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CD53 (CD53 molecule)

Written2007-12Pedro A Lazo
Instituto de Biologia Molecular y Celular del Cancer, CSIC-Universidad de Salamanca, campus Miguel de Unamuno, E-37007 Salamanca, Spain

(Note : for Links provided by Atlas : click)

Identity

Other aliasTSPAN25
Tetraspanin-25
Tspan-25
tetraspanin-25
CD53 glycoprotein
CD53 tetraspan antigen
MOX44
LocusID (NCBI) 963
Atlas_Id 983
Location 1p13.3  [Link to chromosome band 1p13]
Location_base_pair Starts at and ends at bp from pter
Local_order Telomere-KCNA3--Q8NHC3---CD53---C1orf103---TMEM77---CEPT1---DENND2D-Centromere
 
  Map of chromosomal region 1p13.3
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
HLCS (21q22.13) / CD53 (1p13.3)RBPMS (8p12) / CD53 (1p13.3)

DNA/RNA

 
  Exon-Intron structure of human CD53 gene.
Description Gene size: 26,77 Kbp; 8 exons.
Transcription Transcript length: 1,567 bps.

Protein

Note Size: 219 amino acids; 24341 Da; Four transmembrane domains.
Subcellular location: Plasma Membrane; endosomes.
 
  The CD53 protein has four transmembrane domains. Several residues are conserved and define the tetraspanin protein family. The protein is glycosylated (green) in its second extracellular loop. Internally the protein is palmitoylated (red lines). EC: extracellular.
Localisation Plasma membrane; endosomes; exoxomes.
Function Modifier of signal transduction.
Homology Member of the tetraspanin protein family.

Implicated in

Note
  
Entity T-cell acute lymphoblastic leukemia
Cytogenetics t(1;22)(p13;q13)
 
Location of breakpoint in chromosome region 1p13.3 in a case of T-ALL with a t(1;22)(p13;q13). The CD53 gene is not structurally altered. It is not known if its level of expression is affected.
Abnormal Protein None
  

Bibliography

Aberrant expression of tetraspanin molecules in B-cell chronic lymphoproliferative disorders and its correlation with normal B-cell maturation.
Barrena S, Almeida J, Yunta M, López A, Fern´ndez-Mosteirí N, Giralt M, Romero M, Perdiguer L, Delgado M, Orfao A, Lazo PA
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 2005 ; 19 (8) : 1376-1383.
PMID 15931266
 
Increased expression of the tetraspanins CD53 and CD63 on apoptotic human neutrophils.
Beinert T, Münzing S, Possinger K, Krombach F
Journal of leukocyte biology. 2000 ; 67 (3) : 369-373.
PMID 10733097
 
Interleukin-2 receptor beta chain locus rearrangement in a T-cell acute lymphoblastic leukemia.
Berger R, Bernard OA
Pathologie-biologie. 2007 ; 55 (1) : 56-58.
PMID 16697123
 
HindIII RFLP in the human CD53 gene on 1p13.
Gallego MI, Varas F, Lazo PA
Human molecular genetics. 1994 ; 3 (9) : page 1711.
PMID 7833942
 
The human CD53 gene, coding for a four transmembrane domain protein, maps to chromosomal region 1p13.
Gonzalez ME, Pardo-Manuel de Villena F, Fernandez-Ruiz E, Rodriguez de Cordoba S, Lazo PA
Genomics. 1993 ; 18 (3) : 725-728.
PMID 8307585
 
Tetraspanin functions and associated microdomains.
Hemler ME
Nature reviews. Molecular cell biology. 2005 ; 6 (10) : 801-811.
PMID 16314869
 
Differential cooperation between regulatory sequences required for human CD53 gene expression.
Hern´ndez-Torres J, Yunta M, Lazo PA
The Journal of biological chemistry. 2001 ; 276 (38) : 35405-35413.
PMID 11443129
 
Gene expression patterns in renal cell carcinoma assessed by complementary DNA microarray.
Higgins JP, Shinghal R, Gill H, Reese JH, Terris M, Cohen RJ, Fero M, Pollack JR, van de Rijn M, Brooks JD
The American journal of pathology. 2003 ; 162 (3) : 925-932.
PMID 12598325
 
Genomic structure of the human CD53 gene.
Korí V, Horejsí V
Immunogenetics. 1993 ; 38 (4) : 272-279.
PMID 8319976
 
Functional implications of tetraspanin proteins in cancer biology.
Lazo PA
Cancer science. 2007 ; 98 (11) : 1666-1677.
PMID 17727684
 
Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme.
Liang Y, Diehn M, Watson N, Bollen AW, Aldape KD, Nicholas MK, Lamborn KR, Berger MS, Botstein D, Brown PO, Israel MA
Proceedings of the National Academy of Sciences of the United States of America. 2005 ; 102 (16) : 5814-5819.
PMID 15827123
 
The CD53 and CEACAM-1 genes are genetic targets for early B cell factor.
Månsson R, Lagergren A, Hansson F, Smith E, Sigvardsson M
European journal of immunology. 2007 ; 37 (5) : 1365-1376.
PMID 17429843
 
Transmembrane-4 superfamily proteins CD81 (TAPA-1), CD82, CD63, and CD53 specifically associated with integrin alpha 4 beta 1 (CD49d/CD29).
Mannion BA, Berditchevski F, Kraeft SK, Chen LB, Hemler ME
Journal of immunology (Baltimore, Md. : 1950). 1996 ; 157 (5) : 2039-2047.
PMID 8757325
 
Recurrent infectious diseases in human CD53 deficiency.
Mollinedo F, Font´n G, Barasoain I, Lazo PA
Clinical and diagnostic laboratory immunology. 1997 ; 4 (2) : 229-231.
PMID 9067662
 
Gamma-glutamyl transpeptidase, an ecto-enzyme regulator of intracellular redox potential, is a component of TM4 signal transduction complexes.
Nichols TC, Guthridge JM, Karp DR, Molina H, Fletcher DR, Holers VM
European journal of immunology. 1998 ; 28 (12) : 4123-4129.
PMID 9862348
 
CD53, a protein with four membrane-spanning domains, mediates signal transduction in human monocytes and B cells.
Olweus J, Lund-Johansen F, Horejsi V
Journal of immunology (Baltimore, Md. : 1950). 1993 ; 151 (2) : 707-716.
PMID 8335905
 
Cross-linking of CD53 promotes activation of resting human B lymphocytes.
Rasmussen AM, Blomhoff HK, Stokke T, Horejsi V, Smeland EB
Journal of immunology (Baltimore, Md. : 1950). 1994 ; 153 (11) : 4997-5007.
PMID 7963560
 
Supramolecular complexes of MHC class I, MHC class II, CD20, and tetraspan molecules (CD53, CD81, and CD82) at the surface of a B cell line JY.
Szölló J, Horejsí V, Bene L, Angelisov´ P, Damjanovich S
Journal of immunology (Baltimore, Md. : 1950). 1996 ; 157 (7) : 2939-2946.
PMID 8816400
 
Chromosomal localization of the Ox-44 (CD53) leukocyte antigen gene in man and rodents.
Taguchi T, Bellacosa A, Zhou JY, Gilbert DJ, Lazo PA, Copeland NG, Jenkins NA, Tsichlis PN, Testa JR
Cytogenetics and cell genetics. 1993 ; 64 (3-4) : 217-221.
PMID 8404042
 
Determination of stromal signatures in breast carcinoma.
West RB, Nuyten DS, Subramanian S, Nielsen TO, Corless CL, Rubin BP, Montgomery K, Zhu S, Patel R, Hernandez-Boussard T, Goldblum JR, Brown PO, van de Vijver M, van de Rijn M
PLoS biology. 2005 ; 3 (6) : page e187.
PMID 15869330
 
Apoptosis protection and survival signal by the CD53 tetraspanin antigen.
Yunta M, Lazo PA
Oncogene. 2003 ; 22 (8) : 1219-1224.
PMID 12606948
 

Citation

This paper should be referenced as such :
Lazo, PA
CD53 (CD53 molecule)
Atlas Genet Cytogenet Oncol Haematol. 2008;12(4):303-305.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/CD53ID983ch1p13.html


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;21)(p13;q22) HLCS/CD53


External links

Nomenclature
Cards
AtlasCD53ID983ch1p13.txt
Aliases
Genomic and cartography
Gene and transcription
RefSeq transcript (Entrez)
RefSeq genomic (Entrez)
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)963
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Protein Interaction databases
Ontologies - Pathways
Clinical trials, drugs, therapy
Miscellaneous
canSAR (ICR) (select the gene name)
Probes
Litterature
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed


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