Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

BCAS4 (breast carcinoma amplified sequence 4)

Written2004-05Jean-Loup Huret, Sylvie Senon
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)


Other aliasBHLHB4
LocusID (NCBI) 55653
Atlas_Id 767
Location 20q13.13  [Link to chromosome band 20q13]
Location_base_pair Starts at and ends at bp from pter
  Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BAIAP2L1 (7q21.3) / BCAS4 (20q13.13)BCAS4 (20q13.13) / ADNP (20q13.13)BCAS4 (20q13.13) / AURKA (20q13.2)
BCAS4 (20q13.13) / BCAS3 (17q23.2)BCAS4 (20q13.13) / PTPN1 (20q13.13)BCAS4 (20q13.13) / ZMYND8 (20q13.12)
ZNRF1 (16q23.1) / BCAS4 (20q13.13)


Description spans 82 kb; orientation direct strand; 19 exons
Transcription alternate splicings


Expression ubiquitous
Localisation cytoplasmic

Implicated in

Entity BCAS4 is overexpressed in 3.5% of breast cancers, and a hybrid gene BCAS4-BCAS3 was found in breat cancer cell line with a t(17;20)(q23;q13)
Hybrid/Mutated Gene 5' BCAS4 is fused to the 2 last exons (23 and 24) of BCAS3; transcript includes exon 1 from BCAS4 and 21 bp from BCAS3 exon 23; it encodes a 66 aminoacids protein; no reciprocal transcript


p73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation.
Melino G, Bernassola F, Ranalli M, Yee K, Zong WX, Corazzari M, Knight RA, Green DR, Thompson C, Vousden KH
The Journal of biological chemistry. 2004 ; 279 (9) : 8076-8083.
PMID 14634023


This paper should be referenced as such :
Huret, JL ; Senon, S
BCAS4 (breast carcinoma amplified sequence 4)
Atlas Genet Cytogenet Oncol Haematol. 2004;8(3):189-189.
Free journal version : [ pdf ]   [ DOI ]
On line version :

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 5 ]
  t(16;20)(q23;q13) ZNRF1/BCAS4
t(17;20)(q23;q13) BCAS4/BCAS3
BCAS4/AURKA (20q13)
BCAS4/PTPN1 (20q13)
BCAS4/ZMYND8 (20q13)

External links

Genomic and cartography
Gene and transcription
RefSeq transcript (Entrez)
RefSeq genomic (Entrez)
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)55653
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Protein Interaction databases
Ontologies - Pathways
Clinical trials, drugs, therapy
canSAR (ICR) (select the gene name)
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Oct 18 17:29:25 CEST 2018

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us