CAGE-1 (cancer-associated gene-1)

Identity

Hugo	CAGE1
Location	6p24.3

DNA/RNA

Description

spans 63 kb; 11 exons; ORF: 1920 bp

Protein

Description	639 amino acids;73 kDa; carry 2 consensus glycosylation sites, 10 PKC dependent phosphorylation sites
Expression	testis-restricted in normal tissues; wide/high expression in various cancer tissues (lung, cervix, stomach) CAG1 is a probable member of the cancer/testis antigen family
Localisation	mainly nuclear
Function	may be involved in signaling pathway
Homology	with monkey genes with testis specific expression

Mutations

Somatic

may be associated with tumor progression .

External links

	Nomenclature
Hugo	CAGE1
GDB	CAGE1
Entrez_Gene	CAGE1  285782  cancer antigen 1
	Cards
Atlas	CAG1ID475
GeneCards	CAGE1
Ensembl	CAGE1 [Search_View]   ENSG00000175753 [Gene_View]
Genatlas	CAGE1
GeneLynx	CAGE1
eGenome	CAGE1
euGene	285782
	Genomic and cartography
GoldenPath	CAGE1  -  6p24.3   chr6:7271888-7334941 -  6p24.3   [Description]    (hg18-Mar_2006)
Ensembl	CAGE1 - 6p24.3 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	CAGE1
	Gene and transcription
Genbank	AF414185 [ ENTREZ ]
Genbank	AK097760 [ ENTREZ ]
Genbank	BC026188 [ ENTREZ ]
Genbank	BC026194 [ ENTREZ ]
Genbank	BC033545 [ ENTREZ ]
RefSeq	NM_175745 [ SRS ]    NM_175745 [ ENTREZ ]
RefSeq	NM_205864 [ SRS ]    NM_205864 [ ENTREZ ]
RefSeq	AC_000049 [ SRS ]    AC_000049 [ ENTREZ ]
RefSeq	NC_000006 [ SRS ]    NC_000006 [ ENTREZ ]
RefSeq	NT_034880 [ SRS ]    NT_034880 [ ENTREZ ]
RefSeq	NW_922984 [ SRS ]    NW_922984 [ ENTREZ ]
AceView	CAGE1 AceView - NCBI
Unigene	Hs.367936 [ SRS ]    Hs.367936 [ NCBI ]     HS367936 [ spliceNest ]
Fast-db	1908 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q8TC20 [ SRS]    Q8TC20 [ EXPASY ]     Q8TC20 [ INTERPRO ]
CluSTr	Q8TC20
Blocks	Q8TC20
HPRD	10511
	Protein Interaction databases
DIP	Q8TC20
IntAct	Q8TC20
	Polymorphism : SNP, mutations, diseases
OMIM	608304    [ map ]
GENECLINICS	608304
SNP	CAGE1 [dbSNP-NCBI]
SNP	NM_175745 [SNP-NCI]
SNP	NM_205864 [SNP-NCI]
SNP	CAGE1 [GeneSNPs - Utah]  CAGE1] [HGBASE - SRS]
HAPMAP	CAGE1 [HAPMAP]
HGMD	CAGE1
	General knowledge
Family Browser	CAGE1 [UCSC Family Browser]
SOURCE	NM_175745
SOURCE	NM_205864
SMD	Hs.367936
SAGE	Hs.367936
PubGene	CAGE1
TreeFam	CAGE1
CTD	285782 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	CAGE1 Related clones (RZPD - Berlin)
	PubMed
PubMed	8 Pubmed reference(s) in LocusLink

Bibliography

Identification and characterization of a novel cancer/testis antigen gene CAGE-1.

Park S, Lim Y, Lee D, Cho B, Bang YJ, Sung S, Kim HY, Kim DK, Lee YS, Song Y, Jeoung DI

Biochimica et biophysica acta. 2003 ; 1625 (2) : 173-182.

PMID 12531476

REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	07-2003	Jean-Loup Huret, Sylvie Senon

Citation

This paper should be referenced as such :

Huret JL, Senon S . CAGE-1 (cancer-associated gene-1). Atlas Genet Cytogenet Oncol Haematol. July 2003 . URL : http://AtlasGeneticsOncology.org/Genes/CAG1ID475.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Wed Jul 2 08:22:23 2008