| Note | |
| | |
| Entity | Lung cancer |
| Note | Lee et al. (2009) showed that the CASP7 rs2227310 g.C>G polymorphism was associated with the risk of lung cancer.
Yoo et al. (2009) also demonstrated that the CASP7 rs2227310 polymorphism may affect survival in early-stage non-small cell lung cancer (NSCLC), suggesting that the analysis of this polymorphism can help identify patients at high risk for a poor disease outcome.
Qian et al. (2012) also provided evidence that genetic variations of CASP7 may modulate overall survival and progression-free survival of patients with advanced NSCLC treated with platinum-based chemotherapy. |
| | |
| | |
| Entity | Esophageal cancer |
| Note | Liu et al. (2010) described that polymorphisms in CASP7 gene was associated with increased risk of esophageal cancer. |
| | |
| | |
| Entity | Childhood leukemia |
| Note | Park et al. (2012) suggested that three SNPs in CASP7 acts as a strong apoptosis signal that block or delay the apoptosis of childhood leukemia cancer cells. |
| | |
| | |
| Entity | Colorectal cancer |
| Note | Palmerini et al. (2001) described a loss of caspase-7 in 84% of colon cancers, suggesting that caspase-7 deficiency might be used as a new immunohistochemical marker of colonic neoplasia.
Chae et al. (2011) reported that CASP7 rs2227310 polymorphism may be useful marker to predict the prognosis of patients with surgically resected colorectal cancer. |
| | |
| | |
| Entity | Gastric cancer |
| Note | Yoo et al. (2004) observed loss of capase-2, capase-6 and capase-7 expression in gastric cancers irrespective of depth of invasion and histological subtypes suggesting a role in the development of gastric cancers. |
| | |
| | |
| Entity | Endometrial cancer |
| Note | The AA genotype of rs11196445b, the CC genotype of rs3124740, and the GG genotype of rs10787498 in the CASP7 gene were associated with increased risk compared with homozygotes of the major alleles, suggesting that genetic variants in CASP7 may play a role in endometrial cancer susceptibility in a Chinese population (Xu et al., 2009). |
| | |
| | |
| Entity | Renal carcinoma |
| Note | Vilella-Arias et al. (2013) reported loss of CASP7 protein expression in renal cell carcinoma clear cell subtype (ccRCC) and this loss was associated with the agressiveness of ccRCC, suggesting the potential use of CASP7 as a prognostic marker. |
| | |
| | |
| Entity | Oral squamous cell carcinoma |
| Note | Coutinho-Camillo et al. (2011) reported that high expression level of CASP7 protein was associated with poor prognosis in oral squamous cell carcinoma (OSCC) patients. |
| | |
| | |
| Entity | Alzheimer's disease |
| Note | Elevated mRNA levels of caspases-7 and 8 measured by a quantitative PCR method were observed in the Alzheimer's disease (AD) temporal neocortex as compared to the control brains, suggesting that the transcriptional activation of key components of the apoptotic cascade correlates with accumulation of Abeta42. Thus, a principal caspase pathway from caspase-8 to caspase-3 and/or 7 may contribute to neuron loss in AD brain (Matsui et al., 2006). |
| | |
| | |
| Entity | Huntington's disease |
| Note | Hermel et al. (2004) reported that caspase-7 immunoreactivity in post-mortem tissue from Huntington's disease (HD) patients is dramatically enhanced in the medium spiny neurons of the caudate nucleus and neurons in the putamen when compared to age-matched controls. Caspase-7 is able to bind full-length huntingtin (Htt), accelerating the production of Htt fragments and resulting in the eventual induction of apoptosis both in the neuronal processes and somata. |
| | |
| | |
| Entity | Rheumatoid arthritis |
| Note | CASP-7 gene is associated with the susceptibility to rheumatoid arthritis (RA). Genotyping of three single nucleotide polymorphisms (SNPs) of the CASP7 gene: rs11593766 (G/T), rs2227310 (C/G) and rs2227309 (G/A) revealed that rs2227309 SNP was found to be associated with susceptibility to RA. Frequency of the G allele was significantly higher among RA patients and a higher frequency of GG homozygous individuals was found in the RA patient group (Garcia-Lozano et al., 2007).
Teixeira et al. (2008) found that CASP7 rs2227309 SNP was not associated with RA in a European Caucasian population. Nevertheless, CASP7 isoforms alpha and beta could be involved in the apoptosis process in RA. |
| | |
| | |
| Entity | Insulin-dependent diabetes mellitus |
| Note | Babu et al. (2003) studied 18 SNPs in CASP7 and reported that 1 (SNP144692) differed significantly in frequency in the haplotypes found in affected individuals compared to control Bedouin Arab family haplotypes. This same SNP showed evidence of association with diabetes in a subset of patients (DR3/DR4*0302) from Human Biological Data Interchange (HBDI) families, although these results are in conflict with other studies. |
| | |
| Caspase 7 is a positional candidate gene for IDDM 17 in a Bedouin Arab family. |
| Babu SR, Bao F, Roberts CM, Martin AK, Gowan K, Eisenbarth GS, Fain PR. |
| Ann N Y Acad Sci. 2003 Nov;1005:340-3. |
| PMID 14679087 |
| |
| Mechanisms of caspase activation. |
| Boatright KM, Salvesen GS. |
| Curr Opin Cell Biol. 2003 Dec;15(6):725-31. (REVIEW) |
| PMID 14644197 |
| |
| RIPK1 and CASP7 polymorphism as prognostic markers for survival in patients with colorectal cancer after complete resection. |
| Chae YS, Kim JG, Sohn SK, Lee SJ, Kang BW, Moon JH, Park JY, Jeon SW, Bae HI, Choi GS, Jun SH. |
| J Cancer Res Clin Oncol. 2011 Apr;137(4):705-13. doi: 10.1007/s00432-010-0929-1. Epub 2010 Jun 22. |
| PMID 20567846 |
| |
| Caspases: the executioners of apoptosis. |
| Cohen GM. |
| Biochem J. 1997 Aug 15;326 ( Pt 1):1-16. (REVIEW) |
| PMID 9337844 |
| |
| Caspase expression in oral squamous cell carcinoma. |
| Coutinho-Camillo CM, Lourenco SV, Nishimoto IN, Kowalski LP, Soares FA. |
| Head Neck. 2011 Aug;33(8):1191-8. doi: 10.1002/hed.21602. Epub 2010 Nov 12. |
| PMID 21755562 |
| |
| Caspases: keys in the ignition of cell death. |
| Denault JB, Salvesen GS. |
| Chem Rev. 2002 Dec;102(12):4489-500. (REVIEW) |
| PMID 12475198 |
| |
| Caspase 7 influences susceptibility to rheumatoid arthritis. |
| Garcia-Lozano JR, Torres B, Fernandez O, Orozco G, Alvarez-Marquez A, Garcia A, Gonzalez-Gay MA, Garcia A, Nunez-Roldan A, Martin J, Gonzalez-Escribano MF. |
| Rheumatology (Oxford). 2007 Aug;46(8):1243-7. Epub 2007 May 15. |
| PMID 17504820 |
| |
| Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease. |
| Hermel E, Gafni J, Propp SS, Leavitt BR, Wellington CL, Young JE, Hackam AS, Logvinova AV, Peel AL, Chen SF, Hook V, Singaraja R, Krajewski S, Goldsmith PC, Ellerby HM, Hayden MR, Bredesen DE, Ellerby LM. |
| Cell Death Differ. 2004 Apr;11(4):424-38. |
| PMID 14713958 |
| |
| Caspase-7: a protease involved in apoptosis and inflammation. |
| Lamkanfi M, Kanneganti TD. |
| Int J Biochem Cell Biol. 2010 Jan;42(1):21-4. doi: 10.1016/j.biocel.2009.09.013. Epub 2009 Sep 25. (REVIEW) |
| PMID 19782763 |
| |
| Polymorphisms in the Caspase7 gene and the risk of lung cancer. |
| Lee WK, Kim JS, Kang HG, Cha SI, Kim DS, Hyun DS, Kam S, Kim CH, Jung TH, Park JY. |
| Lung Cancer. 2009 Jul;65(1):19-24. doi: 10.1016/j.lungcan.2008.10.022. Epub 2008 Dec 6. |
| PMID 19058873 |
| |
| A Large-scale genetic association study of esophageal adenocarcinoma risk. |
| Liu CY, Wu MC, Chen F, Ter-Minassian M, Asomaning K, Zhai R, Wang Z, Su L, Heist RS, Kulke MH, Lin X, Liu G, Christiani DC. |
| Carcinogenesis. 2010 Jul;31(7):1259-63. doi: 10.1093/carcin/bgq092. Epub 2010 May 7. |
| PMID 20453000 |
| |
| Coordinated expression of caspase 8, 3 and 7 mRNA in temporal cortex of Alzheimer disease: relationship to formic acid extractable abeta42 levels. |
| Matsui T, Ramasamy K, Ingelsson M, Fukumoto H, Conrad C, Frosch MP, Irizarry MC, Yuan J, Hyman BT. |
| J Neuropathol Exp Neurol. 2006 May;65(5):508-15. |
| PMID 16772874 |
| |
| Caspase 7 downregulation as an immunohistochemical marker of colonic carcinoma. |
| Palmerini F, Devilard E, Jarry A, Birg F, Xerri L. |
| Hum Pathol. 2001 May;32(5):461-7. |
| PMID 11381362 |
| |
| Association between CASP7 and CASP14 genetic polymorphisms and the risk of childhood leukemia. |
| Park C, Han S, Lee KM, Choi JY, Song N, Jeon S, Park SK, Ahn HS, Shin HY, Kang HJ, Koo HH, Seo JJ, Choi JE, Kang D. |
| Hum Immunol. 2012 Jul;73(7):736-9. doi: 10.1016/j.humimm.2012.04.017. Epub 2012 Apr 28. |
| PMID 22548721 |
| |
| Association of CASP7 polymorphisms and survival of patients with non-small cell lung cancer with platinum-based chemotherapy treatment. |
| Qian J, Gu S, Wu Q, Zhao X, Wu W, Gao Z, Zhang W, Tan X, Wang H, Wang J, Fan W, Chen H, Han B, Lu D, Wei Q, Jin L. |
| Chest. 2012 Sep;142(3):680-9. |
| PMID 22441531 |
| |
| Inactivating mutations of CASPASE-7 gene in human cancers. |
| Soung YH, Lee JW, Kim HS, Park WS, Kim SY, Lee JH, Park JY, Cho YG, Kim CJ, Park YG, Nam SW, Jeong SW, Kim SH, Lee JY, Yoo NJ, Lee SH. |
| Oncogene. 2003 Sep 11;22(39):8048-52. |
| PMID 12970753 |
| |
| Genetic and expression analysis of CASP7 gene in a European Caucasian population with rheumatoid arthritis. |
| Teixeira VH, Jacq L, Lasbleiz S, Hilliquin P, Oliveira CR, Cornelis F, Petit-Teixeira E; European Consortium on Rheumatoid Arthritis Families. |
| J Rheumatol. 2008 Oct;35(10):1912-8. Epub 2008 Sep 1. |
| PMID 18785314 |
| |
| Apoptosis in the pathogenesis and treatment of disease. |
| Thompson CB. |
| Science. 1995 Mar 10;267(5203):1456-62. (REVIEW) |
| PMID 7878464 |
| |
| Loss of caspase 7 expression is associated with poor prognosis in renal cell carcinoma clear cell subtype. |
| Vilella-Arias SA, Rocha RM, da Costa WH, Zequi Sde C, Guimaraes GC, Verjovski-Almeida S, Soares FA, Reis EM. |
| Urology. 2013 Oct;82(4):974.e1-7. doi: 10.1016/j.urology.2013.06.026. Epub 2013 Aug 3. |
| PMID 23920448 |
| |
| Polymorphisms and haplotypes in the caspase-3, caspase-7, and caspase-8 genes and risk for endometrial cancer: a population-based, case-control study in a Chinese population. |
| Xu HL, Xu WH, Cai Q, Feng M, Long J, Zheng W, Xiang YB, Shu XO. |
| Cancer Epidemiol Biomarkers Prev. 2009 Jul;18(7):2114-22. doi: 10.1158/1055-9965.EPI-09-0152. Epub 2009 Jun 16. |
| PMID 19531679 |
| |
| HuGE systematic review and meta-analysis demonstrate association of CASP-3 and CASP-7 genetic polymorphisms with cancer risk. |
| Yan S, Li YZ, Zhu XW, Liu CL, Wang P, Liu YL. |
| Genet Mol Res. 2013 May 13;12(2):1561-73. doi: 10.4238/2013.May.13.10. (REVIEW) |
| PMID 23765963 |
| |
| Loss of caspase-2, -6 and -7 expression in gastric cancers. |
| Yoo NJ, Lee JW, Kim YJ, Soung YH, Kim SY, Nam SW, Park WS, Lee JY, Lee SH. |
| APMIS. 2004 Jun;112(6):330-5. |
| PMID 15511269 |
| |
| Polymorphisms in the CASPASE genes and survival in patients with early-stage non-small-cell lung cancer. |
| Yoo SS, Choi JE, Lee WK, Choi YY, Kam S, Kim MJ, Jeon HS, Lee EB, Kim DS, Lee MH, Kim IS, Jheon S, Park JY. |
| J Clin Oncol. 2009 Dec 1;27(34):5823-9. doi: 10.1200/JCO.2009.23.1738. Epub 2009 Oct 13. |
| PMID 19826114 |
| |
