PICALM (clathrin assembly lymphoid myeloid leukemia gene)

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PICALM (clathrin assembly lymphoid myeloid leukemia gene)

Written	1998-01	Jean-Loup Huret
		Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)

Identity

Alias_symbol (synonym)	CALM
	CLTH
Other alias
HGNC (Hugo)	PICALM
LocusID (NCBI)	8301
Atlas_Id	64
Location	11q14.2 [Link to chromosome band 11q14]
Location_base_pair	Starts at 85957171 and ends at 86069097 bp from pter ( according to hg19-Feb_2009) [Mapping PICALM.png]


	Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics

Fusion genes
(updated 2017)

Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

ARRB1 (11q13.4) / PICALM (11q14.2)	CCDC83 (11q14.1) / PICALM (11q14.2)	COL6A3 (2q37.3) / PICALM (11q14.2)
DLG2 (11q14.1) / PICALM (11q14.2)	FAM21A (10q11.23) / PICALM (11q14.2)	HIKESHI (11q14.2) / PICALM (11q14.2)
KMT2A (11q23.3) / PICALM (11q14.2)	MLLT10 (10p12.31) / PICALM (11q14.2)	PICALM (11q14.2) / ABRAXAS1 (4q21.23)
PICALM (11q14.2) / BRDT (1p22.1)	PICALM (11q14.2) / CCDC81 (11q14.2)	PICALM (11q14.2) / DIAPH1 (5q31.3)
PICALM (11q14.2) / KMT2A (11q23.3)	PICALM (11q14.2) / MLLT10 (10p12.31)	PICALM (11q14.2) / PICALM (11q14.2)
PICALM (11q14.2) / TF (3q22.1)	RCC1 (1p35.3) / PICALM (11q14.2)	SYTL2 (11q14.1) / PICALM (11q14.2)
TMEM123 (11q22.2) / PICALM (11q14.2)	TMX2 (11q12.1) / PICALM (11q14.2)	TYR (11q14.3) / PICALM (11q14.2)

Note	Must not be confused with CALM1 (calmodulin 1, sitting in 14q24-31), or with neurofibromatosis type 6 (also called CALM, for: cafe au lait spots multiple); therefore the name is likely to change.

DNA/RNA

Transcription

Major mRNA: 4 kb; other: 3 and 9 kb.

Protein



Description	652 amino acids.
Function	Role in the integration of signals from different pathways (clathrin, phosphoinositols, receptor-mediated endocytosis).
Homology	With AP3 (Adaptor Related Proteins), a clathrin assembly protein, and SNAP91 (AP180).

Implicated in


Entity	t(10;11)(p13;q14-21) PICALM / MLLT10
Disease	T-cell acute lymphoblastic leukemia (ALL) mainly; at times acute myeloid leukemia (AML) and/or AML with T-cell markers (Dreyling et al., 1996; Kobayashi et al., 1997).
Prognosis	uncertain (median survival 2 yrs?).
Cytogenetics	may well be confused with the t(10;11)(p12;q23) , where KMT2A in 11q23 is involved, instead of PICALM
Hybrid/Mutated Gene	5' PICALM - 3' MLLT10
Abnormal Protein	Both PICALM-MLLT10 and the reciprocal MLLT10-PICALM are expressed.


Entity	t(11;11)(q14;q23) KMT2A / PICALM
Disease	AML and B-cell ALL (Meyer et al., 2013; Wechsler et al., 2003).
Hybrid/Mutated Gene	5' KMT2A - 3' PICALM
Abnormal Protein	The KMT2A/PICALM fusion protein was contained 1803 amino acids and included 1406 amino acids from KMT2A A-T hooks and repression domain, and a PICALM-derived clathrin-binding domain in Wechsler et al., 2003.

Breakpoints

Bibliography

The t(10;11)(p13;q14) in the U937 cell line results in the fusion of the AF10 gene and CALM, encoding a new member of the AP-3 clathrin assembly protein family.

Dreyling MH, Martinez-Climent JA, Zheng M, Mao J, Rowley JD, Bohlander SK.

Proc Natl Acad Sci U S A. 1996 May 14;93(10):4804-9.

PMID 8643484

Hematologic malignancies with the t(10;11) (p13;q21) have the same molecular event and a variety of morphologic or immunologic phenotypes.

Kobayashi H, Hosoda F, Maseki N, Sakurai M, Imashuku S, Ohki M, Kaneko Y.

Genes Chromosomes Cancer. 1997 Nov;20(3):253-9.

PMID 9365832

The MLL recombinome of acute leukemias in 2013.

Meyer C, Hofmann J, Burmeister T, Gröger D, Park TS, Emerenciano M, Pombo de Oliveira M, Renneville A, Villarese P, Macintyre E, Cavé H, Clappier E, Mass-Malo K, Zuna J, Trka J, De Braekeleer E, De Braekeleer M, Oh SH, Tsaur G, Fechina L, van der Velden VH, van Dongen JJ, Delabesse E, Binato R, Silva ML, Kustanovich A, Aleinikova O, Harris MH, Lund-Aho T, Juvonen V, Heidenreich O, Vormoor J, Choi WW, Jarosova M, Kolenova A, Bueno C, Menendez P, Wehner S, Eckert C, Talmant P, Tondeur S, Lippert E, Launay E, Henry C, Ballerini P, Lapillone H, Callanan MB, Cayuela JM, Herbaux C, Cazzaniga G, Kakadiya PM, Bohlander S, Ahlmann M, Choi JR, Gameiro P, Lee DS, Krauter J, Cornillet-Lefebvre P, Te Kronnie G, Schäfer BW, Kubetzko S, Alonso CN, zur Stadt U, Sutton R, Venn NC, Izraeli S, Trakhtenbrot L, Madsen HO, Archer P, Hancock J, Cerveira N, Teixeira MR, Lo Nigro L, Möricke A, Stanulla M, Schrappe M, Sedék L, Szczepa?ski T, Zwaan CM, Coenen EA, van den Heuvel-Eibrink MM, Strehl S, Dworzak M, Panzer-Grümayer R, Dingermann T, Klingebiel T, Marschalek R.

Leukemia. 2013 Nov;27(11):2165-76. doi: 10.1038/leu.2013.135.

PMID 23628958

A novel chromosomal inversion at 11q23 in infant acute myeloid leukemia fuses MLL to CALM, a gene that encodes a clathrin assembly protein.

Wechsler DS, Engstrom LD, Alexander BM, Motto DG, Roulston D.

Genes Chromosomes Cancer. 2003 Jan;36(1):26-36.

PMID 12461747

Citation

This paper should be referenced as such :

Jean-Loup Huret

PICALM (phosphatidylinositol binding clathrin assembly protein)

Atlas Genet Cytogenet Oncol Haematol. 1998;2(1):1-1.

Free journal version : [ pdf ] [ DOI ]

On line version : http://AtlasGeneticsOncology.org/Genes/CALMID64.html

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 4 ]

Pediatric T-Cell Acute Lymphoblastic Leukemia
t(10;11)(p12;q21) PICALM/MLLT10
t(11;11)(q14;q23) KMT2A/PICALM::inv(11)(q14q23) KMT2A/PICALM
t(1;11)(p35;q14) RCC1/PICALM

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]

Lung: Translocations in Small Cell Carcinoma
t(11;11)(q13;q14) ARRB1/PICALM
SYTL2/PICALM (11q14)
PICALM/CCDC81 (11q14)

External links

	Nomenclature
HGNC (Hugo)	PICALM 15514
	Cards
Atlas	CALMID64
Entrez_Gene (NCBI)	PICALM 8301 phosphatidylinositol binding clathrin assembly protein
Aliases	CALM; CLTH; LAP
GeneCards (Weizmann)	PICALM
Ensembl hg19 (Hinxton)	ENSG00000073921 [Gene_View]
Ensembl hg38 (Hinxton)	ENSG00000073921 [Gene_View] ENSG00000073921 [Sequence] chr11:85957171-86069097 [Contig_View] PICALM [Vega]
ICGC DataPortal	ENSG00000073921
TCGA cBioPortal	PICALM
AceView (NCBI)	PICALM
Genatlas (Paris)	PICALM
WikiGenes	8301
SOURCE (Princeton)	PICALM
Genetics Home Reference (NIH)	PICALM
	Genomic and cartography
GoldenPath hg38 (UCSC)	PICALM - chr11:85957171-86069097 - 11q14.2 [Description] (hg38-Dec_2013)
GoldenPath hg19 (UCSC)	PICALM - 11q14.2 [Description] (hg19-Feb_2009)
GoldenPath	PICALM - 11q14.2 [CytoView hg19] PICALM - 11q14.2 [CytoView hg38]
ImmunoBase	ENSG00000073921
Mapping of homologs : NCBI	PICALM [Mapview hg19] PICALM [Mapview hg38]
OMIM	601626 603025
	Gene and transcription
Genbank (Entrez)	AB210017 AB451308 AF060939 AF060940 AK128786
RefSeq transcript (Entrez)	NM_001008660 NM_001206946 NM_001206947 NM_007166
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)	PICALM
Cluster EST : Unigene	Hs.163893 [ NCBI ]
CGAP (NCI)	Hs.163893
Alternative Splicing Gallery	ENSG00000073921
Gene Expression	PICALM [ NCBI-GEO ] PICALM [ EBI - ARRAY_EXPRESS ] PICALM [ SEEK ] PICALM [ MEM ]
Gene Expression Viewer (FireBrowse)	PICALM [ Firebrowse - Broad ]
SOURCE (Princeton)	Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60]
Genevestigator	Expression in : [tissues] [cell-lines] [cancer] [perturbations]
BioGPS (Tissue expression)	8301
GTEX Portal (Tissue expression)	PICALM
Human Protein Atlas	ENSG00000073921-PICALM [pathology] [cell] [tissue]
	Protein : pattern, domain, 3D structure
UniProt/SwissProt	Q13492 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction]
NextProt	Q13492 [Sequence] [Exons] [Medical] [Publications]
With graphics : InterPro	Q13492
Splice isoforms : SwissVar	Q13492
PhosPhoSitePlus	Q13492
Domaine pattern : Prosite (Expaxy)	ENTH (PS50942)
Domains : Interpro (EBI)	ANTH_dom Clathrin_AP_dom2 ENTH ENTH_VHS PICALM
Domain families : Pfam (Sanger)	ANTH (PF07651)
Domain families : Pfam (NCBI)	pfam07651
Domain families : Smart (EMBL)	ENTH (SM00273)
Conserved Domain (NCBI)	PICALM
DMDM Disease mutations	8301
Blocks (Seattle)	PICALM
Superfamily	Q13492
Human Protein Atlas [tissue]	ENSG00000073921-PICALM [tissue]
Peptide Atlas	Q13492
HPRD	04320
IPI	IPI00290738 IPI00216184 IPI00400849 IPI00981891 IPI00455611 IPI00984627 IPI00980570 IPI00980475 IPI00978502 IPI00977780 IPI00977120 IPI00975853 IPI00976441 IPI00983898 IPI00982453 IPI00983288 IPI00981984
	Protein Interaction databases
DIP (DOE-UCLA)	Q13492
IntAct (EBI)	Q13492
FunCoup	ENSG00000073921
BioGRID	PICALM
STRING (EMBL)	PICALM
ZODIAC	PICALM
	Ontologies - Pathways
QuickGO	Q13492
Ontology : AmiGO	SNARE binding SNARE binding amyloid-beta binding protein binding 1-phosphatidylinositol binding 1-phosphatidylinositol binding phosphatidylinositol-4,5-bisphosphate binding phosphatidylinositol-4,5-bisphosphate binding nucleus early endosome Golgi apparatus cytosol plasma membrane plasma membrane clathrin-coated pit clathrin-coated pit clathrin-coated pit endocytosis endocytosis receptor-mediated endocytosis vesicle budding from membrane vesicle budding from membrane axonogenesis learning or memory synaptic vesicle cell surface negative regulation of gene expression membrane synaptic vesicle budding from presynaptic endocytic zone membrane synaptic vesicle maturation vesicle-mediated transport endosomal transport Rab GTPase binding hemopoiesis regulation of endocytosis AP-2 adaptor complex clathrin coat of coated pit clathrin-coated vesicle clathrin-coated vesicle clathrin binding intrinsic component of membrane receptor internalization vesicle clathrin heavy chain binding clathrin heavy chain binding regulation of protein localization cargo loading into vesicle presynaptic membrane presynaptic membrane neuronal cell body intracellular membrane-bounded organelle positive regulation of GTPase activity postsynaptic membrane cadherin binding clathrin-coated endocytic vesicle positive regulation of transcription, DNA-templated tau protein binding negative regulation of receptor-mediated endocytosis clathrin coat assembly perinuclear region of cytoplasm synaptic vesicle endocytosis dendrite morphogenesis low-density lipoprotein particle receptor binding iron ion homeostasis membrane organization protein-containing complex assembly endosome to plasma membrane transport vesicle clathrin-dependent endocytosis clathrin-dependent endocytosis modulation of age-related behavioral decline neurofibrillary tangle regulation of vesicle size membrane bending extrinsic component of presynaptic endocytic zone membrane amyloid-beta clearance by transcytosis amyloid-beta clearance by transcytosis positive regulation of neuron death regulation of amyloid-beta formation positive regulation of amyloid-beta formation regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process negative regulation of protein localization to plasma membrane clathrin-coated pit assembly negative regulation of protein localization to cell surface
Ontology : EGO-EBI	SNARE binding SNARE binding amyloid-beta binding protein binding 1-phosphatidylinositol binding 1-phosphatidylinositol binding phosphatidylinositol-4,5-bisphosphate binding phosphatidylinositol-4,5-bisphosphate binding nucleus early endosome Golgi apparatus cytosol plasma membrane plasma membrane clathrin-coated pit clathrin-coated pit clathrin-coated pit endocytosis endocytosis receptor-mediated endocytosis vesicle budding from membrane vesicle budding from membrane axonogenesis learning or memory synaptic vesicle cell surface negative regulation of gene expression membrane synaptic vesicle budding from presynaptic endocytic zone membrane synaptic vesicle maturation vesicle-mediated transport endosomal transport Rab GTPase binding hemopoiesis regulation of endocytosis AP-2 adaptor complex clathrin coat of coated pit clathrin-coated vesicle clathrin-coated vesicle clathrin binding intrinsic component of membrane receptor internalization vesicle clathrin heavy chain binding clathrin heavy chain binding regulation of protein localization cargo loading into vesicle presynaptic membrane presynaptic membrane neuronal cell body intracellular membrane-bounded organelle positive regulation of GTPase activity postsynaptic membrane cadherin binding clathrin-coated endocytic vesicle positive regulation of transcription, DNA-templated tau protein binding negative regulation of receptor-mediated endocytosis clathrin coat assembly perinuclear region of cytoplasm synaptic vesicle endocytosis dendrite morphogenesis low-density lipoprotein particle receptor binding iron ion homeostasis membrane organization protein-containing complex assembly endosome to plasma membrane transport vesicle clathrin-dependent endocytosis clathrin-dependent endocytosis modulation of age-related behavioral decline neurofibrillary tangle regulation of vesicle size membrane bending extrinsic component of presynaptic endocytic zone membrane amyloid-beta clearance by transcytosis amyloid-beta clearance by transcytosis positive regulation of neuron death regulation of amyloid-beta formation positive regulation of amyloid-beta formation regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process negative regulation of protein localization to plasma membrane clathrin-coated pit assembly negative regulation of protein localization to cell surface
REACTOME	Q13492 [protein]
REACTOME Pathways	R-HSA-8856828 [pathway]
NDEx Network	PICALM
Atlas of Cancer Signalling Network	PICALM
Wikipedia pathways	PICALM
	Orthology - Evolution
OrthoDB	8301
GeneTree (enSembl)	ENSG00000073921
Phylogenetic Trees/Animal Genes : TreeFam	PICALM
HOGENOM	Q13492
Homologs : HomoloGene	PICALM
Homology/Alignments : Family Browser (UCSC)	PICALM
	Gene fusions - Rearrangements
Fusion : Mitelman	ARRB1/PICALM [11q13.4/11q14.2] [t(11;11)(q13;q14)]
Fusion : Mitelman	MLLT10/PICALM [10p12.31/11q14.2] [t(10;11)(p12;q14)]
Fusion : Mitelman	PICALM/CCDC81 [11q14.2/11q14.2] [t(11;11)(q14;q14)]
Fusion : Mitelman	PICALM/MLLT10 [11q14.2/10p12.31] [t(10;11)(p12;q14)] [t(10;11)(p12;q23)]
	[t(10;19;11)(p12;p13;q14)] [t(9;11)(p12;q14)]
Fusion : Mitelman	RCC1/PICALM [1p35.3/11q14.2] [t(1;11)(p35;q14)]
Fusion : Mitelman	SYTL2/PICALM [11q14.1/11q14.2] [t(11;11)(q14;q14)]
Fusion : COSMIC	KMT2A [11q23.3] - PICALM [11q14.2] [fusion_1966] [fusion_1967]
Fusion Portal	ARRB1 11q13.4 PICALM 11q14.2 BRCA
Fusion Portal	MLLT10 10p12.31 PICALM 11q14.2 LAML
Fusion Portal	PICALM 11q14.2 MLLT10 10p12.31 LAML
Fusion Portal	PICALM 11q14.2 RP11-849H4.2 BRCA
Fusion : TICdb	KMT2A [11q23.3] - PICALM [11q14.2]
Fusion : TICdb	PICALM [11q14.2] - MLLT10 [10p12.31]
Fusion Cancer (Beijing)	cytochrome_b [PICALM] - 11q14.2 [FUSC002836]
Fusion : FusionGDB	1856 19106 22150 27094 27095 27096 27097 27098 27099 27100 27101 27102 27103 2840 38829
	8003
Fusion : Fusion_Hub	AAR2--PICALM AC009403.2--PICALM AF10--PICALM AF1Q--PICALM AKT3--PICALM ALK--PICALM APLP2--PICALM ARHGAP24--PICALM ARHGAP26--PICALM ARRB1--PICALM ASPH--PICALM ATG3--PICALM ATP1A1--PICALM ATP9A--PICALM B2M--PICALM
	BRAF--PICALM C11ORF73--PICALM C2ORF27A--PICALM CALCOCO2--PICALM CBL--PICALM CCDC3--PICALM CCDC81--PICALM CCDC82--PICALM CCDC83--PICALM CCDC90B--PICALM CD44--PICALM CDKAL1--PICALM CHORDC1--PICALM CLIP1--PICALM CLNS1A--PICALM
	COL6A3--PICALM CSNK1E--PICALM CTNND1--PICALM CTSC--PICALM CYTOCHROME_B--PICALM DACT3--PICALM DDN--PICALM DDX10--PICALM DGAT2--PICALM DHTKD1--PICALM DHX36--PICALM DLG2--PICALM DR1--PICALM DTNA--PICALM DYNC2H1--PICALM
	DYSF--PICALM ECHDC2--PICALM EIF3E--PICALM EIF3F--PICALM EP400--PICALM EPS8--PICALM ETV4--PICALM FAM180B--PICALM FAM35A--PICALM FBXL22--PICALM FBXL5--PICALM FBXW2--PICALM FNBP4--PICALM FUCA2--PICALM GAB2--PICALM
	GNPTG--PICALM GPATCH2L--PICALM HIST1H2BD--PICALM HOXB6--PICALM HSD17B7--PICALM IGF2R--PICALM IL15RA--PICALM IL1R2--PICALM JAM3--PICALM KANSL3--PICALM KATNBL1--PICALM KIAA1671--PICALM KMT2A--PICALM LANCL1--PICALM LMCD1--PICALM
	MEF2A--PICALM MGAT4A--PICALM MLL--PICALM MLLT10--PICALM MRAS--PICALM MTMR2--PICALM MTX2--PICALM MYL9--PICALM NBPF24--PICALM NCOR1--PICALM NFRKB--PICALM NME2--PICALM NPTN--PICALM NTRK2--PICALM PCF11--PICALM
	PCNX--PICALM PDE9A--PICALM PDLIM5--PICALM PHLDB1--PICALM PICALM--ALOX5 PICALM--ARPP19 PICALM--BRDT PICALM--C11ORF73 PICALM--CCAR2 PICALM--CCDC81 PICALM--CD59 PICALM--CD82 PICALM--CHD2 PICALM--CHMP1A PICALM--CSNK1D
	PICALM--CYSTM1 PICALM--DDX10 PICALM--DDX21 PICALM--DIAPH1 PICALM--DYNLT1 PICALM--EED PICALM--FAM120B PICALM--FAM192A PICALM--FUS PICALM--HSPA9 PICALM--MARK2 PICALM--MAX PICALM--ME3 PICALM--MINOS1-NBL1 PICALM--MLL
	PICALM--MLLT10 PICALM--NNMT PICALM--PICALM PICALM--PIK3R4 PICALM--PNRC1 PICALM--PPME1 PICALM--PRB3 PICALM--PSMA5 PICALM--PTBP3 PICALM--RCC1 PICALM--RP11-849H4.2 PICALM--SERGEF PICALM--SLC38A1 PICALM--SYTL2 PICALM--TEX10
	PICALM--TF PICALM--THRAP3 PICALM--TMEM135 PICALM--TMEM57 PICALM--UBE2D3 PICALM--YAP1 PILRB--PICALM PJA2--PICALM PNLIPRP1--PICALM PRSS23--PICALM PSPC1--PICALM PTPRG--PICALM RAB10--PICALM RAB12--PICALM RDH10--PICALM
	RDX--PICALM RP11-1055B8.7--PICALM RP2--PICALM RPTOR--PICALM RSF1--PICALM SBF2--PICALM SLC15A4--PICALM SLC24A3--PICALM SLC37A3--PICALM SMCO4--PICALM SNAP91--PICALM SOCS4--PICALM SORCS2--PICALM SSFA2--PICALM STK17B--PICALM
	STK38--PICALM SYTL2--PICALM SYTL3--PICALM TBC1D1--PICALM TBC1D25--PICALM TBCEL--PICALM TCF4--PICALM TGFBR2--PICALM TMEM123--PICALM TMEM126B--PICALM TMEM131--PICALM TMEM135--PICALM TMEM59--PICALM TMTC2--PICALM TMX2--PICALM
	TYR--PICALM U2AF1--PICALM UBE2B--PICALM UBE2D3--PICALM UGT1A6--PICALM UPF3A--PICALM WNK1--PICALM ZBED1--PICALM ZKSCAN1--PICALM ZNF286A--PICALM ZNF395--PICALM ZWILCH--PICALM
Fusion : Quiver	PICALM
	Polymorphisms : SNP and Copy number variants
NCBI Variation Viewer	PICALM [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)	PICALM
dbVar	PICALM
ClinVar	PICALM
1000_Genomes	PICALM
Exome Variant Server	PICALM
ExAC (Exome Aggregation Consortium)	ENSG00000073921
GNOMAD Browser	ENSG00000073921
Varsome Browser	PICALM
Genetic variants : HAPMAP	8301
Genomic Variants (DGV)	PICALM [DGVbeta]
DECIPHER	PICALM [patients] [syndromes] [variants] [genes]
CONAN: Copy Number Analysis	PICALM
	Mutations
ICGC Data Portal	PICALM
TCGA Data Portal	PICALM
Broad Tumor Portal	PICALM
OASIS Portal	PICALM [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMIC	PICALM [overview] [genome browser] [tissue] [distribution]
Somatic Mutations in Cancer : COSMIC3D	PICALM
Mutations and Diseases : HGMD	PICALM
LOVD (Leiden Open Variation Database)	Whole genome datasets
LOVD (Leiden Open Variation Database)	LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)	LOVD 3.0 shared installation
BioMuta	search PICALM
DgiDB (Drug Gene Interaction Database)	PICALM
DoCM (Curated mutations)	PICALM (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)	PICALM (select a term)
intoGen	PICALM
NCG5 (London)	PICALM
Cancer3D	PICALM(select the gene name)
Impact of mutations	[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
	Diseases
OMIM	601626 603025
Orphanet	14434
DisGeNET	PICALM
Medgen	PICALM
Genetic Testing Registry	PICALM
NextProt	Q13492 [Medical]
TSGene	8301
GENETests	PICALM
Target Validation	PICALM
Huge Navigator	PICALM [HugePedia]
snp3D : Map Gene to Disease	8301
BioCentury BCIQ	PICALM
ClinGen	PICALM
	Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD	8301
Chemical/Pharm GKB Gene	PA33287
Clinical trial	PICALM
	Miscellaneous
canSAR (ICR)	PICALM (select the gene name)
DataMed Index	PICALM
	Probes
	Litterature
PubMed	140 Pubmed reference(s) in Entrez
GeneRIFs	Gene References Into Functions (Entrez)
CoreMine	PICALM
EVEX	PICALM
GoPubMed	PICALM
iHOP	PICALM

REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI NCBI

indexed on : Wed Nov 13 21:06:23 CET 2019

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