| Note | |
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| Entity | Prostate Carcinoma |
| Disease | One study shows that the most powerful predictor of time to relapse of prostate cancer is a high ratio of cyclin A and B to the proliferation marker Ki67, i.e., the higher the ratio the longer time to relapse (Marshal et al., 1996). Another study, however, shows that high cyclin B1 expression in prostate cancer correlates with tumor grade and DNA ploidy but does not correlate with disease recurrence (Kallakury et al., 1999). Lower level of endogenous cyclin B1 increases the sensitivity of DNA mismatch repair-deficient prostate cancer cells to alkylating agents (Rasmussen et al., 2000). Overexpression of the oncogenic serine/threonine kinase PIM1 in prostate cancer cells increases cyclin B1 protein expression, which contributes to the development of polyploidy by delaying cytokinesis (Roh et al., 2005). The levels of cyclin B1 protein correlate with the ability of chemotherapy drugs to induce apoptosis of prostate cancer cells in vitro (Gomez et al., 2007). |
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| Entity | Breast Carcinoma |
| Disease | Treatment of MCF7 breast cancer cells with cyclin B1-specific antisense oligonucleotide blocks Taxol-induced apoptosis, suggesting that cyclin B1-associated CDK1 activity plays an important role in the induction of apoptosis by Taxol (Shen et al., 1998). Memory T cells specific for cyclin B1 peptides were isolated from patients with breast cancer (Kao et al., 2001). Nuclear cyclin B1-positive breast carcinoma is resistant to adjuvant therapy, and nuclear cyclin B1 immunoreactivity is a potent prognostic factor in breast carcinoma patients (Suzuki et al., 2007). However, another study did not find a correlation with cyclin B1 overexpression and a worse outcome in breast cancer patients (Peters et al., 2004). Downregulation of cyclin B1 inhibits proliferation of breast cancer cell lines and sensitizes to Taxol (Yuan et al., 2004; Androic et al., 2008). |
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| Entity | Non-Small Cell Lung Carcinoma (NSCLC) |
| Disease | Cyclin B1 is deregulated in NSCLC, particularly in the squamous cell carcinoma subtype (SCC), and a high level of cyclin B1 expression may be a prognostic marker for patients with early-stage SCC of the lung (Soria et al., 2000). Elevated levels of cyclin B1 expression may be an indicator of poor prognosis in NSCLC, particularly in non-SCC (Arinaga et al., 2003; Yoshida et al., 2004; Singhal et al., 2005). One study, however, did not find a prognostic relevance for cyclin B1 in NSCLC (Yoo et al., 2007). |
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| Entity | Small Cell Lung Carcinoma |
| Disease | Cyclin B1 expression closely correlates with the Ki-67 labeling index in small cell lung carcinomas, suggesting that cyclin B1 is one of the key factors regulating cell proliferation in pulmonary neuroendocrine tumors. However, cyclin B1 did not correlate with patient survival (Igarashi et al., 2004). |
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| Entity | Esophageal Squamous Cell Carcinoma (ESCC) |
| Disease | Cyclin B1 expression, especially nuclear, can be significant as a prognostic indicator in ESCC and may indicate a poor prognosis for patients (Murakami et al., 1999; Nozoe et al., 2002; Takeno et al., 2002). Isogenic ESCC cells overexpressing cyclin B1 reveal strong invasive growth and high potential of metastasis to lung in xenograft mice (Song et al., 2008). |
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| Entity | Head and Neck Squamous Carcinoma (HNSCC) |
| Disease | HNSCC overexpressing cyclin B1 may be resistant to radiation therapy and cyclin B1 may be an indicator of the risk of recurrence and metastasis in patients having HNSCC receiving radiation therapy (Hassan et al., 2002). |
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| Entity | Renal Cell Carcinoma (RCC) |
| Disease | Increased cyclin B1 in RCC and aberrant localization within the cytoplasm of tumor cells positively correlates with tumor progression, indicating the significant role of cyclin B1 in the development and pathogenesis of RCC. There may be prognostic value of cyclin B1 for RCC patients (Ikuerowo et al., 2006). |
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| Entity | Cervical Carcinoma |
| Disease | The relationship between human papillomavirus virus (HPV) typing and cyclin B1 expression was not significant in cervical intraepithelial neoplasia and invasive cancer (Hashiguchi et al., 2004). HPV-16 E1 E4 protein sequesters CDK1/cyclin B1 onto the cytokeratin network, prevents the accumulation of active CDK1/cyclin B1 complexes in the nucleus, and hence prevents mitosis. This may create an environment optimal for viral DNA replication (Davy et al., 2005). HPV-18 decreases the fidelity of mitotic checkpoints and increases CDK1-associated kinase activity relative to control populations. The G2 checkpoint is aberrant by virtue of the stabilization of cyclin B1 mRNA through the upregulation of HuR protein (Cho et al., 2006). Up-regulation of cyclin B1 expression occurs in cervical cancer and an aberrant expression of cyclin B1 might play an important role in cervical carcinogenesis (Zhao et al., 2006). Reduction of cyclin B1 in HeLa cervical carcinoma cell lines inhibits proliferation, induces apoptosis, and sensitizes to Taxol (Yuan et al., 2006). |
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| Entity | Ovarian Carcinoma |
| Disease | There is a significant correlation between percentages of polo-like kinase (PLK)-positive cells and histological grade of ovarian cancer. However, the expression of proliferating cell nuclear antigen, Ki-67, and cyclin B1 is independent of PLK expression (Takai et al., 2001). |
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| Entity | Pancreatic Cancer |
| Disease | Overexpression of CDK1, cyclin A, and cyclin B1 occurs in 54.8, 54.9 and 56.4%, respectively, of the pancreatic adenocarcinomas. The findings suggest that CDK1 and cyclin A play a role in the progression of pancreatic adenocarcinoma, while the clinical significance of cyclin B1 remains to be clarified because of its more random expression (Ito et al., 2002). |
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| Entity | Liver Cancer |
| Disease | Fifteen of 100 patients with hepatocellular carcinoma (HCC) have autoantibodies reactive with cyclin B1 (Covini et al., 1997). CDK1 overexpression is directly related to advanced stage, portal invasion, intrahepatic metastasis, poor differentiation, high alpha-fetoprotein level, large size, high Ki-67 labeling index, and poor prognosis. Cyclin A and B1 overexpression shows a similar tendency to that of CDK1, but they are not recognized as independent prognostic factors (Ito et al., 2000). Hepatitis C virus (HCV) proteins increase the activity of the cyclin B1-CDK1 complex via the p38 MAPK and JNK pathways and promotes nuclear import of cyclin B1 (Spaziani et al., 2006). TIS21 negatively regulates hepatocarcinogenesis in part by disruption of the FoxM1-cyclin B1 regulatory loop, thereby inhibiting proliferation of transformed cells developed in mouse and human livers (Park et al., 2008). |
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| Entity | Gastric Cancer |
| Disease | Cyclin B1 overexpression does not correlate with survival of patients with gastric cancer (Brien et al., 1998). Another study shows that cyclin B1 protein overexpression is closely associated with less aggressive gastric cancers (Yasuda et al., 2002). A third study shows that overexpression of cyclin B1 may play an important role in lymph node metastatic potential of gastric cancer (Kim, 2007). |
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| Entity | Colorectal Adenocarcinoma |
| Disease | The majority of colorectal cancers express high levels of cyclin B1, consistent with a high rate of cell proliferation (Wang et al., 1997). Cyclin B1 expression does not change in recurrent colorectal adenocarcinoma compared to primary tumors (Seong et al., 1999). A study suggests a close correlation between a lack of cyclin B1 immunostaining and a stronger metastatic behavior in colorectal cancer (Korenaga et al., 2002). Cyclin B1, but not cyclin G1, may promote colorectal carcinogenesis and later metastasis to lymph nodes (Li et al., 2003). High expression of cyclin B1 is a frequent and early event in colorectal carcinomas. However, cyclin B1 expression is neither a predictor of prognosis or survival in patients with colorectal cancer nor a suitable tool for identifying subgroups of patients at higher risk for disease recurrence (Grabsch et al., 2004; Bondi et al., 2005). Adenomatous polyposis coli (APC) is a substrate for recombinant human CDK1-cyclin B1, implicating phosphorylation as a mechanism for regulating APC function via a link to the cell cycle (Trzepacz et al., 1997). |
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| Entity | Thyroid Carcinoma |
| Disease | Cyclin B1 is overexpressed in four undifferentiated thyroid carcinomas (19.0%), but not in thyroid carcinomas of other types. CDK1 overexpression is also related to carcinoma differentiation (p < 0.0001), and is directly linked to cyclin A overexpression (p < 0.0001), but not to cyclin B1 overexpression (Ito et al., 2002). Cyclin B1 expression does not have any prognostic significance for poorly differentiated follicular thyroid carcinoma (Pulcrano et al., 2007). |
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| Entity | Tongue Carcinoma |
| Disease | Cyclin B1 is overexpressed in a subset of squamous cell carcinoma of the tongue and is associated with a more aggressive biological behavior of the disease (Hassan et al., 2001). |
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| Entity | Skin Melanoma |
| Disease | The expression of cyclin B1 (P < 0.0001) is significantly higher in melanomas in comparison with Spitz nevi (Stefanaki et al., 2007). |
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| Entity | Glioma |
| Disease | Cyclin B1 is a gene identified to be increased in glioma cells invading brain slice cultures (Holtkamp et al., 2005). Human glioma tissue microarrays indicate a positive expression rate of CDK1/cyclin B1 with a positive correlation with pathologic grades (Chen et al., 2008). |
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| Entity | Astrocytoma |
| Disease | Nuclear and cytoplasmic cyclin B1 immunostaining correlates well with the tumor grade but shows poor correlation with Ki-67 in astrocytomas (Allan et al., 2000). There is a significant increase in cyclin B1 (P = 0.002) expression with increasing grade from diffuse astrocytoma through anaplastic astrocytoma to glioblastoma, suggesting a potential as a marker of tumor grade (Scott et al., 2005). |
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| Entity | Medulloblastoma |
| Disease | Cyclin B1 expression shows no statistical significant effect on survival in medulloblastoma (Neben et al., 2004). Another study shows that the combined expression of MYC and the lactate dehydrogenase B (LDHB)/cyclin B1 gene signature is able to predict survival in medulloblastoma patients and are strong prognostic markers independent of the clinical parameters, metastasis, and residual disease (de Haas et al., 2008). |
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| Entity | Osteosarcoma |
| Disease | E2F-1 overexpression in the U2OS osteosarcoma cell line increases cyclin B1, CDK1 activity, sensitivity to paclitaxel, and the cellular growth rate. Knockdown of cyclin B1 using an RNA interference decreases cellular growth rate and an increases resistance to paclitaxel (Russo et al., 2006). |
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| Entity | Leukemia and Lymphoma |
| Disease | Derangement of cyclin B1 and CDK1 kinetics and functions is more profound in Hodgkin's disease than in anaplastic large cell lymphomas (Leoncini et al., 1998). Cyclin B1 and CDK1 appears to be involved in the genesis or progression of malignant lymphoma but only CDK1 is a useful marker for response to chemotherapy (Jin and Park, 2002). Overexpression of cyclin B1 in follicular lymphomas correlates with better response to chemotherapy (Bjorck et al., 2005). Nuclear and/or cytoplasmic staining in > or = 1% of diffuse large B-cell lymphoma cells is significantly associated with shorter overall survival (Obermann et al., 2005). Cyclin B1 protein accumulates in the nucleus of cells that are sensitive to gamma radiation-induced apoptosis (thymocytes, lymphoid cell lines), but remains cytoplasmic in apoptosis-resistant cells (primary and transformed fibroblasts) (Porter et al., 2003). |
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| Entity | Alzheimer's Disease (AD) |
| Disease | Cyclin B1 and CDK1 are enriched in neurons with neurofibrillary tangles (NFT), characteristic of AD. This suggests that aberrantly reexpressed cyclin B1/CDK1 in NFT-bearing neurons in AD brain contributes to the generation of M-phase phospho-epitopes in NFT (Vincent et al., 1997). Cyclin B1 is not detected in control subjects but is expressed in subiculum, dentate gyrus, and CA1 region of patients with AD pathology (Nagy et al., 1997). Aberrant expression of cyclin B1 is identified in the hippocampus, subiculum, locus coeruleus, and dorsal raphe nuclei, but not inferotemporal cortex or cerebellum of AD cases. Control subjects show no significant expression of cyclin B1 in any of the six regions. Disregulation of various components of the cell cycle may be a significant contributor to regionally specific neuronal death in AD (Busser et al., 1998). Direct interactions between cyclin B1 and Abeta may provide potential mechanisms for the cytotoxicity of the Abeta peptide (Milton, 2002). CIP-1-associated regulator of cyclin B (CARB), a protein that associates with cyclin B1, increases in intraneuronal NFT neurofibrillary tangles in susceptible hippocampal and cortical neurons in AD. By marked contrast, CARB is found only at background levels in these neuronal populations in nondiseased age-matched controls (Zhu et al., 2004). Cdh1/Hct1, an activator of the E3-ubiquitin ligase anaphase-promoting complex (APC) that promotes the ubiquitylation and degradation of mitotic cyclins, is required to prevent the accumulation of cyclin B1 in terminally differentiated neurons. By keeping cyclin B1 low, Cdh1 prevents these neurons from entering an aberrant S phase that leads to apoptotic cell death. These results provide an explanation for the mechanism of cyclin B1 reactivation that occurs in the brain of patients suffering from AD (Almeida et al., 2005). |
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| Entity | Neurodegenerative Disease |
| Disease | Neurons containing characteristic neurodegenerative lesions in a subset of diseases including Down Syndrome, Frontotemporal Dementia linked to chromosome 17, Progressive Supranuclear Palsy, Corticobasal Degeneration, Parkinson-Amyotrophic Lateral Sclerosis of Guam, Niemann Pick disease type C, and Pick's disease also display mitotic indices including cyclin B1 expression (Husseman et al., 2000). |
| Cytogenetics | Chromosome instability resulting from Tax-induced deficiency of cyclin B1 and securin may be the explanation for the highly aneuploid nature of adult T-cell leukemia cells (Liu et al., 2003). |
| | |
| Overexpression of cyclin A and cyclin B1 proteins in astrocytomas. |
| Allan K, Jordan RC, Ang LC, Taylor M, Young B. |
| Arch Pathol Lab Med. 2000 Feb;124(2):216-20. |
| PMID 10656729 |
| |
| Cdh1/Hct1-APC is essential for the survival of postmitotic neurons. |
| Almeida A, Bolanos JP, Moreno S. |
| J Neurosci. 2005 Sep 7;25(36):8115-21. |
| PMID 16148219 |
| |
| Targeting cyclin B1 inhibits proliferation and sensitizes breast cancer cells to taxol. |
| Androic I, Kramer A, Yan R, Rodel F, Gatje R, Kaufmann M, Strebhardt K, Yuan J. |
| BMC Cancer. 2008 Dec 29;8(1):391. [Epub ahead of print] |
| PMID 19113992 |
| |
| Clinical implication of cyclin B1 in non-small cell lung cancer. |
| Arinaga M, Noguchi T, Takeno S, Chujo M, Miura T, Kimura Y, Uchida Y. |
| Oncol Rep. 2003 Sep-Oct;10(5):1381-6. |
| PMID 12883711 |
| |
| Distinct sequence elements of cyclin B1 promote localization to chromatin, centrosomes, and kinetochores during mitosis. |
| Bentley AM, Normand G, Hoyt J, King RW. |
| Mol Biol Cell. 2007 Dec;18(12):4847-58. Epub 2007 Sep 19. |
| PMID 17881737 |
| |
| High expression of cyclin B1 predicts a favorable outcome in patients with follicular lymphoma. |
| Bjorck E, Ek S, Landgren O, Jerkeman M, Ehinger M, Bjorkholm M, Borrebaeck CA, Porwit-MacDonald A, Nordenskjold M. |
| Blood. 2005 Apr 1;105(7):2908-15. Epub 2004 Dec 2. |
| PMID 15576476 |
| |
| Expression and gene amplification of primary (A, B1, D1, D3, and E) and secondary (C and H) cyclins in colon adenocarcinomas and correlation with patient outcome. |
| Bondi J, Husdal A, Bukholm G, Nesland JM, Bakka A, Bukholm IR. |
| J Clin Pathol. 2005 May;58(5):509-14. |
| PMID 15858123 |
| |
| Cyclin B2-null mice develop normally and are fertile whereas cyclin B1-null mice die in utero. |
| Brandeis M, Rosewell I, Carrington M, Crompton T, Jacobs MA, Kirk J, Gannon J, Hunt T. |
| Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4344-9. |
| PMID 9539739 |
| |
| Prognostic factors in gastric cancer. |
| Brien TP, Depowski PL, Sheehan CE, Ross JS, McKenna BJ. |
| Mod Pathol. 1998 Sep;11(9):870-7. |
| PMID 9758367 |
| |
| Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain. |
| Busser J, Geldmacher DS, Herrup K. |
| J Neurosci. 1998 Apr 15;18(8):2801-7. |
| PMID 9525997 |
| |
| Overexpression of CDC2/CyclinB1 in gliomas, and CDC2 depletion inhibits proliferation of human glioma cells in vitro and in vivo. |
| Chen H, Huang Q, Dong J, Zhai DZ, Wang AD, Lan Q. |
| BMC Cancer. 2008 Jan 29;8:29. |
| PMID 18230152 |
| |
| Cyclin B1 is localized to unattached kinetochores and contributes to efficient microtubule attachment and proper chromosome alignment during mitosis. |
| Chen Q, Zhang X, Jiang Q, Clarke PR, Zhang C. |
| Cell Res. 2008 Feb;18(2):268-80. |
| PMID 18195732 |
| |
| Elevation of cyclin B1, active cdc2, and HuR in cervical neoplasia with human papillomavirus type 18 infection. |
| Cho NH, Kang S, Hong S, An HJ, Choi YH, Jeong GB, Choi HK. |
| Cancer Lett. 2006 Feb 8;232(2):170-8. |
| PMID 16458113 |
| |
| Immune response to cyclin B1 in hepatocellular carcinoma. |
| Covini G, Chan EK, Nishioka M, Morshed SA, Reed SI, Tan EM. |
| Hepatology. 1997 Jan;25(1):75-80. |
| PMID 8985268 |
| |
| Human papillomavirus type 16 E1 E4-induced G2 arrest is associated with cytoplasmic retention of active Cdk1/cyclin B1 complexes. |
| Davy CE, Jackson DJ, Raj K, Peh WL, Southern SA, Das P, Sorathia R, Laskey P, Middleton K, Nakahara T, Wang Q, Masterson PJ, Lambert PF, Cuthill S, Millar JB, Doorbar J. |
| J Virol. 2005 Apr;79(7):3998-4011. |
| PMID 15767402 |
| |
| Cyclin B1 and other cyclins as tumor antigens in immunosurveillance and immunotherapy of cancer. |
| Egloff AM, Vella LA, Finn OJ. |
| Cancer Res. 2006 Jan 1;66(1):6-9. Review |
| PMID 16397206 |
| |
| Increased expression of cyclin B1 sensitizes prostate cancer cells to apoptosis induced by chemotherapy. |
| Gomez LA, de Las Pozas A, Reiner T, Burnstein K, Perez-Stable C. |
| Mol Cancer Ther. 2007 May;6(5):1534-43. |
| PMID 17513602 |
| |
| Laser scanning cytometric analysis of cyclin B1 in primary human malignancies. |
| Gorczyca W, Sarode V, Juan G, Melamed MR, Darzynkiewicz Z. |
| Mod Pathol. 1997 May;10(5):457-62. |
| PMID 9160310 |
| |
| Prognostic value of cyclin B1 protein expression in colorectal cancer. |
| Grabsch H, Lickvers K, Hansen O, Takeno S, Willers R, Stock W, Gabbert HE, Mueller W. |
| Am J Clin Pathol. 2004 Oct;122(4):511-6. |
| PMID 15487447 |
| |
| Relationship between HPV typing and the status of G2 cell cycle regulators in cervical neoplasia. |
| Hashiguchi Y, Tsuda H, Nishimura S, Inoue T, Kawamura N, Yamamoto K. |
| Oncol Rep. 2004 Sep;12(3):587-91. |
| PMID 15289842 |
| |
| Cyclin B1 overexpression and resistance to radiotherapy in head and neck squamous cell carcinoma. |
| Hassan KA, Ang KK, El-Naggar AK, Story MD, Lee JI, Liu D, Hong WK, Mao L. |
| Cancer Res. 2002 Nov 15;62(22):6414-7. |
| PMID 12438226 |
| |
| Clinical significance of cyclin B1 protein expression in squamous cell carcinoma of the tongue. |
| Hassan KA, El-Naggar AK, Soria JC, Liu D, Hong WK, Mao L. |
| Clin Cancer Res. 2001 Aug;7(8):2458-62. |
| PMID 11489826 |
| |
| Brain slice invasion model reveals genes differentially regulated in glioma invasion. |
| Holtkamp N, Afanasieva A, Elstner A, van Landeghem FK, Konneker M, Kuhn SA, Kettenmann H, von Deimling A. |
| Biochem Biophys Res Commun. 2005 Nov 4;336(4):1227-33. |
| PMID 16171788 |
| |
| Mitotic activation: a convergent mechanism for a cohort of neurodegenerative diseases. |
| Husseman JW, Nochlin D, Vincent I. |
| Neurobiol Aging. 2000 Nov-Dec;21(6):815-28. |
| PMID 11124425 |
| |
| Divergent cyclin B1 expression and Rb/p16/cyclin D1 pathway aberrations among pulmonary neuroendocrine tumors. |
| Igarashi T, Jiang SX, Kameya T, Asamura H, Sato Y, Nagai K, Okayasu I. |
| Mod Pathol. 2004 Oct;17(10):1259-67. |
| PMID 15154011 |
| |
| Alteration of subcellular and cellular expression patterns of cyclin B1 in renal cell carcinoma is significantly related to clinical progression and survival of patients. |
| Ikuerowo SO, Kuczyk MA, Mengel M, van der Heyde E, Shittu OB, Vaske B, Jonas U, Machtens S, Serth J. |
| Int J Cancer. 2006 Aug 15;119(4):867-74. |
| PMID 16557593 |
| |
| Expression of the G2-M modulators in pancreatic adenocarcinoma. |
| Ito Y, Takeda T, Wakasa K, Tsujimoto M, Okada M, Matsuura N. |
| Pancreatology. 2002;2(2):138-45. |
| PMID 12123094 |
| |
| Expression of G2-M modulators in thyroid neoplasms: correlation of cyclin A, B1 and cdc2 with differentiation. |
| Ito Y, Yoshida H, Nakano K, Takamura Y, Kobayashi K, Yokozawa T, Matsuzuka F, Matsuura N, Kuma K, Miyauchi A. |
| Pathol Res Pract. 2002;198(6):397-402. |
| PMID 12166896 |
| |
| Expression of cyclin B1 and cdc2 in nodal non-Hodgkin's lymphoma and its prognostic implications. |
| Jin YH, Park CK. |
| J Korean Med Sci. 2002 Jun;17(3):322-7. |
| PMID 12068134 |
| |
| The prognostic significance of proliferation-associated nucleolar protein p120 expression in prostate adenocarcinoma: a comparison with cyclins A and B1, Ki-67, proliferating cell nuclear antigen, and p34cdc2. |
| Kallakury BV, Sheehan CE, Rhee SJ, Fisher HA, Kaufman RP Jr, Rifkin MD, Ross JS. |
| Cancer. 1999 Apr 1;85(7):1569-76. |
| PMID 10193948 |
| |
| Identification of cyclin B1 as a shared human epithelial tumor-associated antigen recognized by T cells. |
| Kao H, Marto JA, Hoffmann TK, Shabanowitz J, Finkelstein SD, Whiteside TL, Hunt DF, Finn OJ. |
| J Exp Med. 2001 Nov 5;194(9):1313-23. |
| PMID 11696596 |
| |
| Prognostic implications of cyclin B1, p34cdc2, p27(Kip1) and p53 expression in gastric cancer. |
| Kim DH. |
| Yonsei Med J. 2007 Aug 31;48(4):694-700. |
| PMID 17722244 |
| |
| The relationship between cyclin B1 overexpression and lymph node metastasis in human colorectal cancer. |
| Korenaga D, Takesue F, Yasuda M, Honda M, Nozoe T, Inutsuka S. |
| Surgery. 2002 Jan;131(1 Suppl):S114-20. |
| PMID 11821797 |
| |
| Cellular kinetic differences between Hodgkin's and anaplastic large cell lymphomas: relation to the expression of p34cdc2 and cyclin B-1. |
| Leoncini L, Megha T, Lazzi S, Bellan C, Luzi P, Tosi P, Cevenini G, Barbini P, Ascani S, Briskomatis A, Pileri S, Kraft R, Laissue JA, Cottier H. |
| Int J Cancer. 1998 Jul 29;77(3):408-14. |
| PMID 9663604 |
| |
| Cyclin B1, unlike cyclin G1, increases significantly during colorectal carcinogenesis and during later metastasis to lymph nodes. |
| Li JQ, Kubo A, Wu F, Usuki H, Fujita J, Bandoh S, Masaki T, Saoo K, Takeuchi H, Kobayashi S, Imaida K, Maeta H, Ishida T, Kuriyama S. |
| Int J Oncol. 2003 May;22(5):1101-10. |
| PMID 12684677 |
| |
| Human T-lymphotropic virus type 1 oncoprotein tax promotes unscheduled degradation of Pds1p/securin and Clb2p/cyclin B1 and causes chromosomal instability. |
| Liu B, Liang MH, Kuo YL, Liao W, Boros I, Kleinberger T, Blancato J, Giam CZ. |
| Mol Cell Biol. 2003 Aug;23(15):5269-81. |
| PMID 12861013 |
| |
| Expression of cell cycle-regulated proteins in prostate cancer. |
| Mashal RD, Lester S, Corless C, Richie JP, Chandra R, Propert KJ, Dutta A. |
| Cancer Res. 1996 Sep 15;56(18):4159-63. |
| PMID 8797586 |
| |
| The amyloid-beta peptide binds to cyclin B1 and increases human cyclin-dependent kinase-1 activity. |
| Milton NG. |
| Neurosci Lett. 2002 Apr 5;322(2):131-3. |
| PMID 11958860 |
| |
| Determination of the prognostic significance of cyclin B1 overexpression in patients with esophageal squamous cell carcinoma. |
| Murakami H, Furihata M, Ohtsuki Y, Ogoshi S. |
| Virchows Arch. 1999 Feb;434(2):153-8. |
| PMID 10071250 |
| |
| Cell cycle markers in the hippocampus in Alzheimer's disease. |
| Nagy Z, Esiri MM, Cato AM, Smith AD. |
| Acta Neuropathol. 1997 Jul;94(1):6-15. |
| PMID 9224524 |
| |
| Microarray-based screening for molecular markers in medulloblastoma revealed STK15 as independent predictor for survival. |
| Neben K, Korshunov A, Benner A, Wrobel G, Hahn M, Kokocinski F, Golanov A, Joos S, Lichter P. |
| Cancer Res. 2004 May 1;64(9):3103-11. |
| PMID 15126347 |
| |
| Characterization and expression of mammalian cyclin b3, a prepachytene meiotic cyclin. |
| Nguyen TB, Manova K, Capodieci P, Lindon C, Bottega S, Wang XY, Refik-Rogers J, Pines J, Wolgemuth DJ, Koff A. |
| J Biol Chem. 2002 Nov 1;277(44):41960-9. Epub 2002 Aug 15. |
| PMID 12185076 |
| |
| Significance of cyclin B1 expression as an independent prognostic indicator of patients with squamous cell carcinoma of the esophagus. |
| Nozoe T, Korenaga D, Kabashima A, Ohga T, Saeki H, Sugimachi K. |
| Clin Cancer Res. 2002 Mar;8(3):817-22. |
| PMID 11895914 |
| |
| Cyclin B1 expression is an independent prognostic marker for poor outcome in diffuse large B-cell lymphoma. |
| Obermann EC, Went P, Pehrs AC, Tzankov A, Wild PJ, Pileri S, Hofstaedter F, Dirnhofer S. |
| Oncol Rep. 2005 Dec;14(6):1461-7. |
| PMID 16273239 |
| |
| TIS21 negatively regulates hepatocarcinogenesis by disruption of cyclin B1-Forkhead box M1 regulation loop. |
| Park TJ, Kim JY, Oh SP, Kang SY, Kim BW, Wang HJ, Song KY, Kim HC, Lim IK. |
| Hepatology. 2008 May;47(5):1533-43. |
| PMID 18393292 |
| |
| Prognostic value of cell cycle regulator molecules in surgically resected stage I and II breast cancer. |
| Peters MG, Vidal Mdel C, Gimenez L, Mauro L, Armanasco E, Cresta C, Bal de Kier Joffe E, Puricelli L. |
| Oncol Rep. 2004 Nov;12(5):1143-50. |
| PMID 15492807 |
| |
| Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport. |
| Pines J, Hunter T. |
| J Cell Biol. 1991 Oct;115(1):1-17. |
| PMID 1717476 |
| |
| Nuclear localization of cyclin B1 regulates DNA damage-induced apoptosis. |
| Porter LA, Cukier IH, Lee JM. |
| Blood. 2003 Mar 1;101(5):1928-33. Epub 2002 Nov 7. |
| PMID 12424202 |
| |
| Poorly differentiated follicular thyroid carcinoma: prognostic factors and relevance of histological classification. |
| Pulcrano M, Boukheris H, Talbot M, Caillou B, Dupuy C, Virion A, De Vathaire F, Schlumberger M. |
| Thyroid. 2007 Jul;17(7):639-46. |
| PMID 17696834 |
| |
| The human cyclin B1 protein modulates sensitivity of DNA mismatch repair deficient prostate cancer cell lines to alkylating agents. |
| Rasmussen LJ, Rasmussen M, Lutzen A, Bisgaard HC, Singh KK. |
| Exp Cell Res. 2000 May 25;257(1):127-34. |
| PMID 10854060 |
| |
| Chromosomal instability induced by Pim-1 is passage-dependent and associated with dysregulation of cyclin B1. |
| Roh M, Song C, Kim J, Abdulkadir SA. |
| J Biol Chem. 2005 Dec 9;280(49):40568-77. Epub 2005 Oct 12. |
| PMID 16221667 |
| |
| E2F-1 overexpression in U2OS cells increases cyclin B1 levels and cdc2 kinase activity and sensitizes cells to antimitotic agents. |
| Russo AJ, Magro PG, Hu Z, Li WW, Peters R, Mandola J, Banerjee D, Bertino JR. |
| Cancer Res. 2006 Jul 15;66(14):7253-60. |
| PMID 16849574 |
| |
| Cdk1 is sufficient to drive the mammalian cell cycle. |
| Santamaria D, Barriere C, Cerqueira A, Hunt S, Tardy C, Newton K, Caceres JF, Dubus P, Malumbres M, Barbacid M. |
| Nature. 2007 Aug 16;448(7155):811-5. |
| PMID 17700700 |
| |
| Immunohistochemical estimation of cell cycle entry and phase distribution in astrocytomas: applications in diagnostic neuropathology. |
| Scott IS, Morris LS, Rushbrook SM, Bird K, Vowler SL, Burnet NG, Coleman N. |
| Neuropathol Appl Neurobiol. 2005 Oct;31(5):455-66. |
| PMID 16150117 |
| |
| Assessment of biomarkers in paired primary and recurrent colorectal adenocarcinomas. |
| Seong J, Chung EJ, Kim H, Kim GE, Kim NK, Sohn SK, Min JS, Suh CO. |
| Int J Radiat Oncol Biol Phys. 1999 Dec 1;45(5):1167-73. |
| PMID 10613309 |
| |
| Taxol-induced p34cdc2 kinase activation and apoptosis inhibited by 12-O-tetradecanoylphorbol-13-acetate in human breast MCF-7 carcinoma cells. |
| Shen SC, Huang TS, Jee SH, Kuo ML. |
| Cell Growth Differ. 1998 Jan;9(1):23-9. |
| PMID 9438385 |
| |
| Prognostic implications of cell cycle, apoptosis, and angiogenesis biomarkers in non-small cell lung cancer: a review. |
| Singhal S, Vachani A, Antin-Ozerkis D, Kaiser LR, Albelda SM. |
| Clin Cancer Res. 2005 Jun 1;11(11):3974-86. Review |
| PMID 15930332 |
| |
| Overexpression of cyclin B1 in human esophageal squamous cell carcinoma cells induces tumor cell invasive growth and metastasis. |
| Song Y, Zhao C, Dong L, Fu M, Xue L, Huang Z, Tong T, Zhou Z, Chen A, Yang Z, Lu N, Zhan Q. |
| Carcinogenesis. 2008 Feb;29(2):307-15. Epub 2007 Nov 28. |
| PMID 18048386 |
| |
| Overexpression of cyclin B1 in early-stage non-small cell lung cancer and its clinical implication. |
| Soria JC, Jang SJ, Khuri FR, Hassan K, Liu D, Hong WK, Mao L. |
| Cancer Res. 2000 Aug 1;60(15):4000-4. |
| PMID 10945597 |
| |
| Role of p38 MAPK and RNA-dependent protein kinase (PKR) in hepatitis C virus core-dependent nuclear delocalization of cyclin B1. |
| Spaziani A, Alisi A, Sanna D, Balsano C. |
| J Biol Chem. 2006 Apr 21;281(16):10983-9. Epub 2006 Jan 30. |
| PMID 16446363 |
| |
| Cell cycle and apoptosis regulators in Spitz nevi: comparison with melanomas and common nevi. |
| Stefanaki C, Stefanaki K, Antoniou C, Argyrakos T, Patereli A, Stratigos A, Katsambas A. |
| J Am Acad Dermatol. 2007 May;56(5):815-24. |
| PMID 17437889 |
| |
| Nuclear cyclin B1 in human breast carcinoma as a potent prognostic factor. |
| Suzuki T, Urano T, Miki Y, Moriya T, Akahira J, Ishida T, Horie K, Inoue S, Sasano H. |
| Cancer Sci. 2007 May;98(5):644-51. Epub 2007 Mar 14. |
| PMID 17359284 |
| |
| Expression of polo-like kinase in ovarian cancer is associated with histological grade and clinical stage. |
| Takai N, Miyazaki T, Fujisawa K, Nasu K, Hamanaka R, Miyakawa I. |
| Cancer Lett. 2001 Mar 10;164(1):41-9. |
| PMID 11166914 |
| |
| Prognostic value of cyclin B1 in patients with esophageal squamous cell carcinoma. |
| Takeno S, Noguchi T, Kikuchi R, Uchida Y, Yokoyama S, Muller W. |
| Cancer. 2002 Jun 1;94(11):2874-81. |
| PMID 12115375 |
| |
| Phosphorylation of the tumor suppressor adenomatous polyposis coli (APC) by the cyclin-dependent kinase p34. |
| Trzepacz C, Lowy AM, Kordich JJ, Groden J. |
| J Biol Chem. 1997 Aug 29;272(35):21681-4. |
| PMID 9268294 |
| |
| Aberrant expression of mitotic cdc2/cyclin B1 kinase in degenerating neurons of Alzheimer's disease brain. |
| Vincent I, Jicha G, Rosado M, Dickson DW. |
| J Neurosci. 1997 May 15;17(10):3588-98. |
| PMID 9133382 |
| |
| Overexpression of cyclin B1 in human colorectal cancers. |
| Wang A, Yoshimi N, Ino N, Tanaka T, Mori H. |
| J Cancer Res Clin Oncol. 1997;123(2):124-7. |
| PMID 9030252 |
| |
| Overexpression of cyclin B1 in gastric cancer and its clinicopathological significance: an immunohistological study. |
| Yasuda M, Takesue F, Inutsuka S, Honda M, Nozoe T, Korenaga D. |
| J Cancer Res Clin Oncol. 2002 Aug;128(8):412-6. Epub 2002 Jul 26. |
| PMID 12200597 |
| |
| Immunohistochemical analysis of non-small cell lung cancer: correlation with clinical parameters and prognosis. |
| Yoo J, Jung JH, Lee MA, Seo KJ, Shim BY, Kim SH, Cho DG, Ahn MI, Kim CH, Cho KD, Kang SJ, Kim HK. |
| J Korean Med Sci. 2007 Apr;22(2):318-25. |
| PMID 17449943 |
| |
| The clinical significance of Cyclin B1 and Wee1 expression in non-small-cell lung cancer. |
| Yoshida T, Tanaka S, Mogi A, Shitara Y, Kuwano H. |
| Ann Oncol. 2004 Feb;15(2):252-6. |
| PMID 14760118 |
| |
| Stable gene silencing of cyclin B1 in tumor cells increases susceptibility to taxol and leads to growth arrest in vivo. |
| Yuan J, Kramer A, Matthess Y, Yan R, Spankuch B, Gatje R, Knecht R, Kaufmann M, Strebhardt K. |
| Oncogene. 2006 Mar 16;25(12):1753-62. |
| PMID 16278675 |
| |
| Cyclin B1 depletion inhibits proliferation and induces apoptosis in human tumor cells. |
| Yuan J, Yan R, Kramer A, Eckerdt F, Roller M, Kaufmann M, Strebhardt K. |
| Oncogene. 2004 Jul 29;23(34):5843-52. |
| PMID 15208674 |
| |
| Expression profiling of cyclin B1 and D1 in cervical carcinoma. |
| Zhao M, Kim YT, Yoon BS, Kim SW, Kang MH, Kim SH, Kim JH, Kim JW, Park YW. |
| Exp Oncol. 2006 Mar;28(1):44-8. |
| PMID 16614707 |
| |
| Elevated expression of a regulator of the G2/M phase of the cell cycle, neuronal CIP-1-associated regulator of cyclin B, in Alzheimer's disease. |
| Zhu X, McShea A, Harris PL, Raina AK, Castellani RJ, Funk JO, Shah S, Atwood C, Bowen R, Bowser R, Morelli L, Perry G, Smith MA. |
| J Neurosci Res. 2004 Mar 1;75(5):698-703. |
| PMID 14991845 |
| |
| Molecular risk stratification of medulloblastoma patients based on immunohistochemical analysis of MYC, LDHB, and CCNB1 expression. |
| de Haas T, Hasselt N, Troost D, Caron H, Popovic M, Zadravec-Zaletel L, Grajkowska W, Perek M, Osterheld MC, Ellison D, Baas F, Versteeg R, Kool M. |
| Clin Cancer Res. 2008 Jul 1;14(13):4154-60. |
| PMID 18593994 |
| |
