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CDK2 (cyclin dependent kinase 2)

Written2017-12Anette Gjörloff Wingren, Barnabas Nyesiga
Biomedical science, Health and society, Malmö University, Malmö, Sweden nyesigabarnabas@gmail.com; anette.gjorloff-wingren@mah.se

Abstract Review on CDK2, with data on DNA, on the protein encoded, and where the gene is implicated.

Keywords CDK2; Cell cycle; Mitosis; Apoptosis; Glioblastoma; Cholangiocarcinoma; Breast cancer; Prostate cancer; Oral squamous cell carcinoma; Ovarian cancer; Pemphigus vulgaris

(Note : for Links provided by Atlas : click)

Identity

Other aliasCyclin Dependent Kinase 2
Cell Division Protein Kinase 2
EC 2.7.11.22
CDKN2
CDC2-Related Protein Kinase
Cyclin-Dependent Kinase 2
P33(CDK2)
EC 2.7.11
HGNC (Hugo) CDK2
LocusID (NCBI) 1017
Atlas_Id 40031
Location 12q13.2  [Link to chromosome band 12q13]
Location_base_pair Starts at 55966769 and ends at 55972789 bp from pter ( according to hg19-Feb_2009)  [Mapping CDK2.png]
 
  Figure 1. Mapping of CDK2 gene on chromosome 12q13 (from GeneCards CDK2 gene)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

DNA/RNA

Description One of the two different human cDNAs that can complement cdc28 mutations of budding yeast Saccharomyces cerevisiae cloned by Ninomiya et al. corresponds to the CDK2 gene (Ninomiya 1991). Elledge et al. identified CDK2 as a second functional p34 homolog with the help of a human cDNA expression library to search for suppressors of cdc28 mutations in S. cerevisiae (Elledge 1991). CDK2 gene is mapped to 12q13 (Demetrick 1994) (Fig. 1). The cloning of approximately 2.4-kilobase pair genomic DNA fragment from the upstream region of the human CDK2 gene has been described (Shiffman 1996). The CDK2 gene fragment was found to contain 5 transcription initiation sites within a 72-bp stretch. A 200-bp subfragment that confers 70% of maximal basal promoter activity was shown to contain 2 synergistically acting Sp1 sites (Shiffman 1996). The intron-exon boundaries of 7 exons in this gene were also identified (Shiffman 1996). There are other reports of CDK2 gene expressed as a 2.1 kb transcript encoding a polypeptide of 298 amino acids and encodes the human homolog of the Xenopus Eg1 gene, sharing 89% amino acid identity (Elledge 1991).
Transcription The presence of CDK2 mRNA was observed late in G1 or in early S phase, slightly before CDC2 mRNA, under growth stimulation in normal human fibroblast cells (Ninomiya 1991). CDK2 mRNA has also been shown to be induced by serum in several cultured cell types (Shiffman 1996).

Protein

Description The CDK2 protein was found to be highly homologous to p34CDC2 kinase (65% identical) and more significantly homologous to Xenopus Eg1 kinase (89% identical), suggesting that CDK2 is the human homolog of Eg1 (Ninomiya 1991). CDK2 protein has a biological activity closely related to the CDC28 and CDK1 (Cdc2, p34CDC2) kinases (Ninomiya 1991) and the protein retains nearly all of the amino acids highly conserved among previously identified p34 homologs from other species (Elledge 1991). CDK2 is a mammalian Ser/Thr kinase that plays a critical role in controlling the progression from G1 to S phase of the cell cycle (Morgan 1997) and is functionally homologous to the well-studied cdc28a S. cerevisae protein (Zhao 2011). Monomeric CDK2 lacks regulatory activity requiring to be aroused by its positive regulators, cyclins E and A, or catalytic segment phosphorylation (Yan 2015). CDK2 activation is a two-step process; step one requires its association with the regulatory subunit cyclins A or E and step two involves phosphorylation of the residue Thr160 (Marcos 2011, Morris 2002, Pavletich 1999).
The crystal structure of the human CDK2 apoenzyme and its Mg2+ATP complex have been determined to 2.4 Å resolution (De Bondt 1993) while the crystal structure of CDK2-ATP complex has been determined at 2.3 Å resolution (Jeffrey 1995). Monomeric CDK2 is made of 298 amino acids (PDB code: 1HCL, residues 1-298), and folds into a typical bilobal structure, composed of a smaller N-terminal lobe (residues 1-85) that consists of antiparallel five-strand β-sheet and a major C-helix, together with a larger C-terminal lobe primarily composed of α-helix (De Bondt 1993). The two terminal domains are linked by a single peptide strand (residues 81-83) which acts as a hinge linker making sure that the two lobes can rotate with respect to each other without disruption of the secondary structure of this kinase (Cox 1994). Three binding sites have been reported in the monomeric CDK2 structure; the adenosine triphosphate (ATP) binding site (Site I) and two non-competitive binding sites (Site II and III). An allosteric binding site (Site IV) is generated as a result of structural changes that yield a variation of the ATP binding site when the kinase is subjected to the cyclin binding process (Yan 2015). Competitive binding site (Site I) is the most well-known ATP binding site, situated deep at the junction of the N and C domains. It includes the pivotal catalytic residues with high sensitivity and linker region (residues 81-83), and consists of 136 consecutive amino acids (10-145) on the CDK2 (Knockaert 2002). There is no association between non-competitive binding sites (site II and III) and catalytic subunits (Li 2013). Site III is also known to accommodate short peptides that partially dissociate the CDK2/cyclin E complex, thus obstructing the enzymatic activity of CDK2 (Chen 2009). The allosteric binding site (site IV) also known as ANS fluorophore 8-anilino-1-naphthalene sulfonate) binding pocket is located in a region that is adjacent to the C-helix, away from the ATP site, approximately halfway of the ATP site and the C-helix (Yan 2015).
Localisation The nuclear translocation of CDK2/cyclin E and cyclin E binding are needed for CDK2 enzymatic activation and substrate targeting because the CDK2 activating enzyme (CAK) and many of the CDK2 targets reside in the nucleus (Blanchard 2000, Dietrich 1997, Keenan 2001). Intracellular trafficking of CDK2 is unclear though some studies suggest that cyclins may play a role in the translocation of the cyclin/CDK complex via the classical importin α/β pathway (Moore 1999, Moore 2002). It is suggested that importin α binds to the nuclear localization signal on cyclins whereas importin β binds to nuclear transport machinery proteins as well as to cyclin-bound importin α. Translocation of the cyclin/CDK/importin α/β complex into the nucleus then occurs via an energy-dependent process (Flores 2010). Other studies have demonstrated consistent concentration of CDK2/cyclin E in the nucleus in both Drosophila embryos and cultured human cells (Knoblich 1994, Ohtsubo 1995), whereas CDK1 (Cdc2)/ CCNB1 (cyclin B1) is retained in the cytoplasm in interphase, entering the nucleus at the earliest stages of mitosis (Lehner and O'Farrell 1990, Pines and Hunter, 1994).  Other studies using egg extracts have shown how accumulation of CDK2/cyclin E in the nucleus is needed both for initiating DNA replication (Chevalier 1996) and preventing re-replication (Hua 1997, Walter 1998). There are indications that CDK2 nuclear translocation is associated with the formation of molecular complexes containing active MAP Kinase and is dependent on MAP Kinase activation (Blanchard 2000).
Function CDK2 activity has been indicated to be regulated by protein CDNK1B (p27KIP1) which inhibits CDK2 kinase activity in G0 and early G1 phase and leads to cell-cycle arrest (Polyak 1994). Once combined with its positive regulatory subunits, CDK2 fosters the transition of the well-established G1/S phase boundary and drives the cell cycle through S interval (Shapiro 2006, Sherr 1994, Pines 1991). CDK2/cyclin A is a necessity for orderly S-phase progression (Sherr 1994), while phosphorylation of retinoblastoma protein ( RB1) to facilitate the G1/S transition is mediated by CDK2/cyclin E complex (Pines 1991). CDK2/cyclin E phosphorylates Rb leading to the release and activation of E2F transcription factors required to promote transcription of genes that encode proteins required for G1 to S phase progression (Dyson 1998, Nevins 1998). CDK2 associates with both inactive and activated MAP Kinase and its activation is linked to formation of CDK2/ MAP Kinase complexes (Blanchard 2000). CDK2 is one of the most essential regulators for the transition and progression in a cell-division cycle and plays a crucial role in regulating multiple events of cell division cycle including centrosome duplication, DNA synthesis, G1-S transition, and modulation of G2 progression (Chohan 2015, De Boer 2008, Fiset 2011, Omar 2010). CDK2 is a requirement for robust DNA damage checkpoint signalling and loss of CDK2 was observed to cause a marked deficiency in the G2/M arrest which is a basic response to DNA damage in cells that were also nullizygous for P53 (Chung and Bunz, 2010). CDK2 plays a critical role in facilitating robust DNA damage checkpoint control by the ATR- CHEK1- CDC25A pathway. CDK2 seems to promote the formation of active ATR complexes by ATRIP phosphorylation and by CDC6 stabilization (Chung and Bunz, 2010). There is a possibility of CDK2 also controlling checkpoint signaling via additional mechanisms such as the recently described CDK2 interacting protein ( CINP) which facilitates robust ATR signalling (Lovejoy 2009). In addition, loss of CDK2 was demonstrated to alter the regulation of several proteins that are known to regulate S-phase progression, but also control mitotic entry, including CDC25A, CHK1, CDC6 and ATRIP (Donzelli and Draetta, 2003, Borlado and Mendez 2008, Cimprich and Cortez, 2008). Expression of CCNE1-CDK2 at physiologic levels of ATP results in phosphorylation of CDKN1B at thr187, leading to elimination of CDKN1B from the cell and progression of the cell cycle from G1 to S phase (Sheaff 1997). At low ATP levels, the inhibitory functions of CDKN1B are enhanced, thereby arresting cell proliferation (Sheaff 1997). Apoptosis of human endothelial cells after growth factor deprivation is associated with rapid and dramatic upregulation of cyclin A-associated CDK2 activity (Levkau 1998).  In apoptotic cells, the carboxyl-termini of the CDK inhibitors CDKN1A and CDKN1B are truncated by specific cleavage aided by CASP3 and/or a CASP3-like caspase. After cleavage, CDKN1A loses its nuclear localization sequence and exits the nucleus. Cleavage of CDKN1A and CDKN1B resulted in a substantial reduction in their association with nuclear cyclin-CDK2 complexes, leading to a dramatic induction of CDK2 activity. Dominant-negative CDK2, as well as a mutant CDKN1A resistant to caspase cleavage, partially suppressed apoptosis. CDK2 activation, through caspase-mediated cleavage of CDK inhibitors, may be instrumental in the execution of apoptosis following caspase activation (Levkau 1998). Forkhead box O (FOXO) are key regulators of cell survival and CDK2 is known to specifically phosphorylate FOXO1 at ser249 in vitro and in vivo resulting into cytoplasmic localization and inhibition of FOXO1 (Huang 2006).  Functional interaction between CDK2 and FOXO1 provides a mechanism that regulates apoptotic cell death after DNA strand breakage (Huang 2006). Proto-oncogenes such as MYC and RAS promote normal cell growth, fuel tumor development when deregulated and if over-activated can trigger intrinsic tumor suppressor mechanisms leading to apoptosis and senescence (Hydbring and Larsson, 2010). Ras is known to suppress Myc-induced apoptosis while Myc was recently discovered to repress Ras-induced senescence. The ability of Myc to suppress senescence is dependent on its phosphorylation at Ser 62 by CDK2. Using CDK2 as a cofactor, Myc is able to directly control major genes involved in senescence. Selective pharmacological inhibition of CDK2 was observed to force Myc/Ras expressing cells into cellular senescence, an indication that CDK2 is a potential therapeutic target for treatment of tumors driven by Myc or Ras (Hydbring and Larsson, 2010).

Implicated in

Note Among all the CDKs, CDK2 is known to be an important kinase in tumorigenesis and proliferation in many cancer types including lung cancer, liver cancer, colon cancer and breast cancer (Opyrchal 2014, Shi 2015, Lim 2014). There is strong evidence showing that CDK2 is functionally linked with hyper proliferation in multiple cancer cells and is a potential therapeutic target for cancer therapy (Chohan 2015).
  
Entity Prostate cancer
Note CDK2 has been found to play a pivotal role in cell proliferation of prostate cancer (Omar 2010).
  
  
Entity Breast cancer
Note CDK2 is also crucial for malignant transformation of breast epithelial cells. Suppression of CDK2 activity can effectively inhibit the proliferation of human breast cancer cells (Ali 2009). Active CDK2 in the form of a cyclin D1/CDK2 fusion protein induces tumors that contain an invasive component that exhibits multiple features in common with human basal-like tumors and tumor-derived cell lines (Corsino 2008). Cyclin D1/CDK2 complexes were detected in human breast cancer cell lines (Sweeney 1998), and the levels of these complexes correlated well with the degree of cyclin D1 overexpression.
  
  
Entity Ovarian cancer
Note The role of cyclin E and its associated kinase CDK2 in ovarian cancer has been investigated by screening primary, metastatic, recurrent and benign ovarian tumors. Using gene amplification, Cyclin E was shown to be amplified in 21% and CDK2 in 6.4% of the cases analyzed. Additionally, Cyclin E RNA was overexpressed in 29.5% and CDK2 in 6.5% of ovarian tumors tested. Cyclin E and CDK2 were overexpressed mostly in primary ovarian cancers (32% and 10%, respectively) compared to metastatic and recurrent diseases (Marone 1998).
  
  
Entity Glioblastoma
Note Wang et al. identified CDK2 expression to be significantly elevated in glioma tumor especially in Glioblastoma Multiforme (GBM) and was functionally required for GBM cell proliferation and tumorigenesis (Wang 2016). CDK2 expression was identified to be significantly enriched in GBM tumors and functionally required for tumor proliferation both in vitro and in vivo. Additionally, high CDK2 expression was associated to poor prognosis in GBM patients. Radio resistance is a major factor of poor clinical prognosis and tumor recurrence in GBM patients. CDK2 was found to be one of the most up-regulated kinase encoding genes in GBM after radio treatment. CDK2-dependent radio resistance is indispensable for GBM tumorigenesis and recurrence after therapeutic treatment (Wang 2016).
  
  
Entity Cholangiocarcinoma
Note Elevated levels of CDK2 expression have been observed in human cholangiocarcinoma tissues where apoptosis-related protein-1 dependent suppression of CDK2 induced cell cycle arrest and restrained tumor growth (Zheng 2016).
  
  
Entity Oral squamous cell carcinoma (SCC)
Note CDK2 overexpression in oral squamous cell carcinoma (SCC) may elevate pRB phosphorylation and permit more rapid entry of the cancer cells into S phase. In a clinicopathological survey of oral SCC, incidence of CDK2 expression was high in the poorly differentiated lesions, and was associated with the mode of tumor invasion, lymph node involvement and survival, an indication that change in CDK2 expression is associated with oral cancer progression (Mihara 2001). CDK2 expression was significantly correlated with lymph node involvement, tumor differentiation, mode of tumor invasion, and shorter survival period. Increased expression of CDK2 is both a critical factor in oral cancer progression and a negative predictive marker of the patients' prognosis (Mihara 2001).
  
  
Entity Lung cancer
Note CDK2 has been found to play a pivotal role in cell proliferation of non-small cell lung cancer (Kawana 1998).
  
  
Entity Pemphigus vulgaris (PV)
Disease Pemphigus vulgaris (PV) is an autoimmune blistering disease that affects skin and mucous membranes. CDK2 appeared to have a role in the development of PV lesions (Lanza 2008). Exposing of synchronized human keratinocytes to PV serum increased the proportion of cells in S phase, caused cell rounding and cell-cell detachment, elevated CDK2 expression in a dose-dependent manner, and altered the expression of over 500 genes especially those that are involved in cell communication and cell- cell junction formation. Small interfering RNA against CDK2 reversed PV serum-induced CDK2 overexpression and reduced cell-cell detachment. By utilizing a neonatal mouse model in which PV lesions were induced by a single intraperitoneal injection of whole serum obtained from a PV patient, it was shown that pre-treatment of mice with a pharmacologic CDK2 inhibitor prevented skin lesion development and PV serum-induced changes in gene expression. Histochemical analysis of PV patient skin revealed CDK2 overexpression around the site of the acantholytic cleft and along suprabasal layers in perilesional sites. It was finally concluded that activation of CDK2-mediated signaling is an essential event in the development of PV lesions (Lanza 2008).
  

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Citation

This paper should be referenced as such :
Gjörloff Wingren A, Nyesiga B
CDK2 (cyclin dependent kinase 2);
Atlas Genet Cytogenet Oncol Haematol. in press
On line version : http://AtlasGeneticsOncology.org/Genes/CDK2ID40031ch12q13.html


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(7;12)(p12;q13) IKZF1/CDK2


External links

Nomenclature
HGNC (Hugo)CDK2   1771
Cards
AtlasCDK2ID40031ch12q13
Entrez_Gene (NCBI)CDK2  1017  cyclin dependent kinase 2
AliasesCDKN2; p33(CDK2)
GeneCards (Weizmann)CDK2
Ensembl hg19 (Hinxton)ENSG00000123374 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000123374 [Gene_View]  ENSG00000123374 [Sequence]  chr12:55966769-55972789 [Contig_View]  CDK2 [Vega]
ICGC DataPortalENSG00000123374
TCGA cBioPortalCDK2
AceView (NCBI)CDK2
Genatlas (Paris)CDK2
WikiGenes1017
SOURCE (Princeton)CDK2
Genetics Home Reference (NIH)CDK2
Genomic and cartography
GoldenPath hg38 (UCSC)CDK2  -     chr12:55966769-55972789 +  12q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CDK2  -     12q13.2   [Description]    (hg19-Feb_2009)
EnsemblCDK2 - 12q13.2 [CytoView hg19]  CDK2 - 12q13.2 [CytoView hg38]
Mapping of homologs : NCBICDK2 [Mapview hg19]  CDK2 [Mapview hg38]
OMIM116953   
Gene and transcription
Genbank (Entrez)AA789250 AA810989 AB012305 AK291941 AK293246
RefSeq transcript (Entrez)NM_001290230 NM_001798 NM_052827
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CDK2
Cluster EST : UnigeneHs.689624 [ NCBI ]
CGAP (NCI)Hs.689624
Alternative Splicing GalleryENSG00000123374
Gene ExpressionCDK2 [ NCBI-GEO ]   CDK2 [ EBI - ARRAY_EXPRESS ]   CDK2 [ SEEK ]   CDK2 [ MEM ]
Gene Expression Viewer (FireBrowse)CDK2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1017
GTEX Portal (Tissue expression)CDK2
Human Protein AtlasENSG00000123374-CDK2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP24941   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP24941  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP24941
Splice isoforms : SwissVarP24941
Catalytic activity : Enzyme2.7.11.22 [ Enzyme-Expasy ]   2.7.11.222.7.11.22 [ IntEnz-EBI ]   2.7.11.22 [ BRENDA ]   2.7.11.22 [ KEGG ]   
PhosPhoSitePlusP24941
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)CDK2
DMDM Disease mutations1017
Blocks (Seattle)CDK2
PDB (SRS)1AQ1    1B38    1B39    1BUH    1CKP    1DI8    1DM2    1E1V    1E1X    1E9H    1F5Q    1FIN    1FQ1    1FVT    1FVV    1G5S    1GIH    1GII    1GIJ    1GY3    1GZ8    1H00    1H01    1H07    1H08    1H0V    1H0W    1H1P    1H1Q    1H1R    1H1S    1H24    1H25    1H26    1H27    1H28    1HCK    1HCL    1JST    1JSU    1JSV    1JVP    1KE5    1KE6    1KE7    1KE8    1KE9    1OGU    1OI9    1OIQ    1OIR    1OIT    1OIU    1OIY    1OKV    1OKW    1OL1    1OL2    1P2A    1P5E    1PF8    1PKD    1PW2    1PXI    1PXJ    1PXK    1PXL    1PXM    1PXN    1PXO    1PXP    1PYE    1QMZ    1R78    1URC    1URW    1V1K    1VYW    1VYZ    1W0X    1W8C    1W98    1WCC    1Y8Y    1Y91    1YKR    2A0C    2A4L    2B52    2B53    2B54    2B55    2BHE    2BHH    2BKZ    2BPM    2BTR    2BTS    2C4G    2C5N    2C5O    2C5V    2C5X    2C5Y    2C68    2C69    2C6I    2C6K    2C6L    2C6M    2C6O    2C6T    2CCH    2CCI    2CJM    2CLX    2DS1    2DUV    2EXM    2FVD    2G9X    2HIC    2I40    2IW6    2IW8    2IW9    2J9M    2JGZ    2R3F    2R3G    2R3H    2R3I    2R3J    2R3K    2R3L    2R3M    2R3N    2R3O    2R3P    2R3Q    2R3R    2R64    2UUE    2UZB    2UZD    2UZE    2UZL    2UZN    2UZO    2V0D    2V22    2VTA    2VTH    2VTI    2VTJ    2VTL    2VTM    2VTN    2VTO    2VTP    2VTQ    2VTR    2VTS    2VTT    2VU3    2VV9    2W05    2W06    2W17    2W1H    2WEV    2WFY    2WHB    2WIH    2WIP    2WMA    2WMB    2WPA    2WXV    2X1N    2XMY    2XNB    3BHT    3BHU    3BHV    3DDP    3DDQ    3DOG    3EID    3EJ1    3EOC    3EZR    3EZV    3F5X    3FZ1    3IG7    3IGG    3LE6    3LFN    3LFQ    3LFS    3MY5    3NS9    3PJ8    3PXF    3PXQ    3PXR    3PXY    3PXZ    3PY0    3PY1    3QHR    3QHW    3QL8    3QQF    3QQG    3QQH    3QQJ    3QQK    3QQL    3QRT    3QRU    3QTQ    3QTR    3QTS    3QTU    3QTW    3QTX    3QTZ    3QU0    3QWJ    3QWK    3QX2    3QX4    3QXO    3QXP    3QZF    3QZG    3QZH    3QZI    3R1Q    3R1S    3R1Y    3R28    3R6X    3R71    3R73    3R7E    3R7I    3R7U    3R7V    3R7Y    3R83    3R8L    3R8M    3R8P    3R8U    3R8V    3R8Z    3R9D    3R9H    3R9N    3R9O    3RAH    3RAI    3RAK    3RAL    3RJC    3RK5    3RK7    3RK9    3RKB    3RM6    3RM7    3RMF    3RNI    3ROY    3RPO    3RPR    3RPV    3RPY    3RZB    3S00    3S0O    3S1H    3S2P    3SQQ    3SW4    3SW7    3TI1    3TIY    3TIZ    3TNW    3ULI    3UNJ    3UNK    3WBL    4ACM    4BCK    4BCM    4BCN    4BCO    4BCP    4BCQ    4BGH    4BZD    4CFM    4CFN    4CFU    4CFV    4CFW    4CFX    4D1X    4D1Z    4EK3    4EK4    4EK5    4EK6    4EK8    4EOI    4EOJ    4EOK    4EOL    4EOM    4EON    4EOO    4EOP    4EOQ    4EOR    4EOS    4ERW    4EZ3    4EZ7    4FKG    4FKI    4FKJ    4FKL    4FKO    4FKP    4FKQ    4FKR    4FKS    4FKT    4FKU    4FKV    4FKW    4FX3    4GCJ    4I3Z    4II5    4KD1    4LYN    4NJ3    4RJ3    5A14    5AND    5ANE    5ANG    5ANI    5ANJ    5ANK    5ANO    5CYI    5D1J    5FP5    5FP6    5IEV    5IEX    5IEY    5IF1    5K4J    5L2W    5LMK    5LQE   
PDB (PDBSum)1AQ1    1B38    1B39    1BUH    1CKP    1DI8    1DM2    1E1V    1E1X    1E9H    1F5Q    1FIN    1FQ1    1FVT    1FVV    1G5S    1GIH    1GII    1GIJ    1GY3    1GZ8    1H00    1H01    1H07    1H08    1H0V    1H0W    1H1P    1H1Q    1H1R    1H1S    1H24    1H25    1H26    1H27    1H28    1HCK    1HCL    1JST    1JSU    1JSV    1JVP    1KE5    1KE6    1KE7    1KE8    1KE9    1OGU    1OI9    1OIQ    1OIR    1OIT    1OIU    1OIY    1OKV    1OKW    1OL1    1OL2    1P2A    1P5E    1PF8    1PKD    1PW2    1PXI    1PXJ    1PXK    1PXL    1PXM    1PXN    1PXO    1PXP    1PYE    1QMZ    1R78    1URC    1URW    1V1K    1VYW    1VYZ    1W0X    1W8C    1W98    1WCC    1Y8Y    1Y91    1YKR    2A0C    2A4L    2B52    2B53    2B54    2B55    2BHE    2BHH    2BKZ    2BPM    2BTR    2BTS    2C4G    2C5N    2C5O    2C5V    2C5X    2C5Y    2C68    2C69    2C6I    2C6K    2C6L    2C6M    2C6O    2C6T    2CCH    2CCI    2CJM    2CLX    2DS1    2DUV    2EXM    2FVD    2G9X    2HIC    2I40    2IW6    2IW8    2IW9    2J9M    2JGZ    2R3F    2R3G    2R3H    2R3I    2R3J    2R3K    2R3L    2R3M    2R3N    2R3O    2R3P    2R3Q    2R3R    2R64    2UUE    2UZB    2UZD    2UZE    2UZL    2UZN    2UZO    2V0D    2V22    2VTA    2VTH    2VTI    2VTJ    2VTL    2VTM    2VTN    2VTO    2VTP    2VTQ    2VTR    2VTS    2VTT    2VU3    2VV9    2W05    2W06    2W17    2W1H    2WEV    2WFY    2WHB    2WIH    2WIP    2WMA    2WMB    2WPA    2WXV    2X1N    2XMY    2XNB    3BHT    3BHU    3BHV    3DDP    3DDQ    3DOG    3EID    3EJ1    3EOC    3EZR    3EZV    3F5X    3FZ1    3IG7    3IGG    3LE6    3LFN    3LFQ    3LFS    3MY5    3NS9    3PJ8    3PXF    3PXQ    3PXR    3PXY    3PXZ    3PY0    3PY1    3QHR    3QHW    3QL8    3QQF    3QQG    3QQH    3QQJ    3QQK    3QQL    3QRT    3QRU    3QTQ    3QTR    3QTS    3QTU    3QTW    3QTX    3QTZ    3QU0    3QWJ    3QWK    3QX2    3QX4    3QXO    3QXP    3QZF    3QZG    3QZH    3QZI    3R1Q    3R1S    3R1Y    3R28    3R6X    3R71    3R73    3R7E    3R7I    3R7U    3R7V    3R7Y    3R83    3R8L    3R8M    3R8P    3R8U    3R8V    3R8Z    3R9D    3R9H    3R9N    3R9O    3RAH    3RAI    3RAK    3RAL    3RJC    3RK5    3RK7    3RK9    3RKB    3RM6    3RM7    3RMF    3RNI    3ROY    3RPO    3RPR    3RPV    3RPY    3RZB    3S00    3S0O    3S1H    3S2P    3SQQ    3SW4    3SW7    3TI1    3TIY    3TIZ    3TNW    3ULI    3UNJ    3UNK    3WBL    4ACM    4BCK    4BCM    4BCN    4BCO    4BCP    4BCQ    4BGH    4BZD    4CFM    4CFN    4CFU    4CFV    4CFW    4CFX    4D1X    4D1Z    4EK3    4EK4    4EK5    4EK6    4EK8    4EOI    4EOJ    4EOK    4EOL    4EOM    4EON    4EOO    4EOP    4EOQ    4EOR    4EOS    4ERW    4EZ3    4EZ7    4FKG    4FKI    4FKJ    4FKL    4FKO    4FKP    4FKQ    4FKR    4FKS    4FKT    4FKU    4FKV    4FKW    4FX3    4GCJ    4I3Z    4II5    4KD1    4LYN    4NJ3    4RJ3    5A14    5AND    5ANE    5ANG    5ANI    5ANJ    5ANK    5ANO    5CYI    5D1J    5FP5    5FP6    5IEV    5IEX    5IEY    5IF1    5K4J    5L2W    5LMK    5LQE   
PDB (IMB)1AQ1    1B38    1B39    1BUH    1CKP    1DI8    1DM2    1E1V    1E1X    1E9H    1F5Q    1FIN    1FQ1    1FVT    1FVV    1G5S    1GIH    1GII    1GIJ    1GY3    1GZ8    1H00    1H01    1H07    1H08    1H0V    1H0W    1H1P    1H1Q    1H1R    1H1S    1H24    1H25    1H26    1H27    1H28    1HCK    1HCL    1JST    1JSU    1JSV    1JVP    1KE5    1KE6    1KE7    1KE8    1KE9    1OGU    1OI9    1OIQ    1OIR    1OIT    1OIU    1OIY    1OKV    1OKW    1OL1    1OL2    1P2A    1P5E    1PF8    1PKD    1PW2    1PXI    1PXJ    1PXK    1PXL    1PXM    1PXN    1PXO    1PXP    1PYE    1QMZ    1R78    1URC    1URW    1V1K    1VYW    1VYZ    1W0X    1W8C    1W98    1WCC    1Y8Y    1Y91    1YKR    2A0C    2A4L    2B52    2B53    2B54    2B55    2BHE    2BHH    2BKZ    2BPM    2BTR    2BTS    2C4G    2C5N    2C5O    2C5V    2C5X    2C5Y    2C68    2C69    2C6I    2C6K    2C6L    2C6M    2C6O    2C6T    2CCH    2CCI    2CJM    2CLX    2DS1    2DUV    2EXM    2FVD    2G9X    2HIC    2I40    2IW6    2IW8    2IW9    2J9M    2JGZ    2R3F    2R3G    2R3H    2R3I    2R3J    2R3K    2R3L    2R3M    2R3N    2R3O    2R3P    2R3Q    2R3R    2R64    2UUE    2UZB    2UZD    2UZE    2UZL    2UZN    2UZO    2V0D    2V22    2VTA    2VTH    2VTI    2VTJ    2VTL    2VTM    2VTN    2VTO    2VTP    2VTQ    2VTR    2VTS    2VTT    2VU3    2VV9    2W05    2W06    2W17    2W1H    2WEV    2WFY    2WHB    2WIH    2WIP    2WMA    2WMB    2WPA    2WXV    2X1N    2XMY    2XNB    3BHT    3BHU    3BHV    3DDP    3DDQ    3DOG    3EID    3EJ1    3EOC    3EZR    3EZV    3F5X    3FZ1    3IG7    3IGG    3LE6    3LFN    3LFQ    3LFS    3MY5    3NS9    3PJ8    3PXF    3PXQ    3PXR    3PXY    3PXZ    3PY0    3PY1    3QHR    3QHW    3QL8    3QQF    3QQG    3QQH    3QQJ    3QQK    3QQL    3QRT    3QRU    3QTQ    3QTR    3QTS    3QTU    3QTW    3QTX    3QTZ    3QU0    3QWJ    3QWK    3QX2    3QX4    3QXO    3QXP    3QZF    3QZG    3QZH    3QZI    3R1Q    3R1S    3R1Y    3R28    3R6X    3R71    3R73    3R7E    3R7I    3R7U    3R7V    3R7Y    3R83    3R8L    3R8M    3R8P    3R8U    3R8V    3R8Z    3R9D    3R9H    3R9N    3R9O    3RAH    3RAI    3RAK    3RAL    3RJC    3RK5    3RK7    3RK9    3RKB    3RM6    3RM7    3RMF    3RNI    3ROY    3RPO    3RPR    3RPV    3RPY    3RZB    3S00    3S0O    3S1H    3S2P    3SQQ    3SW4    3SW7    3TI1    3TIY    3TIZ    3TNW    3ULI    3UNJ    3UNK    3WBL    4ACM    4BCK    4BCM    4BCN    4BCO    4BCP    4BCQ    4BGH    4BZD    4CFM    4CFN    4CFU    4CFV    4CFW    4CFX    4D1X    4D1Z    4EK3    4EK4    4EK5    4EK6    4EK8    4EOI    4EOJ    4EOK    4EOL    4EOM    4EON    4EOO    4EOP    4EOQ    4EOR    4EOS    4ERW    4EZ3    4EZ7    4FKG    4FKI    4FKJ    4FKL    4FKO    4FKP    4FKQ    4FKR    4FKS    4FKT    4FKU    4FKV    4FKW    4FX3    4GCJ    4I3Z    4II5    4KD1    4LYN    4NJ3    4RJ3    5A14    5AND    5ANE    5ANG    5ANI    5ANJ    5ANK    5ANO    5CYI    5D1J    5FP5    5FP6    5IEV    5IEX    5IEY    5IF1    5K4J    5L2W    5LMK    5LQE   
PDB (RSDB)1AQ1    1B38    1B39    1BUH    1CKP    1DI8    1DM2    1E1V    1E1X    1E9H    1F5Q    1FIN    1FQ1    1FVT    1FVV    1G5S    1GIH    1GII    1GIJ    1GY3    1GZ8    1H00    1H01    1H07    1H08    1H0V    1H0W    1H1P    1H1Q    1H1R    1H1S    1H24    1H25    1H26    1H27    1H28    1HCK    1HCL    1JST    1JSU    1JSV    1JVP    1KE5    1KE6    1KE7    1KE8    1KE9    1OGU    1OI9    1OIQ    1OIR    1OIT    1OIU    1OIY    1OKV    1OKW    1OL1    1OL2    1P2A    1P5E    1PF8    1PKD    1PW2    1PXI    1PXJ    1PXK    1PXL    1PXM    1PXN    1PXO    1PXP    1PYE    1QMZ    1R78    1URC    1URW    1V1K    1VYW    1VYZ    1W0X    1W8C    1W98    1WCC    1Y8Y    1Y91    1YKR    2A0C    2A4L    2B52    2B53    2B54    2B55    2BHE    2BHH    2BKZ    2BPM    2BTR    2BTS    2C4G    2C5N    2C5O    2C5V    2C5X    2C5Y    2C68    2C69    2C6I    2C6K    2C6L    2C6M    2C6O    2C6T    2CCH    2CCI    2CJM    2CLX    2DS1    2DUV    2EXM    2FVD    2G9X    2HIC    2I40    2IW6    2IW8    2IW9    2J9M    2JGZ    2R3F    2R3G    2R3H    2R3I    2R3J    2R3K    2R3L    2R3M    2R3N    2R3O    2R3P    2R3Q    2R3R    2R64    2UUE    2UZB    2UZD    2UZE    2UZL    2UZN    2UZO    2V0D    2V22    2VTA    2VTH    2VTI    2VTJ    2VTL    2VTM    2VTN    2VTO    2VTP    2VTQ    2VTR    2VTS    2VTT    2VU3    2VV9    2W05    2W06    2W17    2W1H    2WEV    2WFY    2WHB    2WIH    2WIP    2WMA    2WMB    2WPA    2WXV    2X1N    2XMY    2XNB    3BHT    3BHU    3BHV    3DDP    3DDQ    3DOG    3EID    3EJ1    3EOC    3EZR    3EZV    3F5X    3FZ1    3IG7    3IGG    3LE6    3LFN    3LFQ    3LFS    3MY5    3NS9    3PJ8    3PXF    3PXQ    3PXR    3PXY    3PXZ    3PY0    3PY1    3QHR    3QHW    3QL8    3QQF    3QQG    3QQH    3QQJ    3QQK    3QQL    3QRT    3QRU    3QTQ    3QTR    3QTS    3QTU    3QTW    3QTX    3QTZ    3QU0    3QWJ    3QWK    3QX2    3QX4    3QXO    3QXP    3QZF    3QZG    3QZH    3QZI    3R1Q    3R1S    3R1Y    3R28    3R6X    3R71    3R73    3R7E    3R7I    3R7U    3R7V    3R7Y    3R83    3R8L    3R8M    3R8P    3R8U    3R8V    3R8Z    3R9D    3R9H    3R9N    3R9O    3RAH    3RAI    3RAK    3RAL    3RJC    3RK5    3RK7    3RK9    3RKB    3RM6    3RM7    3RMF    3RNI    3ROY    3RPO    3RPR    3RPV    3RPY    3RZB    3S00    3S0O    3S1H    3S2P    3SQQ    3SW4    3SW7    3TI1    3TIY    3TIZ    3TNW    3ULI    3UNJ    3UNK    3WBL    4ACM    4BCK    4BCM    4BCN    4BCO    4BCP    4BCQ    4BGH    4BZD    4CFM    4CFN    4CFU    4CFV    4CFW    4CFX    4D1X    4D1Z    4EK3    4EK4    4EK5    4EK6    4EK8    4EOI    4EOJ    4EOK    4EOL    4EOM    4EON    4EOO    4EOP    4EOQ    4EOR    4EOS    4ERW    4EZ3    4EZ7    4FKG    4FKI    4FKJ    4FKL    4FKO    4FKP    4FKQ    4FKR    4FKS    4FKT    4FKU    4FKV    4FKW    4FX3    4GCJ    4I3Z    4II5    4KD1    4LYN    4NJ3    4RJ3    5A14    5AND    5ANE    5ANG    5ANI    5ANJ    5ANK    5ANO    5CYI    5D1J    5FP5    5FP6    5IEV    5IEX    5IEY    5IF1    5K4J    5L2W    5LMK    5LQE   
Structural Biology KnowledgeBase1AQ1    1B38    1B39    1BUH    1CKP    1DI8    1DM2    1E1V    1E1X    1E9H    1F5Q    1FIN    1FQ1    1FVT    1FVV    1G5S    1GIH    1GII    1GIJ    1GY3    1GZ8    1H00    1H01    1H07    1H08    1H0V    1H0W    1H1P    1H1Q    1H1R    1H1S    1H24    1H25    1H26    1H27    1H28    1HCK    1HCL    1JST    1JSU    1JSV    1JVP    1KE5    1KE6    1KE7    1KE8    1KE9    1OGU    1OI9    1OIQ    1OIR    1OIT    1OIU    1OIY    1OKV    1OKW    1OL1    1OL2    1P2A    1P5E    1PF8    1PKD    1PW2    1PXI    1PXJ    1PXK    1PXL    1PXM    1PXN    1PXO    1PXP    1PYE    1QMZ    1R78    1URC    1URW    1V1K    1VYW    1VYZ    1W0X    1W8C    1W98    1WCC    1Y8Y    1Y91    1YKR    2A0C    2A4L    2B52    2B53    2B54    2B55    2BHE    2BHH    2BKZ    2BPM    2BTR    2BTS    2C4G    2C5N    2C5O    2C5V    2C5X    2C5Y    2C68    2C69    2C6I    2C6K    2C6L    2C6M    2C6O    2C6T    2CCH    2CCI    2CJM    2CLX    2DS1    2DUV    2EXM    2FVD    2G9X    2HIC    2I40    2IW6    2IW8    2IW9    2J9M    2JGZ    2R3F    2R3G    2R3H    2R3I    2R3J    2R3K    2R3L    2R3M    2R3N    2R3O    2R3P    2R3Q    2R3R    2R64    2UUE    2UZB    2UZD    2UZE    2UZL    2UZN    2UZO    2V0D    2V22    2VTA    2VTH    2VTI    2VTJ    2VTL    2VTM    2VTN    2VTO    2VTP    2VTQ    2VTR    2VTS    2VTT    2VU3    2VV9    2W05    2W06    2W17    2W1H    2WEV    2WFY    2WHB    2WIH    2WIP    2WMA    2WMB    2WPA    2WXV    2X1N    2XMY    2XNB    3BHT    3BHU    3BHV    3DDP    3DDQ    3DOG    3EID    3EJ1    3EOC    3EZR    3EZV    3F5X    3FZ1    3IG7    3IGG    3LE6    3LFN    3LFQ    3LFS    3MY5    3NS9    3PJ8    3PXF    3PXQ    3PXR    3PXY    3PXZ    3PY0    3PY1    3QHR    3QHW    3QL8    3QQF    3QQG    3QQH    3QQJ    3QQK    3QQL    3QRT    3QRU    3QTQ    3QTR    3QTS    3QTU    3QTW    3QTX    3QTZ    3QU0    3QWJ    3QWK    3QX2    3QX4    3QXO    3QXP    3QZF    3QZG    3QZH    3QZI    3R1Q    3R1S    3R1Y    3R28    3R6X    3R71    3R73    3R7E    3R7I    3R7U    3R7V    3R7Y    3R83    3R8L    3R8M    3R8P    3R8U    3R8V    3R8Z    3R9D    3R9H    3R9N    3R9O    3RAH    3RAI    3RAK    3RAL    3RJC    3RK5    3RK7    3RK9    3RKB    3RM6    3RM7    3RMF    3RNI    3ROY    3RPO    3RPR    3RPV    3RPY    3RZB    3S00    3S0O    3S1H    3S2P    3SQQ    3SW4    3SW7    3TI1    3TIY    3TIZ    3TNW    3ULI    3UNJ    3UNK    3WBL    4ACM    4BCK    4BCM    4BCN    4BCO    4BCP    4BCQ    4BGH    4BZD    4CFM    4CFN    4CFU    4CFV    4CFW    4CFX    4D1X    4D1Z    4EK3    4EK4    4EK5    4EK6    4EK8    4EOI    4EOJ    4EOK    4EOL    4EOM    4EON    4EOO    4EOP    4EOQ    4EOR    4EOS    4ERW    4EZ3    4EZ7    4FKG    4FKI    4FKJ    4FKL    4FKO    4FKP    4FKQ    4FKR    4FKS    4FKT    4FKU    4FKV    4FKW    4FX3    4GCJ    4I3Z    4II5    4KD1    4LYN    4NJ3    4RJ3    5A14    5AND    5ANE    5ANG    5ANI    5ANJ    5ANK    5ANO    5CYI    5D1J    5FP5    5FP6    5IEV    5IEX    5IEY    5IF1    5K4J    5L2W    5LMK    5LQE   
SCOP (Structural Classification of Proteins)1AQ1    1B38    1B39    1BUH    1CKP    1DI8    1DM2    1E1V    1E1X    1E9H    1F5Q    1FIN    1FQ1    1FVT    1FVV    1G5S    1GIH    1GII    1GIJ    1GY3    1GZ8    1H00    1H01    1H07    1H08    1H0V    1H0W    1H1P    1H1Q    1H1R    1H1S    1H24    1H25    1H26    1H27    1H28    1HCK    1HCL    1JST    1JSU    1JSV    1JVP    1KE5    1KE6    1KE7    1KE8    1KE9    1OGU    1OI9    1OIQ    1OIR    1OIT    1OIU    1OIY    1OKV    1OKW    1OL1    1OL2    1P2A    1P5E    1PF8    1PKD    1PW2    1PXI    1PXJ    1PXK    1PXL    1PXM    1PXN    1PXO    1PXP    1PYE    1QMZ    1R78    1URC    1URW    1V1K    1VYW    1VYZ    1W0X    1W8C    1W98    1WCC    1Y8Y    1Y91    1YKR    2A0C    2A4L    2B52    2B53    2B54    2B55    2BHE    2BHH    2BKZ    2BPM    2BTR    2BTS    2C4G    2C5N    2C5O    2C5V    2C5X    2C5Y    2C68    2C69    2C6I    2C6K    2C6L    2C6M    2C6O    2C6T    2CCH    2CCI    2CJM    2CLX    2DS1    2DUV    2EXM    2FVD    2G9X    2HIC    2I40    2IW6    2IW8    2IW9    2J9M    2JGZ    2R3F    2R3G    2R3H    2R3I    2R3J    2R3K    2R3L    2R3M    2R3N    2R3O    2R3P    2R3Q    2R3R    2R64    2UUE    2UZB    2UZD    2UZE    2UZL    2UZN    2UZO    2V0D    2V22    2VTA    2VTH    2VTI    2VTJ    2VTL    2VTM    2VTN    2VTO    2VTP    2VTQ    2VTR    2VTS    2VTT    2VU3    2VV9    2W05    2W06    2W17    2W1H    2WEV    2WFY    2WHB    2WIH    2WIP    2WMA    2WMB    2WPA    2WXV    2X1N    2XMY    2XNB    3BHT    3BHU    3BHV    3DDP    3DDQ    3DOG    3EID    3EJ1    3EOC    3EZR    3EZV    3F5X    3FZ1    3IG7    3IGG    3LE6    3LFN    3LFQ    3LFS    3MY5    3NS9    3PJ8    3PXF    3PXQ    3PXR    3PXY    3PXZ    3PY0    3PY1    3QHR    3QHW    3QL8    3QQF    3QQG    3QQH    3QQJ    3QQK    3QQL    3QRT    3QRU    3QTQ    3QTR    3QTS    3QTU    3QTW    3QTX    3QTZ    3QU0    3QWJ    3QWK    3QX2    3QX4    3QXO    3QXP    3QZF    3QZG    3QZH    3QZI    3R1Q    3R1S    3R1Y    3R28    3R6X    3R71    3R73    3R7E    3R7I    3R7U    3R7V    3R7Y    3R83    3R8L    3R8M    3R8P    3R8U    3R8V    3R8Z    3R9D    3R9H    3R9N    3R9O    3RAH    3RAI    3RAK    3RAL    3RJC    3RK5    3RK7    3RK9    3RKB    3RM6    3RM7    3RMF    3RNI    3ROY    3RPO    3RPR    3RPV    3RPY    3RZB    3S00    3S0O    3S1H    3S2P    3SQQ    3SW4    3SW7    3TI1    3TIY    3TIZ    3TNW    3ULI    3UNJ    3UNK    3WBL    4ACM    4BCK    4BCM    4BCN    4BCO    4BCP    4BCQ    4BGH    4BZD    4CFM    4CFN    4CFU    4CFV    4CFW    4CFX    4D1X    4D1Z    4EK3    4EK4    4EK5    4EK6    4EK8    4EOI    4EOJ    4EOK    4EOL    4EOM    4EON    4EOO    4EOP    4EOQ    4EOR    4EOS    4ERW    4EZ3    4EZ7    4FKG    4FKI    4FKJ    4FKL    4FKO    4FKP    4FKQ    4FKR    4FKS    4FKT    4FKU    4FKV    4FKW    4FX3    4GCJ    4I3Z    4II5    4KD1    4LYN    4NJ3    4RJ3    5A14    5AND    5ANE    5ANG    5ANI    5ANJ    5ANK    5ANO    5CYI    5D1J    5FP5    5FP6    5IEV    5IEX    5IEY    5IF1    5K4J    5L2W    5LMK    5LQE   
CATH (Classification of proteins structures)1AQ1    1B38    1B39    1BUH    1CKP    1DI8    1DM2    1E1V    1E1X    1E9H    1F5Q    1FIN    1FQ1    1FVT    1FVV    1G5S    1GIH    1GII    1GIJ    1GY3    1GZ8    1H00    1H01    1H07    1H08    1H0V    1H0W    1H1P    1H1Q    1H1R    1H1S    1H24    1H25    1H26    1H27    1H28    1HCK    1HCL    1JST    1JSU    1JSV    1JVP    1KE5    1KE6    1KE7    1KE8    1KE9    1OGU    1OI9    1OIQ    1OIR    1OIT    1OIU    1OIY    1OKV    1OKW    1OL1    1OL2    1P2A    1P5E    1PF8    1PKD    1PW2    1PXI    1PXJ    1PXK    1PXL    1PXM    1PXN    1PXO    1PXP    1PYE    1QMZ    1R78    1URC    1URW    1V1K    1VYW    1VYZ    1W0X    1W8C    1W98    1WCC    1Y8Y    1Y91    1YKR    2A0C    2A4L    2B52    2B53    2B54    2B55    2BHE    2BHH    2BKZ    2BPM    2BTR    2BTS    2C4G    2C5N    2C5O    2C5V    2C5X    2C5Y    2C68    2C69    2C6I    2C6K    2C6L    2C6M    2C6O    2C6T    2CCH    2CCI    2CJM    2CLX    2DS1    2DUV    2EXM    2FVD    2G9X    2HIC    2I40    2IW6    2IW8    2IW9    2J9M    2JGZ    2R3F    2R3G    2R3H    2R3I    2R3J    2R3K    2R3L    2R3M    2R3N    2R3O    2R3P    2R3Q    2R3R    2R64    2UUE    2UZB    2UZD    2UZE    2UZL    2UZN    2UZO    2V0D    2V22    2VTA    2VTH    2VTI    2VTJ    2VTL    2VTM    2VTN    2VTO    2VTP    2VTQ    2VTR    2VTS    2VTT    2VU3    2VV9    2W05    2W06    2W17    2W1H    2WEV    2WFY    2WHB    2WIH    2WIP    2WMA    2WMB    2WPA    2WXV    2X1N    2XMY    2XNB    3BHT    3BHU    3BHV    3DDP    3DDQ    3DOG    3EID    3EJ1    3EOC    3EZR    3EZV    3F5X    3FZ1    3IG7    3IGG    3LE6    3LFN    3LFQ    3LFS    3MY5    3NS9    3PJ8    3PXF    3PXQ    3PXR    3PXY    3PXZ    3PY0    3PY1    3QHR    3QHW    3QL8    3QQF    3QQG    3QQH    3QQJ    3QQK    3QQL    3QRT    3QRU    3QTQ    3QTR    3QTS    3QTU    3QTW    3QTX    3QTZ    3QU0    3QWJ    3QWK    3QX2    3QX4    3QXO    3QXP    3QZF    3QZG    3QZH    3QZI    3R1Q    3R1S    3R1Y    3R28    3R6X    3R71    3R73    3R7E    3R7I    3R7U    3R7V    3R7Y    3R83    3R8L    3R8M    3R8P    3R8U    3R8V    3R8Z    3R9D    3R9H    3R9N    3R9O    3RAH    3RAI    3RAK    3RAL    3RJC    3RK5    3RK7    3RK9    3RKB    3RM6    3RM7    3RMF    3RNI    3ROY    3RPO    3RPR    3RPV    3RPY    3RZB    3S00    3S0O    3S1H    3S2P    3SQQ    3SW4    3SW7    3TI1    3TIY    3TIZ    3TNW    3ULI    3UNJ    3UNK    3WBL    4ACM    4BCK    4BCM    4BCN    4BCO    4BCP    4BCQ    4BGH    4BZD    4CFM    4CFN    4CFU    4CFV    4CFW    4CFX    4D1X    4D1Z    4EK3    4EK4    4EK5    4EK6    4EK8    4EOI    4EOJ    4EOK    4EOL    4EOM    4EON    4EOO    4EOP    4EOQ    4EOR    4EOS    4ERW    4EZ3    4EZ7    4FKG    4FKI    4FKJ    4FKL    4FKO    4FKP    4FKQ    4FKR    4FKS    4FKT    4FKU    4FKV    4FKW    4FX3    4GCJ    4I3Z    4II5    4KD1    4LYN    4NJ3    4RJ3    5A14    5AND    5ANE    5ANG    5ANI    5ANJ    5ANK    5ANO    5CYI    5D1J    5FP5    5FP6    5IEV    5IEX    5IEY    5IF1    5K4J    5L2W    5LMK    5LQE   
SuperfamilyP24941
Human Protein Atlas [tissue]ENSG00000123374-CDK2 [tissue]
Peptide AtlasP24941
HPRD00310
IPIIPI00031681   IPI00910650   IPI01025000   IPI01025117   IPI00260318   
Protein Interaction databases
DIP (DOE-UCLA)P24941
IntAct (EBI)P24941
FunCoupENSG00000123374
BioGRIDCDK2
STRING (EMBL)CDK2
ZODIACCDK2
Ontologies - Pathways
QuickGOP24941
Ontology : AmiGOG1/S transition of mitotic cell cycle  G2/M transition of mitotic cell cycle  G2/M transition of mitotic cell cycle  negative regulation of transcription by RNA polymerase II  cyclin-dependent protein kinase holoenzyme complex  chromosome, telomeric region  condensed chromosome  X chromosome  Y chromosome  protein serine/threonine kinase activity  cyclin-dependent protein serine/threonine kinase activity  cyclin-dependent protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  nucleoplasm  transcription factor complex  cytoplasm  endosome  centrosome  centrosome  cytosol  DNA replication  DNA repair  protein phosphorylation  potassium ion transport  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  centriole replication  Ras protein signal transduction  multicellular organism development  positive regulation of cell proliferation  response to organic substance  regulation of G2/M transition of mitotic cell cycle  Cajal body  kinase activity  histone phosphorylation  peptidyl-serine phosphorylation  protein domain specific binding  cyclin binding  cyclin binding  mitotic G1 DNA damage checkpoint  positive regulation of DNA-dependent DNA replication initiation  histone kinase activity  positive regulation of transcription, DNA-templated  metal ion binding  centrosome duplication  cell division  meiotic cell cycle  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  regulation of gene silencing  cellular response to nitric oxide  cyclin A1-CDK2 complex  cyclin A2-CDK2 complex  cyclin E1-CDK2 complex  cyclin E2-CDK2 complex  cyclin-dependent protein kinase activity  regulation of signal transduction by p53 class mediator  
Ontology : EGO-EBIG1/S transition of mitotic cell cycle  G2/M transition of mitotic cell cycle  G2/M transition of mitotic cell cycle  negative regulation of transcription by RNA polymerase II  cyclin-dependent protein kinase holoenzyme complex  chromosome, telomeric region  condensed chromosome  X chromosome  Y chromosome  protein serine/threonine kinase activity  cyclin-dependent protein serine/threonine kinase activity  cyclin-dependent protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  nucleoplasm  transcription factor complex  cytoplasm  endosome  centrosome  centrosome  cytosol  DNA replication  DNA repair  protein phosphorylation  potassium ion transport  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  centriole replication  Ras protein signal transduction  multicellular organism development  positive regulation of cell proliferation  response to organic substance  regulation of G2/M transition of mitotic cell cycle  Cajal body  kinase activity  histone phosphorylation  peptidyl-serine phosphorylation  protein domain specific binding  cyclin binding  cyclin binding  mitotic G1 DNA damage checkpoint  positive regulation of DNA-dependent DNA replication initiation  histone kinase activity  positive regulation of transcription, DNA-templated  metal ion binding  centrosome duplication  cell division  meiotic cell cycle  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  regulation of gene silencing  cellular response to nitric oxide  cyclin A1-CDK2 complex  cyclin A2-CDK2 complex  cyclin E1-CDK2 complex  cyclin E2-CDK2 complex  cyclin-dependent protein kinase activity  regulation of signal transduction by p53 class mediator  
Pathways : BIOCARTARegulation of p27 Phosphorylation during Cell Cycle Progression [Genes]    Cyclin E Destruction Pathway [Genes]    Influence of Ras and Rho proteins on G1 to S Transition [Genes]    Cyclins and Cell Cycle Regulation [Genes]    Estrogen-responsive protein Efp controls cell cycle and breast tumors growth [Genes]    Cell Cycle: G1/S Check Point [Genes]    CDK Regulation of DNA Replication [Genes]    RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage [Genes]    E2F1 Destruction Pathway [Genes]    p53 Signaling Pathway [Genes]   
Pathways : KEGGCell cycle   
REACTOMEP24941 [protein]
REACTOME PathwaysR-HSA-983231 [pathway]   
NDEx NetworkCDK2
Atlas of Cancer Signalling NetworkCDK2
Wikipedia pathwaysCDK2
Orthology - Evolution
OrthoDB1017
GeneTree (enSembl)ENSG00000123374
Phylogenetic Trees/Animal Genes : TreeFamCDK2
HOVERGENP24941
HOGENOMP24941
Homologs : HomoloGeneCDK2
Homology/Alignments : Family Browser (UCSC)CDK2
Gene fusions - Rearrangements
Fusion : QuiverCDK2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCDK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CDK2
dbVarCDK2
ClinVarCDK2
1000_GenomesCDK2 
Exome Variant ServerCDK2
ExAC (Exome Aggregation Consortium)ENSG00000123374
GNOMAD BrowserENSG00000123374
Genetic variants : HAPMAP1017
Genomic Variants (DGV)CDK2 [DGVbeta]
DECIPHERCDK2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCDK2 
Mutations
ICGC Data PortalCDK2 
TCGA Data PortalCDK2 
Broad Tumor PortalCDK2
OASIS PortalCDK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCDK2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCDK2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CDK2
DgiDB (Drug Gene Interaction Database)CDK2
DoCM (Curated mutations)CDK2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CDK2 (select a term)
intoGenCDK2
NCG5 (London)CDK2
Cancer3DCDK2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM116953   
Orphanet
DisGeNETCDK2
MedgenCDK2
Genetic Testing Registry CDK2
NextProtP24941 [Medical]
TSGene1017
GENETestsCDK2
Target ValidationCDK2
Huge Navigator CDK2 [HugePedia]
snp3D : Map Gene to Disease1017
BioCentury BCIQCDK2
ClinGenCDK2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1017
Chemical/Pharm GKB GenePA101
Clinical trialCDK2
Miscellaneous
canSAR (ICR)CDK2 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCDK2
EVEXCDK2
GoPubMedCDK2
iHOPCDK2
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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