BCAS3 (breast carcinoma amplified sequence 3)

2004-05-01   Jean-Loup Huret , Sylvie Senon 

Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Identity

HGNC
LOCATION
17q23.2
LOCUSID
ALIAS
GAOB1,MAAB,PHAF2
FUSION GENES

DNA/RNA

Description

spans 715 kb; orientation direct strand; at least 77 exons

Transcription

alternate splicings: 3.9 kb, 3.3 kb, 2.3 kb, 1.5 kb, 1.3 kb.

Proteins

Expression

ubiquitous

Localisation

nuclear (potential)

Implicated in

Entity name
BCAS3 is overexpressed in about 10% of breast cancers, and a hybrid gene BCAS4-BCAS3 was found in breat cancer cell line with a t(17;20)(q23;q13)
Hybrid gene
5 BCAS4 is fused to the 2 last exons (23 and 24) of BCAS3; transcript includes exon 1 from BCAS4 and 21 bp from BCAS3 exon 23; it encodes a 66 aminoacids protein; no reciprocal transcript

Bibliography

Pubmed IDLast YearTitleAuthors
123785252002Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that undergo amplification, overexpression, and fusion in breast cancer.Bärlund M et al

Other Information

Locus ID:

NCBI: 54828
MIM: 607470
HGNC: 14347
Ensembl: ENSG00000141376

Variants:

dbSNP: 54828
ClinVar: 54828
TCGA: ENSG00000141376
COSMIC: BCAS3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141376ENST00000390652Q9H6U6
ENSG00000141376ENST00000407086Q9H6U6
ENSG00000141376ENST00000408905Q9H6U6
ENSG00000141376ENST00000585744K7ESE9
ENSG00000141376ENST00000586241K7EIR7
ENSG00000141376ENST00000586484K7EML5
ENSG00000141376ENST00000586705K7EKB0
ENSG00000141376ENST00000587002K7EIE2
ENSG00000141376ENST00000588168K7EJU7
ENSG00000141376ENST00000588462Q9H6U6
ENSG00000141376ENST00000588532K7EQA6
ENSG00000141376ENST00000588874Q9H6U6
ENSG00000141376ENST00000589222Q9H6U6
ENSG00000141376ENST00000590128K7EJH7
ENSG00000141376ENST00000591147K7ELH0
ENSG00000141376ENST00000592848K7EQA6
ENSG00000141376ENST00000626960K7EQA6
ENSG00000141376ENST00000639611K7EIR7

Expression (GTEx)

0
5
10
15
20

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203831462010New loci associated with kidney function and chronic kidney disease.337
166171022006MTA1, a transcriptional activator of breast cancer amplified sequence 3.51
205466122010The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature.19
168553962006Breast cancer-amplified sequence 3, a target of metastasis-associated protein 1, contributes to tamoxifen resistance in premenopausal patients with breast cancer.13
175050582007Estrogen induces expression of BCAS3, a novel estrogen receptor-alpha coactivator, through proline-, glutamic acid-, and leucine-rich protein-1 (PELP1).8
217425842011Maesopsin 4-O-beta-D-glucoside, a natural compound isolated from the leaves of Artocarpus tonkinensis, inhibits proliferation and up-regulates HMOX1, SRXN1 and BCAS3 in acute myeloid leukemia.7
180303362007Human BCAS3 expression in embryonic stem cells and vascular precursors suggests a role in human embryogenesis and tumor angiogenesis.6
298799232018Common variant of BCAS3 is associated with gout risk in Japanese population: the first replication study after gout GWAS in Han Chinese.2
309951572019Rudhira/BCAS3 couples microtubules and intermediate filaments to promote cell migration for angiogenic remodeling.0

Citation

Jean-Loup Huret ; Sylvie Senon

BCAS3 (breast carcinoma amplified sequence 3)

Atlas Genet Cytogenet Oncol Haematol. 2004-05-01

Online version: http://atlasgeneticsoncology.org/gene/766/bcas3