CARS (cysteinyj-tRNA synthetase)

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CARS (cysteinyj-tRNA synthetase)

Identity

Other names	cysteine-tRNA ligase
	cysteinease-translase
HGNC (Hugo)	CARS
LocusID (NCBI)	833
Location	11p15.5
Location_base_pair	Starts at 3022152 and ends at 3078681 bp from pter ( according to hg19-Feb_2009) [Mapping]
Local_order	700 kb telomeric to NUP98

DNA/RNA

Description	The gene spans 57 kb; 22 exons; 2,5 kb cDNA
Transcription	alternate splicing

Protein

Description	748 amino acids, 85 kDa. Forms homodimers
Localisation	cytoplasmic

Implicated in

Entity	Inflammatory myofibroblastic tumors with a complex t(2;11)(p23;p15)
Disease	rare soft tissue tumour found in children and young adults
Prognosis	good prognosis
Hybrid/Mutated Gene	5' CARS - 3' ALK
Abnormal Protein	N-term CARS (606 amino acids) fused to the usual 562 C-term amino acids of ALK

External links

	Nomenclature
HGNC (Hugo)	CARS 1493
Entrez_Gene (NCBI)	CARS 833 cysteinyl-tRNA synthetase
	Cards
Atlas	CARSID484
GeneCards (Weizmann)	CARS
Ensembl (Hinxton)	ENSG00000110619 [Gene_View] chr11:3022152-3078681 [Contig_View] CARS [Vega]
AceView (NCBI)	CARS
Genatlas (Paris)	CARS
euGene (Indiana)	833
SOURCE (Stanford)	NM_001014437 NM_001014438 NM_001194997 NM_001751 NM_139273
	Genomic and cartography
GoldenPath (UCSC)	CARS - 11p15.5 chr11:3022152-3078681 - 11p15.5 [Description] (hg19-Feb_2009)
Ensembl	CARS - 11p15.5 [CytoView]
Mapping of homologs : NCBI	CARS [Mapview]
OMIM	123859
	Gene and transcription
Genbank (Entrez)	AB208814 AF288206 AF288207 AI432096 AI608729
RefSeq transcript (SRS)	NM_001014437 NM_001014438 NM_001194997 NM_001751 NM_139273
RefSeq transcript (Entrez)	NM_001014437 NM_001014438 NM_001194997 NM_001751 NM_139273
RefSeq genomic (SRS)	AC_000143 NC_000011 NT_009237 NW_001838018
RefSeq genomic (Entrez)	AC_000143 NC_000011 NT_009237 NW_001838018
Consensus coding sequences : CCDS (NCBI)	CARS
Cluster EST : Unigene	Hs.274873 [ SRS ] Hs.274873 [ NCBI ]
Alternative Splicing : Fast-db (Paris)	1090
Alternative Splicing Gallery	ENSG00000110619
Gene Expression	CARS [ NCBI-GEO ] CARS [ EBI - ARRAY_EXPRESS ]
	Protein : pattern, domain, 3D structure
UniProt/SwissProt	P49589 (SRS) P49589 (Uniprot)
With graphics : InterPro	P49589
Splice isoforms : SwissVar	P49589(Swissvar)
Domaine pattern : Prosite (SRS)	AA_TRNA_LIGASE_I (PS00178)
Domaine pattern : Prosite (Expaxy)	AA_TRNA_LIGASE_I (PS00178)
Domains : Interpro (SRS)	Cys-tRNA-synt Cys-tRNA/MSH_ligase Rossmann-like_a/b/a_fold tRNAsynth_1a_anticodon-bd
Domains : Interpro (EBI)	Cys-tRNA-synt Cys-tRNA/MSH_ligase Rossmann-like_a/b/a_fold tRNAsynth_1a_anticodon-bd
Related proteins : CluSTr	P49589
Domain families : Pfam (SRS)	tRNA-synt_1e (PF01406)
Domain families : Pfam (Sanger)	tRNA-synt_1e (PF01406)
Domain families : Pfam (NCBI)	pfam01406
Blocks (Seattle)	P49589
Human Protein Atlas	ENSG00000110619
HPRD	00464
IPI	IPI00556365 IPI00939491 IPI00556541 IPI00745398 IPI00909763 IPI00027443 IPI00789371 IPI00983051 IPI00980132
	Protein Interaction databases
DIP (DOE-UCLA)	P49589
IntAct (EBI)	P49589
FunCoup	ENSG00000110619
REACTOME	CARS
BioGRID	CARS
InParanoid	P49589
Interologous Interaction database	P49589
	Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)	CARS
SNP (GeneSNP Utah)	CARS
SNP : HGBase	CARS
Genetic variants : HAPMAP	CARS
Cancer Gene: Census	CARS
Somatic Mutations in Cancer : COSMIC	CARS
CONAN: Copy Number Analysis	CARS
Rearrangement : COSMIC	CARS [11p15.4] - ALK [2p23.2]
Translocation Breakpoints in Cancer : TICdb	CARS
Mutations and Diseases : HGMD	CARS
OMIM	123859
GENETests	123859
Disease Genetic Association	CARS
Huge Navigator	CARS [HugePedia] CARS [HugeCancerGEM]
Genomic Variants	CARS
snp3D : Map Gene to Disease	833
	General knowledge
Homologs : HomoloGene	CARS
Homology/Alignments : Family Browser (UCSC)	CARS
Phylogenetic Trees/Animal Genes : TreeFam	CARS
Catalytic activity : Enzyme	6.1.1.16 [ Enzyme-Expasy ] 6.1.1.16 [ Enzyme-SRS ] 6.1.1.16 [ IntEnz-EBI ] 6.1.1.16 [ BRENDA ] 6.1.1.16 [ KEGG ]
Chemical/Protein Interactions : CTD	833
Chemical/Pharm GKB Gene	PA26079
Clinical trial	CARS
Cancer Resource (Charite)	ENSG00000110619
Ontology : AmiGO	tRNA binding tRNA binding tRNA binding nucleotide binding cysteine-tRNA ligase activity cysteine-tRNA ligase activity cysteine-tRNA ligase activity protein binding ATP binding ATP binding cytoplasm cytoplasm cytosol tRNA aminoacylation for protein translation cysteinyl-tRNA aminoacylation cysteinyl-tRNA aminoacylation gene expression ligase activity protein homodimerization activity protein homodimerization activity metal ion binding
Ontology : EGO-EBI	tRNA binding tRNA binding tRNA binding nucleotide binding cysteine-tRNA ligase activity cysteine-tRNA ligase activity cysteine-tRNA ligase activity protein binding ATP binding ATP binding cytoplasm cytoplasm cytosol tRNA aminoacylation for protein translation cysteinyl-tRNA aminoacylation cysteinyl-tRNA aminoacylation gene expression ligase activity protein homodimerization activity protein homodimerization activity metal ion binding
Pathways : KEGG	Cysteine metabolism Aminoacyl-tRNA biosynthesis
	Other databases
	Probes
Probes : Imagenes	CARS Related clones (RZPD - Berlin)
	Litterature
PubMed	24 Pubmed reference(s) in Entrez
PubGene	CARS
iHOP	CARS

Bibliography

Identification of novel fusion partners of ALK, the anaplastic lymphoma kinase, in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor.

Cools J, Wlodarska I, Somers R, Mentens N, Pedeutour F, Maes B, De Wolf-Peeters C, Pauwels P, Hagemeijer A, Marynen P

Genes, chromosomes & cancer. 2002 ; 34 (4) : 354-362.

PMID 12112524

REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI NCBI

Contributor(s)

Written	08-2003	Jean-Loup Huret, Sylvie Senon

Citation
This paper should be referenced as such :
Huret JL, Senon S . CARS (cysteinyj-tRNA synthetase). Atlas Genet Cytogenet Oncol Haematol. August 2003 .
URL : http://AtlasGeneticsOncology.org/Genes/CARSID484.html

This paper is referenced by INIST as such :
http://documents.irevues.inist.fr/bitstream/2042/38006/1/08-2003-CARSID484.pdf [ Bibliographic record ]

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indexed on : Sat Apr 28 15:04:35 CEST 2012

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