| |  |
| |
| | Schematic representation of the CAMTA1 protein. Protein domains are indicated by boxes. NLS, nuclear localization signal. |
| |
| Description | 1673 amino acids; the protein's primary structure contains a nuclear localization signal, two DNA-binding domains (CG-1 and TIG), calmodulin binding motifs (IQ motifs) and ankyrin domains that may mediate protein-protein interactions. |
| Expression | Although expression of CAMTA1 is found in various organs, highest levels are seen in neuronal tissues (Nagase et al., 1998). In the brain, CAMTA1 levels are highest in the temporal cortex, entorhinal cortex and in the cerebellum (Huentelman et al., 2007). |
| Localisation | Nucleus. |
| Function | Largely unknown. CAMTA1 has been shown to act as a transcription activator in a reporter expression system (Bouché et al., 2002). Further data on the functional role are scarce. The homolog CAMTA2 is a co-activator of the transcription factor Nkx2-5. This function is inhibited by binding of class II histone deacetylases (Song et al., 2006). |
| Homology | Members of the CAMTA family are conserved in various eukaryotes including ciliates, plants, nematodes, insects, birds and mammals (Finkler et al., 2007). In human, two homologous CAMTAs are found, CAMTA1 and CAMTA2. |
| Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |
| Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O. |
| DNA Res. 1998 Dec 31;5(6):355-64. |
| PMID 10048485 |
| |
| A novel family of calmodulin-binding transcription activators in multicellular organisms. |
| Bouche N, Scharlat A, Snedden W, Bouchez D, Fromm H. |
| J Biol Chem. 2002 Jun 14;277(24):21851-61. Epub 2002 Mar 29. |
| PMID 11925432 |
| |
| Allelic losses at 1p36 and 19q13 in gliomas: correlation with histologic classification, definition of a 150-kb minimal deleted region on 1p36, and evaluation of CAMTA1 as a candidate tumor suppressor gene. |
| Barbashina V, Salazar P, Holland EC, Rosenblum MK, Ladanyi M. |
| Clin Cancer Res. 2005 Feb 1;11(3):1119-28. |
| PMID 15709179 |
| |
| Reduced expression of CAMTA1 correlates with adverse outcome in neuroblastoma patients. |
| Henrich KO, Fischer M, Mertens D, Benner A, Wiedemeyer R, Brors B, Oberthuer A, Berthold F, Wei JS, Khan J, Schwab M, Westermann F. |
| Clin Cancer Res. 2006 Jan 1;12(1):131-8. |
| PMID 16397034 |
| |
| Recurrent genomic alterations with impact on survival in colorectal cancer identified by genome-wide array comparative genomic hybridization. |
| Kim MY, Yim SH, Kwon MS, Kim TM, Shin SH, Kang HM, Lee C, Chung YJ. |
| Gastroenterology. 2006 Dec;131(6):1913-24. Epub 2006 Oct 15. |
| PMID 17087931 |
| |
| The transcriptional coactivator CAMTA2 stimulates cardiac growth by opposing class II histone deacetylases. |
| Song K, Backs J, McAnally J, Qi X, Gerard RD, Richardson JA, Hill JA, Bassel-Duby R, Olson EN. |
| Cell. 2006 May 5;125(3):453-66. |
| PMID 16678093 |
| |
| CAMTAs: calmodulin-binding transcription activators from plants to human. |
| Finkler A, Ashery-Padan R, Fromm H. |
| FEBS Lett. 2007 Aug 21;581(21):3893-8. Epub 2007 Aug 1. (REVIEW) |
| PMID 17689537 |
| |
| Allelic variants of CAMTA1 and FLJ10737 within a commonly deleted region at 1p36 in neuroblastoma. |
| Henrich KO, Claas A, Praml C, Benner A, Mollenhauer J, Poustka A, Schwab M, Westermann F. |
| Eur J Cancer. 2007 Feb;43(3):607-16. Epub 2007 Jan 11. |
| PMID 17222547 |
| |
| Calmodulin-binding transcription activator 1 (CAMTA1) alleles predispose human episodic memory performance. |
| Huentelman MJ, Papassotiropoulos A, Craig DW, Hoerndli FJ, Pearson JV, Huynh KD, Corneveaux J, Hanggi J, Mondadori CR, Buchmann A, Reiman EM, Henke K, de Quervain DJ, Stephan DA. |
| Hum Mol Genet. 2007 Jun 15;16(12):1469-77. Epub 2007 Apr 30. |
| PMID 17470457 |
| |
| CAMTA1. |
| Henrich KO and Westermann F. |
| Encyclopedia of Cancer 2008; M. Schwab, Ed., Berlin, New York, Heidelberg, Springer. (REVIEW) |
| |
| 1p36 is a preferential target of chromosome 1 deletions in astrocytic tumours and homozygously deleted in a subset of glioblastomas. |
| Ichimura K, Vogazianou AP, Liu L, Pearson DM, Backlund LM, Plant K, Baird K, Langford CF, Gregory SG, Collins VP. |
| Oncogene. 2008 Mar 27;27(14):2097-108. Epub 2007 Oct 15. |
| PMID 17934521 |
| |
