CARS (cysteinyj-tRNA synthetase)

2003-08-01   Jean-Loup Huret , Sylvie Senon 

Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Identity

HGNC
LOCATION
11p15.4
LOCUSID
ALIAS
CARS,CYSRS,MCDDBH,MDBH,MGC:11246
FUSION GENES

DNA/RNA

Description

The gene spans 57 kb; 22 exons; 2,5 kb cDNA

Transcription

alternate splicing

Proteins

Description

748 amino acids, 85 kDa. Forms homodimers

Localisation

cytoplasmic

Implicated in

Entity name
Inflammatory myofibroblastic tumors with a complex t(2;11)(p23;p15)
Disease
rare soft tissue tumour found in children and young adults
Prognosis
good prognosis
Hybrid gene
5 CARS - 3 ALK
Fusion protein
N-term CARS (606 amino acids) fused to the usual 562 C-term amino acids of ALK

Bibliography

Pubmed IDLast YearTitleAuthors
121125242002Identification of novel fusion partners of ALK, the anaplastic lymphoma kinase, in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor.Cools J et al

Citation

Jean-Loup Huret ; Sylvie Senon

CARS (cysteinyj-tRNA synthetase)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/484/cars