (Exome Aggregation Consortium)BAG1 (select the gene name)
Genetic variants : HAPMAP573
Genomic Variants (DGV)BAG1 [DGVbeta]
DECIPHERBAG1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisBAG1 
Mutations
ICGC Data PortalBAG1 
TCGA Data PortalBAG1 
Broad Tumor PortalBAG1
OASIS PortalBAG1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICBAG1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDBAG1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch BAG1
DgiDB (Drug Gene Interaction Database)BAG1
DoCM (Curated mutations)BAG1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)BAG1 (select a term)
intoGenBAG1
NCG5 (London)BAG1
Cancer3DBAG1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601497   
Orphanet
MedgenBAG1
Genetic Testing Registry BAG1
NextProtQ99933 [Medical]
TSGene573
GENETestsBAG1
Target ValidationBAG1
Huge Navigator BAG1 [HugePedia]
snp3D : Map Gene to Disease573
BioCentury BCIQBAG1
ClinGenBAG1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD573
Chemical/Pharm GKB GenePA25237
Clinical trialBAG1
Miscellaneous
canSAR (ICR)BAG1 (select the gene name)
Probes
Litterature
PubMed156 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineBAG1
EVEXBAG1
GoPubMedBAG1
iHOPBAG1
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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