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CAGE1 (cancer-associated gene-1)

Written2003-07Jean-Loup Huret, Sylvie Senon
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)

Identity

Alias_namesCTAG3
cancer/testis antigen 3
Alias_symbol (synonym)bA69L16.7
CT95
Other aliasCAGE-1 (cancer-associated gene-1)
HGNC (Hugo) CAGE1
LocusID (NCBI) 285782
Atlas_Id 475
Location 6p24.3  [Link to chromosome band 6p24]
Location_base_pair Starts at 7326654 and ends at 7389709 bp from pter ( according to hg19-Feb_2009)  [Mapping CAGE1.png]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
RPS3 (11q13.4) / CAGE1 (6p24.3)SSR1 (6p24.3) / CAGE1 (6p24.3)

DNA/RNA

Description spans 63 kb; 11 exons; ORF: 1920 bp

Protein

Description 639 amino acids;73 kDa; carry 2 consensus glycosylation sites, 10 PKC dependent phosphorylation sites
Expression testis-restricted in normal tissues; wide/high expression in various cancer tissues (lung, cervix, stomach) CAG1 is a probable member of the cancer/testis antigen family
Localisation mainly nuclear
Function may be involved in signaling pathway
Homology with monkey genes with testis specific expression

Mutations

Somatic may be associated with tumor progression .

Bibliography

Identification and characterization of a novel cancer/testis antigen gene CAGE-1.
Park S, Lim Y, Lee D, Cho B, Bang YJ, Sung S, Kim HY, Kim DK, Lee YS, Song Y, Jeoung DI
Biochimica et biophysica acta. 2003 ; 1625 (2) : 173-182.
PMID 12531476
 

Citation

This paper should be referenced as such :
Huret, JL ; Senon, S
CAGE-1 (cancer-associated gene-1)
Atlas Genet Cytogenet Oncol Haematol. 2003;7(3):169-169.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/CAG1ID475.html


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  SSR1/CAGE1 (6p24)


External links

Nomenclature
HGNC (Hugo)CAGE1   21622
Cards
AtlasCAG1ID475
Entrez_Gene (NCBI)CAGE1  285782  cancer antigen 1
AliasesCT3; CT95; CTAG3; bA69L16.7
GeneCards (Weizmann)CAGE1
Ensembl hg19 (Hinxton)ENSG00000164304 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000164304 [Gene_View]  ENSG00000164304 [Sequence]  chr6:7326654-7389709 [Contig_View]  CAGE1 [Vega]
ICGC DataPortalENSG00000164304
TCGA cBioPortalCAGE1
AceView (NCBI)CAGE1
Genatlas (Paris)CAGE1
WikiGenes285782
SOURCE (Princeton)CAGE1
Genetics Home Reference (NIH)CAGE1
Genomic and cartography
GoldenPath hg38 (UCSC)CAGE1  -     chr6:7326654-7389709 -  6p24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CAGE1  -     6p24.3   [Description]    (hg19-Feb_2009)
EnsemblCAGE1 - 6p24.3 [CytoView hg19]  CAGE1 - 6p24.3 [CytoView hg38]
Mapping of homologs : NCBICAGE1 [Mapview hg19]  CAGE1 [Mapview hg38]
OMIM608304   
Gene and transcription
Genbank (Entrez)AF414185 AK097760 BC026188 BC026194 BC033545
RefSeq transcript (Entrez)NM_001170692 NM_001170693 NM_175745 NM_205864
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CAGE1
Cluster EST : UnigeneHs.721486 [ NCBI ]
CGAP (NCI)Hs.721486
Alternative Splicing GalleryENSG00000164304
Gene ExpressionCAGE1 [ NCBI-GEO ]   CAGE1 [ EBI - ARRAY_EXPRESS ]   CAGE1 [ SEEK ]   CAGE1 [ MEM ]
Gene Expression Viewer (FireBrowse)CAGE1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)285782
GTEX Portal (Tissue expression)CAGE1
Human Protein AtlasENSG00000164304-CAGE1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TC20   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TC20  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TC20
Splice isoforms : SwissVarQ8TC20
PhosPhoSitePlusQ8TC20
Domains : Interpro (EBI)CAGE1   
Domain families : Pfam (Sanger)CAGE1 (PF15066)   
Domain families : Pfam (NCBI)pfam15066   
Conserved Domain (NCBI)CAGE1
DMDM Disease mutations285782
Blocks (Seattle)CAGE1
SuperfamilyQ8TC20
Human Protein Atlas [tissue]ENSG00000164304-CAGE1 [tissue]
Peptide AtlasQ8TC20
HPRD10511
IPIIPI00830133   IPI00479345   IPI00175214   IPI00964524   IPI00514516   IPI00966465   IPI00965958   IPI00641588   
Protein Interaction databases
DIP (DOE-UCLA)Q8TC20
IntAct (EBI)Q8TC20
FunCoupENSG00000164304
BioGRIDCAGE1
STRING (EMBL)CAGE1
ZODIACCAGE1
Ontologies - Pathways
QuickGOQ8TC20
Ontology : AmiGOprotein binding  
Ontology : EGO-EBIprotein binding  
NDEx NetworkCAGE1
Atlas of Cancer Signalling NetworkCAGE1
Wikipedia pathwaysCAGE1
Orthology - Evolution
OrthoDB285782
GeneTree (enSembl)ENSG00000164304
Phylogenetic Trees/Animal Genes : TreeFamCAGE1
HOVERGENQ8TC20
HOGENOMQ8TC20
Homologs : HomoloGeneCAGE1
Homology/Alignments : Family Browser (UCSC)CAGE1
Gene fusions - Rearrangements
Fusion : MitelmanSSR1/CAGE1 [6p24.3/6p24.3]  [t(6;6)(p24;p24)]  
Fusion PortalSSR1 6p24.3 CAGE1 6p24.3 BRCA
Fusion Cancer (Beijing)RPS3 [11q13.4]  -  CAGE1 [6p24.3]  [FUSC004555]
Fusion : QuiverCAGE1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCAGE1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CAGE1
dbVarCAGE1
ClinVarCAGE1
1000_GenomesCAGE1 
Exome Variant ServerCAGE1
ExAC (Exome Aggregation Consortium)ENSG00000164304
GNOMAD BrowserENSG00000164304
Varsome BrowserCAGE1
Genetic variants : HAPMAP285782
Genomic Variants (DGV)CAGE1 [DGVbeta]
DECIPHERCAGE1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCAGE1 
Mutations
ICGC Data PortalCAGE1 
TCGA Data PortalCAGE1 
Broad Tumor PortalCAGE1
OASIS PortalCAGE1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCAGE1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCAGE1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CAGE1
DgiDB (Drug Gene Interaction Database)CAGE1
DoCM (Curated mutations)CAGE1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CAGE1 (select a term)
intoGenCAGE1
NCG5 (London)CAGE1
Cancer3DCAGE1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608304   
Orphanet
DisGeNETCAGE1
MedgenCAGE1
Genetic Testing Registry CAGE1
NextProtQ8TC20 [Medical]
TSGene285782
GENETestsCAGE1
Target ValidationCAGE1
Huge Navigator CAGE1 [HugePedia]
snp3D : Map Gene to Disease285782
BioCentury BCIQCAGE1
ClinGenCAGE1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD285782
Chemical/Pharm GKB GenePA134933951
Clinical trialCAGE1
Miscellaneous
canSAR (ICR)CAGE1 (select the gene name)
Probes
Litterature
PubMed12 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCAGE1
EVEXCAGE1
GoPubMedCAGE1
iHOPCAGE1
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 12:02:55 CET 2018

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jlhuret@AtlasGeneticsOncology.org.