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CASP7 (caspase 7, apoptosis-related cysteine peptidase)

Written2014-06Cláudia Malheiros Coutinho-Camillo, Fernando Augusto Soares
Department of Anatomic Pathology, AC Camargo Cancer Center, Sao Paulo, Brazil

Abstract Apoptosis is a selective process for deleting cells in various biological systems and plays an essential role in the development and maintenance of tissue homeostasis in multicellular organisms and inappropriate regulation of apoptosis is believed to be the cause of many human diseases, including cancer (Thompson, 1995).
Apoptosis relies on cysteine proteases called caspases (CASPs). Caspases are synthesized as proforms and become activated by cleavage at aspartate residues. Initiator caspases (1, 2, 4, 5, 8, 9, 10, 11, and 12) integrate molecular signals and activate the downstream effector caspases (3, 6, 7, and 14). Because caspases cleave and activate each other, the protease cascade amplifies, ensuring proper apoptotic cell death. In addition, caspases cleave numerous substrates, such as nuclear lamins, inhibitors of DNase, and cytoskeletal proteins, resulting in the typical morphological alterations of apoptosis (Cohen, 1997; Denault and Salvesen, 2002; Boatright and Salvesen, 2003).
Caspase-7 is highly related to caspase-3, and these two caspases are activated by both death receptor- and mitochondria-induced apoptosis (Soung et al., 2003). Besides its activation during apoptosis, proteolytic maturation of caspase-7 has also been observed under inflammatory conditions (Lamkanfi and Kanneganti, 2010).

Keywords Caspase-7, apoptosis, cancer, SNPs

(Note : for Links provided by Atlas : click)

Identity

Alias_namescaspase 7, apoptosis-related cysteine protease
caspase 7, apoptosis-related cysteine peptidase
Alias_symbol (synonym)MCH3
CMH-1
ICE-LAP3
Other aliasCASP-7
LICE2
HGNC (Hugo) CASP7
LocusID (NCBI) 840
Atlas_Id 924
Location 10q25.3  [Link to chromosome band 10q25]
Location_base_pair Starts at 115439428 and ends at 115490668 bp from pter ( according to hg19-Feb_2009)  [Mapping CASP7.png]
Local_order Plus strand.
Fusion genes
(updated 2016)
CASP7 (10q25.3) / EDRF1 (10q26.13)FGFR2 (10q26.13) / CASP7 (10q25.3)GNB1 (1p36.33) / CASP7 (10q25.3)
SGCG (13q12.12) / CASP7 (10q25.3)

DNA/RNA

 
  CASP7 transcript variants. Coding exons are marked by blue blocks, and non-coding exons, 5- and 3-UTRs are marked by white blocks.
Description CASP7 gene contains 8 exons and spans 51.748 Kb of genomic DNA.
Transcription CASP7 gene has 9 transcripts (splice variants):
- CASP7-201: 2694 bp (8 exons; 7 coding exons)
- CASP7-005: 2659 bp (8 exons; 6 coding exons)
- CASP7-002: 2421 bp (8 exons; 6 coding exons)
- CASP7-003: 2380 bp (8 exons; 7 coding exons)
- CASP7-001: 2377 bp (7 exons; 6 coding exons)
- CASP7-202: 1148 bp (6 exons; 6 coding exons)
- CASP7-004: 834 bp (6 exons; 5 coding exons)
- CASP7-007: 607 bp (3 exons; 0 coding exons)
- CASP7-008: 799 bp (5 exons; 0 coding exons).
Pseudogene Not identified.

Protein

 
  Structure of procaspase-7. Numbers below the stick represents the approximate MWs of the resulting subunits and pro-regions. The proenzymes are cleaved at specific Asp residues (Dn, where n is the position in the protein).
Description Caspase-7 is an effector caspase and plays an central role in the execution phase of the apoptosis.
Expression Caspase-7 is widely expressed in human tissues. Highly expressed in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in testis.
Localisation Mainly in the cytoplasm, but also observed in the nucleus.
Function Effector caspases are responsible for initiating the hallmarks of the degradation phase of apoptosis, including DNA fragmentation, cell shrinkage and membrane blebbing. Besides its activation during apoptosis, proteolytic maturation of caspase-7 has also been observed under inflammatory conditions.
Homology CASP7 (P. troglodytes, M. mulatta, C. lupus, B. taurus, G. gallus), Casp7 (M. musculus, R. norvegicus), casp7 (X. tropicalis, D. rerio), Ice (D. melanogaster), Dcp-1 (D. melanogaster), CASPS7 (A. gambiae).

Mutations

Note Soung et al. (2003) detected CASP7 mutations in 2 of 98 colon carcinomas (2%), 1 of 50 esophageal carcinomas (2%), and 1 of 33 head/neck carcinomas (3%). Expression of the tumor-derived CASP7 mutants in 293T cells showed that apoptosis was reduced compared to the wild-type caspase-7, suggesting that inactivating mutations of CASP7 might contribute to the pathogenesis of some human solid cancers.
Genetic polymorphisms in the CASP7 gene may affect cancer risk through altering expression levels and functions of this gene. Several polymorphisms have been associated with susceptibility of cancer development, as will be discussed later (Yan et al., 2013).
A detailed list of genetic variations could be found at: Ensembl.

Implicated in

Note
  
Entity Lung cancer
Note Lee et al. (2009) showed that the CASP7 rs2227310 g.C>G polymorphism was associated with the risk of lung cancer.
Yoo et al. (2009) also demonstrated that the CASP7 rs2227310 polymorphism may affect survival in early-stage non-small cell lung cancer (NSCLC), suggesting that the analysis of this polymorphism can help identify patients at high risk for a poor disease outcome.
Qian et al. (2012) also provided evidence that genetic variations of CASP7 may modulate overall survival and progression-free survival of patients with advanced NSCLC treated with platinum-based chemotherapy.
  
  
Entity Esophageal cancer
Note Liu et al. (2010) described that polymorphisms in CASP7 gene was associated with increased risk of esophageal cancer.
  
  
Entity Childhood leukemia
Note Park et al. (2012) suggested that three SNPs in CASP7 acts as a strong apoptosis signal that block or delay the apoptosis of childhood leukemia cancer cells.
  
  
Entity Colorectal cancer
Note Palmerini et al. (2001) described a loss of caspase-7 in 84% of colon cancers, suggesting that caspase-7 deficiency might be used as a new immunohistochemical marker of colonic neoplasia.
Chae et al. (2011) reported that CASP7 rs2227310 polymorphism may be useful marker to predict the prognosis of patients with surgically resected colorectal cancer.
  
  
Entity Gastric cancer
Note Yoo et al. (2004) observed loss of capase-2, capase-6 and capase-7 expression in gastric cancers irrespective of depth of invasion and histological subtypes suggesting a role in the development of gastric cancers.
  
  
Entity Endometrial cancer
Note The AA genotype of rs11196445b, the CC genotype of rs3124740, and the GG genotype of rs10787498 in the CASP7 gene were associated with increased risk compared with homozygotes of the major alleles, suggesting that genetic variants in CASP7 may play a role in endometrial cancer susceptibility in a Chinese population (Xu et al., 2009).
  
  
Entity Renal carcinoma
Note Vilella-Arias et al. (2013) reported loss of CASP7 protein expression in renal cell carcinoma clear cell subtype (ccRCC) and this loss was associated with the agressiveness of ccRCC, suggesting the potential use of CASP7 as a prognostic marker.
  
  
Entity Oral squamous cell carcinoma
Note Coutinho-Camillo et al. (2011) reported that high expression level of CASP7 protein was associated with poor prognosis in oral squamous cell carcinoma (OSCC) patients.
  
  
Entity Alzheimer's disease
Note Elevated mRNA levels of caspases-7 and 8 measured by a quantitative PCR method were observed in the Alzheimer's disease (AD) temporal neocortex as compared to the control brains, suggesting that the transcriptional activation of key components of the apoptotic cascade correlates with accumulation of Abeta42. Thus, a principal caspase pathway from caspase-8 to caspase-3 and/or 7 may contribute to neuron loss in AD brain (Matsui et al., 2006).
  
  
Entity Huntington's disease
Note Hermel et al. (2004) reported that caspase-7 immunoreactivity in post-mortem tissue from Huntington's disease (HD) patients is dramatically enhanced in the medium spiny neurons of the caudate nucleus and neurons in the putamen when compared to age-matched controls. Caspase-7 is able to bind full-length huntingtin (Htt), accelerating the production of Htt fragments and resulting in the eventual induction of apoptosis both in the neuronal processes and somata.
  
  
Entity Rheumatoid arthritis
Note CASP-7 gene is associated with the susceptibility to rheumatoid arthritis (RA). Genotyping of three single nucleotide polymorphisms (SNPs) of the CASP7 gene: rs11593766 (G/T), rs2227310 (C/G) and rs2227309 (G/A) revealed that rs2227309 SNP was found to be associated with susceptibility to RA. Frequency of the G allele was significantly higher among RA patients and a higher frequency of GG homozygous individuals was found in the RA patient group (Garcia-Lozano et al., 2007).
Teixeira et al. (2008) found that CASP7 rs2227309 SNP was not associated with RA in a European Caucasian population. Nevertheless, CASP7 isoforms alpha and beta could be involved in the apoptosis process in RA.
  
  
Entity Insulin-dependent diabetes mellitus
Note Babu et al. (2003) studied 18 SNPs in CASP7 and reported that 1 (SNP144692) differed significantly in frequency in the haplotypes found in affected individuals compared to control Bedouin Arab family haplotypes. This same SNP showed evidence of association with diabetes in a subset of patients (DR3/DR4*0302) from Human Biological Data Interchange (HBDI) families, although these results are in conflict with other studies.
  

Bibliography

Caspase 7 is a positional candidate gene for IDDM 17 in a Bedouin Arab family.
Babu SR, Bao F, Roberts CM, Martin AK, Gowan K, Eisenbarth GS, Fain PR.
Ann N Y Acad Sci. 2003 Nov;1005:340-3.
PMID 14679087
 
Mechanisms of caspase activation.
Boatright KM, Salvesen GS.
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PMID 14644197
 
RIPK1 and CASP7 polymorphism as prognostic markers for survival in patients with colorectal cancer after complete resection.
Chae YS, Kim JG, Sohn SK, Lee SJ, Kang BW, Moon JH, Park JY, Jeon SW, Bae HI, Choi GS, Jun SH.
J Cancer Res Clin Oncol. 2011 Apr;137(4):705-13. doi: 10.1007/s00432-010-0929-1. Epub 2010 Jun 22.
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Caspases: the executioners of apoptosis.
Cohen GM.
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Caspase expression in oral squamous cell carcinoma.
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PMID 21755562
 
Caspases: keys in the ignition of cell death.
Denault JB, Salvesen GS.
Chem Rev. 2002 Dec;102(12):4489-500. (REVIEW)
PMID 12475198
 
Caspase 7 influences susceptibility to rheumatoid arthritis.
Garcia-Lozano JR, Torres B, Fernandez O, Orozco G, Alvarez-Marquez A, Garcia A, Gonzalez-Gay MA, Garcia A, Nunez-Roldan A, Martin J, Gonzalez-Escribano MF.
Rheumatology (Oxford). 2007 Aug;46(8):1243-7. Epub 2007 May 15.
PMID 17504820
 
Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease.
Hermel E, Gafni J, Propp SS, Leavitt BR, Wellington CL, Young JE, Hackam AS, Logvinova AV, Peel AL, Chen SF, Hook V, Singaraja R, Krajewski S, Goldsmith PC, Ellerby HM, Hayden MR, Bredesen DE, Ellerby LM.
Cell Death Differ. 2004 Apr;11(4):424-38.
PMID 14713958
 
Caspase-7: a protease involved in apoptosis and inflammation.
Lamkanfi M, Kanneganti TD.
Int J Biochem Cell Biol. 2010 Jan;42(1):21-4. doi: 10.1016/j.biocel.2009.09.013. Epub 2009 Sep 25. (REVIEW)
PMID 19782763
 
Polymorphisms in the Caspase7 gene and the risk of lung cancer.
Lee WK, Kim JS, Kang HG, Cha SI, Kim DS, Hyun DS, Kam S, Kim CH, Jung TH, Park JY.
Lung Cancer. 2009 Jul;65(1):19-24. doi: 10.1016/j.lungcan.2008.10.022. Epub 2008 Dec 6.
PMID 19058873
 
A Large-scale genetic association study of esophageal adenocarcinoma risk.
Liu CY, Wu MC, Chen F, Ter-Minassian M, Asomaning K, Zhai R, Wang Z, Su L, Heist RS, Kulke MH, Lin X, Liu G, Christiani DC.
Carcinogenesis. 2010 Jul;31(7):1259-63. doi: 10.1093/carcin/bgq092. Epub 2010 May 7.
PMID 20453000
 
Coordinated expression of caspase 8, 3 and 7 mRNA in temporal cortex of Alzheimer disease: relationship to formic acid extractable abeta42 levels.
Matsui T, Ramasamy K, Ingelsson M, Fukumoto H, Conrad C, Frosch MP, Irizarry MC, Yuan J, Hyman BT.
J Neuropathol Exp Neurol. 2006 May;65(5):508-15.
PMID 16772874
 
Caspase 7 downregulation as an immunohistochemical marker of colonic carcinoma.
Palmerini F, Devilard E, Jarry A, Birg F, Xerri L.
Hum Pathol. 2001 May;32(5):461-7.
PMID 11381362
 
Association between CASP7 and CASP14 genetic polymorphisms and the risk of childhood leukemia.
Park C, Han S, Lee KM, Choi JY, Song N, Jeon S, Park SK, Ahn HS, Shin HY, Kang HJ, Koo HH, Seo JJ, Choi JE, Kang D.
Hum Immunol. 2012 Jul;73(7):736-9. doi: 10.1016/j.humimm.2012.04.017. Epub 2012 Apr 28.
PMID 22548721
 
Association of CASP7 polymorphisms and survival of patients with non-small cell lung cancer with platinum-based chemotherapy treatment.
Qian J, Gu S, Wu Q, Zhao X, Wu W, Gao Z, Zhang W, Tan X, Wang H, Wang J, Fan W, Chen H, Han B, Lu D, Wei Q, Jin L.
Chest. 2012 Sep;142(3):680-9.
PMID 22441531
 
Inactivating mutations of CASPASE-7 gene in human cancers.
Soung YH, Lee JW, Kim HS, Park WS, Kim SY, Lee JH, Park JY, Cho YG, Kim CJ, Park YG, Nam SW, Jeong SW, Kim SH, Lee JY, Yoo NJ, Lee SH.
Oncogene. 2003 Sep 11;22(39):8048-52.
PMID 12970753
 
Genetic and expression analysis of CASP7 gene in a European Caucasian population with rheumatoid arthritis.
Teixeira VH, Jacq L, Lasbleiz S, Hilliquin P, Oliveira CR, Cornelis F, Petit-Teixeira E; European Consortium on Rheumatoid Arthritis Families.
J Rheumatol. 2008 Oct;35(10):1912-8. Epub 2008 Sep 1.
PMID 18785314
 
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Thompson CB.
Science. 1995 Mar 10;267(5203):1456-62. (REVIEW)
PMID 7878464
 
Loss of caspase 7 expression is associated with poor prognosis in renal cell carcinoma clear cell subtype.
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Urology. 2013 Oct;82(4):974.e1-7. doi: 10.1016/j.urology.2013.06.026. Epub 2013 Aug 3.
PMID 23920448
 
Polymorphisms and haplotypes in the caspase-3, caspase-7, and caspase-8 genes and risk for endometrial cancer: a population-based, case-control study in a Chinese population.
Xu HL, Xu WH, Cai Q, Feng M, Long J, Zheng W, Xiang YB, Shu XO.
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PMID 19531679
 
HuGE systematic review and meta-analysis demonstrate association of CASP-3 and CASP-7 genetic polymorphisms with cancer risk.
Yan S, Li YZ, Zhu XW, Liu CL, Wang P, Liu YL.
Genet Mol Res. 2013 May 13;12(2):1561-73. doi: 10.4238/2013.May.13.10. (REVIEW)
PMID 23765963
 
Loss of caspase-2, -6 and -7 expression in gastric cancers.
Yoo NJ, Lee JW, Kim YJ, Soung YH, Kim SY, Nam SW, Park WS, Lee JY, Lee SH.
APMIS. 2004 Jun;112(6):330-5.
PMID 15511269
 
Polymorphisms in the CASPASE genes and survival in patients with early-stage non-small-cell lung cancer.
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Citation

This paper should be referenced as such :
CM Coutinho-Camillo, FA Soares
CASP7 (caspase 7, apoptosis-related cysteine peptidase)
Atlas Genet Cytogenet Oncol Haematol. 2015;19(3):160-163.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/CASP7ID924ch10q25.html


External links

Nomenclature
HGNC (Hugo)CASP7   1508
Cards
AtlasCASP7ID924ch10q25
Entrez_Gene (NCBI)CASP7  840  caspase 7
AliasesCASP-7; CMH-1; ICE-LAP3; LICE2; 
MCH3
GeneCards (Weizmann)CASP7
Ensembl hg19 (Hinxton)ENSG00000165806 [Gene_View]  chr10:115439428-115490668 [Contig_View]  CASP7 [Vega]
Ensembl hg38 (Hinxton)ENSG00000165806 [Gene_View]  chr10:115439428-115490668 [Contig_View]  CASP7 [Vega]
ICGC DataPortalENSG00000165806
TCGA cBioPortalCASP7
AceView (NCBI)CASP7
Genatlas (Paris)CASP7
WikiGenes840
SOURCE (Princeton)CASP7
Genetics Home Reference (NIH)CASP7
Genomic and cartography
GoldenPath hg19 (UCSC)CASP7  -     chr10:115439428-115490668 +  10q25   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CASP7  -     10q25   [Description]    (hg38-Dec_2013)
EnsemblCASP7 - 10q25 [CytoView hg19]  CASP7 - 10q25 [CytoView hg38]
Mapping of homologs : NCBICASP7 [Mapview hg19]  CASP7 [Mapview hg38]
OMIM601761   
Gene and transcription
Genbank (Entrez)AB451281 AB451413 AK223489 AK298964 AK300578
RefSeq transcript (Entrez)NM_001227 NM_001267056 NM_001267057 NM_001267058 NM_001320911 NM_033338 NM_033339 NM_033340
RefSeq genomic (Entrez)NC_000010 NC_018921 NT_030059 NW_004929376
Consensus coding sequences : CCDS (NCBI)CASP7
Cluster EST : UnigeneHs.9216 [ NCBI ]
CGAP (NCI)Hs.9216
Alternative Splicing GalleryENSG00000165806
Gene ExpressionCASP7 [ NCBI-GEO ]   CASP7 [ EBI - ARRAY_EXPRESS ]   CASP7 [ SEEK ]   CASP7 [ MEM ]
Gene Expression Viewer (FireBrowse)CASP7 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)840
GTEX Portal (Tissue expression)CASP7
Protein : pattern, domain, 3D structure
UniProt/SwissProtP55210   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP55210  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP55210
Splice isoforms : SwissVarP55210
Catalytic activity : Enzyme3.4.22.60 [ Enzyme-Expasy ]   3.4.22.603.4.22.60 [ IntEnz-EBI ]   3.4.22.60 [ BRENDA ]   3.4.22.60 [ KEGG ]   
PhosPhoSitePlusP55210
Domaine pattern : Prosite (Expaxy)CASPASE_CYS (PS01122)    CASPASE_HIS (PS01121)    CASPASE_P10 (PS50207)    CASPASE_P20 (PS50208)   
Domains : Interpro (EBI)Caspase-like_dom    Caspase_cys_AS    Caspase_his_AS    Pept_C14_p10    Pept_C14_p20    Pept_C14A    Pept_C14A_HD   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)CASc (SM00115)  
Conserved Domain (NCBI)CASP7
DMDM Disease mutations840
Blocks (Seattle)CASP7
PDB (SRS)1F1J    1GQF    1I4O    1I51    1K86    1K88    1KMC    1MIA    1SHJ    1SHL    2QL5    2QL7    2QL9    2QLB    2QLF    2QLJ    3EDR    3H1P    3IBC    3IBF    3R5K    4FDL    4FEA    4HQ0    4HQR    4JB8    4JJ8    4JR1    4JR2    4LSZ   
PDB (PDBSum)1F1J    1GQF    1I4O    1I51    1K86    1K88    1KMC    1MIA    1SHJ    1SHL    2QL5    2QL7    2QL9    2QLB    2QLF    2QLJ    3EDR    3H1P    3IBC    3IBF    3R5K    4FDL    4FEA    4HQ0    4HQR    4JB8    4JJ8    4JR1    4JR2    4LSZ   
PDB (IMB)1F1J    1GQF    1I4O    1I51    1K86    1K88    1KMC    1MIA    1SHJ    1SHL    2QL5    2QL7    2QL9    2QLB    2QLF    2QLJ    3EDR    3H1P    3IBC    3IBF    3R5K    4FDL    4FEA    4HQ0    4HQR    4JB8    4JJ8    4JR1    4JR2    4LSZ   
PDB (RSDB)1F1J    1GQF    1I4O    1I51    1K86    1K88    1KMC    1MIA    1SHJ    1SHL    2QL5    2QL7    2QL9    2QLB    2QLF    2QLJ    3EDR    3H1P    3IBC    3IBF    3R5K    4FDL    4FEA    4HQ0    4HQR    4JB8    4JJ8    4JR1    4JR2    4LSZ   
Structural Biology KnowledgeBase1F1J    1GQF    1I4O    1I51    1K86    1K88    1KMC    1MIA    1SHJ    1SHL    2QL5    2QL7    2QL9    2QLB    2QLF    2QLJ    3EDR    3H1P    3IBC    3IBF    3R5K    4FDL    4FEA    4HQ0    4HQR    4JB8    4JJ8    4JR1    4JR2    4LSZ   
SCOP (Structural Classification of Proteins)1F1J    1GQF    1I4O    1I51    1K86    1K88    1KMC    1MIA    1SHJ    1SHL    2QL5    2QL7    2QL9    2QLB    2QLF    2QLJ    3EDR    3H1P    3IBC    3IBF    3R5K    4FDL    4FEA    4HQ0    4HQR    4JB8    4JJ8    4JR1    4JR2    4LSZ   
CATH (Classification of proteins structures)1F1J    1GQF    1I4O    1I51    1K86    1K88    1KMC    1MIA    1SHJ    1SHL    2QL5    2QL7    2QL9    2QLB    2QLF    2QLJ    3EDR    3H1P    3IBC    3IBF    3R5K    4FDL    4FEA    4HQ0    4HQR    4JB8    4JJ8    4JR1    4JR2    4LSZ   
SuperfamilyP55210
Human Protein AtlasENSG00000165806
Peptide AtlasP55210
HPRD03457
IPIIPI00221307   IPI00216674   IPI00216675   IPI00910107   IPI01010205   IPI00647486   IPI00514222   
Protein Interaction databases
DIP (DOE-UCLA)P55210
IntAct (EBI)P55210
FunCoupENSG00000165806
BioGRIDCASP7
STRING (EMBL)CASP7
ZODIACCASP7
Ontologies - Pathways
QuickGOP55210
Ontology : AmiGOcysteine-type endopeptidase activity  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  cytosol  proteolysis  apoptotic process  cellular component disassembly involved in execution phase of apoptosis  cysteine-type peptidase activity  activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c  execution phase of apoptosis  cysteine-type endopeptidase activity involved in execution phase of apoptosis  
Ontology : EGO-EBIcysteine-type endopeptidase activity  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  cytosol  proteolysis  apoptotic process  cellular component disassembly involved in execution phase of apoptosis  cysteine-type peptidase activity  activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c  execution phase of apoptosis  cysteine-type endopeptidase activity involved in execution phase of apoptosis  
Pathways : BIOCARTAInduction of apoptosis through DR3 and DR4/5 Death Receptors [Genes]    FAS signaling pathway ( CD95 ) [Genes]    B Cell Survival Pathway [Genes]    Apoptotic Signaling in Response to DNA Damage [Genes]    Role of Mitochondria in Apoptotic Signaling [Genes]    Apoptotic DNA fragmentation and tissue homeostasis [Genes]    HIV-I Nef: negative effector of Fas and TNF [Genes]    Caspase Cascade in Apoptosis [Genes]   
Pathways : KEGGApoptosis    TNF signaling pathway    Non-alcoholic fatty liver disease (NAFLD)    Alzheimer's disease    Pertussis    Legionellosis   
REACTOMEP55210 [protein]
REACTOME Pathways111459 [pathway]   111463 [pathway]   111464 [pathway]   111465 [pathway]   264870 [pathway]   
NDEx NetworkCASP7
Atlas of Cancer Signalling NetworkCASP7
Wikipedia pathwaysCASP7
Orthology - Evolution
OrthoDB840
GeneTree (enSembl)ENSG00000165806
Phylogenetic Trees/Animal Genes : TreeFamCASP7
HOVERGENP55210
HOGENOMP55210
Homologs : HomoloGeneCASP7
Homology/Alignments : Family Browser (UCSC)CASP7
Gene fusions - Rearrangements
Fusion : MitelmanCASP7/EDRF1 [10q25.3/10q26.13]  
Fusion : MitelmanFGFR2/CASP7 [10q26.13/10q25.3]  [t(10;10)(q25;q26)]  
Fusion: TCGACASP7 10q25.3 C10orf137 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCASP7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CASP7
dbVarCASP7
ClinVarCASP7
1000_GenomesCASP7 
Exome Variant ServerCASP7
ExAC (Exome Aggregation Consortium)CASP7 (select the gene name)
Genetic variants : HAPMAP840
Genomic Variants (DGV)CASP7 [DGVbeta]
DECIPHER (Syndromes)10:115439428-115490668  ENSG00000165806
CONAN: Copy Number AnalysisCASP7 
Mutations
ICGC Data PortalCASP7 
TCGA Data PortalCASP7 
Broad Tumor PortalCASP7
OASIS PortalCASP7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCASP7  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCASP7
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CASP7
DgiDB (Drug Gene Interaction Database)CASP7
DoCM (Curated mutations)CASP7 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CASP7 (select a term)
intoGenCASP7
NCG5 (London)CASP7
Cancer3DCASP7(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601761   
Orphanet
MedgenCASP7
Genetic Testing Registry CASP7
NextProtP55210 [Medical]
TSGene840
GENETestsCASP7
Huge Navigator CASP7 [HugePedia]
snp3D : Map Gene to Disease840
BioCentury BCIQCASP7
ClinGenCASP7
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD840
Chemical/Pharm GKB GenePA26091
Clinical trialCASP7
Miscellaneous
canSAR (ICR)CASP7 (select the gene name)
Probes
Litterature
PubMed199 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCASP7
EVEXCASP7
GoPubMedCASP7
iHOPCASP7
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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