CD82 (CD82 molecule)

Alias_names	ST6
	KAI1
	kangai 1 (suppression of tumorigenicity 6, prostate; CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and antibody IA4))
	CD82 antigen
Alias_symbol (synonym)	R2
	IA4
	TSPAN27
Other alias	4F9
	C33
	GR15
	SAR2
	Tetraspanin-27
	Tspan-27
HGNC (Hugo)	CD82
LocusID (NCBI)	3732
Atlas_Id	41045
Location	11p11.2  [Link to chromosome band 11p11]
Location_base_pair	Starts at 44565591 and ends at 44619765 bp from pter ( according to hg19-Feb_2009)  [Mapping CD82.png]
Local_order	LOC729793---LOC729798---ALX4---LOC646535---CD82---TSPAN18---TP53I11---LOC100131432---PRDM11---CHST1

Note	We do notice that, in literature, there is one more splicing variant with functional importance (Lee et al., 2003). In this variant, the 84bp exon that encodes the amino acids 215-242 of CD82/kAI1 protein is selectively deleted. However, the chromosome location and exon numbers of this splicing variant described in the publication are not consistent with those for the other two splicing variants herein. There is no gene accession number be assigned to this slicing variant. Thus, this variant is not presented in the following diagram.
	NM_002231 encodes the longer isoform, i.e., CD82 wild type; NM_001024844 encodes a shorter isoform, which lacks exon 6.
Description	Gene type: protein coding. Gene size: 54.2 kb. Two splicing variants in addition to wild type (NM_002231 or CD82 wild type consists of 10 exons; NM_001024844 or the splicing variant lacking exon 6 and the splicing variant likely lacking exon 8 consist of 9 exons).
Transcription	Transcript length: NM_002231 is 1715 bp; NM_001024844 is 1640 bp; and the splicing variant likely lacking exon 8 is 1631 bp.

	CD82 is a 4-transmembrane glycoprotein and belongs to the tetraspanin superfamily. This family of proteins is characterized by the conservation of several motifs located within the extracellular and transmembrane domains. CD82 undergoes two types of post-translational modifications: glycosylation at its large extracellular loop and palmitoylation at the cysteine residues in or near cytoplasmic domains.
Description	Size: 267 amino acids. Because of the glycosylation, the molecular weight of CD82 proteins ranges between 30-90 kDa depending on tissue and cell types.
Expression	CD82 is ubiquitously expressed in various human tissues such as epithelium and endothelium. CD82 expression is frequently diminished or lost in invasive and metastatic solid-tumor tissues.
Localisation	CD82 is found in the plasma membrane, endosomes, lysosomes, and exosomes.
Function	In relation to cancer, CD82 function is to inhibit tumor invasion and suppresses tumor metastasis. Palmitoylation is essential for CD82 function as well as the presence of three polar residues, NQE, located within its transmembrane domains. CD82 associates with other transmembrane proteins such as tetraspanins, integrins, Ig superfamily members, and growth factor receptors and intracellular signaling proteins to regulate membrane microdomain organization, vesicular trafficking, and transmembrane signaling.
Homology	Mouse and other human tetraspanins.

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