BCL9 (B-cell CLL/lymphoma 9)

Identity

HGNC	BCL9
Location	1q21
Location_base_pair	Starts at 145479806 and ends at 145564639 bp from pter ( according to hg18-Mar_2006).

DNA/RNA

Description	10 exons spanning 85 kb.
Transcription	transcripts of 1.6, 4.2, and 6.3 kb.

Protein

Description	1426 amino acids, 149 kDa.
Expression	wide
Function	Binds to beta-catenin required for Wnt signal transduction
Homology	drosophila segment polarity gene legless, encoding wingless-armadillo (WNT - beta-catenin) signaling molecule

Implicated in

Entity	t(1;14)(q21;q32) and t(1;22)(q21;q11)
Disease	acute lymphoblastic leukemia and non Hodgkin lymphoma
Hybrid/Mutated Gene	BCL9 is juxtaposed either with the immunoglobulin heavy chain locus IgH (14q32) or the lambda light-chain locus Igl (22q11)

External links

	Nomenclature
HGNC	BCL9   1008
Entrez_Gene	BCL9  607  B-cell CLL/lymphoma 9
	Cards
Atlas	BCL9ID466
GeneCards	BCL9
Ensembl	ENSG00000116128 [Gene_View]  BCL9 [Vega]
Genatlas	BCL9
	Genomic and cartography
GoldenPath	BCL9  -  1q21   chr1:145479806-145564639 +  1q21   [Description]    (hg18-Mar_2006)
Ensembl	BCL9 - 1q21 [CytoView]
NCBI	Mapview
OMIM	602597 Disease map [OMIM]
HomoloGene	BCL9
	Gene and transcription
Genbank	BC116451 [ ENTREZ ]
Genbank	CR597072 [ ENTREZ ]
Genbank	Y13620 [ ENTREZ ]
RefSeq	NM_004326 [ SRS ]    NM_004326 [ ENTREZ ]
RefSeq	AC_000044 [ SRS ]    AC_000044 [ ENTREZ ]
RefSeq	AC_000133 [ SRS ]    AC_000133 [ ENTREZ ]
RefSeq	NC_000001 [ SRS ]    NC_000001 [ ENTREZ ]
RefSeq	NT_034400 [ SRS ]    NT_034400 [ ENTREZ ]
RefSeq	NW_001838511 [ SRS ]    NW_001838511 [ ENTREZ ]
RefSeq	NW_924906 [ SRS ]    NW_924906 [ ENTREZ ]
CCDS	BCL9 CCDS - NCBI
AceView	BCL9 AceView - NCBI
Unigene	Hs.415209 [ SRS ]    Hs.415209 [ NCBI ]
Fast-db	17211 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	O00512 [ SRS]    O00512 [ EXPASY ]     O00512 [ INTERPRO ]     O00512 [ UNIPROT ] O00512 [ VarSplice FASTA ]
Interpro	IPR015668 Bcl-9 [ SRS ]    IPR015668 Bcl-9 [ EBI ]
CluSTr	O00512
Blocks	O00512
PDB	2GL7 [ SRS ]    2GL7 [ PdbSum ],   2GL7 [ IMB ]   2GL7 [ RSDB ]
HPRD	04000
	Protein Interaction databases
DIP	O00512
IntAct	O00512
	Polymorphism : SNP, mutations, diseases
OMIM	602597    [ map ]
GENETests	602597
SNP	BCL9 [dbSNP-NCBI]
SNP	NM_004326 [SNP-NCI]
SNP	BCL9 [GeneSNPs - Utah]  BCL9] [HGBASE - SRS]
HAPMAP	BCL9 [HAPMAP]
COSMIC	BCL9 [Somatic mutation (COSMIC-CGP-Sanger)]
TICdb	BCL9 [Translocation breakpoints In Cancer]
HGMD	BCL9
Genetic Association	BCL9
CDC HuGE	BCL9
	General knowledge
Family Browser	BCL9 [UCSC Family Browser]
SOURCE	NM_004326
SMD	Hs.415209
SAGE	Hs.415209
GO	protein binding [Amigo]  protein binding
GO	nucleus [Amigo]  nucleus
GO	Wnt receptor signaling pathway [Amigo]  Wnt receptor signaling pathway
PubGene	BCL9
TreeFam	BCL9
CTD	607 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	BCL9 Related clones (RZPD - Berlin)
	PubMed
PubMed	12 Pubmed reference(s) in Entrez

Bibliography

Molecular cloning of translocation t(1;14)(q21;q32) defines a novel gene (BCL9) at chromosome 1q21.

Willis TG, Zalcberg IR, Coignet LJ, Wlodarska I, Stul M, Jadayel DM, Bastard C, Treleaven JG, Catovsky D, Silva ML, Dyer MJ

Blood. 1998 ; 91 (6) : 1873-1881.

PMID 9490669

Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex.

Kramps T, Peter O, Brunner E, Nellen D, Froesch B, Chatterjee S, Murone M, Zˆºllig S, Basler K

Cell. 2002 ; 109 (1) : 47-60.

PMID 11955446

REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	02-2003	Jean-Loup Huret, Sylvie Senon

Citation

This paper should be referenced as such :

Huret JL, Senon S . BCL9 (B-cell CLL/lymphoma 9). Atlas Genet Cytogenet Oncol Haematol. February 2003 . URL : http://AtlasGeneticsOncology.org/Genes/BCL9ID466.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Dec 6 17:54:09 2008