BCAS3 (breast carcinoma amplified sequence 3)

Identity

Other names	MAAB
	GAOB1
Hugo	BCAS3
Location	17q23

DNA/RNA

Description	spans 715 kb; orientation direct strand; at least 77 exons
Transcription	alternate splicings: 3.9 kb, 3.3 kb, 2.3 kb, 1.5 kb, 1.3 kb.

Protein

Expression	ubiquitous
Localisation	nuclear (potential)

Implicated in

Entity	BCAS3 is overexpressed in about 10% of breast cancers, and a hybrid gene BCAS4-BCAS3 was found in breat cancer cell line with a t(17;20)(q23;q13)
Hybrid/Mutated Gene	5' BCAS4 is fused to the 2 last exons (23 and 24) of BCAS3; transcript includes exon 1 from BCAS4 and 21 bp from BCAS3 exon 23; it encodes a 66 aminoacids protein; no reciprocal transcript

External links

	Nomenclature
Hugo	BCAS3
GDB	BCAS3
Entrez_Gene	BCAS3  54828  breast carcinoma amplified sequence 3
	Cards
Atlas	BCAS3ID766
GeneCards	BCAS3
Ensembl	BCAS3 [Search_View]   ENSG00000141376 [Gene_View]
Genatlas	BCAS3
GeneLynx	BCAS3
eGenome	BCAS3
euGene	54828
	Genomic and cartography
GoldenPath	BCAS3  -  17q23   chr17:56109954-56824981 +  17q23   [Description]    (hg18-Mar_2006)
Ensembl	BCAS3 - 17q23 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	BCAS3
	Gene and transcription
Genbank	AF260268 [ ENTREZ ]
Genbank	AF361219 [ ENTREZ ]
Genbank	AJ511332 [ ENTREZ ]
Genbank	AJ518105 [ ENTREZ ]
Genbank	AJ518836 [ ENTREZ ]
RefSeq	NM_001099432 [ SRS ]    NM_001099432 [ ENTREZ ]
RefSeq	NM_017679 [ SRS ]    NM_017679 [ ENTREZ ]
RefSeq	AC_000060 [ SRS ]    AC_000060 [ ENTREZ ]
RefSeq	NC_000017 [ SRS ]    NC_000017 [ ENTREZ ]
RefSeq	NT_010783 [ SRS ]    NT_010783 [ ENTREZ ]
RefSeq	NW_926907 [ SRS ]    NW_926907 [ ENTREZ ]
AceView	BCAS3 AceView - NCBI
Unigene	Hs.699319 [ SRS ]    Hs.699319 [ NCBI ]     HS699319 [ spliceNest ]
Fast-db	13600 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q9H6U6 [ SRS]    Q9H6U6 [ EXPASY ]     Q9H6U6 [ INTERPRO ]
Prosite	PS00678 WD_REPEATS_1 [ SRS ]    PS00678 WD_REPEATS_1 [ Expasy ]
Prosite	PS50082 WD_REPEATS_2 [ SRS ]    PS50082 WD_REPEATS_2 [ Expasy ]
Prosite	PS50294 WD_REPEATS_REGION [ SRS ]    PS50294 WD_REPEATS_REGION [ Expasy ]
Interpro	IPR001680 WD40_repeat [ SRS ]    IPR001680 WD40_repeat [ EBI ]
CluSTr	Q9H6U6
Smart	SM00320 WD40 [EMBL]
Blocks	Q9H6U6
HPRD	06313
	Protein Interaction databases
DIP	Q9H6U6
IntAct	Q9H6U6
	Polymorphism : SNP, mutations, diseases
OMIM	607470    [ map ]
GENECLINICS	607470
SNP	BCAS3 [dbSNP-NCBI]
SNP	NM_001099432 [SNP-NCI]
SNP	NM_017679 [SNP-NCI]
SNP	BCAS3 [GeneSNPs - Utah]  BCAS3] [HGBASE - SRS]
HAPMAP	BCAS3 [HAPMAP]
HGMD	BCAS3
	General knowledge
Family Browser	BCAS3 [UCSC Family Browser]
SOURCE	NM_001099432
SOURCE	NM_017679
SMD	Hs.699319
SAGE	Hs.699319
GO	nucleus [Amigo]  nucleus
PubGene	BCAS3
TreeFam	BCAS3
CTD	54828 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	BCAS3 Related clones (RZPD - Berlin)
	PubMed
PubMed	10 Pubmed reference(s) in LocusLink

Bibliography

Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that undergo amplification, overexpression, and fusion in breast cancer.

Bˆ§rlund M, Monni O, Weaver JD, Kauraniemi P, Sauter G, Heiskanen M, Kallioniemi OP, Kallioniemi A

Genes, chromosomes & cancer. 2002 ; 35 (4) : 311-317.

PMID 12378525

REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	05-2004	Jean-Loup Huret, Sylvie Senon

Citation

This paper should be referenced as such :

Huret JL, Senon S . BCAS3 (breast carcinoma amplified sequence 3). Atlas Genet Cytogenet Oncol Haematol. May 2004 . URL : http://AtlasGeneticsOncology.org/Genes/BCAS3ID766.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Wed Jul 2 08:22:06 2008