| Cytogenetic analysis of melanocytes from premalignant nevi and melanomas. |
| Cowan JM, Halaban R, Francke U |
| Journal of the National Cancer Institute. 1988 ; 80 (14) : 1159-1164. |
| PMID 3166071 |
| |
| A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. |
| Serrano M, Hannon GJ, Beach D |
| Nature. 1993 ; 366 (6456) : 704-707. |
| PMID 8259215 |
| |
| A cell cycle regulator potentially involved in genesis of many tumor types. |
| Kamb A, Gruis NA, Weaver-Feldhaus J, Liu Q, Harshman K, Tavtigian SV, Stockert E, Day RS 3rd, Johnson BE, Skolnick MH |
| Science (New York, N.Y.). 1994 ; 264 (5157) : 436-440. |
| PMID 8153634 |
| |
| Germline p16 mutations in familial melanoma. |
| Hussussian CJ, Struewing JP, Goldstein AM, Higgins PA, Ally DS, Sheahan MD, Clark WH Jr, Tucker MA, Dracopoli NC |
| Nature genetics. 1994 ; 8 (1) : 15-21. |
| PMID 7987387 |
| |
| Frequent mutations of CDKN2 in primary pancreatic adenocarcinomas. |
| Bartsch D, Shevlin DW, Tung WS, Kisker O, Wells SA Jr, Goodfellow PJ |
| Genes, chromosomes & cancer. 1995 ; 14 (3) : 189-195. |
| PMID 8589035 |
| |
| Frequency of homozygous deletion at p16/CDKN2 in primary human tumours. |
| Cairns P, Polascik TJ, Eby Y, Tokino K, Califano J, Merlo A, Mao L, Herath J, Jenkins R, Westra W |
| Nature genetics. 1995 ; 11 (2) : 210-212. |
| PMID 7550353 |
| |
| Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition. |
| Koh J, Enders GH, Dynlacht BD, Harlow E |
| Nature. 1995 ; 375 (6531) : 506-510. |
| PMID 7777061 |
| |
| Methylation and p16: suppressing the suppressor. |
| Little M, Wainwright B |
| Nature medicine. 1995 ; 1 (7) : 633-634. |
| PMID 7585141 |
| |
| 5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. |
| Merlo A, Herman JG, Mao L, Lee DJ, Gabrielson E, Burger PC, Baylin SB, Sidransky D |
| Nature medicine. 1995 ; 1 (7) : 686-692. |
| PMID 7585152 |
| |
| Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest. |
| Quelle DE, Zindy F, Ashmun RA, Sherr CJ |
| Cell. 1995 ; 83 (6) : 993-1000. |
| PMID 8521522 |
| |
| Complex structure and regulation of the P16 (MTS1) locus. |
| Stone S, Jiang P, Dayananth P, Tavtigian SV, Katcher H, Parry D, Peters G, Kamb A |
| Cancer research. 1995 ; 55 (14) : 2988-2994. |
| PMID 7606716 |
| |
| Role of the INK4a locus in tumor suppression and cell mortality. |
| Serrano M, Lee H, Chin L, Cordon-Cardo C, Beach D, DePinho RA |
| Cell. 1996 ; 85 (1) : 27-37. |
| PMID 8620534 |
| |
| The CDKN2A (p16) gene and human cancer. |
| Foulkes WD, Flanders TY, Pollock PM, Hayward NK |
| Molecular medicine (Cambridge, Mass.). 1997 ; 3 (1) : 5-20. |
| PMID 9132280 |
| |
| Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF. |
| Quelle DE, Cheng M, Ashmun RA, Sherr CJ |
| Proceedings of the National Academy of Sciences of the United States of America. 1997 ; 94 (2) : 669-673. |
| PMID 9012842 |
| |
| Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice. |
| Krimpenfort P, Quon KC, Mooi WJ, Loonstra A, Berns A |
| Nature. 2001 ; 413 (6851) : 83-86. |
| PMID 11544530 |
| |
| Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis. |
| Sharpless NE, Bardeesy N, Lee KH, Carrasco D, Castrillon DH, Aguirre AJ, Wu EA, Horner JW, DePinho RA |
| Nature. 2001 ; 413 (6851) : 86-91. |
| PMID 11544531 |
| |
| The INK4a/ARF locus and melanoma. |
| Sharpless E, Chin L |
| Oncogene. 2003 ; 22 (20) : 3092-3098. |
| PMID 12789286 |
| |
| FAMMM syndrome: pathogenesis and management. |
| Czajkowski R, Placek W, Drewa G, Czajkowska A, Ucha‰Ñska G |
| Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. 2004 ; 30 (2 Pt 2) : 291-296. |
| PMID 14871223 |
| |
| Ink4a/Arf expression is a biomarker of aging. |
| Krishnamurthy J, Torrice C, Ramsey MR, Kovalev GI, Al-Regaiey K, Su L, Sharpless NE |
| The Journal of clinical investigation. 2004 ; 114 (9) : 1299-1307. |
| PMID 15520862 |
| |
| Oncogenic activity of Cdc6 through repression of the INK4/ARF locus. |
| Gonzalez S, Klatt P, Delgado S, Conde E, Lopez-Rios F, Sanchez-Cespedes M, Mendez J, Antequera F, Serrano M |
| Nature. 2006 ; 440 (7084) : 702-706. |
| PMID 16572177 |
| |
| p16INK4a induces an age-dependent decline in islet regenerative potential. |
| Krishnamurthy J, Ramsey MR, Ligon KL, Torrice C, Koh A, Bonner-Weir S, Sharpless NE |
| Nature. 2006 ; 443 (7110) : 453-457. |
| PMID 16957737 |
| |