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BCAS4 (breast carcinoma amplified sequence 4)

Identity

Other namesBHLHB4
FLJ20495
HGNC (Hugo) BCAS4
LocusID (NCBI) 55653
Location 20q13
Location_base_pair Starts at 49411467 and ends at 49493714 bp from pter ( according to hg19-Feb_2009)  [Mapping]
 
  Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics

DNA/RNA

Description spans 82 kb; orientation direct strand; 19 exons
Transcription alternate splicings

Protein

Expression ubiquitous
Localisation cytoplasmic

Implicated in

Entity BCAS4 is overexpressed in 3.5% of breast cancers, and a hybrid gene BCAS4-BCAS3 was found in breat cancer cell line with a t(17;20)(q23;q13)
Hybrid/Mutated Gene 5' BCAS4 is fused to the 2 last exons (23 and 24) of BCAS3; transcript includes exon 1 from BCAS4 and 21 bp from BCAS3 exon 23; it encodes a 66 aminoacids protein; no reciprocal transcript
  

External links

Nomenclature
HGNC (Hugo)BCAS4   14367
Entrez_Gene (NCBI)BCAS4  55653  breast carcinoma amplified sequence 4
Cards
AtlasBCAS4ID767
GeneCards (Weizmann)BCAS4
Ensembl (Hinxton)ENSG00000124243 [Gene_View]  chr20:49411467-49493714 [Contig_View]  BCAS4 [Vega]
AceView (NCBI)BCAS4
Genatlas (Paris)BCAS4
euGene (Indiana)55653
SOURCE (Stanford)NM_001010974 NM_017843 NM_198799
Genomic and cartography
GoldenPath (UCSC)BCAS4  -  20q13   chr20:49411467-49493714 +  20q13.13   [Description]    (hg19-Feb_2009)
EnsemblBCAS4 - 20q13.13 [CytoView]
Mapping of homologs : NCBIBCAS4 [Mapview]
OMIM607471   
Gene and transcription
Genbank (Entrez)AF361220 AJ511266 AK000502 BC038381 BC047337
RefSeq transcript (SRS)NM_001010974 NM_017843 NM_198799
RefSeq transcript (Entrez)NM_001010974 NM_017843 NM_198799
RefSeq genomic (SRS)AC_000152 NC_000020 NT_011362 NW_001838666
RefSeq genomic (Entrez)AC_000152 NC_000020 NT_011362 NW_001838666
Consensus coding sequences : CCDS (NCBI)BCAS4
Cluster EST : UnigeneHs.381178 [ SRS ] Hs.381178 [ NCBI ]
Alternative Splicing : Fast-db (Paris)13476
Alternative Splicing GalleryENSG00000124243
Gene ExpressionBCAS4 [ NCBI-GEO ]   BCAS4 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TDM0 (SRS) Q8TDM0 (Uniprot)
With graphics : InterProQ8TDM0
Splice isoforms : SwissVarQ8TDM0(Swissvar)
Domains : Interpro (SRS)Cappuccino   
Domains : Interpro (EBI)Cappuccino   
Related proteins : CluSTrQ8TDM0
Domain families : Pfam (SRS)
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Blocks (Seattle)Q8TDM0
Human Protein AtlasENSG00000124243
HPRD06314
IPIIPI00333686   IPI00394798   IPI00872439   IPI00333687   IPI00945796   
Protein Interaction databases
DIP (DOE-UCLA)Q8TDM0
IntAct (EBI)Q8TDM0
FunCoupENSG00000124243
REACTOMEBCAS4
BioGRIDBCAS4
InParanoidQ8TDM0
Interologous Interaction database Q8TDM0
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)BCAS4
SNP (GeneSNP Utah)BCAS4
SNP : HGBaseBCAS4
Genetic variants : HAPMAPBCAS4
Somatic Mutations in Cancer : COSMICBCAS4 
CONAN: Copy Number AnalysisBCAS4 
Mutations and Diseases : HGMDBCAS4
OMIM607471   
GENETests607471   
Disease Genetic AssociationBCAS4
Huge Navigator BCAS4 [HugePedia]  BCAS4 [HugeCancerGEM]
Genomic VariantsBCAS4
snp3D : Map Gene to Disease55653
General knowledge
Homologs : HomoloGeneBCAS4
Homology/Alignments : Family Browser (UCSC)BCAS4
Phylogenetic Trees/Animal Genes : TreeFamBCAS4
Chemical/Protein Interactions : CTD55653
Chemical/Pharm GKB GenePA25287
Clinical trialBCAS4
Cancer Resource (Charite)ENSG00000124243
Ontology : AmiGOcytoplasm  
Ontology : EGO-EBIcytoplasm  
Other databases
Probes
Probes : ImagenesBCAS4 Related clones (RZPD - Berlin)
Litterature
PubMed7 Pubmed reference(s) in Entrez
PubGeneBCAS4
iHOPBCAS4

Bibliography

p73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation.
Melino G, Bernassola F, Ranalli M, Yee K, Zong WX, Corazzari M, Knight RA, Green DR, Thompson C, Vousden KH
The Journal of biological chemistry. 2004 ; 279 (9) : 8076-8083.
PMID 14634023
 
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written05-2004Jean-Loup Huret, Sylvie Senon

Citation

This paper should be referenced as such :
Huret JL, Senon S . BCAS4 (breast carcinoma amplified sequence 4). Atlas Genet Cytogenet Oncol Haematol. May 2004 .
URL : http://AtlasGeneticsOncology.org/Genes/BCAS4ID767.html

This paper is referenced by INIST as such :
http://documents.irevues.inist.fr/bitstream/2042/38090/1/05-2004-BCAS4ID767.pdf   [ Bibliographic record ]

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indexed on : Sat Apr 28 15:10:34 CEST 2012
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